{"id":"https://openalex.org/W55509775","doi":"https://doi.org/10.6092/unibo/amsdottorato/2327","title":"Molecular characterization of the human gut microbiota: the effect of aging","display_name":"Molecular characterization of the human gut microbiota: the effect of aging","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W55509775","doi":"https://doi.org/10.6092/unibo/amsdottorato/2327","mag":"55509775"},"language":"en","primary_location":{"id":"pmh:oai:amsdottorato.cib.unibo.it:2327","doi":null,"is_oa":false,"landing_page_url":"http://amsdottorato.unibo.it/2327/2/Biagi_Elena_tesi.pdf","pdf_url":"http://amsdottorato.unibo.it/2327/2/Biagi_Elena_tesi.pdf","source":{"id":"https://openalex.org/S4306400630","display_name":"AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I9360294","host_organization_name":"University of Bologna","host_organization_lineage":["https://openalex.org/I9360294"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Tesi di dottorato"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6092/unibo/amsdottorato/2327","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017282401","display_name":"Elena Biagi","orcid":"https://orcid.org/0000-0002-3927-467X","observed_orcids":["https://orcid.org/0000-0002-3927-467X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Biagi, Elena <1982>","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017282401"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00478083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8510000109672546},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9800000190734863},{"id":"https://openalex.org/keywords/centenarians","display_name":"centenarians","score":0.9829999804496765},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.796999990940094},{"id":"https://openalex.org/keywords/ligase-detection-reaction","display_name":"ligase detection reaction","score":0.902999997138977},{"id":"https://openalex.org/keywords/microbial-diversity","display_name":"microbial diversity","score":0.6489999890327454},{"id":"https://openalex.org/keywords/firmicutes","display_name":"Firmicutes","score":0.9829999804496765},{"id":"https://openalex.org/keywords/facultative-anaerobes","display_name":"facultative anaerobes","score":0.9829999804496765},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.7667877674102783},{"id":"https://openalex.org/C2777695942","wikidata":"https://www.wikidata.org/wiki/Q149075","display_name":"Firmicutes","level":4,"score":0.7268679141998291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6978456377983093},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.5334387421607971},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.507689356803894},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4758712351322174},{"id":"https://openalex.org/C2778546792","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Human gastrointestinal tract","level":3,"score":0.4545939266681671},{"id":"https://openalex.org/C2779676784","wikidata":"https://www.wikidata.org/wiki/Q130999","display_name":"Proteobacteria","level":4,"score":0.43019646406173706},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.41465649008750916},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.40784668922424316},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3004131615161896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21782848238945007},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1881943941116333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11100971698760986},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.08209660649299622},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08132615685462952},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:amsdottorato.cib.unibo.it:2327","doi":null,"is_oa":false,"landing_page_url":"http://amsdottorato.unibo.it/2327/2/Biagi_Elena_tesi.pdf","pdf_url":"http://amsdottorato.unibo.it/2327/2/Biagi_Elena_tesi.pdf","source":{"id":"https://openalex.org/S4306400630","display_name":"AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I9360294","host_organization_name":"University of Bologna","host_organization_lineage":["https://openalex.org/I9360294"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Tesi di dottorato"},{"id":"doi:10.6092/unibo/amsdottorato/2327","doi":"https://doi.org/10.6092/unibo/amsdottorato/2327","is_oa":true,"landing_page_url":"https://doi.org/10.6092/unibo/amsdottorato/2327","pdf_url":null,"source":{"id":"https://openalex.org/S7407050985","display_name":"Universit\u00e0 degli Studi di Bologna","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:2183377039","doi":null,"is_oa":false,"landing_page_url":"http://amsdottorato.unibo.it/2327/2/Biagi_Elena_tesi.