{"id":"https://openalex.org/W560372708","doi":null,"title":"Parkinson's Disease: An Experimental Approach to Model the Visuo-Spatial Learning and Memory Deficits and an Analysis of Evidence Implicating \u03b1-Synuclein in Lewy Body Formation","display_name":"Parkinson's Disease: An Experimental Approach to Model the Visuo-Spatial Learning and Memory Deficits and an Analysis of Evidence Implicating \u03b1-Synuclein in Lewy Body Formation","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W560372708","mag":"560372708"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.umaine.edu:honors-1136","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.umaine.edu/honors/137","pdf_url":"https://digitalcommons.library.umaine.edu/honors/137","source":{"id":"https://openalex.org/S4306402196","display_name":"DigitalCommons (California Polytechnic State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149919469","host_organization_name":"California Polytechnic State University","host_organization_lineage":["https://openalex.org/I149919469"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors College","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.umaine.edu/honors/137","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013919062","display_name":"Caitlyn D. Ahlberg","orcid":"https://orcid.org/0000-0003-4552-4900","observed_orcids":["https://orcid.org/0000-0003-4552-4900"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Caitlyn Dawn Ahlberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5013919062"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/non-motor-symptoms","display_name":"non-motor symptoms","score":0.8550000190734863},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.7749999761581421},{"id":"https://openalex.org/keywords/alpha-synuclein-aggregation","display_name":"alpha-synuclein aggregation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.8949999809265137},{"id":"https://openalex.org/keywords/striatal-lesions","display_name":"striatal lesions","score":0.7919999957084656},{"id":"https://openalex.org/keywords/parkinson-s-disease-model","display_name":"Parkinson's disease model","score":0.8659999966621399},{"id":"https://openalex.org/keywords/calpain","display_name":"calpain","score":0.7929999828338623},{"id":"https://openalex.org/keywords/pin1","display_name":"Pin1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/peptidyl-prolyl-cis-trans-isomerase","display_name":"peptidyl-prolyl isomerase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.8820000290870667},{"id":"https://openalex.org/keywords/protein-fibrillization","display_name":"protein fibrillization","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6712157130241394},{"id":"https://openalex.org/C56928146","wikidata":"https://www.wikidata.org/wiki/Q2934402","display_name":"Calpain","level":3,"score":0.6492472887039185},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5894396901130676},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5643141865730286},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.4703434109687805},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4626048803329468},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.43540680408477783},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4232666492462158},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.41342049837112427},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41286277770996094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34208714962005615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30088722705841064},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.23855888843536377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1827850639820099},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.16449704766273499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13062012195587158},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.08902069926261902},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.084567129611969},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.library.umaine.edu:honors-1136","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.umaine.edu/honors/137","pdf_url":"https://digitalcommons.library.umaine.edu/honors/137","source":{"id":"https://openalex.org/S4306402196","display_name":"DigitalCommons (California Polytechnic State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149919469","host_organization_name":"California Polytechnic State University","host_organization_lineage":["https://openalex.org/I149919469"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors College","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.818.2578","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.818.2578","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://digitalcommons.library.umaine.edu/cgi/viewcontent.cgi?article%3D1136%26context%3Dhonors","raw_type":"text"},{"id":"mag:560372708","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.umaine.edu/cgi/viewcontent.cgi?article=1136&context=honors","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.umaine.edu:honors-1136","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.umaine.edu/honors/137","pdf_url":"https://digitalcommons.library.umaine.edu/honors/137","source":{"id":"https://openalex.org/S4306402196","display_name":"DigitalCommons (California Polytechnic State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149919469","host_organization_name":"California Polytechnic State University","host_organization_lineage":["https://openalex.org/I149919469"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors College","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W560372708.pdf","grobid_xml":"https://content.openalex.org/works/W560372708.