{"id":"https://openalex.org/W53675884","doi":"https://doi.org/10.3760/cma.j.issn.1003-9406.2013.03.019","title":"[Association of P53 gene polymorphisms with susceptibility to endometriosis].","display_name":"[Association of P53 gene polymorphisms with susceptibility to endometriosis].","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W53675884","doi":"https://doi.org/10.3760/cma.j.issn.1003-9406.2013.03.019","mag":"53675884","pmid":"https://pubmed.ncbi.nlm.nih.gov/23744327"},"language":"en","primary_location":{"id":"pmid:23744327","doi":"https://doi.org/10.3760/cma.j.issn.1003-9406.2013.03.019","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23744327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102000308","display_name":"Yuxin Huang","orcid":"https://orcid.org/0000-0003-3056-4168","observed_orcids":["https://orcid.org/0000-0003-3056-4168","https://orcid.org/0000-0001-9327-8914","https://orcid.org/0009-0005-3171-2945"]},"institutions":[{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxin Huang","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China","institution_ids":["https://openalex.org/I4210120929","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103134438","display_name":"Lili Zong","orcid":"https://orcid.org/0000-0002-4962-7643","observed_orcids":["https://orcid.org/0000-0002-4962-7643"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lili Zong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115590509","display_name":"Jianghai Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianghai Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102154335","display_name":"Yonggui Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yonggui Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034164509","display_name":"Zehuan Liu","orcid":"https://orcid.org/0000-0001-5080-1015","observed_orcids":["https://orcid.org/0000-0001-5080-1015"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zehuan Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048942536","display_name":"Ting Mao","orcid":"https://orcid.org/0000-0002-4979-2008","observed_orcids":["https://orcid.org/0000-0002-4979-2008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069567112","display_name":"Jun Zeng","orcid":"https://orcid.org/0000-0002-8185-7940","observed_orcids":["https://orcid.org/0000-0002-8185-7940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Zeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610080","display_name":"Yufeng Wang","orcid":"https://orcid.org/0000-0002-9959-4149","observed_orcids":["https://orcid.org/0000-0002-9959-4149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yufeng Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102913806","display_name":"Xin Zhao","orcid":"https://orcid.org/0000-0003-2025-289X","observed_orcids":["https://orcid.org/0000-0003-2025-289X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4146,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.81097722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"3","first_page":"335","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometriosis","display_name":"endometriosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tp53-gene","display_name":"TP53 gene","score":0.9150000214576721},{"id":"https://openalex.org/keywords/rs1042522","display_name":"rs1042522","score":0.8999999761581421},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9950000047683716},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/han-chinese-women","display_name":"Han Chinese women","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.8435315489768982},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7782855033874512},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7538851499557495},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6177195906639099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.534733772277832},{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.5269036293029785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5253124833106995},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46974021196365356},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.44633305072784424},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.42206352949142456},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34635624289512634},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3408060669898987},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32868197560310364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29898226261138916}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23744327","doi":"https://doi.org/10.3760/cma.j.issn.1003-9406.2013.03.019","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23744327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics","raw_type":"Journal Article"},{"id":"mag:53675884","doi":"https://doi.org/10.3760/cma.j.issn.1003-9406.2013.03.019","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23744327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2358154819","https://openalex.org/W2591824353","https://openalex.org/W2348076134","https://openalex.org/W2360977025","https://openalex.org/W2355028327","https://openalex.org/W1853889937","https://openalex.org/W3029259469","https://openalex.org/W2791073779","https://openalex.org/W2161808406","https://openalex.org/W2356468612"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,16,44,67,75,86,114,132,151,205],"association":[4,203],"of":[5,18,43,69,88,134,218,227],"a":[6,40,201],"single":[7],"nucleotide":[8],"polymorphism(SNP)":[9],"in":[10,21,66,131,212],"tumor":[11],"suppressor":[12],"gene":[13,46],"P53":[14,45],"with":[15,32,104,170,174,185],"risk":[17,87,99,115,152,165],"endometriosis":[19],"(EM)":[20],"Han":[22,213],"Chinese":[23,214],"women.":[24,215],"METHODS:":[25],"For":[26],"460":[27],"EM":[28,76,89,117,211,219],"patients,":[29],"113":[30],"patients":[31,77,142],"endometrial":[33,140,154,186],"carcinoma":[34,141,155,187,223],"and":[35,56,72,78,108,121,137,143,176,191,208],"530":[36],"matched":[37],"unrelated":[38],"controls,":[39],"rs1042522(C/G)":[41],"SNP":[42],"was":[47],"genotyped":[48],"by":[49,90,100,156,166],"polymerase":[50],"chain":[51],"reaction-single":[52],"strand":[53],"polymorphism":[54,207],"(PCR-SSP)":[55],"DNA":[57],"sequencing.":[58],"RESULTS:":[59],"A":[60],"significant":[61,202],"difference":[62],"has":[63,84,96,149,162,199],"been":[64],"detected":[65,130],"distribution":[68,133],"rs1042522":[70,135],"alleles":[71,136],"genotypes":[73,110,138,178],"between":[74,139,204],"controls":[79,144],"(P<":[80,145],"0.01).":[81,146],"Allele":[82,147],"G":[83,148],"increased":[85,113,150],"1.209":[91],"times,":[92,158],"while":[93,159],"allele":[94,160],"C":[95,161],"reduced":[97,163],"this":[98,164],"0.837":[101],"times.":[102,168],"Compared":[103,169],"GG":[105,171],"genotype,":[106],"GC":[107,175],"CC":[109,177],"have":[111],"both":[112],"for":[116],"(OR=2.073,":[118],"95%CI:":[119,123,189,193],"1.521-2.820,":[120],"OR=1.930,":[122],"1.363-2.733,":[124],"respectively).":[125,195],"Significant":[126],"differences":[127],"were":[128],"also":[129],"to":[153,182,210,222],"1.311":[157],"0.757":[167],"genotypes,":[172],"individuals":[173],"are":[179],"more":[180],"likely":[181],"be":[183],"affected":[184],"(OR=2.778,":[188],"1.585-4.870,":[190],"OR=2.864,":[192],"1.557-5.263,":[194],"CONCLUSION:":[196],"Our":[197],"study":[198],"suggested":[200],"rs1042522(G/C)":[206],"susceptibility":[209],"The":[216],"mechanism":[217],"is":[220],"similar":[221],"from":[224],"genetics":[225],"point":[226],"view.":[228]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}