{"id":"https://openalex.org/W55627219","doi":"https://doi.org/10.1021/bi052629q","title":"Deletion of All Cysteines in Tachyplesin I Abolishes Hemolytic Activity and Retains Antimicrobial Activity and Lipopolysaccharide Selective Binding","display_name":"Deletion of All Cysteines in Tachyplesin I Abolishes Hemolytic Activity and Retains Antimicrobial Activity and Lipopolysaccharide Selective Binding","publication_year":2006,"publication_date":"2006-04-26","ids":{"openalex":"https://openalex.org/W55627219","doi":"https://doi.org/10.1021/bi052629q","mag":"55627219","pmid":"https://pubmed.ncbi.nlm.nih.gov/16700563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2515376"},"language":"en","primary_location":{"id":"doi:10.1021/bi052629q","doi":"https://doi.org/10.1021/bi052629q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi052629q","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2515376","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006414766","display_name":"Ayyalusamy Ramamoorthy","orcid":"https://orcid.org/0000-0003-1964-1900","observed_orcids":["https://orcid.org/0000-0003-1964-1900"]},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayyalusamy Ramamoorthy","raw_affiliation_strings":["Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108","institution_ids":["https://openalex.org/I138216421","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011382531","display_name":"Sathiah Thennarasu","orcid":"https://orcid.org/0000-0001-8439-4438","observed_orcids":["https://orcid.org/0000-0001-8439-4438","https://orcid.org/0000-0002-7494-3568"]},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sathiah Thennarasu","raw_affiliation_strings":["Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108","institution_ids":["https://openalex.org/I138216421","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110177592","display_name":"Anmin Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anmin Tan","raw_affiliation_strings":["Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108","institution_ids":["https://openalex.org/I138216421","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003384354","display_name":"Kiran Kumar Gottipati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiran Gottipati","raw_affiliation_strings":["Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108","institution_ids":["https://openalex.org/I138216421","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052376710","display_name":"Sreeja Sreekumar","orcid":"https://orcid.org/0000-0002-6996-5527","observed_orcids":["https://orcid.org/0000-0002-6996-5527"]},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sreeja Sreekumar","raw_affiliation_strings":["Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108","institution_ids":["https://openalex.org/I138216421","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056293361","display_name":"Deborah Heyl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah L. Heyl","raw_affiliation_strings":["Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108","institution_ids":["https://openalex.org/I138216421","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113607940","display_name":"Florence Y. An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florence Y. P. An","raw_affiliation_strings":["Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108","institution_ids":["https://openalex.org/I138216421","https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042119113","display_name":"Charles E. Shelburne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E. Shelburne","raw_affiliation_strings":["Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biophysics Research Division, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan 48197, and Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, Michigan 48108","institution_ids":["https://openalex.org/I138216421","https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":9.6139,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.990721,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"45","issue":"20","first_page":"6529","last_page":"6540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tachyplesin-i","display_name":"tachyplesin I","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.906000018119812},{"id":"https://openalex.org/keywords/hemolytic-activity","display_name":"hemolytic activity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/amphipathicity","display_name":"amphipathicity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/lipopolysaccharide-binding","display_name":"lipopolysaccharide