{"id":"https://openalex.org/W54741981","doi":null,"title":"Abstract 13501: Antioxidant-1, a Novel Transcription Factor for NADPH Oxidase Organizer P47phox, Regulates Postnatal Neovascularization by Modulating Hydrogen Peroxide Production","display_name":"Abstract 13501: Antioxidant-1, a Novel Transcription Factor for NADPH Oxidase Organizer P47phox, Regulates Postnatal Neovascularization by Modulating Hydrogen Peroxide Production","publication_year":2011,"publication_date":"2011-11-22","ids":{"openalex":"https://openalex.org/W54741981","mag":"54741981"},"language":"en","primary_location":{"id":"mag:54741981","doi":null,"is_oa":false,"landing_page_url":"http://circ.ahajournals.org/cgi/content/meeting_abstract/124/21_MeetingAbstracts/A13501","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032012153","display_name":"Gin\u2010Fu Chen","orcid":"https://orcid.org/0000-0003-2015-9943","observed_orcids":["https://orcid.org/0000-0003-2015-9943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gin\u2010Fu Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2015-9943","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089954916","display_name":"Norifumi Urao","orcid":"https://orcid.org/0000-0001-9750-8406","observed_orcids":["https://orcid.org/0000-0001-9750-8406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norifumi Urao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9750-8406","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112664871","display_name":"Ronald D. McKinney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald McKinney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021137697","display_name":"Masuko Ushio\u2010Fukai","orcid":"https://orcid.org/0000-0001-7048-2381","observed_orcids":["https://orcid.org/0000-0001-7048-2381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masuko Ushio\u2010Fukai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7048-2381","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085309946","display_name":"Tohru Fukai","orcid":"https://orcid.org/0000-0001-9864-571X","observed_orcids":["https://orcid.org/0000-0001-9864-571X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tohru Fukai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.46389999985694885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.46389999985694885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.3422999978065491,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.08720000088214874,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atox1","display_name":"Atox1","score":0.949999988079071},{"id":"https://openalex.org/keywords/copper-chaperone","display_name":"copper chaperone","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hindlimb-ischemia","display_name":"hindlimb ischemia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.6840000152587891},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.8370000123977661},{"id":"https://openalex.org/keywords/icam","display_name":"ICAM","score":0.7120000123977661},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8460000157356262},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.6861987709999084},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6474869847297668},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5674279928207397},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.47333770990371704},{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.45275259017944336},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42831045389175415},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41666266322135925},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3968314826488495},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36578935384750366},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.364448606967926},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3219059705734253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30269718170166016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2230658233165741},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2081541121006012},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2019326388835907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:54741981","doi":null,"is_oa":false,"landing_page_url":"http://circ.ahajournals.org/cgi/content/meeting_abstract/124/21_MeetingAbstracts/A13501","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5400000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2272581108","https://openalex.org/W2019071548","https://openalex.org/W2039160568","https://openalex.org/W82382793","https://openalex.org/W2555788587","https://openalex.org/W2086386116","https://openalex.org/W2019650322","https://openalex.org/W2049442343","https://openalex.org/W2177453198","https://openalex.org/W3120039556","https://openalex.org/W3024969376","https://openalex.org/W2802137311","https://openalex.org/W2963422675","https://openalex.org/W2787361651","https://openalex.org/W2001786332","https://openalex.org/W2887822114","https://openalex.org/W2302225802","https://openalex.org/W1828279352","https://openalex.org/W2561472366","https://openalex.org/W3197908494"],"abstract_inverted_index":{"Neovascularization":[0],"is":[1,9],"important":[2,19],"for":[3],"repair":[4],"following":[5],"ischemic":[6,84,103],"injury":[7],"and":[8,13,44,79,105,131,135],"dependent":[10],"on":[11],"angiogenesis":[12],"inflammation.":[14],"Copper":[15],"(Cu)":[16],"plays":[17],"an":[18],"role":[20,53],"in":[21,56,72,102,112,127],"regulating":[22],"angiogenesis;":[23],"however,":[24],"its":[25],"mechanism":[26],"remains":[27],"unknown.":[28],"We":[29,49],"previously":[30],"showed":[31,95],"that":[32],"Cu":[33],"chaperone":[34],"protein":[35],"antioxidant-1":[36],"(Atox1)":[37],"functions":[38],"as":[39],"a":[40,69],"Cu-dependent":[41],"transcription":[42],"factor":[43],"regulates":[45,140],"Cu-induced":[46],"cell":[47],"growth.":[48],"thus":[50],"investigated":[51],"the":[52],"of":[54,81,90],"Atox1":[55,64,121],"postnatal":[57],"neovascularization":[58],"using":[59],"mouse":[60],"hindlimb":[61],"ischemia":[62],"model.":[63],"knockout":[65],"(KO)":[66],"mice":[67],"exhibit":[68],"marked":[70],"reduction":[71],"blood":[73],"flow":[74],"recovery":[75],"at":[76,86],"day":[77,87],"14,":[78],"infiltration":[80],"macrophage":[82],"into":[83],"muscles":[85,104],"3":[88],"(20%":[89],"WT)":[91],"after":[92],"ischemia.":[93],"Atox1KO":[94],"reduced":[96],"adhesion":[97],"molecules":[98],"ICAM/VCAM":[99,128,141],"mRNA":[100,129],"levels":[101,130,133],"superoxide":[106],"production":[107],"(measured":[108],"by":[109],"DHE":[110],"staining)":[111],"CD31+":[113],"endothelial":[114],"cells":[115],"(ECs).":[116],"In":[117],"cultured":[118],"human":[119],"ECs,":[120],"siRNA":[122],"inhibited":[123],"TNF\u03b1":[124],"(100U/ml)-induced":[125],"increase":[126],"H2O2":[132],"(80":[134],"95%":[136],"inhibition,":[137],"respectively).":[138],"NFkB":[139],"pro...":[142]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
