{"id":"https://openalex.org/W55243106","doi":"https://doi.org/10.1182/blood.v122.21.1383.1383","title":"Alteration Of Cytogenetic Risk Stratification In New Diagnosis Of Leukemia By FISH Testing \u2013 Retrospective Review Of The SWOG Experience","display_name":"Alteration Of Cytogenetic Risk Stratification In New Diagnosis Of Leukemia By FISH Testing \u2013 Retrospective Review Of The SWOG Experience","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W55243106","doi":"https://doi.org/10.1182/blood.v122.21.1383.1383","mag":"55243106"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.1383.1383","doi":"https://doi.org/10.1182/blood.v122.21.1383.1383","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.1383.1383","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045975673","display_name":"Min Fang","orcid":"https://orcid.org/0000-0001-6688-437X","observed_orcids":["https://orcid.org/0000-0001-6688-437X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Min Fang","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011060058","display_name":"Shannon L. McDonough","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shannon McDonough","raw_affiliation_strings":["SWOG Statistical Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SWOG Statistical Center, Seattle, WA, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028772063","display_name":"Megan K. D. Othus","orcid":"https://orcid.org/0000-0001-8176-6371","observed_orcids":["https://orcid.org/0000-0001-8176-6371"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Megan Othus","raw_affiliation_strings":["Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114247236","display_name":"Lily T Zhuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lily T Zhuo","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077795391","display_name":"Diane Roulston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diane Roulston","raw_affiliation_strings":["Department of Pathology, University of Michigan, Ann Arbor, MI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, MI, USA,","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050556099","display_name":"Harry Paul Erba","orcid":"https://orcid.org/0000-0003-1093-2189","observed_orcids":["https://orcid.org/0000-0003-1093-2189"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry Paul Erba","raw_affiliation_strings":["University of Alabama, Birmingham, AL, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama, Birmingham, AL, USA,","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056405520","display_name":"Frederick R. Appelbaum","orcid":"https://orcid.org/0000-0002-1839-5069","observed_orcids":["https://orcid.org/0000-0002-1839-5069"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick R. Appelbaum","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011060058","https://openalex.org/A5028772063","https://openalex.org/A5045975673","https://openalex.org/A5077795391","https://openalex.org/A5114247236"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210089486"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00615626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"21","first_page":"1383","last_page":"1383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytogenetic-risk-stratification","display_name":"cytogenetic risk stratification","score":0.8690000176429749},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"fluorescence in situ hybridization","score":0.9520000219345093},{"id":"https://openalex.org/keywords/karyology","display_name":"karyology","score":0.8220000267028809},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8790000081062317},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cryptic-translocation","display_name":"cryptic translocation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/myc-amplification","display_name":"MYC amplification","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mll-rearrangement","display_name":"MLL rearrangement","score":0.9959999918937683},{"id":"https://openalex.org/keywords/5q-deletion","display_name":"5q deletion","score":0.5709999799728394},{"id":"https://openalex.org/keywords/7q-deletion","display_name":"7q