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W199354732","https://openalex.org/W1488313827","https://openalex.org/W1522048223","https://openalex.org/W1567888745","https://openalex.org/W1572679174","https://openalex.org/W1590614500","https://openalex.org/W1807475000","https://openalex.org/W1964188164","https://openalex.org/W1966901093","https://openalex.org/W1967127565","https://openalex.org/W1969049846","https://openalex.org/W1969366577","https://openalex.org/W1976652826","https://openalex.org/W1979285338","https://openalex.org/W1986216002","https://openalex.org/W1986335419","https://openalex.org/W1987917217","https://openalex.org/W1989159103","https://openalex.org/W1989854633","https://openalex.org/W2000631088","https://openalex.org/W2002917813","https://openalex.org/W2005362078","https://openalex.org/W2007473669","https://openalex.org/W2008745352","https://openalex.org/W2012179131","https://openalex.org/W2016343586","https://openalex.org/W2018154493","https://openalex.org/W2019920591","https://openalex.org/W2019978095","https://openalex.org/W2021815999","https://openalex.org/W2022298579","https://openalex.org/W2026982903","https://openalex.org/W2029977896","https://openalex.org/W2036600670","https://openalex.org/W2045825179","https://openalex.org/W2049872195","https://openalex.org/W2051124212","https://openalex.org/W2051126370","https://openalex.org/W2051768564","https://openalex.org/W2055308573","https://openalex.org/W2058333671","https://openalex.org/W2059351781","https://openalex.org/W2059389314","https://openalex.org/W2064996887","https://openalex.org/W2068712507","https://openalex.org/W2070513612","https://openalex.org/W2073449985","https://openalex.org/W2074560876","https://openalex.org/W2075530203","https://openalex.org/W2078715993","https://openalex.org/W2081318350","https://openalex.org/W2081837746","https://openalex.org/W2090302292","https://openalex.org/W2090486901","https://openalex.org/W2095374280","https://openalex.org/W2098132374","https://openalex.org/W2099026501","https://openalex.org/W2100501305","https://openalex.org/W2107658086","https://openalex.org/W2117442313","https://openalex.org/W2126043496","https://openalex.org/W2130323165","https://openalex.org/W2130497877","https://openalex.org/W2131522485","https://openalex.org/W2136372119","https://openalex.org/W2139700140","https://openalex.org/W2140783564","https://openalex.org/W2142520482","https://openalex.org/W2145954079","https://openalex.org/W2148396623","https://openalex.org/W2149550412","https://openalex.org/W2152276356","https://openalex.org/W2152316935","https://openalex.org/W2155875767","https://openalex.org/W2156411508","https://openalex.org/W2160002116","https://openalex.org/W2160422154","https://openalex.org/W2162155268","https://openalex.org/W2169294911","https://openalex.org/W2169833225","https://openalex.org/W2170662223","https://openalex.org/W2264507600","https://openalex.org/W2573367782","https://openalex.org/W2741463045","https://openalex.org/W7096739767"],"related_works":["https://openalex.org/W1590614500","https://openalex.org/W4255916708","https://openalex.org/W3008786370","https://openalex.org/W1575298809","https://openalex.org/W4220801852","https://openalex.org/W3021018862","https://openalex.org/W2062457642","https://openalex.org/W2921053909","https://openalex.org/W2018021052","https://openalex.org/W1890786214"],"abstract_inverted_index":{"Parkinson\u2019s":[0],"disease":[1],"(PD)":[2],"is":[3,16,48,51,69,155],"the":[4,42,55,72,106,114,119,124,144,164,179,183,187,196],"second":[5],"most":[6],"common":[7],"age-related":[8],"neurodegenerative":[9],"disorder.":[10],"Given":[11],"its":[12,204],"prevalence,":[13],"researching":[14],"PD":[15,27,50,93,128],"important":[17],"to":[18,79,94,100,105,157,174,234],"world":[19],"health.":[20],"The":[21,64,221],"well":[22],"known":[23],"motor":[24],"symptoms":[25,33],"of":[26,57,76,88,92,108,163,166,171,182],"are":[28],"often":[29],"accompanied":[30],"by":[31,54],"non-motor":[32],"(NMS)":[34],"including":[35],"visuo-spatial":[36,133],"learning":[37,134],"and":[38,74,121,135,147,186,206,226],"memory":[39,136],"deficits.":[40],"However,":[41],"mechanism":[43,65],"whereby":[44,66],"these":[45,167],"NMS":[46,96],"occur":[47],"unknown.":[49],"also":[52],"characterized":[53],"presence":[56],"protein":[58],"aggregates":[59],"termed":[60],"Lewy":[61],"Bodies":[62],"(LBs).":[63],"LBs":[67],"form":[68],"unclear,":[70],"although":[71],"fibrillization":[73],"aggregation":[75],"\u03b1-synuclein":[77,192],"seem":[78],"be":[80,158,229],"critical":[81],"contributing":[82],"factors.":[83],"This":[84],"thesis":[85],"reports":[86],"development":[87],"an":[89],"animal":[90],"model":[91,154],"study":[95,162],"using":[97,143],"6-Hydroxydopamine":[98],"(6-OHDA)":[99],"produce":[101],"partial":[102],"bilateral":[103],"lesions":[104,111],"striata":[107],"mice.":[109],"These":[110],"significantly":[112],"reduced":[113],"tyrosine":[115],"hydroxylase":[116],"immunoreactivity":[117],"in":[118,127,132,137,191,219,232],"striatum":[120],"hippocampus,":[122],"mimicking":[123],"loss":[125],"observed":[126],"patients.":[129],"A":[130],"deficit":[131],"6-OHDA":[138],"treated":[139],"mice":[140],"was":[141],"documented":[142],"Barnes":[145],"maze":[146],"Spatial":[148],"Object":[149],"Recognition":[150],"test.":[151],"Therefore,":[152],"this":[153],"expected":[156],"useful":[159],"for":[160],"future":[161],"cause":[165],"NMS.":[168],"An":[169],"analysis":[170],"mechanisms":[172],"reported":[173],"underlie":[175],"LB":[176],"formation":[177],"revealed":[178],"potential":[180],"importance":[181],"protease":[184],"calpain":[185,200,210],"peptidyl-prolyl":[188],"isomerase":[189],"PIN1":[190,207,218,227],"fibrillization.":[193],"Data":[194],"from":[195],"literature":[197],"demonstrated":[198],"that":[199,215],"cleaves":[201,217],"\u03b1-synuclein,":[202],"promoting":[203],"aggregation,":[205],"potentially":[208],"regulates":[209],"activity.":[211],"Preliminary":[212],"data":[213],"reveal":[214],"calpain-2":[216],"vitro.":[220],"relationship":[222],"between":[223],"cal":[224],"pain":[225],"should":[228],"examined":[230],"further":[231],"regards":[233],"PD.":[235]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
