{"id":"https://openalex.org/W5447783","doi":null,"title":"Estudio de la participaci\u00f3n del receptor de dopamina D2 en la regulaci\u00f3n de lactotropodos hipofisarios y su influencia en el desarrollo de prolactinomas mediante la generaci\u00f3n de un rat\u00f3n transg\u00e9nico tejido espec\u00edfico","display_name":"Estudio de la participaci\u00f3n del receptor de dopamina D2 en la regulaci\u00f3n de lactotropodos hipofisarios y su influencia en el desarrollo de prolactinomas mediante la generaci\u00f3n de un rat\u00f3n transg\u00e9nico tejido espec\u00edfico","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W5447783","mag":"5447783"},"language":"es","primary_location":{"id":"mag:5447783","doi":null,"is_oa":false,"landing_page_url":"http://digital.bl.fcen.uba.ar/Download/Tesis/Tesis_4611_PerezMillan.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085303773","display_name":"P\u00e9rez Mill\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P\u00e9rez Mill\u00e1n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103724692","display_name":"Mar\u00eda In\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda In\u00e9s","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0008739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.05559999868273735,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d2","display_name":"D2","score":0.6169999837875366},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/lactotrophs","display_name":"lactotrophs","score":0.8100000023841858},{"id":"https://openalex.org/keywords/prolactinoma","display_name":"prolactinoma","score":0.9210000038146973},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.7609999775886536},{"id":"https://openalex.org/keywords/pituitary-adenoma","display_name":"pituitary adenoma","score":0.7039999961853027},{"id":"https://openalex.org/keywords/conditional-knockout","display_name":"conditional knockout","score":0.5450000166893005},{"id":"https://openalex.org/keywords/cre-loxp-system","display_name":"Cre-loxP system","score":0.5709999799728394},{"id":"https://openalex.org/keywords/growth-hormone-axis","display_name":"growth hormone axis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/growth-deficiency","display_name":"growth deficiency","score":0.45899999141693115},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pituitary-development","display_name":"pituitary development","score":0.5009999871253967},{"id":"https://openalex.org/keywords/pituitary-stem-cells","display_name":"pituitary stem cells","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5571293830871582},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.17931264638900757}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:5447783","doi":null,"is_oa":false,"landing_page_url":"http://digital.bl.fcen.uba.ar/Download/Tesis/Tesis_4611_PerezMillan.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":160,"referenced_works":["https://openalex.org/W10638472","https://openalex.org/W11889541","https://openalex.org/W75361961","https://openalex.org/W94005661","https://openalex.org/W121994443","https://openalex.org/W153934429","https://openalex.org/W183745769","https://openalex.org/W1204884779","https://openalex.org/W1235263458","https://openalex.org/W1487222554","https://openalex.org/W1512840340","https://openalex.org/W1554710047","https://openalex.org/W1586539673","https://openalex.org/W1596291999","https://openalex.org/W1600957554","https://openalex.org/W1602913498","https://openalex.org/W1605873295","https://openalex.org/W1678580492","https://openalex.org/W1780720469","https://openalex.org/W1787004460","https://openalex.org/W1816419917","https://openalex.org/W1925492557","https://openalex.org/W1955225173","https://openalex.org/W1963747253","https://openalex.org/W1963805295","https://openalex.org/W1964932039","https://openalex.org/W1964951841","https://openalex.org/W1965093277","https://openalex.org/W1966092598","https://openalex.org/W1967100818","https://openalex.org/W1968674415","https://openalex.org/W1969230829","https://openalex.org/W1970132032","https://openalex.org/W1970417540","https://openalex.org/W1973255852","https://openalex.org/W1974190969","https://openalex.org/W1974816487","https://