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:55509775","doi":null,"is_oa":false,"landing_page_url":"http://amsdottorato.unibo.it/2327/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.6092/unibo/amsdottorato/2327","doi":"https://doi.org/10.6092/unibo/amsdottorato/2327","is_oa":true,"landing_page_url":"https://doi.org/10.6092/unibo/amsdottorato/2327","pdf_url":null,"source":{"id":"https://openalex.org/S7407050985","display_name":"Universit\u00e0 degli Studi di Bologna","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":209,"referenced_works":["https://openalex.org/W6054291","https://openalex.org/W44338824","https://openalex.org/W56273247","https://openalex.org/W131743979","https://openalex.org/W143521294","https://openalex.org/W203609338","https://openalex.org/W317612764","https://openalex.org/W1485953070","https://openalex.org/W1492617550","https://openalex.org/W1503928854","https://openalex.org/W1516370651","https://openalex.org/W1538972034","https://openalex.org/W1573061600","https://openalex.org/W1603763228","https://openalex.org/W1612816063","https://openalex.org/W1647673097","https://openalex.org/W1654600679","https://openalex.org/W1658221551","https://openalex.org/W1661808942","https://openalex.org/W1742880204","https://openalex.org/W1901435509","https://openalex.org/W1905558879","https://openalex.org/W1924144975","https://openalex.org/W1940197145","https://openalex.org/W1941587249","https://openalex.org/W1943641126","https://openalex.org/W1964427610","https://openalex.org/W1964657574","https://openalex.org/W1965037168","https://openalex.org/W1967060514","https://openalex.org/W1967821667","https://openalex.org/W1974109692","https://openalex.org/W1974670959","https://openalex.org/W1974751229","https://openalex.org/W1976130719","https://openalex.org/W1980654673","https://openalex.org/W1980914602","https://openalex.org/W1981560461","https://openalex.org/W1982191305","https://openalex.org/W1982279452","https://openalex.org/W1983972858","https://openalex.org/W1987992874","https://openalex.org/W1988053043","https://openalex.org/W1993179764","https://openalex.org/W1994326378","https://openalex.org/W1995216632","https://openalex.org/W1995359262","https://openalex.org/W1995389811","https://openalex.org/W1996823741","https://openalex.org/W2001343557","https://openalex.org/W2001383615","https://openalex.org/W2002313780","https://openalex.org/W2002578996","https://openalex.org/W2002941870","https://openalex.org/W2003099302","https://openalex.org/W2005080341","https://openalex.org/W2005258869","https://openalex.org/W2005649856","https://openalex.org/W2005741884","https://openalex.org/W2007895693","https://openalex.org/W2009533832","https://openalex.org/W2014216380","https://openalex.org/W2014444740","https://openalex.org/W2015862329","https://openalex.org/W2021251015","https://openalex.org/W2023049843","https://openalex.org/W2023654392","https://openalex.org/W2024601462","https://openalex.org/W2024638601","https://openalex.org/W2025134067","https://openalex.org/W2025465669","https://openalex.org/W2025986883","https://openalex.org/W2027042725","https://openalex.org/W2028520715","https://openalex.org/W2029943794","https://openalex.org/W2030330958","https://openalex.org/W2031647107","https://openalex.org/W2033359899","https://openalex.org/W2036647435","https://openalex.org/W2037833069","https://openalex.org/W2039217252","https://openalex.org/W2040797794","https://openalex.org/W2040840388","https://openalex.org/W2044347768","https://openalex.org/W2045384493","https://openalex.org/W2048887584","https://openalex.org/W2049981976","https://openalex.org/W2050920580","https://openalex.org/W2052342903","https://openalex.org/W2052969143","https://openalex.org/W2053057020","https://openalex.org/W2053430603","https://openalex.org/W2053639892","https