binding","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lipid-peptide-interactions","display_name":"peptide-lipid interactions","score":0.7400000095367432},{"id":"https://openalex.org/keywords/negatively-charged-membranes","display_name":"negatively charged membranes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/membrane-phase-transition","display_name":"membrane phase transition","score":0.46700000762939453},{"id":"https://openalex.org/keywords/peptide-secondary-structure","display_name":"peptide secondary structure","score":0.5440000295639038},{"id":"https://openalex.org/keywords/cholesterol-inhibition","display_name":"cholesterol inhibition","score":0.7960000038146973},{"id":"https://openalex.org/keywords/tachypleus-tridentatus","display_name":"Tachypleus tridentatus","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7839909195899963},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7625100612640381},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.7563480734825134},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6119077205657959},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.5506470203399658},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5270103216171265},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4772327244281769},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.4597049653530121},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.4391995072364807},{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.42910483479499817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3894442915916443},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3866121470928192},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1942598819732666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09732422232627869},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi052629q","doi":"https://doi.org/10.1021/bi052629q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi052629q","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:16700563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16700563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2515376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2515376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2515376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2515376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1706914619","display_name":"Immunodominant Stress Proteins of Porphyromonas gingivalis","funder_award_id":"R01DE011117","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5355133789","display_name":"Structure and function of antimicrobial peptides","funder_award_id":"R01AI054515","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W165853039","https://openalex.org/W1481119266","https://openalex.org/W1483201238","https://openalex.org/W1503300581","https://openalex.org/W1508119641","https://openalex.org/W1555574664","https://openalex.org/W1953843785","https://openalex.org/W1963584412","https://openalex.org/W1966869152","https://openalex.org/W1966910457","https://openalex.org/W1968732465","https://openalex.org/W1968903493","https://openalex.org/W1969650220","https://openalex.org/W1971022618","https://openalex.org/W1972027206","https://openalex.org/W1972672790","https://openalex.org/W1974487582","https://openalex.org/W1974770942","https://openalex.org/W1978873825","https://openalex.org/W1981334795","https://openalex.org/W1987757064","https://openalex.org/W1992331668","https://openalex.org/W1992915003","https://openalex.org/W1993791807","https://openalex.org/W1995601809","https://openalex.org/W1997787796","https://openalex.org/W1999225137","https://openalex.org/W2002288900","https://openalex.org/W2002900567","https://openalex.org/W2003318145","https://openalex.org/W2005719563","https://openalex.org/W2006686408","https://openalex.org/W2007744639","https://openalex.org/W2020154280","https://openalex.org/W2029471041","https://openalex.org/W2031209726","https://openalex.org/W2031408917","https://openalex.org/W2038512626","https://openalex.org/W2039711737","https://openalex.org/W2040727080","https://openalex.org/W2053505375","https://openalex.org/W2054983719","https://openalex.org/W2067812655","https://openalex.org/W2068344275","https://openalex.org/W2070014512","https://openalex.org/W2079079387","https://openalex.org/W2079809606","https://openalex.org/W2081090090","https://openalex.org/W2083504180","https://openalex.org/W2083770549","https://openalex.org/W2087582790","https://openalex.org/W2088355493","https://openalex.org/W2088998395","https