{"id":"https://openalex.org/W54908094","doi":null,"title":"Gangrenous and perforated appendicitis with peritonitis: treatment and bacteriology.","display_name":"Gangrenous and perforated appendicitis with peritonitis: treatment and bacteriology.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W54908094","mag":"54908094","pmid":"https://pubmed.ncbi.nlm.nih.gov/2202510"},"language":"en","primary_location":{"id":"pmid:2202510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2202510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical therapeutics","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030079652","display_name":"Robert S. Bennion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210130891","display_name":"Olive View-UCLA Medical Center","ror":"https://ror.org/03b66rp04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210130891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R S Bennion","raw_affiliation_strings":["Department of Surgery, Olive View Medical Center, UCLA School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Olive View Medical Center, UCLA School of Medicine","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210130891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103378183","display_name":"John E. Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112681334","display_name":"Ellen Jo Baron","orcid":"https://orcid.org/0009-0000-4864-6546","observed_orcids":["https://orcid.org/0009-0000-4864-6546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E J Baron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111878133","display_name":"S M Finegold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S M Finegold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.9316,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.97868613,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12 Suppl C","issue":null,"first_page":"31","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11473","display_name":"Appendicitis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11473","display_name":"Appendicitis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gangrenous-appendicitis","display_name":"gangrenous appendicitis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/appendiceal-perforation","display_name":"appendiceal perforation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/peritonitis","display_name":"peritonitis","score":0.871999979019165},{"id":"https://openalex.org/keywords/ceftizoxime","display_name":"ceftizoxime","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cefoxitin","display_name":"cefoxitin","score":1.0},{"id":"https://openalex.org/keywords/anaerobic-bacteria","display_name":"anaerobic bacteria","score":0.6679999828338623},{"id":"https://openalex.org/keywords/bacteroides-fragilis-group","display_name":"Bacteroides fragilis group","score":0.878000020980835},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9980000257492065},{"id":"https://openalex.org/keywords/peritoneal-fluid-culture","display_name":"peritoneal fluid culture","score":0.7179999947547913},{"id":"https://openalex.org/keywords/abscess","display_name":"abscess","score":0.40799999237060547},{"id":"https://openalex.org/keywords/antibiotic-dosing-regimens","display_name":"antibiotic dosing regimens","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2776124114","wikidata":"https://www.wikidata.org/wiki/Q2353907","display_name":"Cefoxitin","level":4,"score":0.8710334897041321},{"id":"https://openalex.org/C2776869330","wikidata":"https://www.wikidata.org/wiki/Q1082945","display_name":"Ceftizoxime","level":4,"score":0.8446328639984131},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.833354115486145},{"id":"https://openalex.org/C2780246119","wikidata":"https://www.wikidata.org/wiki/Q221817","display_name":"Bacteroides fragilis","level":3,"score":0.8144785761833191},{"id":"https://openalex.org/C2780199535","wikidata":"https://www.wikidata.org/wiki/Q223102","display_name":"Peritonitis","level":2,"score":0.6435791254043579},{"id":"https://openalex.org/C2780016130","wikidata":"https://www.wikidata.org/wiki/Q121041","display_name":"Appendicitis","level":2,"score":0.5242888331413269},{"id":"https://openalex.org/C2992397963","wikidata":"https://www.wikidata.org/wiki/Q189790","display_name":"Anaerobic