{"id":"https://openalex.org/W53846948","doi":null,"title":"Matrix metalloproteinases during wound healing - a double edged sword","display_name":"Matrix metalloproteinases during wound healing - a double edged sword","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W53846948","mag":"53846948"},"language":"en","primary_location":{"id":"pmh:oai:eprints.qut.edu.au:67682","doi":null,"is_oa":false,"landing_page_url":"http://www.woundsaustralia.com.au/journal/2104.php","pdf_url":null,"source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wound Practice and Research","raw_type":"Contribution to Journal"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020014937","display_name":"Joan R\u00f6hl","orcid":"https://orcid.org/0000-0002-6872-8730","observed_orcids":["https://orcid.org/0000-0002-6872-8730"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joan R\u00f6hl","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6872-8730","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088107781","display_name":"Rachael Zoe Murray","orcid":"https://orcid.org/0000-0002-4935-7794","observed_orcids":["https://orcid.org/0000-0002-4935-7794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachael Murray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2015,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.52576725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":96},"biblio":{"volume":"21","issue":"4","first_page":"174","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.37940001487731934,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":1.0},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9990000128746033},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9409999847412109},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9419999718666077},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.9309999942779541},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-inhibitors","display_name":"matrix metalloproteinase inhibitors","score":0.8849999904632568},{"id":"https://openalex.org/keywords/skin","display_name":"skin","score":0.4350000023841858},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.8876694440841675},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.8570040464401245},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.765087366104126},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5921781659126282},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5223996639251709},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4172619879245758},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35911479592323303},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2689644694328308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25383031368255615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22389832139015198},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17187154293060303},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1459728181362152},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.qut.edu.au:67682","doi":null,"is_oa":false,"landing_page_url":"http://www.woundsaustralia.com.au/journal/2104.php","pdf_url":null,"source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wound Practice and Research","raw_type":"Contribution to Journal"},{"id":"mag:53846948","doi":null,"is_oa":false,"landing_page_url":"https://eprints.qut.edu.au/67682/","pdf_url":null,"source":{"id":"https://openalex.org/S2764499933","display_name":"Wound Practice & Research: Journal of the Australian Wound Management Association","issn_l":"1323-2495","issn":["1323-2495"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Wound Practice & Research: Journal of the Australian Wound Management Association","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W13145964","https://openalex.org/W39152348","https://openalex.org/W163554593","https://openalex.org/W1523254950","https://openalex.org/W1573296762","https://openalex.org/W1587671936","https://openalex.org/W1588253900","https://openalex.org/W1591664409","https://openalex.org/W1605513408","https://openalex.org/W1933223805","https://openalex.org/W1943317391","https://openalex.org/W1973756962","https://openalex.org/W1975510222","https://openalex.org/W1982203715","https://openalex.org/W1985914174","https://openalex.org/W1991731944","https://openalex.org/W1992389670","https://openalex.org/W1994374818","https://openalex.org/W2000802362","https://openalex.org/W2003000654","https://openalex.org/W2003500892","https://openalex.org/W2007605838","https://openalex.org/W2009548691","https://openalex.org/W2012955922","https://openalex.org/W2013322971","https://openalex.org/W2024018914","https://openalex.org/W2038981906","https://openalex.org/W2045005706","https://openalex.org/W2051547677","https://openalex.org/W2066439050","https://openalex.org/W2071534864","https://openalex.org/W2072755205","https://openalex.org/W2076452290","https://openalex.org/W2077123765","https://openalex.org/W2089260591","https://openalex.org/W2089310344","https://openalex.org/W2106227402","https://openalex.org/W2107657054","https://openalex.org/W2111189753","https://openalex.org/W2119303645","https://openalex.org/W2120033284","https://openalex.org/W2121317746","https://openalex.org/W2130255071","https://openalex.org/W2135124706","https://openalex.org/W2142036444","https://openalex.org/W2145634832","https://openalex.org/W2155879201","https://openalex.org/W2156994528","https://openalex.org/W2158228532","https://openalex.org/W2417953927"],"related_works":["https://openalex.org/W7204764491","https://openalex.org/W2008956592","https://openalex.org/W2319917718","https://openalex.org/W4291677010","https://openalex.org/W2011569383","https://openalex.org/W2742501995","https://openalex.org/W4389282831","https://openalex.org/W1997830990","https://openalex.org/W1973756962","https://openalex.org/W2148923267"],"abstract_inverted_index":{"Free":[0],"to":[1,44,128,137,154],"read":[2],"The":[3],"extracellular":[4],"matrix":[5,37],"(ECM)":[6],"provides":[7],"a":[8,35,46,86],"framework":[9],"for":[10,107],"cells":[11],"and":[12,18,30,38,67,96,111,119,141],"gives":[13],"skin":[14],"its":[15,22],"tensile":[16],"strength":[17],"elasticity.":[19],"Loss":[20],"of":[21,27,33,41,57,64,71,121,132],"integrity":[23],"necessitates":[24],"the":[25,31,42,62,65,69,78,117],"clearing":[26],"damaged":[28],"components":[29],"deposition":[32],"firstly":[34],"provisional":[36],"later":[39],"remodelling":[40,98],"ECM":[43,66,97],"support":[45],"functionally":[47],"intact":[48],"tissue.":[49],"Matrix":[50],"metalloproteinases":[51],"(MMPs)":[52],"are":[53,150],"an":[54],"important":[55],"family":[56],"enzymes":[58],"that":[59],"function":[60,70],"in":[61,77,88,116],"breakdown":[63],"modulate":[68],"many":[72],"biologically":[73],"active":[74],"molecules":[75],"housed":[76],"ECM.":[79],"Through":[80],"their":[81],"enzymatic":[82],"actions":[83],"MMPs":[84],"play":[85],"role":[87],"fundamental":[89],"processes":[90],"such":[91],"as":[92],"immune":[93],"cell":[94],"infiltration":[95],"during":[99],"wound":[100,109,143,156],"repair.":[101],"Their":[102],"tight":[103],"control":[104],"is":[105],"necessary":[106],"timely":[108],"healing":[110,144,157],"excessive":[112],"MMP":[113,160],"activity":[114,126,140],"participates":[115],"development":[118],"persistence":[120],"chronic":[122],"wounds,":[123],"while":[124],"reduced":[125],"contributes":[127],"fibrosis.":[129],"A":[130],"number":[131],"inhibitors":[133],"have":[134],"been":[135],"designed":[136],"target":[138],"this":[139],"improve":[142,155],"with":[145],"limited":[146],"success.":[147],"Novel":[148],"strategies":[149],"currently":[151],"being":[152],"investigated":[153],"by":[158],"targeting":[159],"modulating":[161],"molecules.":[162]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
