{"id":"https://openalex.org/W54370053","doi":null,"title":"Positive end-expiratory pressure depressed cardiovascular autonomic nervous system activity in acute brain damaged rabbits under general anesthesia.","display_name":"Positive end-expiratory pressure depressed cardiovascular autonomic nervous system activity in acute brain damaged rabbits under general anesthesia.","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W54370053","mag":"54370053","pmid":"https://pubmed.ncbi.nlm.nih.gov/14760994"},"language":"en","primary_location":{"id":"pmid:14760994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14760994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hiroshima journal of medical sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hiroshima.repo.nii.ac.jp/records/2013538","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059195352","display_name":"Shigeaki Kurita","orcid":"https://orcid.org/0000-0001-5997-9784","observed_orcids":["https://orcid.org/0000-0001-5997-9784"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeaki Kurita","raw_affiliation_strings":["Department of Anesthesiology and Critical Care, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan. kuripy@hiroshima-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan. kuripy@hiroshima-u.ac.jp","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022218831","display_name":"Masashi Kawamoto","orcid":"https://orcid.org/0000-0001-5528-6171","observed_orcids":["https://orcid.org/0000-0001-5528-6171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masashi Kawamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035855259","display_name":"Syozo Hidaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syozo Hidaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014642732","display_name":"Osafumi Yuge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Osafumi Yuge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.00778283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"52","issue":"4","first_page":"59","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.48579999804496765,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.48579999804496765,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.4189000129699707,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.05119999870657921,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/positive-end-expiratory-pressure","display_name":"positive end-expiratory pressure","score":1.0},{"id":"https://openalex.org/keywords/acute-brain-injury","display_name":"acute brain injury","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.9150000214576721},{"id":"https://openalex.org/keywords/systolic-arterial-pressure-variability","display_name":"systolic arterial pressure variability","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.7120000123977661},{"id":"https://openalex.org/keywords/sympathovagal-balance","display_name":"sympathovagal balance","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.867772102355957},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.6245406866073608},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6230277419090271},{"id":"https://openalex.org/C2778917391","wikidata":"https://www.wikidata.org/wiki/Q352381","display_name":"Positive end-expiratory pressure","level":3,"score":0.5903931856155396},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.5595142841339111},{"id":"https://openalex.org/C2780954326","wikidata":"https://www.wikidata.org/wiki/Q1416096","display_name":"Intracranial pressure","level":2,"score":0.5383874177932739},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.46810126304626465},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43562716245651245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4184446334838867},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.417895644903183},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3874533176422119},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.28855541348457336},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002320","descriptor_name":"Cardiovascular Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmid:14760994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14760994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hiroshima journal of medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:hiroshima.repo.nii.ac.jp:02013538","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2013538","pdf_url":null,"source":{"id":"https://openalex.org/S7407055456","display_name":"Hiroshima