{"id":"https://openalex.org/W53666519","doi":"https://doi.org/10.1007/978-1-59259-126-8_15","title":"Therapeutic Angiogenesis for the Treatment of Cardiovascular Disease","display_name":"Therapeutic Angiogenesis for the Treatment of Cardiovascular Disease","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W53666519","doi":"https://doi.org/10.1007/978-1-59259-126-8_15","mag":"53666519"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-126-8_15","doi":"https://doi.org/10.1007/978-1-59259-126-8_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-126-8_15","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New Angiotherapy","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2010916388","display_name":"The New Angiotherapy"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103487235","display_name":"Jeffrey M. Isner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey M. Isner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079342872","display_name":"Takayuki Asahara","orcid":"https://orcid.org/0000-0001-8272-2055","observed_orcids":["https://orcid.org/0000-0001-8272-2055","https://orcid.org/0000-0002-2354-9325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takayuki Asahara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02787647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"249","last_page":"277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-angiogenesis","display_name":"therapeutic angiogenesis","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8849999904632568},{"id":"https://openalex.org/keywords/ischemia","display_name":"ischemia","score":0.6039999723434448},{"id":"https://openalex.org/keywords/vasculogenesis","display_name":"vasculogenesis","score":0.6620000004768372},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8040000200271606},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pathological-angiogenesis","display_name":"pathological angiogenesis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.941417396068573},{"id":"https://openalex.org/C60781801","wikidata":"https://www.wikidata.org/wiki/Q1424593","display_name":"Vasculogenesis","level":4,"score":0.8244521617889404},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.791153073310852},{"id":"https://openalex.org/C2781188250","wikidata":"https://www.wikidata.org/wiki/Q4455440","display_name":"Therapeutic angiogenesis","level":4,"score":0.7170486450195312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5163992047309875},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.4943375587463379},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.46962690353393555},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43921196460723877},{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.4326152801513672},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35827478766441345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3560488522052765},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34773045778274536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2654542326927185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18413841724395752},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.175462007522583},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.13517320156097412},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.11857816576957703},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11565235257148743}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59259-126-8_15","doi":"https://doi.org/10.1007/978-1-59259-126-8_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-126-8_15","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New Angiotherapy","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":172,"referenced_works":["https://openalex.org/W8819763","https://openalex.org/W12613825","https://openalex.org/W20584199","https://openalex.org/W29925897","https://openalex.org/W32167704","https://openalex.org/W32701116","https://openalex.org/W59205775","https://openalex.org/W59328567","https://openalex.org/W59778569","https://openalex.org/W60847448","https://openalex.org/W68773001","https://openalex.org/W70271102","https://openalex.org/W88241752","https://openalex.org/W92307352","https://openalex.org/W105106768","https://openalex.org/W174631577","https://openalex.org/W274829841","https://openalex.org/W277929075","https://openalex.org/W284870166","https://openalex.org/W322859384","https://openalex.org/W582962088","https://openalex.org/W1489873347","https://openalex.org/W1495712810","https://openalex.org/W1496598319","https://openalex.org/W1503883962","https://openalex.org/W1536635467","https://openalex.org/W1537712767","https://openalex.org/W1587020653","https://openalex.org/W1624346216","https://openalex.org/W1721827275","https://openalex.org/W1740440689","https://openalex.org/W1807482481","https://openalex.org/W1810166418","https://openalex.org/W1826880678","https://openalex.org/W1838110840","https://openalex.org/W1893070603","https://openalex.org/W1917066306","https://openalex.org/W1936643702","https://openalex.org/W1947889127","https://openalex.org/W1957871175","https://openalex.org/W1963669837","https://openalex.org/W1965686689","https://openalex.org/W1966932577","https://openalex.org/W1969084423","https://openalex.org/W1970614272","https://openalex.org/W1975250411","https://openalex.org/W1977158361","https://openalex.org/W1977380140","https://openalex.org/W1978139448","https://openalex.org/W1981096586","https://openalex.org/W1982362333","https://openalex.org/W1982405831","https://openalex.org/W1982799013","https://openalex.org/W1983072511","https://openalex.org/W1983318028","https://openalex.org/W1983763042","https://openalex.org/W1986559037","https://openalex.org/W1990494380","https://openalex.org/W1991101091","https://openalex.org/W1993593600","https://openalex.org/W1994014733","https://openalex.org/W1996313200","https://openalex.org/W1996430165","https://openalex.org/W1999171451","https://openalex.org/W2000000541","https://openalex.org/W2001753204","https://openalex.org/W2003598961","https://openalex.org/W2008305464","https://openalex.org/W2010710364","https://openalex.org/W