{"id":"https://openalex.org/W53499084","doi":null,"title":"Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus.","display_name":"Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus.","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W53499084","mag":"53499084","pmid":"https://pubmed.ncbi.nlm.nih.gov/8256853","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887270"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1887270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887270","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887270","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057689148","display_name":"Yoshiyuki Nakamura","orcid":"https://orcid.org/0000-0003-0166-2658","observed_orcids":["https://orcid.org/0000-0003-0166-2658"]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Nakamura","raw_affiliation_strings":["First Department of Internal Medicine, Nara Medical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Nara Medical University, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y Horii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Horii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023887089","display_name":"T Nishino","orcid":"https://orcid.org/0000-0002-6441-7572","observed_orcids":["https://orcid.org/0000-0002-6441-7572"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nishino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100877244","display_name":"Hideo Shiiki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Shiiki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111944727","display_name":"Yasuhiro Sakaguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Sakaguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100899770","display_name":"Tadashi Kagoshima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kagoshima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111838006","display_name":"Kazuhiro Dohi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Dohi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020525832","display_name":"Zenji Makita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Makita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021790851","display_name":"Helen Vlassara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Vlassara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020928977","display_name":"Richard Bucala","orcid":"https://orcid.org/0000-0001-5783-5736","observed_orcids":["https://orcid.org/0000-0001-5783-5736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Bucala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2522,"has_fulltext":false,"cited_by_count":285,"citation_normalized_percentile":{"value":0.98040962,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"143","issue":"6","first_page":"1649","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9890000224113464},{"id":"https://openalex.org/keywords/coronary-atheroma","display_name":"coronary atheroma","score":0.718999981880188},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7720000147819519},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/extracellular-matrix-proteins","display_name":"extracellular matrix proteins","score":0.6869999766349792},{"id":"https://openalex.org/keywords/vascular-wall","display_name":"vascular wall","score":0.46299999952316284},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.6790000200271606},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8980000019073486},{"id":"https://openalex.org/keywords/diabetic-vascular-complications","display_name":"diabetic vascular complications","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2779318932","wikidata":"https://www.wikidata.org/wiki/Q1058276","display_name":"Atheroma","level":2,"score":0.793707013130188},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7792600393295288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6645051836967468},{"id":"https://openalex.org/C2776997535","wikidata":"https://www.wikidata.org/wiki/Q2556837","display_name":"Advanced glycation end-product","level":4,"score":0.6356828212738037},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5745469927787781},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.5686308145523071},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4890457093715668},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48286038637161255},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.44131579995155334},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.4310452342033386},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3811667263507843},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37800002098083496},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34297823905944824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22301527857780457},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.16519290208816528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09443911910057068}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1887270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887270","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:8256853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8256853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Comparative Study"},{"id":"mag:53499084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8256853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1887270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887270","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8482084698","display_name":"AGING AND VASCULAR DISEASE: ROLE OF GLYCATION","funder_award_id":"R01AG009453","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W28432897","https://openalex.org/W96621201","https://openalex.org/W1483156553","https://openalex.org/W1561751955","https://openalex.org/W1609735481","https://openalex.org/W1637445535","https://openalex.org/W1762471665","https://openalex.org/W1857052429","https://openalex.org/W1970936597","https://openalex.org/W1976068063","https://openalex.org/W1984649628","https://openalex.org/W1992592000","https://openalex.org/W1998614770","https://openalex.org/W2012365138","https://openalex.org/W2026703782","https://openalex.org/W2032055976","https://openalex.org/W2032794311","https://openalex.org/W2040005689","https://openalex.org/W2059736408","https://openalex.org/W2060895623","https://openalex.org/W2061755142","https://openalex.org/W2067829426","https://openalex.org/W2073713671","https://openalex.org/W2088844252","https://openalex.org/W2103815847","https://openalex.org/W2128469136","https://openalex.org/W2155456675","https://openalex.org/W2158363331","https://openalex.org/W2321057355","https://openalex.org/W2324513730","https://openalex.org/W2438873404","https://openalex.org/W4213295061","https://openalex.org/W4254523290"],"related_works":["https://openalex.org/W655711621","https://openalex.org/W2416380578","https://openalex.org/W6979785228","https://openalex.org/W2285865115","https://openalex.org/W2108762011","https://openalex.org/W2033066650","https://openalex.org/W2888680705","https://openalex.org/W149477983","https://openalex.org/W178145706","https://openalex.org/W2056010931"],"abstract_inverted_index":{"Advanced":[0],"glycosylation":[1,103],"end":[2],"products":[3],"(AGEs)":[4],"accumulate":[5],"on":[6,92],"long-lived":[7],"extracellular":[8],"matrix":[9],"proteins":[10,29],"and":[11,18,37,62],"have":[12],"been":[13],"implicated":[14],"in":[15,50,77,104],"the":[16,25,39,73,87,99,105],"micro-":[17],"macrovascular":[19],"complications":[20],"of":[21,41,54,67,90,101],"diabetes":[22,111],"mellitus.":[23,112],"Within":[24],"arterial":[26],"wall,":[27],"AGE-modified":[28],"increase":[30],"vascular":[31,93],"permeability,":[32],"inactivate":[33],"nitric":[34],"oxide":[35],"activity,":[36],"induce":[38],"release":[40],"growth-promoting":[42],"cytokines.":[43],"Recently":[44],"developed":[45],"anti-AGE":[46],"antibodies":[47],"were":[48,70],"used":[49],"an":[51],"immunohistochemical":[52],"analysis":[53],"coronary":[55],"arteries":[56],"obtained":[57],"from":[58,79],"type":[59],"II":[60],"diabetic":[61],"nondiabetic":[63],"patients.":[64],"High":[65],"levels":[66],"AGE":[68],"reactivity":[69],"observed":[71],"within":[72],"atherosclerotic":[74],"plaque":[75],"present":[76],"vessels":[78],"selected":[80],"patients":[81],"with":[82,86,110],"diabetes.":[83],"Considered":[84],"together":[85],"pathological":[88],"effects":[89],"AGEs":[91],"wall":[94],"homeostasis,":[95],"these":[96],"data":[97],"support":[98],"role":[100],"advanced":[102],"rapidly":[106],"progressive":[107],"atherosclerosis":[108],"associated":[109]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}