{"id":"https://openalex.org/W54875067","doi":null,"title":"Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 1: clinical and historical background.","display_name":"Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 1: clinical and historical background.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W54875067","mag":"54875067","pmid":"https://pubmed.ncbi.nlm.nih.gov/23375011"},"language":"en","primary_location":{"id":"pmid:23375011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23375011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043056372","display_name":"Tam\u00e0s F\u00fcl\u00f6p","orcid":"https://orcid.org/0000-0001-5835-7449","observed_orcids":["https://orcid.org/0000-0001-5835-7449","https://orcid.org/0000-0003-2708-7065"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]},{"id":"https://openalex.org/I4405254049","display_name":"Centre de recherche sur le vieillissement","ror":"https://ror.org/01bpsk167","country_code":"CA","type":"facility","lineage":["https://openalex.org/I135117807","https://openalex.org/I2801825082","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405254049","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tamas Fulop","raw_affiliation_strings":["Research Center on Aging, University of Sherbrooke, Sherbrooke, Quebec J1H 4C4, Canada. tamas.fulop@usherbrooke.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center on Aging, University of Sherbrooke, Sherbrooke, Quebec J1H 4C4, Canada. tamas.fulop@usherbrooke.ca","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I4405254049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109948410","display_name":"Guy Lacombe","orcid":"https://orcid.org/0009-0000-9245-404X","observed_orcids":["https://orcid.org/0009-0000-9245-404X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guy Lacombe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088681787","display_name":"Stephen C. Cunnane","orcid":"https://orcid.org/0000-0003-4003-9762","observed_orcids":["https://orcid.org/0000-0003-4003-9762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Cunnane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033834114","display_name":"Aur\u00e9lie Y. Le Page","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aur\u00e9lie Le Page","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086629950","display_name":"Gilles Dupuis","orcid":"https://orcid.org/0000-0003-4216-5201","observed_orcids":["https://orcid.org/0000-0003-4216-5201"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilles Dupuis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031636337","display_name":"Eric H. Frost","orcid":"https://orcid.org/0000-0001-8958-4388","observed_orcids":["https://orcid.org/0000-0001-8958-4388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric H Frost","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055132205","display_name":"Karine Bourgade","orcid":"https://orcid.org/0000-0002-2802-2469","observed_orcids":["https://orcid.org/0000-0002-2802-2469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karine Bourgade-Navarro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018302394","display_name":"David Goldeck","orcid":"https://orcid.org/0000-0001-6220-1527","observed_orcids":["https://orcid.org/0000-0001-6220-1527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Goldeck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031563087","display_name":"Anis Larbi","orcid":"https://orcid.org/0000-0001-8805-5433","observed_orcids":["https://orcid.org/0000-0001-8805-5433"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anis Larbi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027331206","display_name":"Graham Pawelec","orcid":"https://orcid.org/0000-0002-3600-0163","observed_orcids":["https://orcid.org/0000-0002-3600-0163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graham Pawelec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4812,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.54196604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"80","first_page":"23","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.746999979019165},{"id":"https://openalex.org/keywords/amyloid-hypothesis","display_name":"amyloid hypothesis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/immune-signatures","display_name":"immune signatures","score":0.746999979019165},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8149999976158142},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.6430000066757202},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.574999988079071},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.5770000219345093},{"id":"https://openalex.org/keywords/treatment-goals","display_name":"treatment goals","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7601311206817627},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7070474624633789},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.661910891532898},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.49440813064575195},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.4643784761428833},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43975958228111267},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.42249488830566406},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.42066141963005066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41000494360923767},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4081830084323883},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2528369128704071},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16672834753990173}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23375011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23375011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"mag:54875067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23375011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W81096875","https://openalex.org/W4407953924","https://openalex.org/W2116792132","https://openalex.org/W3109697380","https://openalex.org/W4389440046","https://openalex.org/W2151485719","https://openalex.org/W2012782698","https://openalex.org/W2955757641","https://openalex.org/W2364621991","https://openalex.org/W1787022386"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,162],"(AD)":[2],"is":[3,64,83,94,103,121,142],"the":[4,57,68,76,133,214,219,223,228,233,256,270],"most":[5,11,58,77],"common":[6,78],"form":[7,79],"of":[8,20,27,56,70,80,110,135,143,177,190,230,258,272],"dementia.":[9,81],"Its":[10],"important":[12,44,59],"pathological":[13],"hallmarks":[14],"are":[15],"profound":[16],"neuronal":[17,39],"loss,":[18],"presence":[19],"intracellular":[21],"neurofibrillary":[22],"tangles,":[23],"and":[24,66,116,128,218,232,243,260],"extracellular":[25],"deposition":[26],"beta-amyloid":[28,32],"protein":[29],"(A\u03b2)":[30],"as":[31,173],"plaques.":[33],"These":[34],"latter":[35],"aggregations":[36],"result":[37],"in":[38,41,199,205,227,266],"degeneration":[40],"brain":[42,119],"regions":[43],"not":[45,95],"only":[46],"for":[47,51,62,158,269],"memory,":[48],"but":[49],"also":[50],"other":[52],"cognitive":[53],"functions.":[54],"One":[55],"risk":[60],"factors":[61],"AD":[63,72,93,111,136,231,259],"age":[65],"with":[67,213],"increase":[69],"life-expectancy":[71],"has":[73,169,192],"thus":[74],"become":[75],"It":[82],"now":[84],"formally":[85],"recognized":[86],"by":[87,222],"several":[88],"new":[89,246],"diagnostic":[90],"criteria":[91],"that":[92,131,154,248],"a":[96,174,182],"homogeneous":[97],"disease.":[98],"The":[99],"current":[100,215,241],"\"Holy":[101],"Grail\"":[102],"to":[104,107,138,152,238,244,255],"be":[105,139,156,181,204],"able":[106],"diagnose":[108],"variants":[109],"before":[112,117],"they":[113],"manifest":[114],"clinically":[115],"irreparable":[118],"damage":[120],"done.":[122],"To":[123],"achieve":[124],"this":[125,208],"goal,":[126],"robust":[127],"reliable":[129],"biomarkers":[130,148],"reflect":[132],"pathogenesis":[134,229],"have":[137],"implemented.":[140],"This":[141,201],"paramount":[144],"importance":[145],"because":[146],"such":[147],"may":[149,180,253,261],"provide":[150,263],"clues":[151],"pathways":[153],"can":[155],"targeted":[157],"interventions":[159],"aimed":[160],"at":[161],"prevention":[163],"or":[164],"improvement.":[165],"Although":[166],"much":[167],"attention":[168],"focused":[170],"on":[171],"A\u03b2":[172,179,224],"major":[175],"component":[176],"AD,":[178],"less":[183],"attractive":[184],"target":[185],"since":[186],"an":[187],"increasing":[188],"amount":[189],"data":[191,247],"raised":[193,221],"concerns":[194],"about":[195],"its":[196],"causative":[197],"role":[198],"AD.":[200,273],"review":[202],"will":[203,211,236],"two":[206],"parts,":[207],"first":[209],"part":[210,235],"deal":[212],"clinical":[216],"knowledge":[217,242],"questions":[220],"cascade":[225],"hypothesis":[226],"second":[234],"aim":[237],"synthesize":[239],"our":[240],"discuss":[245],"suggest":[249],"how":[250],"immune":[251],"alterations":[252],"contribute":[254],"development":[257],"therefore":[262],"beneficial":[264],"targets":[265],"novel":[267],"approaches":[268],"treatment":[271]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
