{"id":"https://openalex.org/W54722650","doi":null,"title":"Modelling the affinity maturation of B lymphocytes in the germinal centre","display_name":"Modelling the affinity maturation of B lymphocytes in the germinal centre","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W54722650","mag":"54722650"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:1080","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/1080/1/Reynolds10MPhil.pdf","pdf_url":"http://etheses.bham.ac.uk/1080/1/Reynolds10MPhil.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.bham.ac.uk/1080/1/Reynolds10MPhil.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075272287","display_name":"Adam Thomas Reynolds","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adam Thomas Reynolds","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075272287"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12391","display_name":"Artificial Immune Systems Applications","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/affinity-maturation","display_name":"affinity maturation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.9940000176429749},{"id":"https://openalex.org/keywords/computer-modelling","display_name":"computer modelling","score":0.38999998569488525},{"id":"https://openalex.org/keywords/high-affinity-antibodies","display_name":"high-affinity antibodies","score":0.6940000057220459},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.7369999885559082},{"id":"https://openalex.org/keywords/follicular-dendritic-cells","display_name":"follicular dendritic cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/population-dynamics","display_name":"population dynamics","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.9611721634864807},{"id":"https://openalex.org/C2781377902","wikidata":"https://www.wikidata.org/wiki/Q21418769","display_name":"Affinity maturation","level":3,"score":0.8775869607925415},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5554460287094116},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5173277854919434},{"id":"https://openalex.org/C3753494","wikidata":"https://www.wikidata.org/wiki/Q2631550","display_name":"Follicular dendritic cells","level":5,"score":0.4818778932094574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4201478660106659},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4146282374858856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39290356636047363},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.3801542818546295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3590857982635498},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35826030373573303},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35653790831565857},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3367151916027069},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.19185027480125427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12349554896354675},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.08638438582420349},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:1080","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/1080/1/Reynolds10MPhil.pdf","pdf_url":"http://etheses.bham.ac.uk/1080/1/Reynolds10MPhil.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:40712","doi":null,"is_oa":false,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/40712","pdf_url":null,"source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:54722650","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/1080/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etheses.bham.ac.uk:1080","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/1080/1/Reynolds10MPhil.pdf","pdf_url":"http://etheses.bham.ac.uk/1080/1/Reynolds10MPhil.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W54722650.pdf","grobid_xml":"https://content.openalex.org/works/W54722650.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1583022267","https://openalex.org/W1960192018","https://openalex.org/W1965915234","https://openalex.org/W1969804838","https://openalex.org/W1976759658","https://openalex.org/W1980628113","https://openalex.org/W1981197474","https://openalex.org/W1982573460","https://openalex.org/W1984940660","https://openalex.org/W1987781975","https://openalex.org/W1989134497","https://openalex.org/W1993103220","https://openalex.org/W1995482598","https://openalex.org/W1999033892","https://openalex.org/W2002098652","https://openalex.org/W2010843874","https://openalex.org/W2014113929","https://openalex.org/W2014504285","https://openalex.org/W2016932039","https://openalex.org/W2024276432","https://openalex.org/W2024310886","https://openalex.org/W2034152629","https://openalex.org/W2036217549","https://openalex.org/W2053247044","https://openalex.org/W2058981079","https://openalex.org/W2059033421","https://openalex.org/W2060983388","https://openalex.org/W2062218415","https://openalex.org/W2073961772","https://openalex.org/W2076747220","https://openalex.org/W2076763656","https://openalex.org/W2082871926","https://openalex.org/W2090391670","https://openalex.org/W2094011807","https://openalex.org/W2095423829","https://openalex.org/W2097591929","https://openalex.org/W2116537839","https://openalex.org/W2120496123","https://openalex.org/W2121686754","https://openalex.org/W2122632662","https://openalex.org/W2133951067","https://openalex.org/W2134443084","https://openalex.org/W2136695636","https://openalex.org/W2137783233","https://openalex.org/W2140190241","https://openalex.org/W2142351226","https://openalex.org/W2163267311","https://openalex.org/W2168907141","https://openalex.org/W2240274733","https://openalex.org/W2292261517","https://openalex.org/W2432517183","https://openalex.org/W2752932982","https://openalex.org/W2798695934"],"related_works":["https://openalex.org/W6989209418","https://openalex.org/W2097591929","https://openalex.org/W148382624","https://openalex.org/W2623925688","https://openalex.org/W1979068967","https://openalex.org/W2168907141","https://openalex.org/W2024310886","https://openalex.org/W7100537375","https://openalex.org/W183964797","https://openalex.org/W7095806038"],"abstract_inverted_index":{"This":[0,59,134,156],"study":[1],"involved":[2],"the":[3,12,19,37,40,45,56,61,64,68,81,109,118,123,126,130,137],"successful":[4],"development":[5],"of":[6,15,39,63,67,139],"a":[7,99],"computer":[8],"model":[9,77],"to":[10,48,71,143],"simulate":[11],"affinity":[13,65,74,111,141,149],"maturation":[14,66],"B":[16,46,69,154],"lymphocytes":[17],"in":[18,22],"germinal":[20,41,57,119],"centre":[21,42,120],"3-D":[23],"because":[24],"certain":[25],"behavioural":[26],"aspects":[27],"cannot":[28],"currently":[29],"be":[30,144],"examined":[31],"experimentally.":[32],"The":[33,76,95],"software":[34],"tool":[35],"recreates":[36],"structure":[38],"that":[43,87,108,114],"enables":[44],"cells":[47,54,70,113],"move":[49],"and":[50,146,152],"interact":[51],"with":[52,102],"other":[53],"inside":[55],"centre.":[58],"allows":[60],"modelling":[62,96],"produce":[72],"high":[73,110,140,148],"antibodies.":[75],"was":[78],"validated":[79],"against":[80],"available":[82],"published":[83,103],"population":[84,89],"dynamics":[85],"data":[86],"shows":[88],"sizes":[90],"on":[91,125,129],"different":[92],"days":[93],"post-immunisation.":[94],"results":[97,165],"show":[98],"reasonable":[100],"correspondence":[101],"data.":[104],"They":[105],"also":[106],"suggest":[107],"plasma":[112,150],"are":[115],"produced":[116],"from":[117],"reaction":[121],"displace":[122],"antibodies":[124],"immune":[127],"complexes":[128],"follicular":[131],"dendritic":[132],"cell.":[133],"feed-back":[135],"drives":[136],"selection":[138],"centrocytes":[142],"selected":[145],"become":[147],"blasts":[151],"memory":[153],"cells.":[155],"conclusion":[157],"has":[158],"been":[159],"partially":[160],"confirmed":[161],"by":[162],"recent":[163],"experimental":[164],"(Toellner,":[166],"unpublished).":[167]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}