{"id":"https://openalex.org/W55433023","doi":null,"title":"Benefits and risks due to animal serum used in cell culture production.","display_name":"Benefits and risks due to animal serum used in cell culture production.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W55433023","mag":"55433023","pmid":"https://pubmed.ncbi.nlm.nih.gov/10404869"},"language":"en","primary_location":{"id":"pmid:10404869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10404869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developments in biological standardization","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064754965","display_name":"Stephen J. Wessman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288380561","display_name":"Animal and Plant Health Inspection Service","ror":"https://ror.org/0599wfz09","country_code":"US","type":"government","lineage":["https://openalex.org/I1288380561","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S J Wessman","raw_affiliation_strings":["USDA, APHIS, VS, Center for Veterinary Biologics-Laboratory, Ames, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA, APHIS, VS, Center for Veterinary Biologics-Laboratory, Ames, Iowa, USA","institution_ids":["https://openalex.org/I1288380561","https://openalex.org/I1336096307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074373063","display_name":"Randall L. Levings","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Levings","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2764,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.76524888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"99","issue":null,"first_page":"3","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.2295999974012375,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.18790000677108765,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-viral-diarrhea-virus","display_name":"bovine viral diarrhea virus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cell-culture-production","display_name":"cell culture production","score":0.800000011920929},{"id":"https://openalex.org/keywords/vaccine-contamination","display_name":"vaccine contamination","score":0.7799999713897705},{"id":"https://openalex.org/keywords/intrauterine-infection","display_name":"intrauterine infection","score":0.7239999771118164},{"id":"https://openalex.org/keywords/vaccine-production","display_name":"vaccine production","score":0.39899998903274536},{"id":"https://openalex.org/keywords/virus-detection","display_name":"virus detection","score":0.5329999923706055},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.5770000219345093},{"id":"https://openalex.org/keywords/viral-diagnosis","display_name":"viral diagnosis","score":0.4790000021457672},{"id":"https://openalex.org/keywords/bovine-viral-infections","display_name":"bovine viral infections","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C2777451964","wikidata":"https://www.wikidata.org/wiki/Q2141450","display_name":"Seroconversion","level":3,"score":0.8185281753540039},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7066518068313599},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.609117329120636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5941805839538574},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.52257239818573},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5102534294128418},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.48693931102752686},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.4813321530818939},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47469133138656616},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.44340789318084717},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3301602602005005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30149418115615845},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.17049342393875122},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.16753509640693665},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.05863189697265625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D001908","descriptor_name":"Diarrhea Viruses, Bovine Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001912","descriptor_name":"Bovine Virus Diarrhea-Mucosal Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001912","descriptor_name":"Bovine Virus Diarrhea-Mucosal Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10404869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10404869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developments in biological standardization","raw_type":"Journal Article"},{"id":"mag:55433023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10404869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W73438327","https://openalex.org/W299674","https://openalex.org/W2002971350","https://openalex.org/W2136077679","https://openalex.org/W4256364828","https://openalex.org/W2416383507","https://openalex.org/W2040251482","https://openalex.org/W2025195581","https://openalex.org/W4206826371","https://openalex.org/W108227483"],"abstract_inverted_index":{"Infection":[0],"with":[1,67],"bovine":[2,14],"viral":[3,71],"diarrhoea":[4],"virus":[5,21],"(BVDV)":[6],"and":[7,22,27,79,88,93,110],"other":[8,28,80],"viruses":[9,81,87],"is":[10],"frequent":[11],"in":[12,31,45,55,82,106],"the":[13,56,68,75,91,94,111],"population.":[15],"In":[16],"utero":[17],"infection":[18],"leads":[19],"to":[20,51],"antibody":[23],"contamination":[24],"of":[25,37,70,77,96,104,113],"foetal":[26],"serum":[29,60,105],"used":[30],"cell":[32,62,84,107],"culture":[33,108],"production.":[34],"The":[35],"use":[36,103],"contaminated":[38,46],"cells":[39],"for":[40,74,101],"vaccine":[41],"production":[42],"may":[43,49,64],"result":[44],"vaccines,":[47],"which":[48],"lead":[50],"seroconversion":[52],"or":[53,61],"disease":[54],"vaccinated":[57],"animal.":[58],"Contaminated":[59],"cultures":[63],"also":[65],"interfere":[66],"diagnosis":[69],"infections.":[72],"Methods":[73],"detection":[76,97],"BVDV":[78],"serum,":[83,115],"cultures,":[85],"seed":[86],"vaccines":[89],"at":[90],"CVB-L,":[92],"frequency":[95],"are":[98,116],"described.":[99],"Reasons":[100],"continued":[102],"production,":[109],"risks":[112],"using":[114],"discussed.":[117]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}