openalex.org/W1976046984","https://openalex.org/W1976918496","https://openalex.org/W1977341142","https://openalex.org/W1981736657","https://openalex.org/W1982514291","https://openalex.org/W1987145582","https://openalex.org/W1987268488","https://openalex.org/W1988309865","https://openalex.org/W1991594161","https://openalex.org/W1992450113","https://openalex.org/W1997845538","https://openalex.org/W1998632384","https://openalex.org/W2003589817","https://openalex.org/W2004618736","https://openalex.org/W2009886857","https://openalex.org/W2011465733","https://openalex.org/W2011788467","https://openalex.org/W2011821840","https://openalex.org/W2012919466","https://openalex.org/W2013133422","https://openalex.org/W2017283375","https://openalex.org/W2018448974","https://openalex.org/W2019731371","https://openalex.org/W2020899639","https://openalex.org/W2023675791","https://openalex.org/W2024868821","https://openalex.org/W2025161521","https://openalex.org/W2026495777","https://openalex.org/W2027156335","https://openalex.org/W2028425454","https://openalex.org/W2028980876","https://openalex.org/W2029177264","https://openalex.org/W2029484561","https://openalex.org/W2030620101","https://openalex.org/W2032996888","https://openalex.org/W2035669202","https://openalex.org/W2036001954","https://openalex.org/W2036926504","https://openalex.org/W2037761545","https://openalex.org/W2038148790","https://openalex.org/W2038197766","https://openalex.org/W2038970416","https://openalex.org/W2041545601","https://openalex.org/W2042297802","https://openalex.org/W2044093653","https://openalex.org/W2046251165","https://openalex.org/W2047133544","https://openalex.org/W2047585250","https://openalex.org/W2049149497","https://openalex.org/W2049162449","https://openalex.org/W2050433177","https://openalex.org/W2051417420","https://openalex.org/W2054067116","https://openalex.org/W2054278011","https://openalex.org/W2054979979","https://openalex.org/W2055155243","https://openalex.org/W2055784254","https://openalex.org/W2055785133","https://openalex.org/W2060098417","https://openalex.org/W2060571381","https://openalex.org/W2063758018","https://openalex.org/W2065981672","https://openalex.org/W2067269714","https://openalex.org/W2069087871","https://openalex.org/W2070521267","https://openalex.org/W2073502655","https://openalex.org/W2073664351","https://openalex.org/W2074037214","https://openalex.org/W2074070420","https://openalex.org/W2076058111","https://openalex.org/W2078423419","https://openalex.org/W2081612350","https://openalex.org/W2082151327","https://openalex.org/W2084367644","https://openalex.org/W2086337886","https://openalex.org/W2088822460","https://openalex.org/W2090816512","https://openalex.org/W2091710956","https://openalex.org/W2094983352","https://openalex.org/W2095098999","https://openalex.org/W2095310293","https://openalex.org/W2096552592","https://openalex.org/W2101361680","https://openalex.org/W2101998219","https://openalex.org/W2104854307","https://openalex.org/W2107689453","https://openalex.org/W2110570575","https://openalex.org/W2113103296","https://openalex.org/W2114029663","https://openalex.org/W2114290020","https://openalex.org/W2115958543","https://openalex.org/W2116593856","https://openalex.org/W2117766577","https://openalex.org/W2124982499","https://openalex.org/W2125153669","https://openalex.org/W2125363287","https://openalex.org/W2131928291","https://openalex.org/W2142173484","https://openalex.org/W2143828869","https://openalex.org/W2144880166","https://openalex.org/W2145533695","https://openalex.org/W2146432074","https://openalex.org/W2147745959","https://openalex.org/W2148583270","https://openalex.org/W2149965578","https://openalex.org/W2152708945","https://openalex.org/W2153780972","https://openalex.org/W2154104720","https://openalex.org/W2154536753","https://openalex.org/W2154890688","https://openalex.org/W2156424672","https://openalex.org/W2157863718","https://openalex.org/W2158162758","https://openalex.org/W2162783545","https://openalex.org/W2164875032","https://openalex.org/W2167650288","https://openalex.org/W2168932510","https://openalex.org/W2170613693","https://openalex.org/W2171418226","https://openalex.org/W2184607590","https://openalex.org/W2319