{"id":"https://openalex.org/W55539197","doi":null,"title":"Immunohistochemical localization of extracellular matrix components in human diabetic glomerular lesions.","display_name":"Immunohistochemical localization of extracellular matrix components in human diabetic glomerular lesions.","publication_year":1991,"publication_date":"1991-10-01","ids":{"openalex":"https://openalex.org/W55539197","mag":"55539197","pmid":"https://pubmed.ncbi.nlm.nih.gov/1928305","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886324"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886324","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886324","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886324","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058718221","display_name":"Michael L. Nerlich","orcid":"https://orcid.org/0000-0001-6562-1017","observed_orcids":["https://orcid.org/0000-0001-6562-1017"]},"institutions":[{"id":"https://openalex.org/I4405259543","display_name":"Pathologisches Institut","ror":"https://ror.org/02cqe8q68","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Nerlich","raw_affiliation_strings":["Pathologisches Institut, Universit\u00e4t M\u00fcnchen, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathologisches Institut, Universit\u00e4t M\u00fcnchen, Federal Republic of Germany","institution_ids":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110875909","display_name":"E. Schleicher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Schleicher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":15.6764,"has_fulltext":false,"cited_by_count":188,"citation_normalized_percentile":{"value":0.99420452,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"139","issue":"4","first_page":"889","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.3467000126838684,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/diabetic-glomerulosclerosis","display_name":"diabetic glomerulosclerosis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9010000228881836},{"id":"https://openalex.org/keywords/glomerular-basement-membrane","display_name":"glomerular basement membrane","score":0.9620000123977661},{"id":"https://openalex.org/keywords/heparan-sulfate-proteoglycans","display_name":"heparan sulfate proteoglycans","score":0.9670000076293945},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.8560000061988831},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/type-v-collagen","display_name":"type V collagen","score":0.9340000152587891},{"id":"https://openalex.org/keywords/type-iii-collagen","display_name":"type III collagen","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mesangial-matrix","display_name":"mesangial matrix","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.817200243473053},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.8070622682571411},{"id":"https://openalex.org/C2779937669","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Mesangium","level":4,"score":0.7872596979141235},{"id":"https://openalex.org/C2910125355","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Glomerular mesangium","level":4,"score":0.7468071579933167},{"id":"https://openalex.org/C2777107211","wikidata":"https://www.wikidata.org/wiki/Q7860610","display_name":"Type IV collagen","level":4,"score":0.7184410095214844},{"id":"https://openalex.org/C2776115139","wikidata":"https://www.wikidata.org/wiki/Q1753456","display_name":"Glomerular basement membrane","level":4,"score":0.693511426448822},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.6597250699996948},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6233036518096924},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6061884164810181},{"id":"https://openalex.org/C3060791","wikidata":"https://www.wikidata.org/wiki/Q3216737","display_name":"Lamina densa","level":3,"score":0.47346797585487366},{"id":"https://openalex.org/C44843598","wikidata":"https://www.wikidata.org/wiki/Q6481904","display_name":"Lamina lucida","level":4,"score":0.45297613739967346},{"id":"https://openalex.org/C3018920779","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Renal