deletion","score":0.9710000157356262},{"id":"https://openalex.org/keywords/inv-16","display_name":"inv(16)","score":0.6570000052452087},{"id":"https://openalex.org/keywords/16q-deletion","display_name":"16q deletion","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.612044095993042},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6110783219337463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5896484851837158},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5815265774726868},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5552136301994324},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.5537847876548767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5312324166297913},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.5247226357460022},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.44098618626594543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3364607095718384},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14716142416000366},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.06717589497566223},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.1383.1383","doi":"https://doi.org/10.1182/blood.v122.21.1383.1383","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.1383.1383","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2605824340","https://openalex.org/W2340184096","https://openalex.org/W2082189946","https://openalex.org/W4389037340","https://openalex.org/W2024890786","https://openalex.org/W1971984788","https://openalex.org/W2102352875","https://openalex.org/W7099849588","https://openalex.org/W2049365932","https://openalex.org/W2465578297"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Fluorescence":[2],"in":[3,16,143,171,254,403,548],"situ":[4],"hybridization":[5],"(FISH)":[6],"is":[7,99],"an":[8,121],"invaluable":[9],"tool":[10],"for":[11,32,93,124,264,312,337,520,540],"complementing":[12],"conventional":[13],"karyotype":[14,30,46,77,91,317,333],"analysis":[15,92,519],"the":[17,71,109,159,218,235,255,258,265,305,320,372,427,451,474,487,596],"diagnosis":[18,95,163,269,522],"of":[19,35,96,111,161,167,184,260,267,270,291,302,328,344,494,503,511,523,607],"leukemia.":[20],"FISH":[21,48,67,80,116,155,224,261,279,323,331,407,443,516,537,544],"panels":[22,81],"are":[23,88,175],"often":[24,66],"requested":[25],"by":[26,76,115,234,316,467,506,515,569,589,595],"clinicians,":[27],"along":[28],"with":[29,151,178,192,199,281,447,469,551],"analysis,":[31,47,318],"molecular":[33],"determination":[34],"clinically":[36],"actionable":[37],"abnormalities.":[38,442],"For":[39],"most":[40,277],"cooperative":[41],"group":[42],"clinical":[43,130,529],"trials,":[44],"unlike":[45],"has":[49],"not":[50,534],"been":[51,465],"required":[52],"to":[53,107,118,149,412,421,463,501,557,565,609],"determine":[54,108],"eligibility":[55],"or":[56],"risk":[57,73,113,404,513,559],"stratification.":[58,560],"Yet":[59],"no":[60,310],"previous":[61],"studies":[62,146],"have":[63,464],"shown":[64],"how":[65],"results":[68,156,225],"might":[69],"alter":[70],"cytogenetic":[72,112,153,222,512],"category":[74],"determined":[75],"analysis.":[78],"Furthermore,":[79],"which":[82,495,554],"may":[83,562],"include":[84],"5\u223c10":[85],"probe":[86],"sets":[87],"costly":[89],"while":[90],"new":[94,268,521],"myeloid":[97,180,194],"leukemia":[98,140,145,181,189,195,202,271,524],"routine":[100],"and":[101,128,133,154,197,223,231,246,257,300,332,346,349,367,389,417,436,486,579,583,601],"highly":[102],"informative.":[103],"Therefore":[104],"we":[105],"aim":[106],"frequency":[110,510],"alteration":[114,514],"testing":[117,539],"serve":[119],"as":[120,342,498,572],"evidence":[122],"base":[123],"future":[125],"study":[126,136,219],"design":[127],"best":[129],"practice.":[131],"Patients":[132,212],"Methods":[134],"Our":[135],"set":[137],"includes":[138],"all":[139,353,434],"patients":[141,169,177,399,438,446],"enrolled":[142,170],"SWOG":[144,236,245],"from":[147,228,410,419],"2002":[148],"2012":[150],"both":[152],"available":[157],"at":[158],"time":[160],"initial":[162],"(n=248),":[164],