{"id":"https://openalex.org/W55742246","doi":null,"title":"Anticossos contra ant\u00edgens de membrana neuronal en encefalitis paraneopl\u00e0sica i idiop\u00e0tica","display_name":"Anticossos contra ant\u00edgens de membrana neuronal en encefalitis paraneopl\u00e0sica i idiop\u00e0tica","publication_year":2012,"publication_date":"2012-11-27","ids":{"openalex":"https://openalex.org/W55742246","mag":"55742246"},"language":"ca","primary_location":{"id":"pmh:oai:www.tdx.cat:10803/112119","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/112119","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10803/112119","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027048525","display_name":"Anna Boronat Barado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna Boronat Barado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5027048525"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paraneoplastic-encephalitis","display_name":"paraneoplastic encephalitis","score":0.925000011920929},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7390000224113464},{"id":"https://openalex.org/keywords/lgi1","display_name":"LGI1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cntnap2","display_name":"CNTNAP2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/mglur5","display_name":"mGluR5","score":0.9800000190734863},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.6669999957084656},{"id":"https://openalex.org/keywords/limbic-encephalitis","display_name":"limbic encephalitis","score":0.7509999871253967},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5329999923706055},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.7253870964050293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.638900637626648},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.11353656649589539}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:www.tdx.cat:10803/112119","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/112119","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:dnet:tdr_________::291bd67b8f4c14d8b60709d5437de797","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/112119","pdf_url":"http://hdl.handle.net/10803/112119","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:diposit.ub.edu:2445/43544","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2445/43544","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Facultat - Medicina","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:55742246","doi":null,"is_oa":false,"landing_page_url":"http://diposit.ub.edu/dspace/bitstream/2445/43544/1/ABB_TESI.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:dnet:tdr_________::291bd67b8f4c14d8b60709d5437de797","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/112119","pdf_url":"http://hdl.handle.net/10803/112119","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3925920735","display_name":null,"funder_award_id":"RO1NS077851","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5720032886","display_name":"Paraneoplastic Disorders of the CNS: Autoantigen Profiling","funder_award_id":"R01NS077851","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7409939284","display_name":"Autoimmunity Against Novel Antigens in Neuropsychiatric Dysfunction","funder_award_id":"R01MH094741","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320308324","display_name":"McKnight Foundation","ror":"https://ror.org/003ghvj67"},{"id":"https://openalex.org/F4320310701","display_name":"Fundaci\u00f3 la Marat\u00f3 de TV3","ror":"https://ror.org/00t5xc355"},{"id":"https://openalex.org/F4320323428","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57"},{"id":"https://openalex.org/F4320324660","display_name":"Red Espa\u00f1ola de Esclerosis M\u00faltiple","ror":"https://ror.org/00dgcm453"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W55742246.pdf","grobid_xml":"https://content.openalex.org/works/W55742246.grobid-xml"},"referenced_works_count":139,"referenced_works":["https://openalex.org/W15490775","https://openalex.org/W197729456","https://openalex.org/W1501351278","https://openalex.org/W1567744215","https://openalex.org/W1571221565","https://openalex.org/W1571495508","https://openalex.org/W1600764625","https://openalex.org/W1659305873","https://openalex.org/W1904691554","https://openalex.org/W1920479780","https://openalex.org/W1966404127","https://openalex.org/W1967636880","https://openalex.org/W1969168264","https://openalex.org/W1975434091","https://openalex.org/W1975958907","https://openalex.org/W1979369853","https://openalex.org/W1981569193","https://openalex.org/W1983883744","https://openalex.org/W1986772640","https://openalex.org/W1987877477","https