{"id":"https://openalex.org/W55595804","doi":null,"title":"Combined cisplatin and gemcitabine for non-small cell lung cancer: influence of scheduling on toxicity and drug delivery.","display_name":"Combined cisplatin and gemcitabine for non-small cell lung cancer: influence of scheduling on toxicity and drug delivery.","publication_year":1998,"publication_date":"1998-08-01","ids":{"openalex":"https://openalex.org/W55595804","mag":"55595804","pmid":"https://pubmed.ncbi.nlm.nih.gov/9728583"},"language":"en","primary_location":{"id":"pmid:9728583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9728583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110510963","display_name":"Raymond Pierre Abratt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"R P Abratt","raw_affiliation_strings":["University of Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078389632","display_name":"Alan B. Sandler","orcid":"https://orcid.org/0009-0004-5397-5247","observed_orcids":["https://orcid.org/0009-0004-5397-5247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Sandler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008403882","display_name":"Lucio Crin\u00f2","orcid":"https://orcid.org/0000-0001-5745-6429","observed_orcids":["https://orcid.org/0000-0001-5745-6429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Crin\u00f2","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109832911","display_name":"William P. Steward","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W P Steward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075347427","display_name":"Frances A. Shepherd","orcid":"https://orcid.org/0000-0002-3610-3533","observed_orcids":["https://orcid.org/0000-0002-3610-3533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F A Shepherd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011409049","display_name":"Mark R. Green","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Green","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111427389","display_name":"Bobbie Nguyen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035296183","display_name":"Godefridus J. Peters","orcid":"https://orcid.org/0000-0002-5447-2877","observed_orcids":["https://orcid.org/0000-0002-5447-2877"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G J Peters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.4985,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.96819943,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"25","issue":"4 Suppl 9","first_page":"35","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.08889999985694885,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.925000011920929},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chemotherapy-schedule","display_name":"chemotherapy schedule","score":0.7870000004768372},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.5950000286102295},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.7350000143051147},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.7080000042915344},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.7039999961853027},{"id":"https://openalex.org/keywords/advanced-lung-cancer","display_name":"advanced lung cancer","score":0.5400000214576721},{"id":"https://openalex.org/keywords/dose-de-escalation","display_name":"dose de-escalation","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.9375698566436768},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8828369379043579},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7823116779327393},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7784072160720825},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5835044384002686},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5542982220649719},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4643310606479645},{"id":"https://openalex.org/C2781047374","wikidata":"https://www.wikidata.org/wiki/Q2100012","display_name":"Pulmonary toxicity","level":3,"score":0.4535972476005554},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44191479682922363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4402504563331604},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3429279625415802}],"mesh":[{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017322","descriptor_name":"Clinical Trials, Phase II