://openalex.org/W2057857185","https://openalex.org/W2059005097","https://openalex.org/W2061453528","https://openalex.org/W2062073449","https://openalex.org/W2062661305","https://openalex.org/W2064410624","https://openalex.org/W2064642161","https://openalex.org/W2064894235","https://openalex.org/W2066452478","https://openalex.org/W2072212459","https://openalex.org/W2072315314","https://openalex.org/W2072622521","https://openalex.org/W2073332363","https://openalex.org/W2073359524","https://openalex.org/W2075059238","https://openalex.org/W2075138494","https://openalex.org/W2080032018","https://openalex.org/W2080860848","https://openalex.org/W2082704291","https://openalex.org/W2083537767","https://openalex.org/W2083839994","https://openalex.org/W2084237578","https://openalex.org/W2088029800","https://openalex.org/W2088284295","https://openalex.org/W2090490364","https://openalex.org/W2090925778","https://openalex.org/W2091273397","https://openalex.org/W2091309425","https://openalex.org/W2094732337","https://openalex.org/W2095724872","https://openalex.org/W2095795158","https://openalex.org/W2095860497","https://openalex.org/W2096059629","https://openalex.org/W2096154600","https://openalex.org/W2096707864","https://openalex.org/W2097875133","https://openalex.org/W2097937398","https://openalex.org/W2097988818","https://openalex.org/W2099866694","https://openalex.org/W2102615343","https://openalex.org/W2103592347","https://openalex.org/W2104037158","https://openalex.org/W2104490782","https://openalex.org/W2104881665","https://openalex.org/W2105349209","https://openalex.org/W2106249800","https://openalex.org/W2107378563","https://openalex.org/W2107414352","https://openalex.org/W2107853514","https://openalex.org/W2109744701","https://openalex.org/W2110714820","https://openalex.org/W2110785364","https://openalex.org/W2111458006","https://openalex.org/W2111570096","https://openalex.org/W2111775329","https://openalex.org/W2113000633","https://openalex.org/W2113466108","https://openalex.org/W2113854409","https://openalex.org/W2114081392","https://openalex.org/W2116531370","https://openalex.org/W2117065897","https://openalex.org/W2117121624","https://openalex.org/W2117130914","https://openalex.org/W2118405849","https://openalex.org/W2118867520","https://openalex.org/W2120291810","https://openalex.org/W2120459847","https://openalex.org/W2120955876","https://openalex.org/W2121673355","https://openalex.org/W2122007620","https://openalex.org/W2123870698","https://openalex.org/W2125718892","https://openalex.org/W2125755185","https://openalex.org/W2126788366","https://openalex.org/W2127405064","https://openalex.org/W2128989044","https://openalex.org/W2129130754","https://openalex.org/W2130802610","https://openalex.org/W2131186249","https://openalex.org/W2132829999","https://openalex.org/W2134419472","https://openalex.org/W2135947850","https://openalex.org/W2140497145","https://openalex.org/W2141125135","https://openalex.org/W2142149155","https://openalex.org/W2142536690","https://openalex.org/W2143462304","https://openalex.org/W2145336165","https://openalex.org/W2146178402","https://openalex.org/W2147726663","https://openalex.org/W2148067809","https://openalex.org/W2148651797","https://openalex.org/W2149573313","https://openalex.org/W2149988544","https://openalex.org/W2150243977","https://openalex.org/W2152417392","https://openalex.org/W2152769261","https://openalex.org/W2152885278","https://openalex.org/W2153103916","https://openalex.org/W2153827064","https://openalex.org/W2154401636","https://openalex.org/W2155765902","https://openalex.org/W2155806125","https://openalex.org/W2156522926","https://openalex.org/W2158820172","https://openalex.org/W2163248301","https://openalex.org/W2165003751","https://openalex.org/W2165924947","https://openalex.org/W2165971615","https://openalex.org/W2167062509","https://openalex.org/W2168296283","https://openalex.org/W2171361501","https://openalex.org/W2338541571","https://openalex.org/W2442390795","https://openalex.org/W2912979477","https://openalex.org/W3137695655"],"related_works":["https://openalex.org/W3151304283","https://openalex.org/W2082704291","https://openalex.org/W7095226112","https://openalex.org/W82981598","https://openalex.org/W7203754500","https://openalex.org