{"id":"https://openalex.org/W54041995","doi":"https://doi.org/10.1177/120347549800300103","title":"Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne","display_name":"Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W54041995","doi":"https://doi.org/10.1177/120347549800300103","mag":"54041995","pmid":"https://pubmed.ncbi.nlm.nih.gov/9677254"},"language":"en","primary_location":{"id":"doi:10.1177/120347549800300103","doi":"https://doi.org/10.1177/120347549800300103","is_oa":false,"landing_page_url":"https://doi.org/10.1177/120347549800300103","pdf_url":null,"source":{"id":"https://openalex.org/S142488290","display_name":"Journal of Cutaneous Medicine and Surgery","issn_l":"1203-4754","issn":["1203-4754","1615-7109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cutaneous Medicine and Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075588699","display_name":"Marty E. Sawaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marty E. Sawaya","raw_affiliation_strings":["ARATEC: Alopecia Research & Associated Technologies, and University of Florida, Departments of Medicine and Dermatology, Gainesville, Florida","ARATEC: Alopecia Research and Associated Technologies, and University of Florida, Departments of Medicine and Dermatology, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARATEC: Alopecia Research & Associated Technologies, and University of Florida, Departments of Medicine and Dermatology, Gainesville, Florida","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"ARATEC: Alopecia Research and Associated Technologies, and University of Florida, Departments of Medicine and Dermatology, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072950389","display_name":"Alan R. Shalita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan R. Shalita","raw_affiliation_strings":["Department of Dermatology, SUNY Health Science Center at Brooklyn, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, SUNY Health Science Center at Brooklyn, New York, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":7.3961,"has_fulltext":false,"cited_by_count":204,"citation_normalized_percentile":{"value":0.97516519,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"9","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cag-repeat-polymorphism","display_name":"CAG repeat polymorphism","score":0.9290000200271606},{"id":"https://openalex.org/keywords/androgenetic-alopecia","display_name":"androgenetic alopecia","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hirsutism","display_name":"hirsutism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.9829999804496765},{"id":"https://openalex.org/keywords/polyglutamine","display_name":"polyglutamine","score":0.734000027179718},{"id":"https://openalex.org/keywords/trinucleotide-repeat-expansion","display_name":"trinucleotide repeat expansion","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hair-follicle","display_name":"hair follicle","score":0.7829999923706055},{"id":"https://openalex.org/keywords/sebaceous-glands","display_name":"sebaceous glands","score":0.9539999961853027},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9098305702209473},{"id":"https://openalex.org/C2776371013","wikidata":"https://www.wikidata.org/wiki/Q1620594","display_name":"hirsutism","level":5,"score":0.8337106108665466},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.8289676904678345},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6965659856796265},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6881678700447083},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.4818616807460785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.353085458278656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35047435760498047},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.11120471358299255},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09494057297706604},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.08856427669525146},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006628","descriptor_name":"Hirsutism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018911","descriptor_name":"Trinucleotide Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/120347549800300103","doi":"https://doi.org/10.1177/120347549800300103","is_oa":false,"landing_page_url":"https://doi.org/10.1177/120347549800300103","pdf_url":null,"source":{"id":"https://openalex.org/S142488290","display_name":"Journal of Cutaneous Medicine and Surgery","issn_l":"1203-4754","issn":["1203-4754","1615-7109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cutaneous