962899","https://openalex.org/W2344340092","https://openalex.org/W2470979191"],"related_works":["https://openalex.org/W2239100352","https://openalex.org/W2153780972","https://openalex.org/W2035500336","https://openalex.org/W6981613888","https://openalex.org/W4231563022","https://openalex.org/W2054278011","https://openalex.org/W2000255044","https://openalex.org/W1997845538","https://openalex.org/W3084438407","https://openalex.org/W1605873295"],"abstract_inverted_index":{"Con":[0],"el":[1,25,54,73,102,111,255,310],"objetivo":[2],"de":[3,16,23,27,40,59,61,105,131,136,150,167,170,176,178,185,191,196,199,213,216,241,243,257,259,271,274,282,286,291,296,319,333],"estudiar":[4],"la":[5,50,106,168,186,214,239,272,326,331],"participacion":[6],"del":[7,57,75,119,189,229,250,277],"receptor":[8],"dopaminergico":[9],"D2":[10],"(RD2)":[11],"en":[12,31,101,110,115,156,219,225,254,304,316,325,330],"celulas":[13],"hipofisarias":[14],"productoras":[15],"prolactina":[17,60,151,177],"hemos":[18],"desarrollado":[19],"ratones":[20,36,46,69,80,95,132,145,180,201,226,261],"mutantes":[21,70,81,227],"incapaces":[22],"expresar":[24],"gen":[26,74],"RD2":[28,76,172,230],"(Drd2)":[29],"selectivamente":[30],"lactotropos.":[32],"Para":[33],"producir":[34,79],"estos":[35],"con":[37,68,133,222],"mutaciones":[38,134],"nulas":[39,135],"Drd2":[41,100,122,137],"restringidas":[42,138],"a":[43,139,280,312,337,342],"lactrotropos":[44],"generamos":[45],"transgenicos":[47,83],"que":[48,93,152,160,232,238],"expresan":[49,99],"recombinasa":[51],"Cre":[52],"bajo":[53],"control":[55],"transcripcional":[56],"promotor":[58],"raton":[62],"(Prl-Cre)":[63],"y":[64,82,90,114,276,308,329],"luego":[65,184],"los":[66,94,174,179,200,207,244,260,283,292,300,334],"cruzamos":[67],"condicionales":[71],"para":[72,78],"(Drd2^flox/flox)":[77],"compuestos":[84],"(Drd2^flox/flox.Tg":[85],"Prl-Cre).":[86],"La":[87],"caracterizacion":[88],"molecular":[89],"bioquimica":[91],"mostro":[92],"Drd2^flox/flox.Tg":[96],"Prl-Cre":[97],"no":[98,182,247],"lobulo":[103,112],"anterior":[104],"hipofisis":[107,339],"pero":[108],"si":[109],"intermedio":[113],"todas":[116],"las":[117,264,338],"areas":[118],"cerebro":[120],"donde":[121],"se":[123],"expresa":[124],"normalmente.":[125],"En":[126],"consecuencia,":[127],"esta":[128],"nueva":[129],"cepa":[130],"lactotropos":[140,245],"fue":[141],"denominada":[142],"pitD2RKO.":[143],"Los":[144],"pitD2RKO":[146,181,202,266],"presentan":[147,267],"niveles":[148,175,294],"elevados":[149,293],"resultan":[153],"extremadamente":[154],"altos":[155],"hembras":[157,265],"adultas":[158],"desarrollan":[162],"prolactinomas":[163,301],"hipofisarios.":[164],"Como":[165],"consecuencia":[166,290],"falta":[169],"receptores":[171],"lactotropicos,":[173],"aumentan":[183],"administracion":[187],"aguda":[188],"antagonista":[190],"RD2s,":[192],"haloperidol.":[193],"Las":[194],"curvas":[195],"crecimiento":[197,217],"corporal":[198,279],"resultaron":[203],"normales":[204],"asi":[205],"como":[206,289],"distintos":[208],"parametros":[209],"asociados":[210],"al":[211],"eje":[212,256],"hormona":[215],"(GH),":[218],"marcado":[220],"contraste":[221],"lo":[223,343],"estudiado":[224],"totales":[228],"(Drd2^+)":[231],"son":[233],"enanos.":[234],"Esta":[235],"observacion":[236],"indica":[237],"ausencia":[240],"RD2s":[242],"hipofisarios":[246,314],"es":[248],"responsable":[249],"deficit":[251],"severo":[252],"presente":[253],"GH":[258],"Drd2^+.":[262],"Sorprendentemente,":[263],"un":[268,323],"aumento":[269,324],"considerable":[270],"ingesta":[273],"alimento":[275],"peso":[278],"partir":[281],"90":[284],"dias":[285],"edad,":[287],"probablemente":[288],"cronicos":[295],"prolactina.":[297],"Finalmente,":[298],"analizamos":[299],"experimentales":[302],"resultantes":[303],"nuestro":[305],"nuevo":[306],"modelo":[307],"ampliamos":[309],"estudio":[311],"adenomas":[313,335],"humanos;":[315],"ambos":[317],"casos,":[318],"manera":[320],"interesante,":[321],"observamos":[322],"proliferacion":[327],"celular":[328],"angiogenesis":[332],"respecto":[336],"controles,":[340],"contrariamente":[341],"publicado.":[344]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-08-08T07:41:36.138363","created_date":"2016-06-24T00:00:00"}