bacteria","level":3,"score":0.5134321451187134},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.49103689193725586},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4760724902153015},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.46516090631484985},{"id":"https://openalex.org/C2777035434","wikidata":"https://www.wikidata.org/wiki/Q164655","display_name":"Abscess","level":2,"score":0.4469173550605774},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.42367738485336304},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36957502365112305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34759700298309326},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.26661697030067444},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.24461719393730164},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1613903045654297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12330827116966248},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001064","descriptor_name":"Appendicitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001064","descriptor_name":"Appendicitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D001064","descriptor_name":"Appendicitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001420","descriptor_name":"Bacteria, Aerobic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001421","descriptor_name":"Bacteria, Anaerobic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002440","descriptor_name":"Cefoxitin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002440","descriptor_name":"Cefoxitin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005734","descriptor_name":"Gangrene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007416","descriptor_name":"Intestinal Perforation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007416","descriptor_name":"Intestinal Perforation","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007416","descriptor_name":"Intestinal Perforation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012422","descriptor_name":"Rupture, Spontaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015296","descriptor_name":"Ceftizoxime","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015296","descriptor_name":"Ceftizoxime","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2202510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2202510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical therapeutics","raw_type":"Clinical Trial"},{"id":"mag:54908094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2202510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2160648945","https://openalex.org/W2418929737","https://openalex.org/W2150478590","https://openalex.org/W2408759998","https://openalex.org/W2520001030","https://openalex.org/W7095611907","https://openalex.org/W2078844994","https://openalex.org/W1980813838","https://openalex.org/W2401137247","https://openalex.org/W9661049"],"abstract_inverted_index":{"A":[0],"comparison":[1],"of":[2,9,28,69,76,95,106,148,206],"single-agent":[3,228],"antimicrobial":[4,229],"therapy":[5,230],"in":[6,20,40,89,222,231],"the":[7,41,64,93,102,138,196,216,219],"treatment":[8,65],"patients":[10,70,111,232],"with":[11,72,79,112,233,244],"perforated":[12],"or":[13,83,151],"gangrenous":[14],"appendicitis":[15,30,114,235],"and":[16,31,49,74,99,104,130,155,167,185,194,211,236,241],"peritonitis":[17,237],"was":[18,86],"performed":[19],"a":[21,175,250],"double-blind,":[22],"randomized,":[23],"prospective":[24],"trial.":[25],"Pathologic":[26],"documentation":[27],"advanced":[29,113,234],"positive":[32],"intraoperative":[33],"specimen":[34],"cultures":[35],"were":[36,56,59,81,115,140,159,172,188,202],"required":[37],"for":[38,218],"inclusion":[39],"study.":[42],"Ceftizoxime":[43],"(2":[44,51],"gm":[45,52],"every":[46,53],"12":[47],"hours)":[48,55],"cefoxitin":[50,80],"six":[54],"compared.":[57],"There":[58],"no":[60,87],"significant":[61],"differences":[62],"between":[63],"groups.":[66],"Ninety-seven":[67],"percent":[68],"treated":[71,78],"ceftizoxime":[73],"89%":[75],"those":[77],"cured":[82],"improved;":[84],"there":[85],"mortality":[88],"either":[90],"group.":[91],"By":[92],"use":[94],"optimal":[96],"sampling,":[97],"transport,":[98],"culture":[100],"techniques,":[101],"number":[103,147],"diversity":[105],"bacteria":[107,153],"recovered":[108],"from":[109,142,161,190],"these":[110,223],"found":[116],"to":[117,136],"be":[118,215,247],"much":[119],"larger":[120],"than":[121,169],"previously":[122,176],"suspected.":[123],"Peritoneal":[124],"fluid,":[125],"abscess":[126],"contents":[127],"(if":[128],"present),":[129],"appendiceal":[131],"tissue":[132],"(obtained":[133],"so":[134],"as":[135],"exclude":[137],"lumen)":[139],"cultured":[141],"all":[143,192],"patients.":[144,224],"An":[145],"average":[146],"3.1":[149],"aerobic":[150],"facultative":[152],"species":[154,158,171,201],"8.5":[156],"anaerobic":[157,180],"isolated":[160,189],"each":[162],"specimen.":[163],"Twenty-eight":[164],"different":[165],"genera":[166],"more":[168],"55":[170],"encountered,":[173],"including":[174],"undescribed":[177],"fastidious":[178],"gram-negative":[179],"bacillus.":[181],"Bacteroides":[182],"fragilis":[183,198],"group":[184],"Escherichia":[186],"coli":[187],"almost":[191],"specimens,":[193],"within":[195],"B":[197],"group,":[199],"eight":[200],"represented.":[203],"The":[204],"recovery":[205],"such":[207],"an":[208],"unexpectedly":[209],"large":[210],"diverse":[212],"flora":[213],"may":[214],"reason":[217],"therapeutic":[220],"failures":[221],"We":[225],"conclude":[226],"that":[227],"is":[238],"both":[239],"safe":[240],"effective,":[242],"and,":[243],"ceftizoxime,":[245],"can":[246],"accomplished":[248],"by":[249],"twice-daily":[251],"dosing":[252],"regimen.":[253]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