/W2048676453","https://openalex.org/W4251820669","https://openalex.org/W2620676440","https://openalex.org/W2982520321","https://openalex.org/W1987296519"],"abstract_inverted_index":{"Age-related":[0],"physiological":[1],"changes":[2,92],"in":[3,11,155,172,266,312],"the":[4,18,24,34,44,47,51,54,60,63,67,74,83,90,97,111,117,136,145,148,156,173,200,214,217,242,259,262,271,283,293,301,316,321,324,328,332,335,349,358],"gastrointestinal":[5],"tract,":[6],"as":[7,9,184,186,280,282,345],"well":[8,281],"modification":[10],"lifestyle,":[12],"nutritional":[13],"behaviour,":[14],"and":[15,36,53,114,123,159,238,255,351],"functionality":[16],"of":[17,38,46,62,69,93,116,120,135,141,162,167,191,202,211,216,261,268,270,323,327,334,357],"host":[19],"immune":[20],"system,":[21],"inevitably":[22],"affect":[23],"gut":[25,49,94,118,219,264,303],"microbiota.":[26],"The":[27,86,165,226,274],"study":[28,285],"presented":[29],"here":[30],"is":[31,127,150,175],"focused":[32],"on":[33,66,241,276,331],"application":[35],"comparison":[37],"two":[39],"different":[40],"microarray":[41,206],"approaches":[42],"for":[43,258],"characterization":[45],"human":[48,146,218,263,302],"microbiota,":[50,304],"HITChip":[52,352],"HTF-Microb.Array,":[55],"with":[56,144,177,207,315],"particular":[57],"attention":[58],"to":[59,106,251,298,307],"effects":[61],"aging":[64],"process":[65],"composition":[68,113],"this":[70],"ecosystem.":[71],"By":[72],"using":[73],"Human":[75],"Intestinal":[76],"Tract":[77],"Chip":[78],"(HITChip),":[79],"recently":[80],"developed":[81],"at":[82,222],"Wageningen":[84],"University,":[85],"Netherland,":[87],"we":[88,198],"explored":[89],"age-related":[91],"microbiota":[95,149,171,220,265],"during":[96],"whole":[98],"adult":[99],"lifespan,":[100],"from":[101,133],"young":[102,121,289],"adults,":[103,290],"through":[104],"elderly":[105],"centenarians.":[107,137,360],"We":[108],"observed":[109],"that":[110,134,292],"microbial":[112],"diversity":[115],"ecosystem":[119],"adults":[122],"seventy-years":[124],"old":[125],"people":[126],"highly":[128],"similar":[129],"but":[130],"differs":[131],"significantly":[132],"After":[138],"100":[139],"years":[140],"symbiotic":[142],"association":[143],"host,":[147],"characterized":[151],"by":[152,188,347],"a":[153,169,189,208,253],"rearrangement":[154],"Firmicutes":[157],"population":[158],"an":[160,178],"enrichment":[161],"facultative":[163],"anaerobes.":[164],"presence":[166],"such":[168],"compromised":[170],"centenarians":[174],"associated":[176],"increased":[179],"inflammation":[180],"status,":[181],"also":[182],"known":[183],"inflamm-aging,":[185],"determined":[187],"range":[190],"peripheral":[192],"blood":[193],"inflammatory":[194],"markers.":[195],"In":[196],"parallel,":[197],"overtook":[199],"development":[201],"our":[203],"own":[204],"phylogenetic":[205],"lower":[209],"number":[210],"targets,":[212],"aiming":[213],"description":[215],"structure":[221],"high":[223,353],"taxonomic":[224,354],"level.":[225],"resulting":[227],"chip":[228],"was":[229,239],"called":[230],"High":[231],"Taxonomic":[232],"level":[233,355],"Fingerprinting":[234],"Microbiota":[235],"Array":[236],"(HTF-Microb.Array),":[237],"based":[240],"Ligase":[243],"Detection":[244],"Reaction":[245],"(LDR)":[246],"technology,":[247],"which":[248,310],"allowed":[249],"us":[250,306],"develop":[252],"fast":[254],"sensitive":[256],"tool":[257],"fingerprint":[260],"terms":[267],"presence/absence":[269],"principal":[272],"groups.":[273],"validation":[275],"artificial":[277],"DNA":[278],"mixes,":[279],"pilot":[284],"involving":[286],"eight":[287],"healthy":[288],"demonstrated":[291,346],"HTF-Microb.Array":[294],"can":[295],"be":[296],"used":[297],"successfully":[299],"characterize":[300],"allowing":[305],"obtain":[308],"results":[309],"are":[311],"approximate":[313],"accordance":[314],"most":[317],"recent":[318],"characterizations.":[319],"Conversely,":[320],"evaluation":[322],"relative":[325,336],"abundance":[326],"target":[329],"groups":[330],"bases":[333],"fluorescence":[337],"intensity":[338],"probes":[339],"response":[340],"still":[341],"has":[342],"some":[343],"hindrances,":[344],"comparing":[348],"HTF.Microb.Array":[350],"fingerprints":[356],"same":[359]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