University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"departmental bulletin paper"},{"id":"pmh:oai:ir.lib.hiroshima-u.ac.jp:00017681","doi":null,"is_oa":false,"landing_page_url":"http://ir.lib.hiroshima-u.ac.jp/00017681","pdf_url":null,"source":{"id":"https://openalex.org/S4377196292","display_name":"Hiroshima University Acedemic Information Repository (Hiroshima University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I113306721","host_organization_name":"Hiroshima University","host_organization_lineage":["https://openalex.org/I113306721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"departmental bulletin paper"},{"id":"pmh:oai:irdb.nii.ac.jp:01372:0006666702","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2013538","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hiroshima Journal of Medical Sciences","raw_type":"departmental bulletin paper"},{"id":"mag:54370053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14760994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:hiroshima.repo.nii.ac.jp:02013538","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2013538","pdf_url":null,"source":{"id":"https://openalex.org/S7407055456","display_name":"Hiroshima University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"departmental bulletin paper"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7130414237","https://openalex.org/W2395841888","https://openalex.org/W2161702155","https://openalex.org/W2724411430","https://openalex.org/W4367852247","https://openalex.org/W1965356380","https://openalex.org/W2080600752","https://openalex.org/W2412138145","https://openalex.org/W2007335351","https://openalex.org/W4384406032"],"abstract_inverted_index":{"Artificial":[0],"ventilation":[1,19],"with":[2,76,146,157,191],"positive":[3],"end-expiratory":[4,159],"pressure":[5,93],"(PEEP)":[6],"is":[7,30],"commonly":[8],"applied":[9],"for":[10,98,166],"brain":[11,21,48,57,170,187,233,242,269,281],"damaged":[12,49],"patients.":[13],"However,":[14],"the":[15,18,38,80,99,107,134,167,173,195,239,254,266],"effect":[16,39,178],"of":[17,40,71,79,85,101,110,119,137,169,186,194,241,251,268],"on":[20,44,179],"function,":[22],"including":[23],"cardiovascular":[24],"autonomic":[25],"nervous":[26],"system":[27],"(CANS)":[28],"activity,":[29],"not":[31],"well":[32],"elucidated.":[33],"In":[34,172],"order":[35],"to":[36,112,121,279],"investigate":[37],"5":[41,147,259],"cmH2O":[42,148,260],"PEEP":[43,175,252,261],"CANS":[45,102,263],"activity":[46,264],"in":[47,106,141,152,202,208,211,217,223,226,271],"rabbits":[50,272],"under":[51],"general":[52],"anesthesia,":[53],"we":[54],"produced":[55],"acute":[56],"damage":[58,243,270],"by":[59,284],"intracranial":[60],"balloon":[61],"inflation.":[62],"Measurements":[63],"were":[64,96,125,144,155,205],"made":[65],"before":[66,184],"(control)":[67],"and":[68,73,90,116,127,181,199,214,244,273],"after":[69,74,249],"application":[70,250],"PEEP,":[72,149],"inflation":[75,190],"incremental":[77,192],"volume":[78,193],"balloon.":[81],"Power":[82],"spectral":[83],"analyses":[84],"heart":[86],"rate":[87],"variability":[88,94],"(HRV)":[89],"systolic":[91],"arterial":[92],"(SAPV)":[95],"used":[97,165],"assessment":[100,168],"activity.":[103],"Spectral":[104],"powers":[105],"low-frequency":[108],"range":[109,118],"0.04":[111],"0.40":[113],"Hz":[114,123],"(LF)":[115,201,216],"high-frequency":[117],"0.75":[120],"1.40":[122],"(HF)":[124,198],"computed,":[126],"their":[128],"ratio":[129],"LF/HF":[130],"was":[131,164,220,236,276],"assessed":[132],"as":[133],"neural":[135],"balance":[136],"CANS.":[138],"The":[139],"animals":[140],"group":[142,153,203,209,218,224],"P":[143,204,219],"ventilated":[145,156],"while":[150],"those":[151],"Z":[154,210,225],"zero":[158],"pressure.":[160],"Colored":[161],"microsphere":[162],"counting":[163,230],"circulation.":[171],"results,":[174],"had":[176],"no":[177],"HRV":[180,212],"SAPV":[182,227],"parameters":[183],"induction":[185],"damage.":[188],"After":[189],"balloon,":[196],"log":[197,200,215],"lower":[206,221],"than":[207,222],"analysis,":[213],"analysis.":[228],"Microsphere":[229],"revealed":[231],"that":[232,258,274],"blood":[234],"flow":[235],"reduced":[237],"during":[238,265],"progression":[240,267],"showed":[245],"a":[246],"significant":[247],"difference":[248],"between":[253],"groups.":[255],"We":[256],"concluded":[257],"depressed":[262],"this":[275],"partly":[277],"due":[278],"aggravated":[280],"function":[282],"induced":[283],"PEEP.":[285]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}