{"id":"https://openalex.org/W55065340","doi":null,"title":"Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum.","display_name":"Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum.","publication_year":1976,"publication_date":"1976-02-01","ids":{"openalex":"https://openalex.org/W55065340","mag":"55065340","pmid":"https://pubmed.ncbi.nlm.nih.gov/61710"},"language":"en","primary_location":{"id":"pmid:61710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/61710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Okayama","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ousar.lib.okayama-u.ac.jp/files/public/3/31433/20160528024139979436/fulltext.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110058893","display_name":"Hidemasa Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"H Yamasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110058893"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":137,"citation_normalized_percentile":{"value":0.00352388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"30","issue":"1","first_page":"1","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.14339999854564667,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sinomenine","display_name":"sinomenine","score":1.0},{"id":"https://openalex.org/keywords/sinomenium-acutum","display_name":"Sinomenium acutum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plant-alkaloids","display_name":"plant alkaloids","score":0.7269999980926514},{"id":"https://openalex.org/keywords/antirheumatic-activity","display_name":"antirheumatic activity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/histamine-h2-receptor","display_name":"histamine H2 receptor","score":0.843999981880188},{"id":"https://openalex.org/keywords/adjuvant-induced-arthritis","display_name":"adjuvant-induced arthritis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/granulation-tissue-formation","display_name":"granulation tissue formation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.800000011920929},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.6290000081062317},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.4740000069141388},{"id":"https://openalex.org/keywords/burimamide","display_name":"burimamide","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mepyramine","display_name":"mepyramine","score":0.7630000114440918},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2777662524","wikidata":"https://www.wikidata.org/wiki/Q7524904","display_name":"Sinomenine","level":2,"score":0.9937727451324463},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6261299848556519},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.5956569910049438},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5035948157310486},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5011608600616455},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.49370941519737244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39755165576934814},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.07298204302787781}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002049","descriptor_name":"Burimamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003238","descriptor_name":"Connective Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008738","descriptor_name":"Methyl Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009019","descriptor_name":"Morphinans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011738","descriptor_name":"Pyrilamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012216","descriptor_name":"Rheumatic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:61710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/61710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Okayama","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01081:0000646849","doi":null,"is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/31433","pdf_url":"https://ousar.lib.okayama-u.ac.jp/files/public/3/31433/20160528024139979436/fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"journal article"},{"id":"pmh:oai:EPrintsOUDIR.lib.okayama-u.ac.jp:31433","doi":null,"is_oa":false,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/31433","pdf_url":null,"source":{"id":"https://openalex.org/S4377196325","display_name":"Okayama University Scientific Achievement Repository (Okayama University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I163770644","host_organization_name":"Okayama University","host_organization_lineage":["https://openalex.org/I163770644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"Journal Article"},{"id":"mag:55065340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/61710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01081:0000646849","doi":null,"is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/31433","pdf_url":"https://ousar.lib.okayama-u.ac.jp/files/public/3/31433/20160528024139979436/fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Okayama","raw_type":"journal article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W55065340.pdf","grobid_xml":"https://content.openalex.org/works/W55065340.