glomerulus","level":4,"score":0.44697487354278564},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4086242616176605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3814013600349426},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.3414499759674072},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21182766556739807},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2092157006263733},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.1949673295021057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19103333353996277}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005921","descriptor_name":"Glomerulonephritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1886324","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886324","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:1928305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1928305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:55539197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1928305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886324","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886324","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W26133879","https://openalex.org/W29671035","https://openalex.org/W172207939","https://openalex.org/W290286809","https://openalex.org/W1966970425","https://openalex.org/W1970248029","https://openalex.org/W1990366315","https://openalex.org/W1996336220","https://openalex.org/W2006741091","https://openalex.org/W2011520451","https://openalex.org/W2013936938","https://openalex.org/W2025871503","https://openalex.org/W2062347550","https://openalex.org/W2067415033","https://openalex.org/W2084297297","https://openalex.org/W2089691974","https://openalex.org/W2090935242","https://openalex.org/W2124314287","https://openalex.org/W2125357370","https://openalex.org/W2135845349","https://openalex.org/W2141581995","https://openalex.org/W2150912407","https://openalex.org/W2151084936","https://openalex.org/W2164287441","https://openalex.org/W2167578487","https://openalex.org/W2314185779","https://openalex.org/W2315008419","https://openalex.org/W2326855146","https://openalex.org/W2396245893","https://openalex.org/W2411023590","https://openalex.org/W2416247371"],"related_works":["https://openalex.org/W1936824174","https://openalex.org/W2086836368","https://openalex.org/W2083074809","https://openalex.org/W2987864280","https://openalex.org/W2020603589","https://openalex.org/W2022787091","https://openalex.org/W2066837348","https://openalex.org/W1965044378","https://openalex.org/W2057763782","https://openalex.org/W1710725509"],"abstract_inverted_index":{"The":[0,216],"immunohistochemical":[1],"localization":[2],"of":[3,15,61,128,145,160,214,219,236],"the":[4,45,51,58,108,125,146,158,161,164,197,200,228,232,237],"extracellular":[5],"matrix":[6,111,202],"was":[7,41,130],"examined":[8],"in":[9,44,50,57,72,78,137,157,185,188,199,203,222],"31":[10],"cases":[11],"with":[12],"different":[13],"degrees":[14],"human":[16,22],"diabetic":[17,105,138,204],"nephropathy":[18,205],"using":[19],"antisera":[20],"to":[21,54,101,231],"collagen":[23,91,102,118,181],"types":[24],"I,":[25,182],"III,":[26,178],"IV,":[27,119],"V,":[28,120],"fibronectin,":[29],"laminin,":[30,121],"and":[31,49,53,63,68,76,122,177,211],"basement-membrane-associated":[32],"heparan":[33],"sulfate":[34],"proteoglycan":[35],"(HSPG).":[36],"In":[37,104],"normal":[38],"glomeruli,":[39],"HSPG":[40,129,151,220],"predominantly":[42],"localized":[43],"glomerular":[46,73,98,201,238],"basement":[47,59,74,147,169,239],"membrane":[48,75,148,170],"mesangium,":[52],"minor":[55,79],"extent":[56],"membranes":[60],"tubules":[62],"Bowman's":[64],"capsule.":[65],"Collagen":[66],"IV":[67],"laminin":[69],"were":[70,140,183],"distributed":[71],"mesangium":[77],"amounts.":[80,190],"Interstitial":[81],"collagens":[82,175],"usually":[83],"do":[84],"not":[85,180],"occur":[86],"within":[87],"glomeruli":[88,139],"except":[89],"for":[90,117,143,167],"V":[92,176],"which":[93],"has":[94],"a":[95],"light":[96],"microscopic":[97],"distribution":[99],"similar":[100],"IV.":[103],"diffuse":[106],"glomerulosclerosis,":[107],"enlarged":[109],"mesangial":[110],"showed":[112],"an":[113,155],"increased":[114],"staining":[115,126,165],"reaction":[116,166],"fibronectin":[123],"whereas":[124,150,173],"pattern":[127],"markedly":[131],"reduced.":[132],"Early,":[133],"small":[134],"nodular":[135],"lesions":[136,225],"similarly":[141],"positive":[142],"most":[144],"components,":[149],"remained":[152],"absent.":[153],"With":[154],"increase":[156],"diameter":[159],"noduli,":[162],"however,":[163],"all":[168],"components":[171],"diminished,":[172],"interstitial":[174],"but":[179],"present":[184],"these":[186],"noduli":[187],"substantial":[189],"These":[191],"initial":[192],"studies":[193],"provide":[194],"evidence":[195],"that":[196],"changes":[198],"may":[206,226],"be":[207],"divided":[208],"into":[209],"distinct":[210],"progressing":[212],"stages":[213],"lesions.":[215],"reduced":[217],"amount":[218],"even":[221],"slight,":[223],"early":[224],"represent":[227],"morphologic":[229],"correlate":[230],"impaired":[233],"filter":[234],"function":[235],"membrane.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}