{"id":"https://openalex.org/W53275632","doi":null,"title":"The teleost taar family of olfactory receptors: From rapidly evolving receptor genes to ligand-induced behavior","display_name":"The teleost taar family of olfactory receptors: From rapidly evolving receptor genes to ligand-induced behavior","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W53275632","mag":"53275632"},"language":"en","primary_location":{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:3265","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/3265/1/Ashiq_Hussain_Thesis_2010.pdf","pdf_url":"https://kups.ub.uni-koeln.de/3265/1/Ashiq_Hussain_Thesis_2010.pdf","source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042208983","display_name":"Ashiq Hussain","orcid":"https://orcid.org/0000-0002-5239-4641","observed_orcids":["https://orcid.org/0000-0002-5239-4641"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ashiq Hussain","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5239-4641","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042208983"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trace-amine-associated-receptors","display_name":"trace amine-associated receptors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/olfactory-receptors","display_name":"olfactory receptors","score":0.8790000081062317},{"id":"https://openalex.org/keywords/teleosts","display_name":"teleosts","score":0.8569999933242798},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8349999785423279},{"id":"https://openalex.org/keywords/taar1","display_name":"TAAR1","score":0.7429999709129333},{"id":"https://openalex.org/keywords/intron-gain","display_name":"intron gain","score":0.781000018119812},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.9800000190734863},{"id":"https://openalex.org/keywords/diamine-ligands","display_name":"diamine ligands","score":0.7760000228881836},{"id":"https://openalex.org/keywords/putrescine","display_name":"putrescine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cadaverine","display_name":"cadaverine","score":1.0},{"id":"https://openalex.org/keywords/olfactory-receptor-neurons","display_name":"olfactory sensory neurons","score":0.7459999918937683},{"id":"https://openalex.org/keywords/c-fos-expression","display_name":"Fos expression","score":0.7269999980926514},{"id":"https://openalex.org/keywords/olfactory-epithelium","display_name":"olfactory epithelium","score":0.6240000128746033},{"id":"https://openalex.org/keywords/lamprey","display_name":"lamprey","score":0.47999998927116394},{"id":"https://openalex.org/keywords/chondrichthyes","display_name":"Chondrichthyes","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.824798047542572},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6853539943695068},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5865175127983093},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.575222909450531},{"id":"https://openalex.org/C2780417240","wikidata":"https://www.wikidata.org/wiki/Q261485","display_name":"Lamprey","level":2,"score":0.556557297706604},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.5356450080871582},{"id":"https://openalex.org/C2779980732","wikidata":"https://www.wikidata.org/wiki/Q24774756","display_name":"Olfactory receptor","level":3,"score":0.46607705950737},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.4440156817436218},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.4144345223903656},{"id":"https://openalex.org/C2780187430","wikidata":"https://www.wikidata.org/wiki/Q3052544","display_name":"Olfactory epithelium","level":3,"score":0.41400226950645447},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.32354438304901123},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3203703463077545},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.14233699440956116},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:3265","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/3265/1/Ashiq_Hussain_Thesis_2010.pdf","pdf_url":"https://kups.ub.uni-koeln.de/3265/1/Ashiq_Hussain_Thesis_2010.pdf","source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},{"id":"mag:53275632","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/3265/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":156,"referenced_works":["https://openalex.org/W19237578","https://openalex.org/W127222816","https://openalex.org/W174804078","https://openalex.org/W1494442509","https://openalex.org/W1528612804","https://openalex.org/W1532139541","https://openalex.org/W1543159687","https://openalex.org/W1590728260","https://openalex.org/W1592275382","https://openalex.org/W1628580856","https://openalex.org/W1638185552","https://openalex.org/W1908833672","https://openalex.org/W1967865492","https://openalex.org/W1968006659","https://openalex.org/W1968309063","https://openalex.org/W1968835030","https://openalex.org/W1970256374","https://openalex.org/W1970326829","https://openalex.org/W1970842110","https://openalex.org/W1972132824","https://openalex.org/W1