{"id":"https://openalex.org/W5572009","doi":null,"title":"Influence of kinnow juice on the pharmacokinetics of sustained release theophylline in healthy male volunteers.","display_name":"Influence of kinnow juice on the pharmacokinetics of sustained release theophylline in healthy male volunteers.","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W5572009","mag":"5572009","pmid":"https://pubmed.ncbi.nlm.nih.gov/10941621"},"language":"en","primary_location":{"id":"pmid:10941621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10941621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of physiology and pharmacology","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103275093","display_name":"Monika Gupta","orcid":"https://orcid.org/0000-0003-2988-3356","observed_orcids":["https://orcid.org/0000-0003-2988-3356"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M C Gupta","raw_affiliation_strings":["Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101727199","display_name":"S K Garg","orcid":"https://orcid.org/0009-0008-1138-1837","observed_orcids":["https://orcid.org/0009-0008-1138-1837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S K Garg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111267754","display_name":"V.K. Bhargava","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V K Bhargava","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00047763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"3","first_page":"323","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/citrus-juice","display_name":"citrus juice","score":0.8009999990463257},{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sustained-release-theophylline","display_name":"sustained-release theophylline","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9350000023841858},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.6930000185966492},{"id":"https://openalex.org/keywords/food-drug-interactions","display_name":"food-drug interactions","score":0.9470000267028809},{"id":"https://openalex.org/keywords/plasma-theophylline-concentration","display_name":"plasma theophylline concentration","score":0.8370000123977661},{"id":"https://openalex.org/keywords/healthy-men","display_name":"healthy men","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.9687097072601318},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8666905760765076},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5323007106781006},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.5198062658309937},{"id":"https://openalex.org/C2776773239","wikidata":"https://www.wikidata.org/wiki/Q1138468","display_name":"Grapefruit juice","level":3,"score":0.5014176368713379},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4915824830532074},{"id":"https://openalex.org/C3018968983","wikidata":"https://www.wikidata.org/wiki/Q8492","display_name":"Fruit juice","level":2,"score":0.4552759528160095},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.43376877903938293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3841240108013153},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.35321465134620667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12422013282775879},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.11230987310409546},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001628","descriptor_name":"Beverages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002957","descriptor_name":"Citrus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10941621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10941621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of physiology and pharmacology","raw_type":"Clinical Trial"},{"id":"mag:5572009","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10941621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1976328537","https://openalex.org/W1972307458","https://openalex.org/W2023703737","https://openalex.org/W2417615668","https://openalex.org/W2045763099","https://openalex.org/W2418325825","https://openalex.org/W1973050732","https://openalex.org/W2005584393","https://openalex.org/W2114749653","https://openalex.org/W2034861158"],"abstract_inverted_index":{"The":[0,85,115,147],"effect":[1],"of":[2,8,12,45,138,159,182,185,203],"kinnow":[3,48,96,129,170,192],"juice":[4,54,97,130,171,193],"on":[5,124],"the":[6,92,109,119,125,157,160,162,180],"pharmacokinetics":[7],"a":[9,23,50,74,174],"single":[10],"dose":[11],"sustained":[13,36],"release":[14,37,176],"theophylline":[15,38,72,86,177,186],"was":[16,69,134,141],"investigated":[17],"in":[18,55,187,194,200],"healthy":[19,31],"male":[20,32],"volunteers.":[21],"In":[22],"two":[24],"phased":[25],"open":[26],"cross-over":[27],"randomized":[28],"study,":[29],"ten":[30],"volunteers":[33],"were":[34,59,81,88,104,123],"given":[35],"(300":[39],"mg)":[40],"along":[41],"with":[42,95,128,156],"300":[43],"ml":[44],"water":[46,102],"or":[47],"juice,":[49],"routinely":[51,190],"used":[52],"citrus":[53],"India.":[56],"Blood":[57],"samples":[58],"collected":[60],"at":[61,90],"different":[62],"time":[63,93],"points":[64,94],"from":[65,112],"0-48":[66],"hours.":[67,114],"Plasma":[68],"assayed":[70],"for":[71,117],"by":[73],"HPLC":[75],"method":[76],"and":[77,83,179],"various":[78],"pharmacokinetic":[79,120],"parameters":[80,121],"calculated":[82],"compared.":[84],"levels":[87],"lower":[89,126],"all":[91,118],"co-administration":[98],"as":[99],"compared":[100],"to":[101,143,168],"but":[103],"significantly":[105,145],"so":[106],"only":[107],"during":[108],"absorption":[110,158],"phase":[111],"1-4":[113],"values":[116],"evaluated":[122],"side":[127],"except":[131],"Tmax":[132],"which":[133],"slightly":[135],"delayed.":[136],"None":[137],"these":[139,204],"alterations":[140],"found":[142],"be":[144,165,198],"different.":[146],"results":[148],"indicate":[149],"that":[150],"since":[151],"there":[152],"is":[153],"an":[154],"interference":[155],"drug,":[161],"patients":[163,188],"may":[164],"advised":[166],"not":[167],"consume":[169,191],"when":[172],"taking":[173],"slow":[175],"preparation":[178],"monitoring":[181],"plasma":[183],"concentrations":[184],"who":[189],"their":[195],"diet":[196],"might":[197],"helpful":[199],"better":[201],"management":[202],"patients.":[205]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}