as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9728583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9728583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"},{"id":"mag:55595804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9728583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2025939205","https://openalex.org/W2129785672","https://openalex.org/W2008027755","https://openalex.org/W2252858287","https://openalex.org/W2147906262","https://openalex.org/W2169274051","https://openalex.org/W2105772085","https://openalex.org/W72672147","https://openalex.org/W2052515011","https://openalex.org/W2047517255"],"abstract_inverted_index":{"The":[0,112,217,253,322,355,431,461,545],"scheduling":[1,85],"of":[2,29,32,45,76,86,160,219,255,303,317,325,343,384,402,422,433,463,471,516,529,562,571],"cytotoxic":[3],"chemotherapy":[4,15],"has":[5],"important":[6,535],"bearing":[7],"on":[8,26,36,70,93,145],"the":[9,27,84,158,172,179,226,273,282,285,289,301,311,318,334,344,358,382,414,423,439,475,488,498,505,512,520,526,553,558,569],"toxicity":[10,37,166,188,193,275,283],"and":[11,34,38,74,89,107,124,140,149,196,212,236,240,251,269,365,369,377,395,446,450,458,483,494,557,566],"ability":[12],"to":[13,19,564],"deliver":[14],"at":[16,284,348,392,575],"or":[17,103,163,203,222,258,298,306],"close":[18],"full":[20,393,576],"dose.":[21],"We":[22],"report":[23],"new":[24],"data":[25],"influence":[28],"different":[30],"schedules":[31,154,312],"cisplatin":[33,87,175,245,337,371,417,452,508,523,548],"gemcitabine":[35,67,118,326,388,403,437,472,500,530,540],"drug":[39,165,294],"delivery":[40,295],"in":[41,51,80,157,177,197,300,386,396,413,465,496,578],"phase":[42,53],"II":[43,54],"studies":[44,55,169,234,243],"non-small":[46,62],"cell":[47,63],"lung":[48,64],"cancer.":[49,65],"Patients":[50],"six":[52],"had":[56],"standard":[57],"entry":[58],"criteria":[59],"for":[60,117,129,167,171,183,474,511,536],"advanced":[61],"Whereas":[66],"was":[68,90,119,132,181,189,194,207,215,247,265,296,330,373,454,479,502],"given":[69,91,136,144,391],"days":[71,104,146,237,366,447],"1,":[72,95,105,147,228,238,360,367,441,448,492],"8,":[73,106,148,239,368,449,493],"15":[75,99,108,232,241,336,370,416,451,507,522,547],"a":[77,542],"28-day":[78],"cycle":[79,139],"all":[81,168],"these":[82,262],"studies,":[83],"varied":[88],"either":[92],"day":[94,96,98,173,227,229,231,335,359,361,363,415,440,442,444,506,521,546],"2,":[97,230,362,443],"(in":[100,109],"two":[101,110],"studies),":[102],"studies).":[111],"protocol":[113,499],"dose":[114,152,180,356,394,408,501,555],"per":[115,138,327],"infusion":[116,329],"1,000":[120,349],"mg/m2":[121,126,134,142,350],"(five":[122],"studies)":[123],"1,500":[125],"(one":[127],"study);":[128],"cisplatin,":[130],"it":[131,280],"100":[133],"when":[135,143],"once":[137],"30":[141],"15.":[150],"Similar":[151],"reduction":[153],"were":[155,390,399,410,468],"implemented":[156],"event":[159,302],"grade":[161,184,201,220,256,304],"3":[162,202,221,257,305],"higher":[164,332,412],"except":[170],"1":[174],"study,":[176],"which":[178,387,397,466,497,532],"omitted":[182,299],"2":[185],"thrombocytopenia.":[186],"Nonhematologic":[187],"very":[190],"low.":[191],"Hematologic":[192],"moderate,":[195],"patients":[198],"who":[199],"developed":[200],"4":[204,223,259,307],"toxicity,":[205],"there":[206,398,467],"no":[208,400,469],"hemorrhage":[209],"from":[210,487],"thrombocytopenia":[211,224],"neutropenic":[213],"sepsis":[214],"rare.":[216],"incidence":[218,254],"with":[225,261,333,341,357,407,420,438,552],"(two":[233,242],"combined),":[235],"combined)":[244],"regimens":[246,264,338,346,372,425,453,477],"50%,":[248],"52%,":[249],"26%,":[250],"38%.":[252],"neutropenia":[260],"four":[263,476],"51%,":[266],"37%,":[267],"56%,":[268],"49%,":[270],"respectively.":[271,380,460,485],"Although":[272],"hematologic":[274],"might":[276],"appear":[277],"relatively":[278],"similar,":[279],"represents":[281],"administered":[286],"rather":[287],"than":[288,419],"intended":[290],"(protocol)":[291],"dose,":[292],"because":[293],"reduced":[297],"toxicity.":[308],"Differences":[309],"between":[310],"are":[313],"revealed":[314],"by":[315],"analysis":[316],"actual":[319],"dosages":[320],"delivered.":[321],"median":[323,514,560],"dosage":[324],"scheduled":[328],"statistically":[331,411],"(combined)":[339],"compared":[340],"any":[342,421],"other":[345,424],"treating":[347],"(P":[351,426],"<":[352,427],".003,":[353],"z-score).":[354],"15,":[364,445],"664,":[374],"829,":[375],"889,":[376],"774":[378],"mg/m2,":[379,504],"Both":[381],"percentages":[383],"cycles":[385,434,464],"infusions":[389,404,406,473],"omissions":[401,470],"(including":[405],"reductions)":[409],"regimen":[418,490],".0001,":[428],"chi-square":[429],"test).":[430],"percentage":[432,462],"containing":[435],"full-dose":[436],"24%,":[455],"44%,":[456],"75%,":[457],"46%,":[459],"above":[478],"32%,":[480],"55%,":[481],"83%,":[482],"72%,":[484],"Apart":[486],"once-weekly":[489],"(days":[491],"15)":[495],"1,250":[503],"schedule":[509,524,549],"allowed":[510],"highest":[513],"concentration":[515],"gemcitabine.":[517],"More":[518],"importantly,":[519],"provided":[525],"longest":[527,559],"duration":[528,561],"exposure,":[531],"is":[533,541,550],"particularly":[534],"its":[537],"activity":[538],"as":[539],"phase-specific":[543],"agent.":[544],"associated":[551],"best":[554,567],"intensity":[556],"exposure":[563],"gemcitabine,":[565],"meets":[568],"goal":[570],"administering":[572],"both":[573],"agents":[574],"doses":[577],"combination.":[579]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
