{"id":"https://openalex.org/W56015030","doi":null,"title":"In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X.","display_name":"In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X.","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W56015030","mag":"56015030","pmid":"https://pubmed.ncbi.nlm.nih.gov/8874378"},"language":"en","primary_location":{"id":"pmid:8874378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8874378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067870214","display_name":"Singanallore V. Thiruvikraman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S V Thiruvikraman","raw_affiliation_strings":["Division of Thrombosis Research, Mount Sinai School of Medicine, City University of New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Thrombosis Research, Mount Sinai School of Medicine, City University of New York, New York, USA","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Guha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Guha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008498747","display_name":"John Roboz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Roboz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083323694","display_name":"Mark B. Taubman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M B Taubman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054254125","display_name":"Yale Nemerson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Nemerson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081230469","display_name":"John T. Fallon","orcid":"https://orcid.org/0000-0002-7677-4868","observed_orcids":["https://orcid.org/0000-0002-7677-4868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J T Fallon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.3628,"has_fulltext":false,"cited_by_count":184,"citation_normalized_percentile":{"value":0.98593578,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"75","issue":"4","first_page":"451","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":1.0},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.9269999861717224},{"id":"https://openalex.org/keywords/factor-viia","display_name":"factor VIIa","score":0.8309999704360962},{"id":"https://openalex.org/keywords/factor-x","display_name":"factor X","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/plaque-rupture","display_name":"plaque rupture","score":0.8109999895095825},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8429999947547913},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/calcium-dependent-binding","display_name":"calcium-dependent binding","score":0.8690000176429749},{"id":"https://openalex.org/keywords/digoxigenin-labeling","display_name":"digoxigenin labeling","score":0.7630000114440918},{"id":"https://openalex.org/keywords/in-situ-localization","display_name":"in situ localization","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.8202176094055176},{"id":"https://openalex.org/C2776552150","wikidata":"https://www.wikidata.org/wiki/Q420728","display_name":"Digoxigenin","level":5,"score":0.6809175610542297},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.6469469666481018},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.633062481880188},{"id":"https://openalex.org/C2776716733","wikidata":"https://www.wikidata.org/wiki/Q1890226","display_name":"Adventitia","level":2,"score":0.6292104721069336},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5952299237251282},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.491627037525177},{"id":"https://openalex.org/C2779179121","wikidata":"https://www.wikidata.org/wiki/Q559362","display_name":"Fibrous cap","level":2,"score":0.4147375226020813},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.41106978058815},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40207475423812866},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.33565956354141235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2809830904006958},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.27745693922042847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20566442608833313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1814553439617157},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17570927739143372},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14367800951004028},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004076","descriptor_name":"Digoxigenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005170","descriptor_name":"Factor X","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015942","descriptor_name":"Factor VIIa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8874378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8874378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:56015030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8874378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5315656881","display_name":"TISSUE FACTOR, THROMBOSIS AND THE ARTERIAL WALL","funder_award_id":"P50HL054469","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5995386111","display_name":"TISSUE FACTOR IN BLOOD COAGULATION","funder_award_id":"P01HL029019","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2143201729","https://openalex.org/W1971585818","https://openalex.org/W1897671456","https://openalex.org/W2085059196","https://openalex.org/W2587151694","https://openalex.org/W2052128666","https://openalex.org/W2145483534","https://openalex.org/W1992803891","https://openalex.org/W204623194","https://openalex.org/W2606537142"],"abstract_inverted_index":{"The":[0,40,147],"mechanism":[1],"responsible":[2,223],"for":[3,17,90,151,161,224],"the":[4,29,48,79,103,125,131,206,225,237],"thrombotic":[5],"complications":[6],"of":[7,35,42,50,76,84,94,130,175,187,198,210,216,228],"atherosclerotic":[8,38,54,95,211,233],"plaques":[9,136,212,234],"is":[10],"not":[11],"well":[12],"understood.":[13],"Although":[14],"a":[15,121,172,181],"role":[16],"tissue":[18,129],"factor":[19,81,163,177],"(TF)":[20],"has":[21],"been":[22],"hypothesized,":[23],"there":[24],"are":[25,240],"scant":[26],"data":[27],"on":[28],"presence,":[30],"location,":[31],"quantity,":[32],"and":[33,59,82,115,137,156,191,202,236],"activity":[34],"TF":[36,51,152,184],"in":[37,52,69,102,113,124,153],"plaques.":[39,55],"purpose":[41],"this":[43],"study":[44],"was":[45,99,109,165,193],"to":[46,63,120,242],"show":[47],"localization":[49,83],"human":[53,72],"Digoxigenin-labeled":[56],"factors":[57,189,200],"VIIa":[58,164,178,190,201],"X":[60,192,203],"were":[61,169],"used":[62],"demonstrate":[64],"their":[65],"specific":[66],"binding":[67,197],"sites":[68],"formalin-fixed,":[70],"paraffin-embedded":[71],"arteries":[73],"by":[74,87],"incubation":[75],"sections":[77,93,168],"with":[78,171,180],"labeled":[80,162,188],"TF:factor(s)":[85],"complexes":[86],"immunohistochemical":[88],"staining":[89,98],"digoxigenin.":[91],"In":[92,195],"plaques,":[96],"diffuse":[97],"most":[100],"intense":[101],"relatively":[104,126],"acellular,":[105],"lipid-rich":[106],"core":[107,209,238],"but":[108],"also":[110],"present":[111],"intracellularly":[112],"macrophages":[114],"smooth":[116,140],"muscle":[117,141],"cells":[118,134,142],"and,":[119],"lesser":[122],"extent,":[123],"acellular":[127],"fibrous":[128],"plaque.":[132],"Endothelial":[133],"overlying":[135],"occasional":[138],"medial":[139],"stained":[143,150],"positively":[144],"as":[145],"well.":[146],"adventitia":[148],"routinely":[149],"both":[154],"normal":[155],"diseased":[157],"artery":[158],"segments.":[159],"Staining":[160],"blocked":[166],"when":[167,230],"preincubated":[170],"10-fold":[173],"excess":[174],"unlabeled":[176],"or":[179],"polyclonal":[182],"antihuman":[183],"antibody.":[185],"Binding":[186],"Ca(2+)-dependent.":[194],"conclusion,":[196],"digoxigenin-labeled":[199],"shows":[204],"that":[205],"lipid":[207,231],"rich":[208,232],"contains":[213],"high":[214],"levels":[215],"extracellular":[217],"TF.":[218],"This":[219],"location":[220],"may":[221],"be":[222],"rapid":[226],"initiation":[227],"thrombosis":[229],"rupture":[235],"contents":[239],"exposed":[241],"flowing":[243],"blood.":[244]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}