{"id":"https://openalex.org/W54444632","doi":"https://doi.org/10.1176/ajp.153.10.1313","title":"Exaggerated platelet reactivity in major depression","display_name":"Exaggerated platelet reactivity in major depression","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W54444632","doi":"https://doi.org/10.1176/ajp.153.10.1313","mag":"54444632","pmid":"https://pubmed.ncbi.nlm.nih.gov/8831440"},"language":"en","primary_location":{"id":"doi:10.1176/ajp.153.10.1313","doi":"https://doi.org/10.1176/ajp.153.10.1313","is_oa":false,"landing_page_url":"https://doi.org/10.1176/ajp.153.10.1313","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020326824","display_name":"Dominique L. Musselman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Musselman","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051689895","display_name":"Aaron Tomer","orcid":"https://orcid.org/0000-0002-7025-5792","observed_orcids":["https://orcid.org/0000-0002-7025-5792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Tomer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061689743","display_name":"Amita K. Manatunga","orcid":"https://orcid.org/0000-0002-2289-563X","observed_orcids":["https://orcid.org/0000-0002-2289-563X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A K Manatunga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081344435","display_name":"Bettina T. Knight","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B T Knight","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110654649","display_name":"Maryfrances R. Porter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Porter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006770431","display_name":"Suha Kasey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Kasey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084568262","display_name":"Ulla M. Marzec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Marzec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112132885","display_name":"Laurence A. Harker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L A Harker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050356892","display_name":"Charles B. Nemeroff","orcid":"https://orcid.org/0000-0001-7867-1160","observed_orcids":["https://orcid.org/0000-0001-7867-1160"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C B Nemeroff","raw_affiliation_strings":["Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2757,"has_fulltext":false,"cited_by_count":566,"citation_normalized_percentile":{"value":0.97089359,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"153","issue":"10","first_page":"1313","last_page":"1317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.890999972820282},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/platelet-reactivity","display_name":"platelet reactivity","score":0.765999972820282},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/orthostatic-challenge","display_name":"orthostatic challenge","score":0.8999999761581421},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.8539999723434448},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/prothrombinase-complex","display_name":"prothrombinase complex","score":0.8429999947547913},{"id":"https://openalex.org/keywords/ischemic-heart-disease","display_name":"ischemic heart disease","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.556242823600769},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5549639463424683},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5445762276649475},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.5100842118263245},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.47276952862739563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4599778354167938},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35902392864227295},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3368719816207886},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33662405610084534},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012146","descriptor_name":"Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017304","descriptor_name":"Annexin A5","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017304","descriptor_name":"Annexin A5","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1176/ajp.153.10.1313","doi":"https://doi.org/10.1176/ajp.153.10.1313","is_oa":false,"landing_page_url":"https://doi.org/10.1176/ajp.153.10.1313","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:8831440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8831440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6399999856948853,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1143685601","display_name":null,"funder_award_id":"RR00039","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3049175085","display_name":"PANCREATIC CANCER, DEPRESSION AND IMMUNE FUNCTION","funder_award_id":"5r01mh049523-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3340735645","display_name":null,"funder_award_id":"DK07298","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6268398817","display_name":null,"funder_award_id":"MH 49523","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W133668382","https://openalex.org/W147525296","https://openalex.org/W1494142194","https://openalex.org/W1516766157","https://openalex.org/W1520666812","https://openalex.org/W1542978449","https://openalex.org/W1601529928","https://openalex.org/W1965296270","https://openalex.org/W1979680135","https://openalex.org/W1985400269","https://openalex.org/W1990374302","https://openalex.org/W1999869254","https://openalex.org/W2001059064","https://openalex.org/W2023574802","https://openalex.org/W2036891077","https://openalex.org/W2058472215","https://openalex.org/W2059242346","https://openalex.org/W2106503056","https://openalex.org/W2125354973","https://openalex.org/W2132072846","https://openalex.org/W2143465004","https://openalex.org/W2335529663","https://openalex.org/W3113058496"],"related_works":["https://openalex.org/W2086617357","https://openalex.org/W1993801891","https://openalex.org/W1986176290","https://openalex.org/W2056881602","https://openalex.org/W2017693202","https://openalex.org/W104710191","https://openalex.org/W2033362793","https://openalex.org/W2086635859","https://openalex.org/W2089803892","https://openalex.org/W2094007798"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1],"study":[2],"investigated":[3],"whether":[4],"depressed":[5,24,41,70],"patients":[6,25,42,71,106],"exhibit":[7,107],"exaggerated":[8],"platelet":[9,14,45,99,110,122],"reactivity.":[10],"METHOD:":[11],"In":[12],"vivo":[13],"activation,":[15],"secretion,":[16],"and":[17,26,35,79,85,112,139],"dose-response":[18],"aggregation":[19],"were":[20],"measured":[21],"in":[22,74,98,114],"12":[23],"eight":[27],"normal":[28,93,117],"comparison":[29,94,115],"subjects":[30,95],"after":[31,144],"overnight":[32],"bed":[33],"rest":[34],"following":[36],"orthostatic":[37,67],"challenge.":[38],"RESULTS:":[39],"The":[40,92],"exhibited":[43,72,96],"increased":[44,51],"activation":[46,100,111,123],"at":[47],"baseline,":[48],"demonstrated":[49],"by":[50,128],"binding":[52,64,75],"of":[53,76],"monoclonal":[54],"antibody":[55],"(moAb)":[56],"annexin":[57],"V":[58],"protein":[59],"reacting":[60],"with":[61,102,116],"prothrombinase":[62],"complex":[63],"sites.":[65],"Following":[66],"challenge,":[68],"the":[69],"increases":[73,97],"moAbs":[77],"PAC1":[78],"anti-LIBS1":[80],"against":[81,87],"activated":[82],"glycoprotein":[83],"IIb/IIIa":[84],"GE12":[86],"P-selectin":[88],"expressed":[89],"upon":[90],"secretion.":[91],"only":[101],"GE12.":[103],"CONCLUSIONS:":[104],"Depressed":[105],"enhanced":[108],"baseline":[109],"responsiveness":[113],"subjects.":[118],"Heightened":[119],"susceptibility":[120],"to":[121],"may":[124],"be":[125],"a":[126,132],"mechanism":[127],"which":[129],"depression":[130],"is":[131],"significant":[133],"risk":[134],"factor":[135],"for":[136],"ischemic":[137],"heart":[138],"cerebrovascular":[140],"disease":[141],"and/or":[142],"mortality":[143],"myocardial":[145],"infarction.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":22}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
