{"id":"https://openalex.org/W55052422","doi":null,"title":"Lack of association between smoking and CYP2A6 gene polymorphisms in A Japanese population.","display_name":"Lack of association between smoking and CYP2A6 gene polymorphisms in A Japanese population.","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W55052422","mag":"55052422","pmid":"https://pubmed.ncbi.nlm.nih.gov/11725533"},"language":"en","primary_location":{"id":"pmid:11725533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11725533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100461932","display_name":"Xia Zhang","orcid":"https://orcid.org/0009-0005-1159-9631","observed_orcids":["https://orcid.org/0009-0005-1159-9631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Zhang","raw_affiliation_strings":["Department of Forensic Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki, Kita, Kagawa 761-0793, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki, Kita, Kagawa 761-0793, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082186094","display_name":"K Amemo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Amemo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113648881","display_name":"Setsuko Ameno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ameno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071575605","display_name":"K Iwahashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Iwahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102004648","display_name":"Hiroshi Kinoshita","orcid":"https://orcid.org/0000-0002-3904-2641","observed_orcids":["https://orcid.org/0000-0002-3904-2641"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kinoshita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021757506","display_name":"Tomoya Kubota","orcid":"https://orcid.org/0000-0003-1004-8537","observed_orcids":["https://orcid.org/0000-0003-1004-8537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kubota","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011754698","display_name":"J. Mostofa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Mostofa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014706648","display_name":"Iwao Ijiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Ijiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8408,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.82852527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"36","issue":"5","first_page":"486","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.22010000050067902,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2a6","display_name":"CYP2A6","score":0.9390000104904175},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6740000247955322},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8980000019073486},{"id":"https://openalex.org/keywords/smoking-behavior","display_name":"smoking behavior","score":0.6230000257492065},{"id":"https://openalex.org/keywords/nicotine-metabolism","display_name":"nicotine metabolism","score":0.6909999847412109},{"id":"https://openalex.org/keywords/japanese-population","display_name":"Japanese population","score":0.6510000228881836},{"id":"https://openalex.org/keywords/genotype-frequency","display_name":"genotype frequency","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C196013638","wikidata":"https://www.wikidata.org/wiki/Q14874295","display_name":"CYP2A6","level":5,"score":0.9621639251708984},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.6956428289413452},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6876508593559265},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5721641778945923},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5616961717605591},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5260467529296875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5239829421043396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4440804421901703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4076520800590515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.274194598197937},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.09329435229301453},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065637","descriptor_name":"Cytochrome P-450 CYP2A6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11725533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11725533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence","raw_type":"Journal Article"},{"id":"mag:55052422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11725533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2033977600","https://openalex.org/W1983615857","https://openalex.org/W2117343856","https://openalex.org/W1801981734","https://openalex.org/W2104582828","https://openalex.org/W2400281311","https://openalex.org/W1601283237","https://openalex.org/W1992094340","https://openalex.org/W1909912097","https://openalex.org/W1979296926"],"abstract_inverted_index":{"This":[0],"study":[1],"determined":[2],"the":[3,6,24,34,58,68,77,89,95,102,106,115,120,131],"genotypes":[4],"of":[5,21,23,33,91,108,119],"CYP2A6":[7,35,78,121],"gene":[8,36,122],"in":[9,15,43,52,67,76,88],"96":[10,44],"smokers":[11,82],"and":[12,27,40,46,49,83,94,105],"141":[13],"non-smokers":[14],"a":[16,30],"Japanese":[17,132],"population.":[18],"The":[19],"frequencies":[20,80],"wild-type":[22],"CYP2A6*":[25,59,62,103],"1":[26,104],"those":[28],"with":[29],"whole":[31],"deletion":[32,107,116],"were":[37,65,72],"93":[38],"(96.9%)":[39],"3":[41,63],"(3.1%)":[42],"smokers,":[45],"134":[47],"(95.0%)":[48],"7":[50],"(5.0%)":[51],"non-smokers,":[53,84],"respectively.":[54],"In":[55],"addition,":[56],"neither":[57],"2":[60],"nor":[61],"alleles":[64],"observed":[66],"population":[69,133],"studied.":[70],"There":[71],"no":[73,124],"significant":[74,125],"differences":[75],"genotype":[79],"between":[81,101],"as":[85,87],"well":[86],"number":[90],"cigarettes":[92],"smoked":[93],"nicotine":[96],"amounts":[97],"inhaled":[98],"per":[99],"day":[100],"CYP2A6.":[109],"These":[110],"results":[111],"suggest":[112],"that":[113],"either":[114],"or":[117],"non-deletion":[118],"shows":[123],"effect":[126],"on":[127],"smoking":[128],"behavior":[129],"for":[130],"examined.":[134]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}