{"id":"https://openalex.org/W5452096","doi":null,"title":"The Investigation of Innate Immune Pathways in the Yellow Fever Mosquito, Aedes aegypti","display_name":"The Investigation of Innate Immune Pathways in the Yellow Fever Mosquito, Aedes aegypti","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W5452096","mag":"5452096"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt6qx1q2cw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6qx1q2cw","pdf_url":"https://escholarship.org/uc/item/6qx1q2cw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/6qx1q2cw","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044885742","display_name":"Kanwal S. Alvarez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kanwal S. Alvarez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044885742"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aedes-aegypti","display_name":"Aedes aegypti","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mosquito-innate-immunity","display_name":"mosquito innate immunity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/toll-signaling-pathway","display_name":"Toll pathway","score":0.9269999861717224},{"id":"https://openalex.org/keywords/imd-pathway","display_name":"Imd pathway","score":0.9850000143051147},{"id":"https://openalex.org/keywords/irak4","display_name":"IRAK4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/imd","display_name":"IMD","score":0.8029999732971191},{"id":"https://openalex.org/keywords/ikkbeta","display_name":"IKK\u03b2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fadd","display_name":"FADD","score":0.9990000128746033},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.6809999942779541},{"id":"https://openalex.org/keywords/arbovirus-vectors","display_name":"arbovirus vectors","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7732163667678833},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7072852849960327},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6990371942520142},{"id":"https://openalex.org/C2777775583","wikidata":"https://www.wikidata.org/wiki/Q1148004","display_name":"Aedes aegypti","level":3,"score":0.6697790026664734},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.4633638560771942},{"id":"https://openalex.org/C171279029","wikidata":"https://www.wikidata.org/wiki/Q5128320","display_name":"Classical complement pathway","level":4,"score":0.4243807792663574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3784676194190979},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3366956114768982},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.12023374438285828},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.0},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt6qx1q2cw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6qx1q2cw","pdf_url":"https://escholarship.org/uc/item/6qx1q2cw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:5452096","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt6qx1q2cw/qt6qx1q2cw.pdf?t=mg2atl","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt6qx1q2cw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6qx1q2cw","pdf_url":"https://escholarship.org/uc/item/6qx1q2cw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W5452096.pdf","grobid_xml":"https://content.openalex.org/works/W5452096.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W84508205","https://openalex.org/W121555879","https://openalex.org/W1581197340","https://openalex.org/W1963568761","https://openalex.org/W1964985092","https://openalex.org/W1966772446","https://openalex.org/W1967412391","https://openalex.org/W1969584390","https://openalex.org/W1970195004","https://openalex.org/W1977023068","https://openalex.org/W1977922844","https://openalex.org/W1979128283","https://openalex.org/W1981440814","https://openalex.org/W1982264720","https://openalex.org/W1982481323","https://openalex.org/W1984133423","https://openalex.org/W1993536449","https://openalex.org/W2000399655","https://openalex.org/W2000912815","https://openalex.org/W2001809367","https://openalex.org/W2003736763","https://openalex.org/W2011247119","https://openalex.org/W2018807760","https://openalex.org/W2025393612","https://openalex.org/W2026457004","https://openalex.org/W2027583953","https://openalex.org/W2027831884","https://openalex.org/W2030551855","https://openalex.org/W2031747611","https://openalex.org/W2038076327","https://openalex.org/W2038410742","https://openalex.org/W2043981380","https://openalex.org/W2056232623","https://openalex.org/W2064434771","https://openalex.org/W2071889908","https://openalex.org/W2077906612","https://openalex.org/W2079156871","https://openalex.org/W2079955869","https://openalex.org/W2080485420","https://openalex.org/W2085017982","https://openalex.org/W2089938437","https://openalex.org/W2092713838","https://openalex.org/W2095017048","https://openalex.org/W2097042447","https://openalex.org/W2101396620","https://openalex.org/W2104957057","https://openalex.org/W2110969747","https://openalex.org/W2117936709","https://openalex.org/W2121705472","https://openalex.org/W2125912444","https://openalex.org/W2128238781","https://openalex.org/W2133375947","https://openalex.org/W2141150979","https://openalex.org/W2146325354","https://openalex.org/W2149118112","https://openalex.org/W2150467736","https://openalex.org/W2171158206","https://openalex.org/W2186269059","https://openalex.org/W2187705722"],"related_works":["https://openalex.org/W3182827365","https://openalex.org/W2030551855","https://openalex.org/W1575736068","https://openalex.org/W2150717572","https://openalex.org/W7098024982","https://openalex.org/W2905827736","https://openalex.org/W4404171681","https://openalex.org/W3164783274","https://openalex.org/W3131386831","https://openalex.org/W1993536449"],"abstract_inverted_index":{"Mosquitoes":[0],"are":[1],"vectors":[2],"of":[3,22,28,50,58,77,90,97,134],"many":[4],"parasitic":[5],"and":[6,42,61,81,144],"viral":[7],"diseases":[8],"that":[9,118],"continue":[10],"to":[11,67,73],"burden":[12],"the":[13,25,48,56,59,75,78,91,98,110,126,135],"global":[14],"public":[15],"health":[16],"system.":[17,94],"The":[18,95],"innate":[19],"immune":[20,93,123,128],"system":[21,34],"insects":[23],"is":[24,35],"first":[26,99],"line":[27],"defense":[29],"against":[30],"invading":[31],"pathogens.":[32],"This":[33,45],"governed":[36],"by":[37],"two":[38],"major":[39],"pathways,":[40],"Toll,":[41],"IMD":[43,79,136],"pathways.":[44,52],"dissertation":[46],"involves":[47,55],"investigation":[49],"these":[51],"Aim":[53,70,83],"1":[54],"exploration":[57],"Toll":[60,127],"PPO":[62],"activation":[63],"pathway":[64,80,137],"in":[65,109,125],"response":[66],"pathogen":[68],"invasion.":[69],"2":[71],"seeks":[72],"investigate":[74],"components":[76,133],"lastly,":[82],"3":[84],"provides":[85],"a":[86],"comparative":[87],"genomic":[88],"study":[89],"mosquito":[92],"results":[96],"aim":[100],"identified":[101,139],"an":[102,121],"interleukin":[103],"receptor":[104],"associated":[105],"kinase":[106],"(IRAK),":[107],"IRAK4,":[108],"mosquito,":[111],"Aedes":[112],"aegyti.":[113],"Furthermore,":[114],"it":[115],"was":[116],"found":[117],"IRAK4":[119],"serves":[120],"important":[122],"function":[124],"pathway.":[129],"Addtionally,":[130],"several":[131],"cytoplasmic":[132],"were":[138],"including":[140],"PGRPLC,":[141],"IMD,":[142],"IKK\u03b2,":[143],"FADD":[145],"(Aim":[146],"2).":[147]},"counts_by_year":[],"updated_date":"2026-08-29T07:29:34.045763","created_date":"2016-06-24T00:00:00"}