://openalex.org/W2096442705","https://openalex.org/W2108896356","https://openalex.org/W2114526613","https://openalex.org/W2115201792","https://openalex.org/W2115960347","https://openalex.org/W2124846900","https://openalex.org/W2126055537","https://openalex.org/W2129772562","https://openalex.org/W2149947053","https://openalex.org/W2158482458","https://openalex.org/W2159359219","https://openalex.org/W2160038693","https://openalex.org/W2165500804","https://openalex.org/W2170995397","https://openalex.org/W2332146149","https://openalex.org/W2417967861","https://openalex.org/W3022057079"],"related_works":["https://openalex.org/W2109331116","https://openalex.org/W2004808583","https://openalex.org/W2067812655","https://openalex.org/W1998131996","https://openalex.org/W2005719563","https://openalex.org/W885691231","https://openalex.org/W1972027206","https://openalex.org/W2088998395","https://openalex.org/W2319778626","https://openalex.org/W2060994087"],"abstract_inverted_index":{"Tachyplesin":[0],"I":[1,21,53],"is":[2,127,239,244,322],"a":[3,23,187,209,232],"cyclic":[4],"beta-sheet":[5],"antimicrobial":[6,68,313],"peptide":[7,31,88,139,175,243,265,271,296],"isolated":[8],"from":[9],"the":[10,30,44,120,138,160,174,212,217,223,227,242,247,264,270,290,295,299,317],"hemocytes":[11],"of":[12,46,51,122,154,157,222,236,250,263,277,292,319,326],"Tachypleus":[13],"tridentatus.":[14],"The":[15,86,149,168,197,252],"four":[16,60],"cysteine":[17,307],"residues":[18,308],"in":[19,26,57,181,211,266],"tachyplesin":[20,52],"play":[22],"structural":[24],"role":[25,45],"imparting":[27],"amphipathicity":[28,47],"to":[29,36,94,193,204,298,304,312,324],"which":[32,58],"has":[33],"been":[34],"shown":[35],"be":[37],"essential":[38],"for":[39],"its":[40],"activity.":[41],"We":[42],"investigated":[43],"using":[48,134],"an":[49,128,178,182],"analogue":[50],"(TP-I),":[54],"CDT":[55,66,87,123,140,202],"(KWFRVYRGIYRRR-NH(2)),":[56],"all":[59],"cysteines":[61],"were":[62],"deleted.":[63],"Like":[64],"TP-I,":[65],"shows":[67,172],"activity":[69,314,321],"and":[70,76,106,142,159,185,230,285,315,328],"disrupts":[71],"Escherichia":[72],"coli":[73],"outer":[74],"membrane":[75,237],"model":[77],"membranes":[78,82,126],"mimicking":[79],"bacterial":[80],"inner":[81],"at":[83,103,110,260],"micromolar":[84],"concentrations.":[85],"does":[89],"not":[90,310],"cause":[91],"hemolysis":[92,102,109],"up":[93],"200":[95],"microg/mL":[96,105],"while":[97],"TP-I":[98],"showed":[99],"about":[100,107],"10%":[101],"100":[104],"25%":[108],"150":[111],"microg/mL.":[112],"Peptide-into-lipid":[113],"titrations":[114],"under":[115],"isothermal":[116],"conditions":[117],"reveal":[118],"that":[119,137,173,201,269,289,306,316],"interaction":[121],"with":[124,216],"lipid":[125,213,218],"enthalpy-driven":[129],"process.":[130],"Binding":[131],"assays":[132],"performed":[133],"fluorometry":[135],"demonstrate":[136],"binds":[141],"inserts":[143],"into":[144],"only":[145],"negatively":[146,194,205],"charged":[147,195,206],"membranes.":[148],"peptide-induced":[150],"thermotropic":[151],"phase":[152,254],"transition":[153],"MLVs":[155],"formed":[156],"DMPC":[158],"DMPC/DMPG":[161],"(7:3)":[162],"mixture":[163],"suggests":[164],"specific":[165],"lipid-peptide":[166],"interactions.":[167],"circular":[169],"dichroism":[170],"study":[171],"exists":[176],"as":[177,241],"unordered":[179],"structure":[180],"aqueous":[183],"buffer":[184],"adopts":[186],"more":[188],"ordered":[189],"beta-structure":[190],"upon":[191],"binding":[192,203,297],"membrane.":[196],"NMR":[198,284],"data":[199,287],"suggest":[200,268,288],"bilayers":[207,267,278],"induces":[208],"change":[210],"headgroup":[214,219,248],"conformation":[215],"moving":[220],"out":[221],"bilayer":[224],"surface":[225],"toward":[226],"water":[228],"phase,":[229],"therefore,":[231],"barrel":[233],"stave":[234],"mechanism":[235],"disruption":[238],"unlikely":[240],"located":[245],"near":[246],"region":[249],"lipids.":[251],"lamellar":[253],"(31)P":[255],"chemical":[256],"shift":[257],"spectra":[258],"observed":[259],"various":[261],"concentrations":[262],"may":[272,309],"function":[273],"neither":[274],"via":[275],"fragmentation":[276],"nor":[279],"by":[280],"promoting":[281],"nonlamellar":[282],"structures.":[283],"fluorescence":[286],"presence":[291],"cholesterol":[293],"inhibits":[294],"bilayers.":[300],"These":[301],"properties":[302],"help":[303],"explain":[305],"contribute":[311],"loss":[318],"hemolytic":[320],"due":[323],"lack":[325],"hydrophobicity":[327],"amphipathicity.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}