{"id":"https://openalex.org/W560802965","doi":null,"title":"The synapse : structure and function","display_name":"The synapse : structure and function","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W560802965","mag":"560802965"},"language":"en","primary_location":{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-027737101","doi":null,"is_oa":false,"landing_page_url":"http://www.sciencedirect.com/science/book/9780124186750","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"software, multimedia"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079818001","display_name":"Virginia M. Pickel","orcid":"https://orcid.org/0000-0001-9374-724X","observed_orcids":["https://orcid.org/0000-0001-9374-724X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Virginia M. Pickel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5107517985","display_name":"Menahem Segal","orcid":"https://orcid.org/0000-0001-7592-0408","observed_orcids":["https://orcid.org/0000-0001-7592-0408"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Menahem Segal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7592-0408","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synapses","display_name":"synapses","score":0.7570000290870667},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.9940000176429749},{"id":"https://openalex.org/keywords/glutamatergic-synapses","display_name":"glutamatergic synapses","score":0.902999997138977},{"id":"https://openalex.org/keywords/synaptic-proteins","display_name":"synaptic proteins","score":0.6990000009536743},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tripartite-synapse","display_name":"tripartite synapse","score":0.9980000257492065},{"id":"https://openalex.org/keywords/calcium-sequestration","display_name":"calcium sequestration","score":0.9110000133514404},{"id":"https://openalex.org/keywords/local-protein-synthesis","display_name":"local protein synthesis","score":0.972000002861023},{"id":"https://openalex.org/keywords/axon-terminals","display_name":"axon terminals","score":0.8349999785423279},{"id":"https://openalex.org/keywords/synaptic-degeneration","display_name":"synaptic degeneration","score":0.6420000195503235},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.972000002861023},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.816565990447998},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.7813127040863037},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.6861437559127808},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.6284200549125671},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5408061742782593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5245388150215149},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.516000509262085},{"id":"https://openalex.org/C99223954","wikidata":"https://www.wikidata.org/wiki/Q5419646","display_name":"Excitatory synapse","level":4,"score":0.44943109154701233},{"id":"https://openalex.org/C154559735","wikidata":"https://www.wikidata.org/wiki/Q7514768","display_name":"Silent synapse","level":5,"score":0.41737979650497437},{"id":"https://openalex.org/C65232495","wikidata":"https://www.wikidata.org/wiki/Q1813773","display_name":"Synaptogenesis","level":2,"score":0.41695988178253174},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.4107131361961365},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.27335745096206665},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.15273571014404297},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06765663623809814},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.0},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-027737101","doi":null,"is_oa":false,"landing_page_url":"http://www.sciencedirect.com/science/book/9780124186750","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"software, multimedia"},{"id":"mag:560802965","doi":null,"is_oa":false,"landing_page_url":"https://ci.nii.ac.jp/ncid/BB14356609","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Elsevier eBooks","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1994769969","https://openalex.org/W633764906","https://openalex.org/W655933443","https://openalex.org/W4410523137","https://openalex.org/W7073743922","https://openalex.org/W3044288639","https://openalex.org/W1993853592","https://openalex.org/W4236395094","https://openalex.org/W2073746087","https://openalex.org/W2039503157"],"abstract_inverted_index":{"The":[0,67],"Synapse":[1],"summarizes":[2],"recent":[3],"advances":[4],"in":[5,106,143,174],"cellular":[6,22,88,206],"and":[7,13,20,36,41,48,56,77,87,93,100,113,152,171,177,189,201,204,218],"molecular":[8],"mechanisms":[9],"of":[10,24,38,95,119,125,133,191,208,215,228],"synaptic":[11,110],"transmission":[12,92],"provides":[14,29,116],"new":[15],"insights":[16],"into":[17],"neuronal":[18],"plasticity":[19,203],"the":[21,64,84,120,123,130,187,192,196,199,205],"basis":[23,207],"neurological":[25],"diseases.":[26],"Part":[27,49,81,114],"1":[28],"an":[30,117],"in-depth":[31,226],"look":[32],"at":[33,45],"structural":[34],"differences":[35,89],"distribution":[37],"various":[39],"pre-":[40],"post-synaptic":[42],"proteins":[43],"found":[44,105],"glutamatergic":[46,91],"synapses;":[47],"2":[50],"is":[51,148,165,181],"dedicated":[52],"to":[53,127,140,232,238],"dendritic":[54,216],"spines":[55,68,217],"their":[57],"associated":[58,219],"perisynaptic":[59,220],"glia,":[60],"which":[61],"together":[62],"constitute":[63],"tripartite":[65,222],"synapse.":[66,193,223],"are":[69,103],"portrayed":[70],"as":[71,98],"major":[72],"sites":[73],"for":[74,169],"calcium":[75,156],"sequestration":[76],"local":[78],"protein":[79],"synthesis.":[80],"3":[82],"highlights":[83],"important":[85],"regional":[86],"between":[90,198],"that":[94,102,138],"neurotransmitters":[96],"such":[97],"dopamine":[99],"acetylcholine":[101],"commonly":[104],"axon":[107],"terminals":[108],"without":[109],"membrane":[111],"specializations;":[112],"4":[115],"overview":[118],"synapse":[121,200,229],"from":[122,155],"time":[124],"formation":[126],"degeneration":[128,230],"under":[129],"powerful":[131],"influence":[132],"aging":[134,233],"or":[135,161,234],"hormonal":[136,235],"decline":[137,236],"leads":[139],"severe":[141,239],"deficits":[142],"cognitive":[144,240],"function.":[145],"Each":[146],"chapter":[147],"illustrated":[149],"with":[150],"drawings":[151],"images":[153],"derived":[154],"imaging,":[157],"electron":[158],"microscopic":[159],"immunolabeling,":[160],"electrophysiology.":[162],"This":[163],"book":[164],"a":[166,182],"valuable":[167],"reference":[168,184],"neuroscientists":[170],"clinical":[172,178],"neurologists":[173],"both":[175],"research":[176],"settings.":[179],"It":[180,194,211,224],"comprehensive":[183],"focused":[185],"on":[186],"structure":[188],"function":[190],"covers":[195],"links":[197],"neural":[202],"neurologic":[209],"disease.":[210],"includes":[212,225],"detailed":[213],"coverage":[214,227],"glia-the":[221],"due":[231],"related":[237],"impairment.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}