2011366314","https://openalex.org/W2012596140","https://openalex.org/W2013097801","https://openalex.org/W2014402245","https://openalex.org/W2015344488","https://openalex.org/W2016904444","https://openalex.org/W2019555687","https://openalex.org/W2021324624","https://openalex.org/W2025640298","https://openalex.org/W2026325139","https://openalex.org/W2028796640","https://openalex.org/W2029763523","https://openalex.org/W2029773366","https://openalex.org/W2030602309","https://openalex.org/W2031906832","https://openalex.org/W2034393061","https://openalex.org/W2034842897","https://openalex.org/W2038449972","https://openalex.org/W2039222035","https://openalex.org/W2039317622","https://openalex.org/W2039920167","https://openalex.org/W2040472471","https://openalex.org/W2043863730","https://openalex.org/W2045247659","https://openalex.org/W2046516822","https://openalex.org/W2047408781","https://openalex.org/W2049569341","https://openalex.org/W2049827480","https://openalex.org/W2049963602","https://openalex.org/W2053704719","https://openalex.org/W2054275704","https://openalex.org/W2054728198","https://openalex.org/W2055299311","https://openalex.org/W2055717387","https://openalex.org/W2056146626","https://openalex.org/W2056242981","https://openalex.org/W2056576549","https://openalex.org/W2058651524","https://openalex.org/W2061230824","https://openalex.org/W2061312392","https://openalex.org/W2061892936","https://openalex.org/W2066043796","https://openalex.org/W2066888615","https://openalex.org/W2066991122","https://openalex.org/W2067055348","https://openalex.org/W2069092801","https://openalex.org/W2070188380","https://openalex.org/W2071140757","https://openalex.org/W2075578776","https://openalex.org/W2076888919","https://openalex.org/W2080356707","https://openalex.org/W2081580391","https://openalex.org/W2082267164","https://openalex.org/W2083092621","https://openalex.org/W2083241474","https://openalex.org/W2084506573","https://openalex.org/W2084582669","https://openalex.org/W2084691868","https://openalex.org/W2085061661","https://openalex.org/W2086865079","https://openalex.org/W2089961321","https://openalex.org/W2092077170","https://openalex.org/W2092150075","https://openalex.org/W2092246905","https://openalex.org/W2093498435","https://openalex.org/W2101536802","https://openalex.org/W2108145145","https://openalex.org/W2112128801","https://openalex.org/W2113271100","https://openalex.org/W2114696647","https://openalex.org/W2122226633","https://openalex.org/W2123340693","https://openalex.org/W2123598120","https://openalex.org/W2126611738","https://openalex.org/W2131419480","https://openalex.org/W2133762215","https://openalex.org/W2134582008","https://openalex.org/W2135960037","https://openalex.org/W2138229905","https://openalex.org/W2141906543","https://openalex.org/W2142012532","https://openalex.org/W2142401146","https://openalex.org/W2144712422","https://openalex.org/W2144789700","https://openalex.org/W2145150521","https://openalex.org/W2150419292","https://openalex.org/W2155783433","https://openalex.org/W2158059999","https://openalex.org/W2162249561","https://openalex.org/W2164923772","https://openalex.org/W2168476587","https://openalex.org/W2172264076","https://openalex.org/W2324910780","https://openalex.org/W2341579207","https://openalex.org/W2397439757","https://openalex.org/W2401720357","https://openalex.org/W2405611595","https://openalex.org/W2411074463","https://openalex.org/W2412594790","https://openalex.org/W2412980596","https://openalex.org/W4245635197","https://openalex.org/W4249388929","https://openalex.org/W4386772731"],"related_works":["https://openalex.org/W154610216","https://openalex.org/W4248753785","https://openalex.org/W2395564026","https://openalex.org/W2053290954","https://openalex.org/W2906809551","https://openalex.org/W567009720","https://openalex.org/W1580244038","https://openalex.org/W21541059","https://openalex.org/W131807045","https://openalex.org/W2285358943"],"abstract_inverted_index":{"The":[0,80],"development":[1,20,63,132],"of":[2,21,40,46,64,82,112,129,142,153],"blood":[3,66],"vessels":[4,67],"may":[5,162,185],"be":[6,186],"considered":[7,157],"in":[8,29,43,74],"several":[9],"contexts.":[10],"Vasculogenesis":[11],"and":[12,55,173,182],"angiogenesis":[13,36,60,137],"are":[14,133,156],"the":[15,19,22,25,30,38,44,62,88,113,117,140,143,159,176,183,189],"processes":[16],"responsible":[17,90],"for":[18,91,120,158,164],"circulatory":[23],"system,":[24],"first":[26],"functional":[27],"unit":[28],"developing":[31],"embryo":[32],"(1)":[33],".":[34,58],"Pathologic":[35],"includes":[37],"role":[39],"post-natal":[41],"neovascularization":[42,155],"pathogenesis":[45],"arthritis,":[47],"diabetic":[48],"retinopathy,":[49],"and,":[50],"most":[51],"notably,":[52],"tumor":[53],"growth":[54,78],"metastasis":[56],"(2)":[57],"Therapeutic":[59],"involves":[61],"collateral":[65],"supplying":[68],"ischemic":[69],"tissues,":[70],"either":[71],"endogenously":[72],"or":[73],"response":[75],"to":[76,86,106],"administered":[77],"factors.":[79],"purpose":[81],"this":[83,108],"review":[84],"is":[85,138,180],"consider":[87],"mechanisms":[89],"therapeutic":[92],"angiogenesis,":[93,126],"which":[94,102,148],"develops":[95],"endogenously,":[96],"as":[97,99,122,124,188],"well":[98,123],"novel":[100],"strategies,":[101],"have":[103,149,163],"been":[104],"devised":[105],"augment":[107],"response.":[109],"Because":[110],"recapitulation":[111],"embryonic":[114,130],"paradigm":[115],"forms":[116],"conceptual":[118],"basis":[119],"therapeutic,":[121],"pathologic":[125,136,154],"selected":[127],"aspects":[128],"blood-vessel":[131],"included.":[134],"While":[135],"beyond":[139],"scope":[141],"current":[144],"paper,":[145],"certain":[146],"principles":[147],"emerged":[150],"from":[151],"studies":[152],"implications":[160],"they":[161],"cardiovascular":[165],"disease.":[166],"These":[167],"keywords":[168,184],"were":[169],"added":[170],"by":[171,175],"machine":[172],"not":[174],"authors.":[177],"This":[178],"process":[179],"experimental":[181],"updated":[187],"learning":[190],"algorithm":[191],"improves.":[192]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