://openalex.org/W1988126651","https://openalex.org/W1991893050","https://openalex.org/W1992692157","https://openalex.org/W1993102668","https://openalex.org/W1996510251","https://openalex.org/W1999290750","https://openalex.org/W2001711511","https://openalex.org/W2002426329","https://openalex.org/W2003179182","https://openalex.org/W2004104083","https://openalex.org/W2007508740","https://openalex.org/W2009224548","https://openalex.org/W2012932372","https://openalex.org/W2013484205","https://openalex.org/W2014191362","https://openalex.org/W2014266239","https://openalex.org/W2015265210","https://openalex.org/W2019355614","https://openalex.org/W2020634566","https://openalex.org/W2021035407","https://openalex.org/W2021370224","https://openalex.org/W2022498096","https://openalex.org/W2024566031","https://openalex.org/W2025325056","https://openalex.org/W2026492454","https://openalex.org/W2029658560","https://openalex.org/W2030214963","https://openalex.org/W2035869111","https://openalex.org/W2037704820","https://openalex.org/W2040065191","https://openalex.org/W2041129046","https://openalex.org/W2041525670","https://openalex.org/W2044031472","https://openalex.org/W2045072632","https://openalex.org/W2045529714","https://openalex.org/W2048977435","https://openalex.org/W2054231441","https://openalex.org/W2054943928","https://openalex.org/W2057481627","https://openalex.org/W2058534813","https://openalex.org/W2061056490","https://openalex.org/W2063313274","https://openalex.org/W2063516590","https://openalex.org/W2063820008","https://openalex.org/W2067685678","https://openalex.org/W2072513771","https://openalex.org/W2072718666","https://openalex.org/W2072953729","https://openalex.org/W2073352417","https://openalex.org/W2073532542","https://openalex.org/W2075429637","https://openalex.org/W2078631326","https://openalex.org/W2078947806","https://openalex.org/W2078967407","https://openalex.org/W2078990452","https://openalex.org/W2081428705","https://openalex.org/W2084985198","https://openalex.org/W2085335048","https://openalex.org/W2085856553","https://openalex.org/W2087363103","https://openalex.org/W2090515316","https://openalex.org/W2091765514","https://openalex.org/W2092876789","https://openalex.org/W2093777694","https://openalex.org/W2099917041","https://openalex.org/W2100064685","https://openalex.org/W2100252544","https://openalex.org/W2100837670","https://openalex.org/W2104318721","https://openalex.org/W2110141158","https://openalex.org/W2112605335","https://openalex.org/W2114398221","https://openalex.org/W2114935132","https://openalex.org/W2117525719","https://openalex.org/W2121402661","https://openalex.org/W2122971055","https://openalex.org/W2123057330","https://openalex.org/W2123159874","https://openalex.org/W2123679223","https://openalex.org/W2124472369","https://openalex.org/W2124517960","https://openalex.org/W2126538155","https://openalex.org/W2127043216","https://openalex.org/W2128488290","https://openalex.org/W2130355701","https://openalex.org/W2131446968","https://openalex.org/W2133138154","https://openalex.org/W2133263385","https://openalex.org/W2133623572","https://openalex.org/W2134093662","https://openalex.org/W2135607798","https://openalex.org/W2140152000","https://openalex.org/W2140481777","https://openalex.org/W2141440491","https://openalex.org/W2141550849","https://openalex.org/W2143285990","https://openalex.org/W2146199022","https://openalex.org/W2147259071","https://openalex.org/W2147542138","https://openalex.org/W2148226248","https://openalex.org/W2148458906","https://openalex.org/W2150735552","https://openalex.org/W2159119710","https://openalex.org/W2159289827","https://openalex.org/W2160577692","https://openalex.org/W2162846693","https://openalex.org/W2164187120","https://openalex.org/W2164392039","https://openalex.org/W2167675656","https://openalex.org/W2169033404","https://openalex.org/W2169354261","https://openalex.org/W2268679957","https://openalex.org/W2315537939","https://openalex.org/W2318455805","https://openalex.org/W2328983104","https://openalex.org/W2341543030","https://openalex.org/W2417646497","https://openalex.org/W2418810988","https://openalex.org/W2424829358"],"related_works":["https://openalex.org/W2264363935","https://openalex.org/W2544123997","https://openalex.org/W2073688289","https://openalex.org/W2123159874","https://openalex.org/W2501809058","https://openalex.org/W3028932629","https://openalex.org/W1548073886","https://openalex.org/W3024989374","https://openalex.org/W2329271273","https://openalex.org/W3084125168"],"abstract_inverted_index":{"Inicialment":[0],"s\u2019havia":[1],"descrit":[2],"el":[3,23,80,121,172,197,220,224,256,290,314,323