{"id":"https://openalex.org/W54700548","doi":"https://doi.org/10.1016/s0021-9258(18)81292-3","title":"The Use of C14O2 Yields from Glucose-1- and -6-C14 for the Evaluation of the Pathways of Glucose Metabolism","display_name":"The Use of C14O2 Yields from Glucose-1- and -6-C14 for the Evaluation of the Pathways of Glucose Metabolism","publication_year":1963,"publication_date":"1963-02-01","ids":{"openalex":"https://openalex.org/W54700548","doi":"https://doi.org/10.1016/s0021-9258(18)81292-3","mag":"54700548","pmid":"https://pubmed.ncbi.nlm.nih.gov/13958489"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)81292-3","doi":"https://doi.org/10.1016/s0021-9258(18)81292-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)81292-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W54700548"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)81292-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109954022","display_name":"Joseph J Katz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Katz","raw_affiliation_strings":["Depart-ment of Biochemistry, Western Reserve University School of Medicine, Cleveland 6, Ohio","From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles 29, California,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depart-ment of Biochemistry, Western Reserve University School of Medicine, Cleveland 6, Ohio","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles 29, California,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104350128","display_name":"Harland Goff Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harland G. Wood","raw_affiliation_strings":["Depart-ment of Biochemistry, Western Reserve University School of Medicine, Cleveland 6, Ohio","From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles 29, California,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depart-ment of Biochemistry, Western Reserve University School of Medicine, Cleveland 6, Ohio","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles 29, California,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":61.5529,"has_fulltext":false,"cited_by_count":377,"citation_normalized_percentile":{"value":0.99923489,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"238","issue":"2","first_page":"517","last_page":"523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.31130000948905945,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.31130000948905945,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.12489999830722809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.07280000299215317,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7710000276565552},{"id":"https://openalex.org/keywords/carbon-14-labeling","display_name":"carbon-14 labeling","score":0.6370000243186951},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":0.7910000085830688},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/co2-yield","display_name":"CO2 yield","score":0.42800000309944153},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"pathway analysis","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.7170035243034363},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.675704836845398},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5706878900527954},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5367547273635864}],"mesh":[{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050260","descriptor_name":"Carbohydrate Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)81292-3","doi":"https://doi.org/10.1016/s0021-9258(18)81292-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)81292-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:13958489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13958489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)81292-3","doi":"https://doi.org/10.1016/s0021-9258(18)81292-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)81292-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1586740285","https://openalex.org/W2145304144","https://openalex.org/W2155433572","https://openalex.org/W4231389817","https://openalex.org/W4254186892"],"related_works":["https://openalex.org/W125579703","https://openalex.org/W2411903955","https://openalex.org/W1550570112","https://openalex.org/W1986321234","https://openalex.org/W153097348","https://openalex.org/W1764737285","https://openalex.org/W1967789361","https://openalex.org/W2145304144","https://openalex.org/W1591269448","https://openalex.org/W1601782018"],"abstract_inverted_index":{"Katz":[0],"and":[1,38,55,86,133],"Wood":[2],"(1,":[3,101],"2)":[4,102],"examined":[5],"methods":[6],"that":[7,23,125],"use":[8],"differently":[9],"labeled":[10],"types":[11],"of":[12,17,19,35,44,59,72,82,108,145],"glucose":[13,20],"for":[14],"the":[15,30,45,52,60,70,119,130,137,143],"evaluation":[16],"pathways":[18,135,138],"metabolism.They":[21],"indicated":[22],"any":[24],"method":[25],"must":[26],"encompass":[27],"several":[28],"considerations:(a)":[29],"pentose":[31,53,131],"cycle'":[32],"entails":[33],"synthesis":[34],"fructose":[36],"6-phosphate":[37],"therefore":[39],"there":[40],"may":[41,62],"be":[42,63,104,140],"recycling":[43],"hexose":[46],"phosphates;":[47],"(b)":[48],"in":[49,88,147],"addition":[50],"to":[51,75,103,118],"cycle":[54,132],"Embden-Meyerhof":[56,134],"pathways,":[57],"some":[58],"carbohydrate":[61],"metabolized":[64],"by":[65,128],"nontriose":[66],"phosphate":[67,74,90],"pathways;'":[68],"(c)":[69],"oxidation":[71],"triose":[73,89],"CO2":[76],"usually":[77],"is":[78],"incomplete.The":[79],"relative":[80],"yield":[81],"Cl4":[83,146],"from":[84,142],"glucose-l-Cl4":[85],"glucose-6-Cl4":[87],"derivatives":[91],"such":[92],"as":[93],"lactate,":[94],"fatty":[95],"acids,":[96],"or":[97,110],"CO%":[98],"was":[99,123],"shown":[100,124],"a":[105],"nonlinear":[106],"function":[107],"two":[109],"three":[111],"independent":[112],"variables":[113],"with":[114],"no":[115],"simple":[116],"relationship":[117],"separate":[120],"pathways.However,":[121],"it":[122],"when":[126],"metabolism":[127],"only":[129],"occurs,":[136],"can":[139],"evaluated":[141],"ratio":[144],"triose-P":[148]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}