972673599","https://openalex.org/W1974326501","https://openalex.org/W1978331009","https://openalex.org/W1982657303","https://openalex.org/W1983500946","https://openalex.org/W1991113624","https://openalex.org/W1991376061","https://openalex.org/W1991578536","https://openalex.org/W1995844073","https://openalex.org/W1997858734","https://openalex.org/W1999620096","https://openalex.org/W2002854942","https://openalex.org/W2003391273","https://openalex.org/W2004251962","https://openalex.org/W2006210645","https://openalex.org/W2007272533","https://openalex.org/W2007952774","https://openalex.org/W2008376263","https://openalex.org/W2010895009","https://openalex.org/W2012056998","https://openalex.org/W2013083006","https://openalex.org/W2013114654","https://openalex.org/W2013540201","https://openalex.org/W2013978625","https://openalex.org/W2014012238","https://openalex.org/W2017458710","https://openalex.org/W2018348038","https://openalex.org/W2020078066","https://openalex.org/W2020791858","https://openalex.org/W2021903377","https://openalex.org/W2022713347","https://openalex.org/W2023527603","https://openalex.org/W2023631751","https://openalex.org/W2024504055","https://openalex.org/W2026662988","https://openalex.org/W2034911512","https://openalex.org/W2036068632","https://openalex.org/W2037515617","https://openalex.org/W2038316650","https://openalex.org/W2038680771","https://openalex.org/W2040119784","https://openalex.org/W2042176420","https://openalex.org/W2042475203","https://openalex.org/W2044708785","https://openalex.org/W2047445649","https://openalex.org/W2047458612","https://openalex.org/W2047563641","https://openalex.org/W2047651536","https://openalex.org/W2049176073","https://openalex.org/W2050766695","https://openalex.org/W2051154660","https://openalex.org/W2052820536","https://openalex.org/W2053467427","https://openalex.org/W2054895562","https://openalex.org/W2056529429","https://openalex.org/W2056992462","https://openalex.org/W2058286904","https://openalex.org/W2058351795","https://openalex.org/W2060063624","https://openalex.org/W2063337445","https://openalex.org/W2063825440","https://openalex.org/W2064605292","https://openalex.org/W2066179262","https://openalex.org/W2066923846","https://openalex.org/W2067353157","https://openalex.org/W2067860373","https://openalex.org/W2069186336","https://openalex.org/W2070907334","https://openalex.org/W2074769709","https://openalex.org/W2075198018","https://openalex.org/W2075422189","https://openalex.org/W2075935823","https://openalex.org/W2082137952","https://openalex.org/W2082908197","https://openalex.org/W2083106723","https://openalex.org/W2086033868","https://openalex.org/W2087981739","https://openalex.org/W2090401135","https://openalex.org/W2092254747","https://openalex.org/W2092797581","https://openalex.org/W2094897592","https://openalex.org/W2094992682","https://openalex.org/W2096090167","https://openalex.org/W2096591863","https://openalex.org/W2097186487","https://openalex.org/W2098417231","https://openalex.org/W2104093308","https://openalex.org/W2104912633","https://openalex.org/W2105585336","https://openalex.org/W2109258478","https://openalex.org/W2109840317","https://openalex.org/W2111553530","https://openalex.org/W2115031948","https://openalex.org/W2116439093","https://openalex.org/W2118115132","https://openalex.org/W2118660857","https://openalex.org/W2120729067","https://openalex.org/W2121986992","https://openalex.org/W2122315165","https://openalex.org/W2124490975","https://openalex.org/W2129147686","https://openalex.org/W2129588834","https://openalex.org/W2129605594","https://openalex.org/W2131544728","https://openalex.org/W2133831748","https://openalex.org/W2134468750","https://openalex.org/W2135119536","https://openalex.org/W2135652771","https://openalex.org/W2138777912","https://openalex.org/W2139034316","https://openalex.org/W2139301588","https://openalex.org/W2141885448","https://openalex.org/W2144368480","https://openalex.org/W2146172141","https://openalex.org/W2146264423","https://openalex.org/W2147881169","https://openalex.org/W2150448038","https://openalex.org/W2154999279","https://openalex.org/W2156179741","https://openalex.org/W2156272197","https://openalex.org/W2157480322","https://openalex.org/W2158223356","https://openalex.org/W2159898375","https://openalex.org/W2161659751","https://openalex.org/W2162422624","https://openalex.org/W2163237124","https://openalex.org/W2163629303","https://openalex.org/W2170816999","https://openalex.org/W2171295428","https://openalex.org/W2171434741","https://openalex.org/W2241482212","https://openalex.org/W2298923310","https://openalex.org/W4235679071","https://openalex.org/W4255893942","https://openalex.org/W4298251825","https://openalex.org/W7100317091"],"related_works":["https://openalex.org/W19237578","https://openalex.org/W2008136094","https://openalex.org/W3144971905","https://openalex.org/W2156272197","https://openalex.org/W2508129144","https://openalex.org/W2233727379","https://openalex.org/W2036946326","https://openalex