,339,394,414],"perfil":[4,198,257,421],"cl\u00ednic":[5,199,258],"d\u2019un":[6,49],"grup":[7,82,90,291],"concret":[8],"de":[9,32,34,87,91,119,202,210,213,240,259,292,301,303,318,343,350,362,376,389],"malalts":[10,92,310],"amb":[11,53,65,93,174,246,261,311,398],"encefalitis":[12,94,204,215,296,355],"l\u00edmbica":[13,297,356],"paraneopl\u00e0sica":[14],"i":[15,37,59,128,145,147,165,200,223,264,328,357,360,416],"anticossos":[16,38,207,265,312,404],"(Acs)":[17],"contra":[18,85,208,219,237,266,322,338,405],"diferents":[19],"prote\u00efnes":[20],"onconeuronals,":[21],"en":[22,67,136,249,275,289,331,345,393,413],"que":[24,148,158,353,365],"gaireb\u00e9":[25],"la":[26,102,137,140,161,238,267,316,401,406],"meitat":[27],"d\u2019aquests":[28,51],"pacients":[29,245,260,293,397],"tenien":[30],"c\u00e0ncer":[31,300],"pulm\u00f3":[33,302],"c\u00e8l\u2022lula":[35,304],"petita":[36],"associats":[39,106],"principalment":[40,55,186],"a":[41,108,152,160,177,195,206,244,299,379,419],"l\u2019antigen":[42],"(Ag)":[43],"Hu,":[44],"per\u00f2":[45],"encara":[46],"quedava":[47],"m\u00e9s":[48,287],"50%":[50],"malalts,":[52],"afecci\u00f3":[54],"al":[56,63,190,229,251],"sistema":[57,385],"l\u00edmbic":[58],"una":[60,367],"resposta":[61],"favorable":[62],"tractament":[64,173],"immunosupressors,":[66],"els":[68,410],"quals":[69,96],"no":[70,97,417],"se\u2019ls":[71,98],"hi":[72,99],"havia":[73,100],"detectat":[74,101],"cap":[75],"Ac":[76],"onconeuronal":[77],"associat.":[78],"Amb":[79],"nou":[81,235,374],"d\u2019Acs":[83,104,337],"dirigits":[84],"Ags":[86],"membrana,":[88,211],"aquell":[89],"als":[95,217],"presencia":[103],"onconeuronals":[105],"comen\u00e7ava":[107],"definir-se.":[109],"En":[110,188,227,309],"total,":[111],"des":[112],"del":[113,283,384],"2007":[114],"s\u2019havien":[115],"identificat":[116],"7":[117],"autoant\u00edgens":[118,154],"membrana:":[120],"R-NMDA,":[122],"RAMPA,":[123],"R-GABAB,":[124],"LGI1,":[125],"Caspr2,":[126],"R-Glicina":[127],"mGluR5.":[129],"Totes":[130],"aquestes":[131],"dianes":[132],"antig\u00e8niques":[133],"estan":[134],"implicades":[135],"transmissi\u00f3":[138],"sin\u00e0ptica,":[139],"plasticitat":[141],"o":[142],"l\u2019excitabilitat":[143],"nerviosa,":[144],"tot":[146],"les":[149,203,214],"s\u00edndromes":[150,156],"associades":[151,205,216],"aquests":[153],"s\u00f3n":[155],"severes,":[157],"afecten":[159],"mem\u00f2ria,":[162],"comportament,":[163],"cognici\u00f3,":[164],"molts":[166],"cops":[167],"van":[168,184],"acompanyats":[169],"d\u2019alteracions":[170],"psiqui\u00e0triques,":[171],"immunoter\u00e0pia":[175],"acostuma":[176],"ser":[178,185],"efectiu.":[179],"Els":[180],"objectius":[181],"d\u2019aquesta":[182],"tesi":[183,277],"tres.":[187],"refer\u00e8ncia":[189,228,250],"primer":[191],"objectiu,":[192,231],"vam":[193,232,254,278,371],"contribuir":[194],"caracteritzar":[196,255],"immunol\u00f2gic":[201],"ant\u00edgens":[209],"concretament":[212],"Acs":[218,321,411],"receptor":[221,225,282,324,340],"AMPA":[222,341],"GABAB.":[226],"segon":[230],"identificar":[233,372],"un":[234,332,373,420],"antic\u00f2s":[236],"prote\u00efna":[239,268],"membrana":[241,377],"DPPX,":[242],"associat":[243,378],"encefalitis.":[247],"I":[248,392],"tercer":[252],"objectiu":[253],"esclerosi":[262,399],"m\u00faltiple":[263],"contactina-2.":[269],"A":[270],"partir":[271],"dels":[272,396,403],"estudis":[273],"realitzats":[274],"aquesta":[276],"concloure":[279],"que:":[280],"El":[281],"GABAB":[284,325],"\u00e9s":[285,326,408],"l\u2019autoant\u00edgen":[286],"com\u00fa":[288],"caracteritzats":[294],"per":[295,382],"associada":[298],"petita,":[305],"pr\u00e8viament":[306],"considerats":[307],"\u201cseronegatius\u201d.":[308],"conta":[313],"GAD,":[315],"freq\u00fc\u00e8ncia":[317,402],"tenir":[319],"tamb\u00e9":[320],"baixa,":[327,409],"nom\u00e9s":[329],"s\u2019observa":[330],"context":[333],"paraneopl\u00e0sic.":[334],"La":[335],"detecci\u00f3":[336],"s\u2019hauria":[342],"considerar":[344],"pacients,":[346],"particularment":[347],"dones,":[348],"majors":[349],"50":[351],"anys":[352],"presentin":[354],"canvis":[358],"r\u00e0pids":[359],"progressius":[361],"comportaments":[363],"anormals":[364],"recorden":[366],"psicosi":[368],"aguda.":[369],"Tamb\u00e9":[370],"autoant\u00edgen":[375],"l\u2019encefalitis":[380],"caracteritzada":[381],"hiperexcitabilitat":[383],"nervi\u00f3s":[386],"central,":[387],"precedida":[388],"diarrea":[390],"desconeguda.":[391],"cas":[395],"m\u00faltiple,":[400],"contactina-2":[407],"persisteixen":[412],"temps,":[415],"s\u2019associen":[418],"clinico-radiol\u00f2gic":[422],"caracter\u00edstic.":[423]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
