{"id":"https://openalex.org/W53729142","doi":null,"title":"Tissue reaction to collagen-coated porous hydroxyapatite.","display_name":"Tissue reaction to collagen-coated porous hydroxyapatite.","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W53729142","mag":"53729142","pmid":"https://pubmed.ncbi.nlm.nih.gov/2060216"},"language":"en","primary_location":{"id":"pmid:2060216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2060216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical orthopaedics and related research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071001024","display_name":"T Iwano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Iwano","raw_affiliation_strings":["Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111814707","display_name":"H. Kurosawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kurosawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Murase","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Murase","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110327824","display_name":"Hiroyasu Takeuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Takeuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113929332","display_name":"Yuko Ohkubo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ohkubo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7833,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.68646602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"268","first_page":"243","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porous-hydroxyapatite","display_name":"porous hydroxyapatite","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bone-substitutes","display_name":"bone substitutes","score":0.8149999976158142},{"id":"https://openalex.org/keywords/foreign-body-reaction","display_name":"foreign body reaction","score":0.7409999966621399},{"id":"https://openalex.org/keywords/new-bone-formation","display_name":"new bone formation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/compressive-strength","display_name":"compressive strength","score":0.8309999704360962},{"id":"https://openalex.org/keywords/multinucleated-giant-cells","display_name":"multinucleated giant cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/femoral-condyle-implantation","display_name":"femoral condyle implantation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tissue-response","display_name":"tissue reaction","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C77076574","wikidata":"https://www.wikidata.org/wiki/Q2152526","display_name":"Giant cell","level":2,"score":0.689160168170929},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5941442847251892},{"id":"https://openalex.org/C2910895738","wikidata":"https://www.wikidata.org/wiki/Q12151385","display_name":"FEMORAL CONDYLE","level":3,"score":0.496326744556427},{"id":"https://openalex.org/C2779995113","wikidata":"https://www.wikidata.org/wiki/Q1455142","display_name":"Foreign body","level":2,"score":0.4842359721660614},{"id":"https://openalex.org/C96646087","wikidata":"https://www.wikidata.org/wiki/Q978198","display_name":"Condyle","level":2,"score":0.46423831582069397},{"id":"https://openalex.org/C108657112","wikidata":"https://www.wikidata.org/wiki/Q3332118","display_name":"Foreign-body giant cell","level":2,"score":0.43321582674980164},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.4292317032814026},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.38735896348953247},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26083511114120483},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15118619799613953},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.14858940243721008},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.14309704303741455},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.14164289832115173}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005549","descriptor_name":"Foreign-Body Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006882","descriptor_name":"Hydroxyapatites","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013718","descriptor_name":"Tensile Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2060216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2060216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical orthopaedics and related research","raw_type":"Comparative Study"},{"id":"mag:53729142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2060216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2067059603","https://openalex.org/W21260808","https://openalex.org/W2460686530","https://openalex.org/W2388830315","https://openalex.org/W2089441979","https://openalex.org/W2053605886","https://openalex.org/W2082722562","https://openalex.org/W2033228857","https://openalex.org/W2199781338","https://openalex.org/W2352440619"],"abstract_inverted_index":{"To":[0],"give":[1],"tenacity":[2],"to":[3,10,145,152,158],"high":[4],"porosity":[5],"(80%-90%)":[6],"hydroxyapatite":[7],"(HA)":[8],"and":[9,23,45,154,165,178,186],"make":[11],"a":[12,16],"stronger":[13,175],"bone":[14,43,80,143,192],"substitute,":[15],"collagen-coated":[17],"porous":[18],"HA":[19,54,99,130,162,177,185],"(C-HA)":[20],"was":[21,27,61,88,91,121],"prepared,":[22],"its":[24],"compressive":[25,57],"strength":[26,58],"examined.":[28],"By":[29],"implanting":[30],"C-HA":[31,60,83,136,172,187],"into":[32],"the":[33,39,72,77,82,95,98,101,115,126,129,138,147,155,159],"femoral":[34],"condyle":[35],"of":[36,53,59,76,104,141,149],"adult":[37],"rabbits,":[38],"capacity":[40,189],"for":[41,190],"new":[42,142,191],"formation":[44,193],"foreign-body":[46,195],"reactivity":[47],"were":[48],"quantitatively":[49],"compared":[50,157],"with":[51],"those":[52],"alone.":[55],"The":[56],"4.3":[62],"times":[63],"greater":[64],"than":[65,94,125,176],"HA.":[66],"At":[67],"four":[68],"weeks":[69,134],"after":[70,135],"implantation,":[71,137],"mean":[73,102],"areal":[74,139],"ratio":[75,140],"newly":[78],"formed":[79],"in":[81,85,97,114,118,128,161,188],"block":[84],"each":[86,119],"rabbit":[87,120],"9.9%,":[89],"which":[90],"somewhat":[92],"less":[93],"13.7%":[96],"block;":[100],"number":[103,148],"multinucleated":[105],"giant":[106],"cells":[107],"(MGC)":[108],"per":[109],"visual":[110],"field":[111],"at":[112],"x25":[113],"C-HA-implanted":[116],"specimens":[117],"14.4,":[122],"significantly":[123],"larger":[124],"6.1":[127],"specimens.":[131],"However,":[132],"12":[133],"increased":[144],"32.7%,":[146],"MGC":[150],"decreased":[151],"9.4,":[153],"differences":[156],"values":[160],"cases,":[163],"31.5%":[164],"6.8,":[166],"disappeared.":[167],"These":[168],"results":[169],"showed":[170],"that":[171,179],"is":[173,181],"mechanically":[174],"there":[180],"no":[182],"difference":[183],"between":[184],"or":[194],"reaction.":[196]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
