{"id":"https://openalex.org/W53991744","doi":null,"title":"MicroRNA in Diabetic and TGFbeta-Related Renal Glomerulopathy.","display_name":"MicroRNA in Diabetic and TGFbeta-Related Renal Glomerulopathy.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W53991744","mag":"53991744"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/100077","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/100077","pdf_url":"https://hdl.handle.net/2027.42/100077","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/100077","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101952204","display_name":"Yi-Chun Lai","orcid":"https://orcid.org/0000-0002-4673-7492","observed_orcids":["https://orcid.org/0000-0002-4673-7492","https://orcid.org/0000-0002-1377-9637"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yi-Chun Lai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4673-7492","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101952204"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.21969999372959137,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.949999988079071},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.800000011920929},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mir-200a","display_name":"miR-200a","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9089999794960022},{"id":"https://openalex.org/keywords/glomerular-injury","display_name":"glomerular injury","score":0.8360000252723694},{"id":"https://openalex.org/keywords/podocyte-apoptosis","display_name":"podocyte apoptosis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mesangial-proliferation","display_name":"mesangial cell proliferation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8289999961853027},{"id":"https://openalex.org/keywords/albumin-creatinine-ratio","display_name":"albumin-creatinine ratio","score":0.8939999938011169},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.7360000014305115},{"id":"https://openalex.org/keywords/smad7","display_name":"Smad7","score":0.7509999871253967},{"id":"https://openalex.org/keywords/pdcd4","display_name":"PDCD4","score":0.7289999723434448},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2780199430","wikidata":"https://www.wikidata.org/wiki/Q3347169","display_name":"Glomerulopathy","level":4,"score":0.7422769069671631},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5824898481369019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40379828214645386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3188740313053131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2716066539287567},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2366538643836975},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.08490657806396484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0758688747882843},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04431471228599548}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/100077","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/100077","pdf_url":"https://hdl.handle.net/2027.42/100077","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:53991744","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/100077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/100077","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/100077","pdf_url":"https://hdl.handle.net/2027.42/100077","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W53991744.pdf","grobid_xml":"https://content.openalex.org/works/W53991744.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W34078041","https://openalex.org/W84759460","https://openalex.org/W89222015","https://openalex.org/W1965098283","https://openalex.org/W1971079672","https://openalex.org/W1971441087","https://openalex.org/W1971687038","https://openalex.org/W1973632433","https://openalex.org/W1976324983","https://openalex.org/W1977281562","https://openalex.org/W1983832181","https://openalex.org/W1985401585","https://openalex.org/W1987254708","https://openalex.org/W1988107261","https://openalex.org/W1990488096","https://openalex.org/W1995675330","https://openalex.org/W1998630181","https://openalex.org/W1999360191","https://openalex.org/W2000093333","https://openalex.org/W2004102471","https://openalex.org/W2007701028","https://openalex.org/W2008971670","https://openalex.org/W2011298151","https://openalex.org/W2014739284","https://openalex.org/W2014954416","https://openalex.org/W2015284016","https://openalex.org/W2026884441","https://openalex.org/W2030339637","https://openalex.org/W2033753222","https://openalex.org/W2042750069","https://openalex.org/W2047362768","https://openalex.org/W2049562411","https://openalex.org/W2050332600","https://openalex.org/W2052487210","https://openalex.org/W2058004680","https://openalex.org/W2062219923","https://openalex.org/W2068108407","https://openalex.org/W2068429410","https://openalex.org/W2069104846","https://openalex.org/W2070196854","https://openalex.org/W2072670533","https://openalex.org/W2076100820","https://openalex.org/W2081052078","https://openalex.org/W2081236497","https://openalex.org/W2086078092","https://openalex.org/W2097588661","https://openalex.org/W2103643300","https://openalex.org/W2104610341","https://openalex.org/W2107854932","https://openalex.org/W2108024676","https://openalex.org/W2112894886","https://openalex.org/W2115280144","https://openalex.org/W2115590702","https://openalex.org/W2118842534","https://openalex.org/W2120827689","https://openalex.org/W2121629705","https://openalex.org/W2131349854","https://openalex.org/W2132093971","https://openalex.org/W2134975242","https://openalex.org/W2135613885","https://openalex.org/W2135763351","https://openalex.org/W2136598700","https://openalex.org/W2138561620","https://openalex.org/W2142583406","https://openalex.org/W2148652246","https://openalex.org/W2149450389","https://openalex.org/W2150037286","https://openalex.org/W2151383898","https://openalex.org/W2155131748","https://openalex.org/W2155285019","https://openalex.org/W2155874171","https://openalex.org/W2157726708","https://openalex.org/W2159864284","https://openalex.org/W2163145740","https://openalex.org/W2163655902","https://openalex.org/W2168992353","https://openalex.org/W2170081060","https://openalex.org/W2416046640","https://openalex.org/W2419679229"],"related_works":["https://openalex.org/W2119591380","https://openalex.org/W2575562298","https://openalex.org/W131577330","https://openalex.org/W7101138900","https://openalex.org/W2512599453","https://openalex.org/W4224956347","https://openalex.org/W603958691","https://openalex.org/W2017077598","https://openalex.org/W2132286418","https://openalex.org/W2082644193"],"abstract_inverted_index":{"Chronic":[0],"kidney":[1,106],"disease":[2],"(CKD)":[3],"decreases":[4],"quality":[5],"of":[6,21,30,42,52,60,94,108,139,146,157,169,198,204,209,248,279,288,292,299,305,346],"life,":[7],"increases":[8],"mortality,":[9],"and":[10,32,39,44,77,114,132,149,180,206,225,233,235,282,337],"has":[11],"limited":[12],"treatment":[13],"options.":[14],"Glomerular":[15],"injury":[16,245],"is":[17,26,33,142,152],"an":[18],"early":[19,112],"stage":[20],"diabetic":[22,189],"nephropathy":[23],"(DN),":[24],"which":[25,333],"a":[27,74,143,256,302,322],"leading":[28],"cause":[29],"CKD,":[31],"characterized":[34],"by":[35,58,339],"mesangial":[36,211],"cell":[37,227],"proliferation":[38,208],"hypertrophy,":[40],"loss":[41,168,195],"podocytes,":[43],"increased":[45,202,207],"extracellular":[46],"matrix":[47],"(ECM)":[48],"deposition.":[49],"Critical":[50],"aspects":[51],"these":[53],"cellular":[54],"events":[55],"are":[56,276],"mediated":[57],"activation":[59],"the":[61,86,92,116,267,285,297,331],"Transforming":[62],"Growth":[63],"Factor-beta":[64],"(TGF\u03b2)":[65],"signaling":[66,88,148,251],"cascade.":[67,89],"MicroRNAs":[68],"(miRNAs)":[69],"regulate":[70],"gene":[71],"expression":[72,101,117,128,265,311],"in":[73,85,96,102,129,160,171,176,187,266,327],"post-transcriptional":[75],"level":[76,151],"have":[78],"been":[79],"implicated":[80],"as":[81,231,301],"important":[82],"regulatory":[83],"elements":[84],"TGF\u03b2":[87,147,161,172],"To":[90,253],"determine":[91],"role":[93,324],"miRNAs":[95,281,336],"DN,":[97,320],"we":[98,262],"examined":[99,263],"miRNA":[100,310],"micro-dissected":[103],"glomeruli":[104,131],"from":[105],"biopsies":[107],"patients":[109],"with":[110,119,135,155,312],"clinically":[111],"DN":[113,260],"correlated":[115],"levels":[118],"clinical":[120,314],"manifestations.":[121],"We":[122,164,271],"determined":[123],"that":[124,167,216,241,275],"miR-21":[125,141,170,199,217,242,326],"exhibits":[126],"high":[127],"renal":[130,158],"significant":[133],"correlation":[134],"urine":[136],"albumin-to-creatinine-ratio":[137],"(ACR)":[138],"patients.":[140],"known":[144],"regulator":[145],"its":[150],"positively":[153],"associated":[154],"severity":[156],"phenotype":[159,184],"transgenic":[162,173],"mice.":[163,190],"further":[165,254],"found":[166],"mice":[174],"resulted":[175],"accelerated":[177],"podocyte":[178],"apoptosis":[179,203],"glomerulosclerosis.":[181],"A":[182],"similar":[183],"was":[185],"detected":[186],"streptozotocin-induced":[188],"In":[191,307],"cultured":[192],"glomerular":[193,244,269,328],"cells,":[194],"or":[196],"inhibition":[197],"led":[200,295],"to":[201,296,343],"podocytes":[205],"primary":[210],"cells.":[212],"Further":[213],"studies":[214],"showed":[215],"represses":[218],"multiple":[219,249],"pro-apoptotic":[220],"pathways,":[221],"including":[222,321],"TGF\u03b2/Smad7,":[223],"P53,":[224],"PDCD4,":[226],"cycle-related":[228],"genes":[229,274,291],"such":[230],"Cdk6":[232],"Cdc25a,":[234],"ECM-related":[236],"genes.":[237],"These":[238],"results":[239],"suggest":[240],"ameliorates":[243],"through":[246],"repression":[247,287],"injury-mediating":[250],"pathways.":[252],"elucidate":[255],"miRNA-mediated":[257],"network":[258],"mediating":[259],"progression,":[261],"mRNA":[264],"same":[268],"samples.":[270],"identified":[272,316],"ACR-associated":[273,280],"predicted":[277],"targets":[278],"experimentally":[283],"validated":[284],"sequence-dependent":[286,303],"candidate":[289],"target":[290,304,340],"miR-200a.":[293,306],"This":[294],"discovery":[298],"EXOC7":[300],"summary,":[308],"correlating":[309],"specific":[313],"outcomes":[315],"novel":[317],"mechanisms":[318],"regulating":[319],"protective":[323],"for":[325],"injury.":[329],"Furthermore,":[330],"approach,":[332],"links":[334],"disease-associated":[335],"mRNAs":[338],"prediction,":[341],"appears":[342],"facilitate":[344],"identification":[345],"context-relevant":[347],"miRNA-mRNA":[348],"interactions.":[349]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}