{"id":"https://openalex.org/W54459662","doi":null,"title":"Detection of spatially regulated gene expression by hybridization histochemistry.","display_name":"Detection of spatially regulated gene expression by hybridization histochemistry.","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W54459662","mag":"54459662","pmid":"https://pubmed.ncbi.nlm.nih.gov/1697694"},"language":"en","primary_location":{"id":"pmid:1697694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1697694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de fisiologia","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066286305","display_name":"Anna Meseguer","orcid":"https://orcid.org/0000-0003-3833-2249","observed_orcids":["https://orcid.org/0000-0003-3833-2249"]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Meseguer","raw_affiliation_strings":["Population Council, Rockefeller University, New York, N.Y. 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Council, Rockefeller University, New York, N.Y. 10021","institution_ids":["https://openalex.org/I4210132262","https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074183604","display_name":"James F. Catterall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F Catterall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00507084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"1","first_page":"69","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8489999771118164},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.4959999918937683},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.8640000224113464},{"id":"https://openalex.org/keywords/beta-estradiol","display_name":"beta-estradiol","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pituitary-hormones","display_name":"pituitary hormones","score":0.8259999752044678},{"id":"https://openalex.org/keywords/castration","display_name":"castration","score":0.578000009059906},{"id":"https://openalex.org/keywords/hypophysectomy","display_name":"hypophysectomy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/spatial-regulation-of-gene-expression","display_name":"spatial regulation of gene expression","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7688394784927368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7430881261825562},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.7193273901939392},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6821576356887817},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.671933650970459},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.6564788818359375},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6265415549278259},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5887607336044312},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5671571493148804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48348313570022583},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37532249093055725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35528019070625305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12956082820892334},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.0915764570236206},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007016","descriptor_name":"Hypophysectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009919","descriptor_name":"Orchiectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011061","descriptor_name":"Poly A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013196","descriptor_name":"Dihydrotestosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013734","descriptor_name":"Androgen-Insensitivity Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013734","descriptor_name":"Androgen-Insensitivity Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015347","descriptor_name":"RNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016372","descriptor_name":"RNA, Antisense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1697694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1697694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de fisiologia","raw_type":"Journal Article"},{"id":"mag:54459662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1697694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985728790","https://openalex.org/W1983983373","https://openalex.org/W1998109084","https://openalex.org/W1983772774","https://openalex.org/W2007684068","https://openalex.org/W2144974537","https://openalex.org/W1982493291","https://openalex.org/W2064487242","https://openalex.org/W2115315087","https://openalex.org/W2028334434"],"abstract_inverted_index":{"Steady":[0],"state":[1],"measurements":[2],"of":[3,22,44,60,71,78,105,118,120,146,153,166,184,208,228,246,264,286],"kidney":[4,271],"androgen-regulated":[5],"protein":[6],"(KAP)":[7],"mRNA":[8,92,139,148,186],"suggested":[9],"that":[10,75,90,132,141,160,176,205,261],"KAP":[11,62,91,138,147,185,221,250,265,293],"gene":[12,46,63,222,251,266,294],"expression":[13,93,183,230,252,267],"was":[14,94,231],"unusually":[15],"sensitive":[16],"to":[17,26,33,64,66,96,212],"low":[18,69],"hormone-receptor":[19],"levels.":[20],"Two":[21],"the":[23,45,58,61,76,102,111,134,144,164,196,200,206,226,234,244,254,262,269,284],"criteria":[24],"used":[25],"reach":[27],"this":[28],"conclusion":[29],"involved":[30],"relative":[31],"insensitivity":[32],"treatment":[34,130,162],"with":[35,156],"a":[36,40],"competitive":[37],"antiandrogen":[38],"and":[39,126,140,178,288],"partial":[41],"androgen":[42,49],"response":[43],"in":[47,83,87,101,114,149,187,199,225,237,249,253,268,292],"Tfm/Y":[48,123,154,201],"receptor":[50],"(AR)":[51],"deficient":[52],"mice.":[53],"These":[54,240,257],"data":[55],"may":[56,203],"indicate":[57,204,243],"ability":[59],"respond":[65],"an":[67,213],"extremely":[68],"level":[70,145],"androgen-AR":[72],"complex":[73,275],"or":[74],"effect":[77,165,194],"androgens":[79],"is,":[80],"at":[81],"least":[82],"part,":[84],"indirect.":[85],"Hybridization":[86],"situ":[88],"revealed":[89,131],"restricted":[95],"proximal":[97],"tubule":[98],"epithelial":[99],"cells":[100,198],"juxtamedullary":[103,135,197,255],"region":[104],"castrated":[106],"animals":[107,155,189],"rather":[108],"than":[109,276],"throughout":[110,233],"cortex":[112,235],"as":[113,236],"intact":[115,238],"males.":[116,239],"Examination":[117],"sections":[119],"kidneys":[121],"from":[122],"mice":[124],"before":[125],"after":[127],"testosterone":[128],"(T)":[129],"only":[133],"tubules":[136],"expressed":[137],"T":[142,167,179,209],"increased":[143],"these":[150],"cells.":[151],"Treatment":[152],"other":[157],"steroids":[158],"showed":[159],"beta-estradiol":[161],"mimicked":[163],"while":[168,224],"dihydrotestosterone":[169],"(DHT)":[170],"had":[171],"no":[172,193,220],"effect.":[173],"The":[174],"facts":[175],"DHT":[177,191],"both":[180],"stimulate":[181],"cortical":[182],"normal":[188],"but":[190],"has":[192],"on":[195],"variant":[202],"action":[207],"is":[210,272],"due":[211],"estrogenic":[214],"metabolite.":[215],"Castrated,":[216],"hypophysectomized":[217],"males":[218],"exhibited":[219],"expression,":[223],"presence":[227],"T,":[229],"observed":[232],"results":[241],"clearly":[242],"involvement":[245],"pituitary":[247,290],"hormones":[248,291],"tubules.":[256],"studies":[258,280],"have":[259],"shown":[260],"regulation":[263],"mouse":[270],"much":[273],"more":[274],"originally":[277],"believed.":[278],"Future":[279],"will":[281],"further":[282],"investigate":[283],"roles":[285],"estrogen":[287],"specific":[289],"expression.":[295]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}