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W26198313","https://openalex.org/W66267511","https://openalex.org/W980819941","https://openalex.org/W1549898790","https://openalex.org/W1560876437","https://openalex.org/W1695975627","https://openalex.org/W1905718194","https://openalex.org/W1906504131","https://openalex.org/W2002633951","https://openalex.org/W2017029801","https://openalex.org/W2017989732","https://openalex.org/W2032950311","https://openalex.org/W2033531589","https://openalex.org/W2036943380","https://openalex.org/W2050123409","https://openalex.org/W2056604126","https://openalex.org/W2058765369","https://openalex.org/W2068949704","https://openalex.org/W2071662183","https://openalex.org/W2074949244","https://openalex.org/W2075223697","https://openalex.org/W2079749808","https://openalex.org/W2090334210","https://openalex.org/W2100481933","https://openalex.org/W2118030037","https://openalex.org/W2126375428","https://openalex.org/W2146711033","https://openalex.org/W2155777872","https://openalex.org/W2253008479","https://openalex.org/W2315777807","https://openalex.org/W2318774498","https://openalex.org/W2321262033","https://openalex.org/W2325915931","https://openalex.org/W2327071943","https://openalex.org/W2331238711","https://openalex.org/W2332966107","https://openalex.org/W2335475959","https://openalex.org/W2338415259","https://openalex.org/W2409595757","https://openalex.org/W2415539447","https://openalex.org/W2419268976","https://openalex.org/W2515851896","https://openalex.org/W2518277744","https://openalex.org/W2519634975","https://openalex.org/W2606733666","https://openalex.org/W2607067811","https://openalex.org/W2607269944","https://openalex.org/W3103293547","https://openalex.org/W4406975111"],"related_works":["https://openalex.org/W2032950311","https://openalex.org/W2074663443","https://openalex.org/W2031490255","https://openalex.org/W4229485013","https://openalex.org/W4281703286","https://openalex.org/W4402645331","https://openalex.org/W802209332","https://openalex.org/W4391638344","https://openalex.org/W1963948906","https://openalex.org/W611695858"],"abstract_inverted_index":{"The":[0,133,316],"root":[1],"and":[2,29,41,98,130,155,168,211,221,223,257,294,325],"stem":[3],"decoctions":[4],"of":[5,17,35,67,116,143,152,160,165,170,177,195,199,214,227,241,269,273,334],"Sinomenium":[6,12,201,320],"acutum":[7,202,321],"Rehd.":[8],"et":[9],"Wils.":[10],"(formerly":[11],"diversifolius":[13],"Diels,":[14],"one":[15,246],"type":[16],"Fang-chi":[18,50,69,77],"(Chinese))":[19],"have":[20,46],"been":[21,47,82],"used":[22],"as":[23,49,107,146],"a":[24,103,270],"folk":[25],"remedy":[26],"for":[27,138,243],"neuralgia":[28,97],"rheumatoid":[30],"arthritis":[31,259],"in":[32,52,71,96,112,120,127,184,208,252,261],"many":[33],"areas":[34],"the":[36,65,68,72,86,128,139,153,166,209,215,219,307,313,331],"Far":[37],"East.":[38],"In":[39],"Japan":[40],"China":[42],"various":[43],"viny":[44],"plants":[45,78],"identified":[48],"(Boi":[51],"Japanese)":[53],"since":[54,300],"antiquity.":[55],"This":[56,123],"uncertain":[57],"nomenclature":[58],"has":[59,81],"made":[60],"it":[61,108],"difficult":[62],"to":[63,84,93,330],"evaluate":[64],"efficacy":[66],"described":[70],"classic":[73],"literature.":[74],"Among":[75],"traditional":[76],"only":[79],"Sinomeniumacutum":[80],"demonstrated":[83],"contain":[85],"alkaloid":[87],"sinomenine,":[88,144,178],"which":[89],"is":[90,102,136],"now":[91],"known":[92],"be":[94,328],"effective":[95],"rheumatic":[99],"diseases.":[100],"Sinomenine":[101],"unique":[104],"plant":[105],"alkaloid,":[106],"potently":[109],"releases":[110],"histamine":[111,135,277,285],"association":[113],"with":[114,192],"degranulation":[115],"tissue":[117,255,292],"mast":[118],"cells":[119],"mammalian":[121],"tissues.":[122],"action":[124],"occurs":[125],"preferentially":[126],"skin":[129],"joint":[131],"capsules.":[132],"released":[134],"responsible":[137],"dominant":[140],"pharmacological":[141],"actions":[142],"such":[145],"vasodilatation,":[147],"increased":[148,163],"vascular":[149],"permeability,":[150],"acceleration":[151],"thoracic":[154],"peripheral":[156],"lymph":[157],"flow,":[158],"contraction":[159],"plain":[161],"muscles,":[162],"peristalsis":[164],"intestines,":[167],"stimulation":[169],"gastric":[171],"acid":[172],"secretion.":[173],"At":[174],"toxic":[175],"doses":[176,194],"convulsive":[179],"central":[180],"excitation":[181],"was":[182],"observed":[183],"most":[185],"laboratory":[186],"animals.":[187],"Clinical":[188],"side":[189,229],"effects":[190,230,281,302],"encountered":[191],"high":[193],"injected":[196],"sinomenine":[197,242,274],"or":[198,276],"decocted":[200],"were:":[203],"injection":[204],"site":[205],"flare,":[206],"pruritus":[207],"head":[210],"upper":[212],"part":[213],"body,":[216],"edema":[217],"around":[218],"lips":[220],"eyelids,":[222],"temporary":[224],"cephalalgia.":[225],"Most":[226],"these":[228,301],"were":[231,263,282,303],"reduced":[232],"by":[233,266,306,312],"classical":[234],"antihistamines":[235],"(H1-receptor":[236],"antagonists).":[237],"Daily":[238],"subcutaneous":[239],"injections":[240,268],"more":[244],"than":[245],"week":[247],"produced":[248],"an":[249],"analgesic":[250],"effect":[251,318],"mice.":[253],"Granulation":[254],"growth":[256],"adjuvant":[258,298],"induced":[260],"rats":[262],"both":[264],"inhibited":[265,305],"daily":[267],"small":[271],"dose":[272],"hydrochloride":[275],"dihydrochloride.":[278],"These":[279],"inhibitory":[280],"mediated":[283],"through":[284],"H2-receptors":[286],"probably":[287,323,327],"on":[288,295,319],"fibroblasts":[289],"(for":[290,297],"granulation":[291],"growth)":[293],"T-cells":[296],"arthritis),":[299],"clearly":[304],"H2-antagonist":[308],"burimamide":[309],"but":[310],"not":[311],"H1-antagonist":[314],"mepyramine.":[315],"anti-rheumatic":[317],"are":[322],"genuine":[324],"can":[326],"attributed":[329],"histamine-releasing":[332],"properties":[333],"sinomenine.":[335]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
