{"id":"https://openalex.org/W55994113","doi":null,"title":"Inflammatory disease and the human microbiome.","display_name":"Inflammatory disease and the human microbiome.","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W55994113","mag":"55994113","pmid":"https://pubmed.ncbi.nlm.nih.gov/24882717"},"language":"en","primary_location":{"id":"pmid:24882717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24882717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046952154","display_name":"Amy D. Proal","orcid":"https://orcid.org/0009-0001-9495-8572","observed_orcids":["https://orcid.org/0009-0001-9495-8572"]},"institutions":[{"id":"https://openalex.org/I4210105550","display_name":"Autoimmunity Research Foundation","ror":"https://ror.org/01gmgva47","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105550"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy D Proal","raw_affiliation_strings":["Autoimmunity Research Foundation, 3423 Hill Canyon Ave., Thousand Oaks, CA 91360, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autoimmunity Research Foundation, 3423 Hill Canyon Ave., Thousand Oaks, CA 91360, USA","institution_ids":["https://openalex.org/I4210105550"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015341418","display_name":"Paul J. Albert","orcid":"https://orcid.org/0000-0001-8220-272X","observed_orcids":["https://orcid.org/0000-0001-8220-272X"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J Albert","raw_affiliation_strings":["Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023169385","display_name":"Trevor G Marshall","orcid":"https://orcid.org/0000-0003-0024-2854","observed_orcids":["https://orcid.org/0000-0003-0024-2854"]},"institutions":[{"id":"https://openalex.org/I4210105550","display_name":"Autoimmunity Research Foundation","ror":"https://ror.org/01gmgva47","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105550"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor G Marshall","raw_affiliation_strings":["Autoimmunity Research Foundation, 3423 Hill Canyon Ave., Thousand Oaks, CA 91360, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autoimmunity Research Foundation, 3423 Hill Canyon Ave., Thousand Oaks, CA 91360, USA","institution_ids":["https://openalex.org/I4210105550"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8726,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.85523991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"95","first_page":"257","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-microbiome","display_name":"human microbiome","score":0.8379999995231628},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.8610000014305115},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.875},{"id":"https://openalex.org/keywords/innate-immune-dysregulation","display_name":"innate immune dysregulation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/intracellular-pathogens","display_name":"intracellular pathogens","score":0.9769999980926514},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.699999988079071},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7717369794845581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6963514685630798},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6426492929458618},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6137272715568542},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6015510559082031},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5630950331687927},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.5422166585922241},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47773879766464233},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4618375301361084},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.44354724884033203},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.42613688111305237},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39642593264579773},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35026273131370544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1747261881828308},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1739501655101776},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:24882717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24882717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"mag:55994113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24882717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9908999800682068,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2945309926","https://openalex.org/W7140279959","https://openalex.org/W1998169884","https://openalex.org/W1510302634","https://openalex.org/W7162309124","https://openalex.org/W2090377140","https://openalex.org/W2297898664","https://openalex.org/W2972383398","https://openalex.org/W2618591706","https://openalex.org/W2089102191"],"abstract_inverted_index":{"The":[0,97],"human":[1,16],"body":[2],"is":[3],"a":[4],"superorganism":[5],"in":[6,31,79],"which":[7],"thousands":[8],"of":[9,20,43,64,73,140],"microbial":[10],"genomes":[11],"continually":[12],"interact":[13],"with":[14,29,50,92,122],"the":[15,57,65,71,93,132],"genome.":[17],"A":[18],"range":[19],"physical":[21],"and":[22,81,87],"neurological":[23],"inflammatory":[24,36,51,113],"diseases":[25],"are":[26,53,104],"now":[27],"associated":[28,49],"shifts":[30],"microbiome":[32,44],"composition.":[33],"Seemingly":[34],"disparate":[35],"conditions":[37],"may":[38],"arise":[39],"from":[40,107],"similar":[41],"disruption":[42],"homeostasis.":[45],"Intracellular":[46],"pathogens":[47,116],"long":[48],"disease":[52,114],"able":[54],"to":[55,76,101,120,127,136],"slow":[56],"innate":[58],"immune":[59,133],"response":[60],"by":[61],"dysregulating":[62],"activity":[63],"VDR":[66],"nuclear":[67],"receptor.":[68],"This":[69],"facilitates":[70],"ability":[72],"other":[74],"species":[75],"gradually":[77],"accumulate":[78],"tissue":[80],"blood,":[82],"where":[83],"they":[84],"generate":[85],"proteins":[86],"metabolites":[88],"that":[89,99,130],"significantly":[90],"interfere":[91],"body's":[94],"metabolic":[95],"processes.":[96],"microbes":[98],"contribute":[100],"this":[102,141],"dysfunction":[103],"often":[105],"inherited":[106],"family":[108],"members.":[109],"Immunosuppressive":[110],"therapies":[111],"for":[112,138],"allow":[115,137],"driving":[117],"these":[118],"processes":[119],"spread":[121],"greater":[123],"ease.":[124],"In":[125],"contrast":[126],"immunosuppression,":[128],"treatments":[129],"stimulate":[131],"system":[134],"seem":[135],"reversal":[139],"pathogen-induced":[142],"genomic":[143],"dysregulation.":[144]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}