"representing":[165],"12%":[166],"total":[168],"these":[172],"studies.":[173],"There":[174,250],"169":[176],"acute":[179,187,200],"(AML),":[182],"22":[183],"whom":[185],"had":[186,358,379,480],"promyelocytic":[188],"(APL);":[190],"45":[191,428],"chronic":[193],"(CML-CP);":[196],"34":[198,475],"lymphocytic":[201],"(ALL).":[203],"The":[204,276,509],"age":[205],"range":[206],"was":[207,241,251,455,496,525,587],"19-87":[208],"(median":[209],"51)":[210],"years.":[211],"received":[213],"various":[214],"therapies":[215],"based":[216,242],"on":[217,243,450],"protocols.":[220],"All":[221],"were":[226,232,284,309,335],"submitted":[227,306],"SWOG-approved":[229],"laboratories":[230],"reviewed":[233],"Cytogenetics":[237],"Committee.":[238],"Risk":[239],"categorization":[240,405],"combined":[244],"MRC":[247],"criteria.":[248],"Results":[249],"great":[252],"variation":[253],"number":[256],"type":[259],"probes":[262],"used":[263],"workup":[266],"(range":[272],"1-12":[273],"per":[274],"patient).":[275],"frequent":[278],"findings":[280],"added":[282],"value":[283,547],"cryptic":[285,552],"translocations,":[286],"including":[287,319],"amplification":[288,582],"and/or":[289],"rearrangement":[290,301],"MYC":[292,580],"(mean":[293],"overall":[294],"survival":[295],"8.2":[296],"months":[297],"without":[298],"remission)":[299],"MLL.":[303],"In":[304],"studies,":[307],"there":[308],"misses":[311],"subtle":[313,567],"chromosome":[314,339],"abnormalities":[315,340],"inv(16),":[321,574],"although":[322],"clarified":[324],"deletion":[325],"16q":[326],"instead":[327],"inv(16)":[329],"occasionally.":[330],"analyses":[334],"consistent":[336],"large":[338],"such":[341,571],"deletions":[343,449],"5q":[345],"7q,":[347],"t(8;21),":[348],"trisomy":[350],"8.":[351],"Of":[352,371,426,473],"248":[354],"patients,":[355,376,416,430,477],"47":[356],"(19.0%)":[357],"favorable":[359,380,420,491],"cytogenetics,":[360,381],"133":[361],"(53.6%)":[362],"intermediate,":[363],"64":[364,390],"(25.8%)":[365],"unfavorable,":[366],"4":[368],"(1.6%)":[369],"unknown.":[370],"147":[373],"non-APL":[374],"AML":[375,415],"23":[377],"(15.6%)":[378],"79":[382],"(53.7%)":[383],"intermediate":[384,411,422,499],"[72":[385],"(49.0%)":[386],"after":[387,395,406,517],"FISH],":[388],"(43.5%)":[391],"unfavorable":[392,413,481],"[71":[393],"(48.3%)":[394],"FISH].":[396],"Overall,":[397],"eight":[398],"(3.2%)":[400],"demonstrated":[401,439],"alterations":[402],"analysis:":[408],"7":[409],"among":[414,423],"1":[418],"ALL":[424,476],"patients.":[425],"CML":[429],"karyotyping":[431,518],"adequately":[432],"identified":[433,444],"t(9;22),":[435],"3":[437],"additional":[440],"secondary":[441],"5":[445],"submicroscopic":[448],"derivative":[452],"9":[453],"(which":[454],"once":[456],"considered":[457],"a":[458],"higher-risk":[459],"feature":[460],"but":[461],"appears":[462],"overcome":[466],"therapy":[468],"tyrosine":[470],"kinase":[471],"inhibitors).":[472],"16":[478],"(47.1%)":[479],"cytogenetics;":[482],"12":[483],"(35.3%)":[484],"intermediate;":[485],"remaining":[488],"2":[489],"showed":[490],"hyperdiploidy,":[492],"one":[493],"reclassified":[497],"due":[500],"detection":[502],"structural":[504],"rearrangements":[505,568],"FISH.":[507],"Conclusion":[508],"low,":[526],"supporting":[527],"current":[528],"trial":[530],"designs":[531],"that":[532],"do":[533],"require":[535],"extensive":[536],"panel":[538],"protocol":[541],"eligibility.":[542],"However,":[543],"clearly":[545],"adds":[546],"detecting":[549],"cases":[550],"rearrangements,":[553],"can":[555],"contribute":[556],"altered":[558],"It":[561],"be":[563],"helpful":[564],"ascertain":[566],"FISH,":[570],"inv(3),":[573],"t(6;9),":[575],"MLL":[576],"(11q23)":[577],"rearrangement,":[578],"(8q24)":[581],"rearrangement.":[584],"This":[585],"work":[586],"supported":[588],"PHS":[590],"Cooperative":[591],"Agreement":[592],"grants":[593],"awarded":[594],"National":[597],"Cancer":[598],"Institute,":[599],"CA32102":[600],"CA38926.":[602],"Disclosures:":[603],"No":[604],"relevant":[605],"conflicts":[606],"interest":[608],"declare.":[610]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}