.org/W2300548355","https://openalex.org/W4205235246","https://openalex.org/W2012875123"],"abstract_inverted_index":{"Trace":[0],"amine-associated":[1],"receptors":[2,12,264,289],"(TAARs)":[3],"have":[4,255,276],"recently":[5],"been":[6,24,257,277],"shown":[7],"to":[8,72,302,375,386],"function":[9,121,151],"as":[10,122,227,298,315,333,352],"olfactory":[11,54,116,123,138,150,250,263,274,288,330,339,443],"in":[13,26,61,112,136,178,191,338,370,447],"mammals.":[14],"In":[15,380],"this":[16,153],"current":[17],"study,":[18],"the":[19,41,49,101,137,143,168,172,183,201,246,282,303,306,376,381,415,426,448],"taar":[20,42,77,95,162,194,241,320],"gene":[21,252],"family":[22],"has":[23],"delineated":[25],"jawless,":[27],"cartilaginous,":[28],"and":[29,34,52,82,130,140,164,219,267,343,362,403],"bony":[30,83],"fish":[31,69,84],"(zero,":[32],"2,":[33],">100":[35],"genes,":[36],"respectively).":[37],"I":[38],"conclude":[39],"that":[40,349,433],"genes":[43,70,96,105,163,181,195,242],"are":[44,58,110,292,345],"evolutionary":[45,198],"much":[46],"younger":[47],"than":[48],"related":[50],"OR":[51],"ORA/V1R":[53],"receptor":[55,117,251,275],"families,":[56],"which":[57],"present":[59],"already":[60],"lamprey,":[62],"a":[63,88,147,260,271,279,319,326,353,429,435,441,445],"jawless":[64],"vertebrate.":[65],"The":[66,125,210,234,365,408],"2":[67,76,185],"cartilaginous":[68],"appear":[71],"be":[73],"ancestral":[74],"for":[75,259,295,318,406],"classes,":[78],"each":[79],"with":[80,425],"mammalian":[81],"(teleost)":[85],"representatives.":[86],"Unexpectedly,":[87],"whole":[89],"new":[90],"clade,":[91],"class":[92,192,231,238],"III,":[93],"of":[94,114,146,152,159,171,182,204,223,230,237,248,262,265,281,290,305,329,355,358,368,378,390,411,418,428,440,451],"originated":[97],"even":[98,387],"later,":[99],"within":[100],"teleost":[102,131,161,240,273],"lineage.":[103],"Taar":[104],"from":[106],"all":[107,160,179],"3":[108],"classes":[109],"expressed":[111,135],"subsets":[113],"zebrafish":[115,384],"neurons,":[118,332],"supporting":[119],"their":[120,371],"receptors.":[124],"highly":[126],"conserved":[127,177],"TAAR1":[128],"(shark,mammalian,":[129],"orthologs)":[132],"is":[133,165,373,423],"not":[134],"epithelium":[139],"may":[141],"constitute":[142],"sole":[144],"remnant":[145],"primordial,":[148],"non":[149],"family.":[154,253],"Class":[155],"III":[156,193,232,239],"comprises":[157],"three-fourths":[158],"characterized":[166],"by":[167,335],"complete":[169],"loss":[170],"aminergic":[173,307],"ligand-binding":[174],"motif,":[175],"stringently":[176],"25":[180],"other":[184],"classes.":[186],"Two":[187],"independent":[188],"intron":[189,205],"gains":[190,206],"represent":[196],"extraordinary":[197],"dynamics,":[199],"considering":[200],"virtual":[202],"absence":[203],"during":[207],"vertebrate":[208,449],"evolution.":[209],"dN/dS":[211],"analysis":[212],"suggests":[213],"both":[214],"minimal":[215],"global":[216],"negative":[217],"selection":[218,226],"an":[220],"unparalleled":[221],"degree":[222,377],"local":[224],"positive":[225],"another":[228,249],"hallmark":[229],"genes.":[233],"accelerated":[235],"evolution":[236],"conceivably":[243],"might":[244],"mark":[245],"birth":[247],"Ligands":[254],"only":[256,270],"identified":[258],"handful":[261],"mammals":[266],"insects,":[268],"while":[269,396],"single":[272,442],"deorphanized,":[278],"member":[280],"OlfC":[283],"family,":[284],"OlfCa.":[285],"Zebrafish":[286],"TAAR":[287],"classI":[291],"good":[293],"candidates":[294],"having":[296],"amines":[297],"possible":[299],"ligands,":[300],"due":[301],"presence":[304],"ligand":[308,409],"binding":[309],"motifs.":[310],"This":[311,421],"study":[312],"identifies":[313],"diamines":[314,324,369,391],"specific":[316],"ligands":[317],"receptor,":[321,444],"DrTAAR13c.":[322],"These":[323],"activate":[325],"sparse":[327],"subset":[328],"sensory":[331],"indicated":[334],"c-Fos":[336],"expression":[337],"epithelium.":[340],"Diamines,":[341],"putrescine":[342],"cadaverine,":[344],"foul-smelling":[346],"aliphatic":[347],"polycations":[348],"occur":[350],"naturally":[351],"result":[354],"bacterial":[356],"decarboxylation":[357],"amino":[359],"acids":[360],"lysine":[361],"arginine,":[363],"respectively.":[364],"15":[366],"concentration":[367,389],"environment":[372],"correlated":[374],"putrefication.":[379],"behavioral":[382,416],"assay,":[383],"exposed":[385],"low":[388],"show":[392],"dramatic,":[393],"quantifiable":[394],"aversion,":[395],"it":[397],"shows":[398],"attraction":[399],"towards":[400],"food":[401],"stimulus":[402],"no":[404],"response":[405],"water.":[407],"spectrum":[410],"TAAR13c":[412],"closely":[413],"parallels":[414],"effectiveness":[417],"these":[419],"diamines.":[420],"data":[422],"consistent":[424],"existence":[427],"defined":[430],"neuronal":[431],"microcircuit":[432],"elicits":[434],"characteristic":[436],"behavior":[437],"upon":[438],"activation":[439],"novum":[446],"sense":[450],"smell.":[452]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}