{"id":"https://openalex.org/W53330591","doi":null,"title":"Multidisciplinary structured lifestyle intervention reduces the estimated risk of cardiovascular morbidity and mortality.","display_name":"Multidisciplinary structured lifestyle intervention reduces the estimated risk of cardiovascular morbidity and mortality.","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W53330591","mag":"53330591","pmid":"https://pubmed.ncbi.nlm.nih.gov/25696263","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2497152"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2497152","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2497152","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neth Heart J","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2497152","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056904303","display_name":"Ren\u00e9 L. H. Sprangers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L H Sprangers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113543629","display_name":"Frank Stam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Stam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082009757","display_name":"H.E.C. Smid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H E C Smid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016620300","display_name":"Coen D.A. Stehouwer","orcid":"https://orcid.org/0000-0001-8752-3223","observed_orcids":["https://orcid.org/0000-0001-8752-3223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C D A Stehouwer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046801242","display_name":"Irene M Hellemans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I M Hellemans","raw_affiliation_strings":["Nutrition and Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Health","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0067972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"10","first_page":"443","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.3765000104904175,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.3765000104904175,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14212","display_name":"Health Promotion and Cardiovascular Prevention","score":0.3765000104904175,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health","score":0.11720000207424164,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lifestyle-intervention","display_name":"lifestyle intervention","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cardiovascular-morbidity","display_name":"cardiovascular morbidity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.9980000257492065},{"id":"https://openalex.org/keywords/multidisciplinary-intervention","display_name":"multidisciplinary intervention","score":0.8090000152587891},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7739999890327454},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.9490000009536743},{"id":"https://openalex.org/keywords/physical-fitness","display_name":"physical fitness","score":0.8399999737739563},{"id":"https://openalex.org/keywords/vo2max","display_name":"VO2max","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.753000020980835},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.5889999866485596},{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9044259786605835},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7031102776527405},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6702219843864441},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5485292077064514},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.5348507165908813},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5042871236801147},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.47350767254829407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41031917929649353},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3774302005767822},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.08230391144752502},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2497152","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2497152","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neth Heart J","raw_type":"Text"},{"id":"pmid:25696263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25696263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.219.2160","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.219.2160","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.nhj.nl/cardiologie.nl/2/pagecontent/main_nhj/nhj_2004_10_443.pdf","raw_type":"text"},{"id":"pmh:vu:oai:research.vu.nl:publications/667e5d43-6c77-4fae-ac84-087ba742447c","doi":null,"is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/667e5d43-6c77-4fae-ac84-087ba742447c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Netherlands Heart Journal, 12, 443 - 449. Bohn Stafleu van Loghum","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:53330591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25696263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2497152","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2497152","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neth Heart J","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W66233099","https://openalex.org/W318730606","https://openalex.org/W1550111394","https://openalex.org/W1599595176","https://openalex.org/W1817200870","https://openalex.org/W1960623258","https://openalex.org/W1965567689","https://openalex.org/W1969982512","https://openalex.org/W1971474283","https://openalex.org/W1973624054","https://openalex.org/W1982080117","https://openalex.org/W2030042443","https://openalex.org/W2044274972","https://openalex.org/W2052176508","https://openalex.org/W2060204451","https://openalex.org/W2105604630","https://openalex.org/W2110061973","https://openalex.org/W2133500224","https://openalex.org/W2139634859","https://openalex.org/W2159990773","https://openalex.org/W2416785758","https://openalex.org/W4244168426"],"related_works":["https://openalex.org/W7099662066","https://openalex.org/W2779575286","https://openalex.org/W2142524048","https://openalex.org/W2805003071","https://openalex.org/W2140045485","https://openalex.org/W3174175329","https://openalex.org/W2030185544","https://openalex.org/W2030788622","https://openalex.org/W3091840617","https://openalex.org/W2414194650"],"abstract_inverted_index":{"BACKGROUND:":[0],"Current":[1],"guidelines":[2],"for":[3,28,164],"prevention":[4],"and":[5,47,55,74,93,104,128,132,137,148,167,198],"treatment":[6,45],"of":[7,14,33,36,52,60,78,90,108,121,145,158,201],"cardiovascular":[8,40,53,91,187,202],"disease":[9],"(CVD)":[10],"emphasise":[11],"the":[12,34,49,86,110,133],"importance":[13],"a":[15,26,61,76,106,119,156],"healthy":[16],"lifestyle.":[17],"However,":[18],"successful":[19],"lifestyle":[20,37,65,83,181],"intervention":[21,38,66,84,182],"is":[22,205],"proving":[23],"to":[24,207],"be":[25,214],"challenge":[27],"healthcare":[29],"professionals.":[30],"OBJECTIVES:":[31],"Evaluation":[32],"effect":[35,59],"on":[39,43,48,186],"risk":[41,51,89,97,112,188,191],"factors,":[42],"reaching":[44],"targets":[46],"estimated":[50,87],"morbidity":[54,92],"mortality.":[56,94],"METHODS:":[57],"The":[58,95],"six-month":[62],"multidisciplinary":[63],"structured":[64,82,180],"programme":[67],"was":[68,99,114,193],"assessed":[69],"in":[70,101,116,153,174,195],"186":[71],"patients":[72,102,117,154,196],"with":[73,103,118,155,197],"without":[75,105,199],"history":[77,107,120,157],"CVD.":[79,122,159],"RESULTS:":[80],"Multidisciplinary":[81,179],"reduced":[85],"ten-year":[88],"relative":[96],"reduction":[98,113,192],"similar":[100,194],"CVD,":[109],"absolute":[111],"higher":[115],"In":[123,160],"both":[124,175],"groups":[125],"blood":[126,165],"pressure":[127,166],"body":[129],"weight":[130],"decreased,":[131],"maximal":[134,138],"work":[135],"rate":[136],"oxygen":[139],"uptake":[140],"increased":[141],"significantly.":[142],"Blood":[143],"levels":[144,163],"total":[146],"cholesterol":[147],"cholesterol/HDL":[149],"ratio":[150],"decreased":[151],"significantly":[152],"addition,":[161],"target":[162],"physical":[168],"fitness":[169],"were":[170],"more":[171],"frequently":[172],"reached":[173],"patient":[176],"groups.":[177],"CONCLUSION:":[178],"had":[183],"beneficial":[184],"effects":[185,212],"factors.":[189],"Relative":[190],"evidence":[200],"disease.":[203],"Follow-up":[204],"needed":[206],"see":[208],"how":[209],"well":[210],"these":[211],"can":[213],"maintained.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}