Medicine and Surgery","raw_type":"journal-article"},{"id":"pmid:9677254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9677254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cutaneous medicine and surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3079976788","display_name":"ANDROGEN RECEPTOR AND REGULATION FACTORS IN SKIN","funder_award_id":"R29AR041924","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320310009","display_name":"University of Florida","ror":"https://ror.org/02y3ad647"},{"id":"https://openalex.org/F4320323032","display_name":"Asia University","ror":"https://ror.org/038a1tp19"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1971507786","https://openalex.org/W1974998400","https://openalex.org/W1976706733","https://openalex.org/W1989187665","https://openalex.org/W2001401515","https://openalex.org/W2010950293","https://openalex.org/W2012481532","https://openalex.org/W2013098053","https://openalex.org/W2021443932","https://openalex.org/W2022077084","https://openalex.org/W2023654765","https://openalex.org/W2029180509","https://openalex.org/W2031559689","https://openalex.org/W2058378922","https://openalex.org/W2101065984","https://openalex.org/W2113333419","https://openalex.org/W2121642311","https://openalex.org/W2137374371","https://openalex.org/W2149919973","https://openalex.org/W2172256092","https://openalex.org/W2255469197","https://openalex.org/W2413780236","https://openalex.org/W2442785944"],"related_works":["https://openalex.org/W2076858631","https://openalex.org/W2358626114","https://openalex.org/W2125883635","https://openalex.org/W3012269387","https://openalex.org/W4382139676","https://openalex.org/W2945579395","https://openalex.org/W4239381553","https://openalex.org/W2429651110","https://openalex.org/W2366413021","https://openalex.org/W4386105153"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,15,82,116],"androgen":[2,251],"receptor":[3,13],"(AR)":[4],"is":[5,18,41,87],"a":[6,25,108,145,214],"structurally":[7],"conserved":[8],"member":[9],"of":[10,27,38,44,76,84,110,120,147,216,233],"the":[11,36,48,65,73,121,131,231],"nuclear":[12],"superfamily.":[14],"amino-terminal":[16],"domain":[17],"required":[19],"for":[20,53,90],"transcriptional":[21],"activation":[22],"and":[23,63,96,113,130,142,198,204,239,258,263],"contains":[24],"region":[26,119],"polyglutamine":[28],"encoded":[29],"by":[30,125],"CAG":[31,39,45,68,97,117],"trinucleotide":[32,151,226],"repeats.":[33,227],"In":[34,139],"humans,":[35],"number":[37],"repeats":[40,46,152],"polymorphic.":[42],"Expansion":[43],"in":[47,67,237,247,255,261],"AR":[49,122,248],"has":[50],"clinical":[51,74],"implications":[52],"human":[54],"disease.":[55],"OBJECTIVE:":[56],"Androgens":[57],"influence":[58],"androgenetic":[59],"alopecia":[60],"(AGA),":[61],"hirsutism,":[62],"acne;":[64],"polymorphisms":[66],"repeat":[69,98,118],"length":[70,246],"may":[71,249],"affect":[72,250],"course":[75],"patients":[77],"with":[78,155,169,177,184,196,206,213,230,265],"these":[79,94,266],"cutaneous":[80],"disorders.":[81,269],"purpose":[83],"this":[85],"study":[86],"to":[88,149],"test":[89],"an":[91],"association":[92],"between":[93],"disorders":[95,220,236],"length.":[99],"METHODS:":[100],"We":[101],"analyzed":[102],"normal":[103,140],"lymphocyte":[104],"genomic":[105],"DNA":[106],"from":[107],"total":[109],"48":[111],"men":[112,141,156,195,238,262],"60":[114],"women.":[115,240],"was":[123,153],"amplified":[124],"polymerase":[126],"drain":[127],"reaction":[128],"(PCR)":[129],"products":[132],"were":[133],"sized":[134],"on":[135],"polyacrylamide":[136],"gels.":[137],"RESULTS:":[138],"women":[143,164,176,191,205,264],"controls,":[144],"range":[146],"12":[148],"29":[150],"found,":[154],"having":[157],"22":[158],"+/-":[159,166,173,181,188,202,210,224],"4":[160],"(M":[161],"6":[162],"SD),":[163],"21":[165,187],"3.":[167,182,211],"Men":[168,183],"AGA":[170,178,197],"had":[171,179,186,192,200,208,222],"19":[172],"3,":[174,189],"whereas":[175,190],"17":[180],"acne":[185,199],"20+/-":[193],"3;":[194],"18":[201],"4;":[203],"hirsutism":[207],"16":[209,223],"Women":[212],"combination":[215],"at":[217],"least":[218],"two":[219],"also":[221],"3":[225],"CONCLUSION:":[228],"associated":[229],"development":[232],"androgen-mediated":[234],"skin":[235,268],"These":[241],"data":[242],"suggest":[243],"that":[244],"CAG-repeat":[245],"mediated":[252],"gene":[253],"expression":[254],"hair":[256],"follicles":[257],"sebaceous":[259],"glands":[260],"androgenic":[267]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
