{"id":"https://openalex.org/W54046239","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.167.12","title":"Phosphorylation of beta\u2010amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis","display_name":"Phosphorylation of beta\u2010amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W54046239","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.167.12","mag":"54046239"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.167.12","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.167.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.167.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048895495","display_name":"Numa R. Gottardi-Littell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Numa R Gottardi\u2010Littell","raw_affiliation_strings":["Pathology Northwestern University Feinberg School of Medicine Chicago IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Northwestern University Feinberg School of Medicine Chicago IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042211554","display_name":"Chhinder Pal Sodhi","orcid":"https://orcid.org/0000-0002-1366-4813","observed_orcids":["https://orcid.org/0000-0002-1366-4813"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chhinder P Sodhi","raw_affiliation_strings":["Pathology Northwestern University Feinberg School of Medicine Chicago IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Northwestern University Feinberg School of Medicine Chicago IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056694554","display_name":"Ruth G. Perez","orcid":"https://orcid.org/0000-0001-9930-7333","observed_orcids":["https://orcid.org/0000-0001-9930-7333"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth G Perez","raw_affiliation_strings":["University of Pittsburgh School of Medicine Pittsburgh PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine Pittsburgh PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.6784,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71243079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.906000018119812},{"id":"https://openalex.org/keywords/amyloidogenic-processing","display_name":"amyloidogenic processing","score":0.7879999876022339},{"id":"https://openalex.org/keywords/amyloid-beta-secretion","display_name":"amyloid-beta secretion","score":0.8690000176429749},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8100000023841858},{"id":"https://openalex.org/keywords/staurosporine-induced-apoptosis","display_name":"staurosporine-induced apoptosis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/erk1","display_name":"ERK1","score":0.8640000224113464},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C2779084600","wikidata":"https://www.wikidata.org/wiki/Q5957181","display_name":"Staurosporine","level":4,"score":0.9551388025283813},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7157589793205261},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6269958019256592},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.540768027305603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5386327505111694},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.508047342300415},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5060936808586121},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.49135199189186096},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.4559139013290405},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.4525545835494995},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4230252504348755},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4203242063522339},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.37796682119369507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33197829127311707},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3275580108165741},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2097528576850891},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1544571816921234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05679163336753845},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.167.12","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.167.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.167.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000025507","display_name":null,"funder_award_id":"AG15066","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1967650975","https://openalex.org/W2005795337","https://openalex.org/W1457945162","https://openalex.org/W2159556212","https://openalex.org/W2018733967","https://openalex.org/W2149117501","https://openalex.org/W2528458814","https://openalex.org/W1976891965","https://openalex.org/W2142623116","https://openalex.org/W143822372"],"abstract_inverted_index":{"Secretion":[0],"and":[1,23],"progressive":[2],"cerebral":[3],"accumulation":[4],"of":[5,14,29,37,62,94,118,126],"\u03b2\u2010amyloid":[6,15],"peptides":[7],"(A\u03b2)":[8],"derived":[9],"by":[10,162],"endoproteolytic":[11],"(\u2018amyloidogenic\u2019)":[12],"processing":[13],"precursor":[16],"protein":[17,99],"(APP)":[18],"represent":[19],"collectively":[20],"an":[21,51],"early":[22],"necessary":[24],"event":[25],"in":[26,46,50,90,116],"the":[27,38,55,63,95,127,151],"pathogenesis":[28],"Alzheimer's":[30],"disease.":[31],"We":[32,74,102],"previously":[33],"demonstrated":[34],"that":[35,76,105],"secretion":[36,148],"neurotoxic":[39],"species":[40],"A\u03b242":[41,147],"increases":[42,86],"during":[43,87,109,141],"staurosporine\u2010induced":[44,88],"apoptosis":[45,142],"undifferentiated":[47],"PC12":[48],"cells,":[49],"endocytosis\u2010dependent":[52],"manner.":[53],"In":[54],"present":[56],"study,":[57],"we":[58],"tested":[59],"whether":[60],"phosphorylation":[61,78,120,138],"APP":[64,119,136],"cytoplasmic\u2010tail":[65,77,137],"is":[66],"contributory":[67,144],"to":[68,145,167],"this":[69],"apoptosis\u2010related":[70],"increased":[71,128,146],"A\u03b2\u2010secretory":[72,129],"response.":[73,130],"demonstrate":[75,103],"specifically":[79],"at":[80,121,139],"amino\u2010acid":[81],"residue":[82],"T668":[83,140],"(APP\u2010695":[84],"numbering)":[85],"apoptosis,":[89],"parallel":[91],"with":[92,112,124,135,155],"activation":[93],"mitogen\u2010activated,":[96],"proline\u2010directed":[97],"serine/threonine":[98],"kinase":[100],"ERK1.":[101],"additionally":[104],"specific":[106],"ERK":[107],"inhibition":[108],"staurosporine":[110],"induction,":[111],"serum\u2010free":[113],"conditions,":[114],"results":[115,132],"down\u2010regulation":[117],"T668,":[122],"together":[123],"attenuation":[125],"These":[131],"are":[133],"consistent":[134],"as":[143],"originating":[149],"from":[150],"endocytotic":[152],"pathway,":[153],"likely":[154],"cell\u2010line":[156],"restriction.":[157],"This":[158],"work":[159],"was":[160],"supported":[161],"NIH":[163],"grant":[164],"AG15066":[165],"awarded":[166],"NR":[168],"Gottardi\u2010Littell.":[169]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}