{"id":"https://openalex.org/W53255435","doi":null,"title":"Neuroendocrine differentiation of prostate cancer: a review.","display_name":"Neuroendocrine differentiation of prostate cancer: a review.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W53255435","mag":"53255435","pmid":"https://pubmed.ncbi.nlm.nih.gov/25606573","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4297323"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3266404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4297323","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4297323","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047701478","display_name":"Vamsi Parimi","orcid":"https://orcid.org/0000-0001-5193-387X","observed_orcids":["https://orcid.org/0000-0001-5193-387X"]},"institutions":[{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vamsi Parimi","raw_affiliation_strings":["Robert H Lurie Comprehensive Cancer Center Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert H Lurie Comprehensive Cancer Center Chicago, IL","institution_ids":["https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018375146","display_name":"Rajen Goyal","orcid":"https://orcid.org/0009-0005-3507-3319","observed_orcids":["https://orcid.org/0009-0005-3507-3319"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajen Goyal","raw_affiliation_strings":["Department of Pathology, Northwestern University Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Northwestern University Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057145723","display_name":"Kate Poropatich","orcid":"https://orcid.org/0000-0001-9031-2144","observed_orcids":["https://orcid.org/0000-0001-9031-2144"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate Poropatich","raw_affiliation_strings":["Department of Pathology, Northwestern University Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Northwestern University Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080276829","display_name":"Ximing J. Yang","orcid":"https://orcid.org/0000-0002-3370-6208","observed_orcids":["https://orcid.org/0000-0002-3370-6208"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ximing J Yang","raw_affiliation_strings":["Robert H Lurie Comprehensive Cancer Center Chicago, IL ; Department of Pathology, Northwestern University Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert H Lurie Comprehensive Cancer Center Chicago, IL ; Department of Pathology, Northwestern University Chicago, IL","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.4318,"has_fulltext":false,"cited_by_count":218,"citation_normalized_percentile":{"value":0.98645341,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"2","issue":"4","first_page":"273","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroendocrine-differentiation","display_name":"neuroendocrine differentiation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuroendocrine-carcinoma","display_name":"neuroendocrine carcinoma","score":0.7149999737739563},{"id":"https://openalex.org/keywords/prostate-adenocarcinoma","display_name":"prostate adenocarcinoma","score":0.8560000061988831},{"id":"https://openalex.org/keywords/small-cell-neuroendocrine-carcinoma","display_name":"small cell neuroendocrine carcinoma","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tumor-morphology","display_name":"tumor morphology","score":0.7990000247955322},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.6740000247955322},{"id":"https://openalex.org/keywords/clinical-management","display_name":"clinical management","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2780341458","wikidata":"https://www.wikidata.org/wiki/Q18391873","display_name":"Neuroendocrine differentiation","level":4,"score":0.8622252941131592},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7481981515884399},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.7063663005828857},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.6548165082931519},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5820853114128113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5222614407539368},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5137794613838196},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.5116653442382812},{"id":"https://openalex.org/C2777858994","wikidata":"https://www.wikidata.org/wiki/Q10599959","display_name":"Neuroendocrine cell","level":3,"score":0.4937537610530853},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47217100858688354},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40863507986068726},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3341931700706482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29149606823921204},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.11996737122535706},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:europepmc.org:3266404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4297323","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4297323","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4297323","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Urol","raw_type":"Text"},{"id":"pmid:25606573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25606573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical and experimental urology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3266404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4297323","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W32258014","https://openalex.org/W62062723","https://openalex.org/W267655585","https://openalex.org/W1576786159","https://openalex.org/W1605211533","https://openalex.org/W1861026401","https://openalex.org/W1965147203","https://openalex.org/W1965846839","https://openalex.org/W1966553997","https://openalex.org/W1970079291","https://openalex.org/W1971016259","https://openalex.org/W1975356306","https://openalex.org/W1976061123","https://openalex.org/W1976491226","https://openalex.org/W1979645421","https://openalex.org/W1983704893","https://openalex.org/W1985636605","https://openalex.org/W1987780384","https://openalex.org/W1989514276","https://openalex.org/W1995113386","https://openalex.org/W2002546470","https://openalex.org/W2003579486","https://openalex.org/W2004188200","https://openalex.org/W2006027491","https://openalex.org/W2007091955","https://openalex.org/W2007845017","https://openalex.org/W2007879490","https://openalex.org/W2012232831","https://openalex.org/W2016052374","https://openalex.org/W2017437369","https://openalex.org/W2017903463","https://openalex.org/W2018258622","https://openalex.org/W2020326980","https://openalex.org/W2024399360","https://openalex.org/W2031208489","https://openalex.org/W2032418160","https://openalex.org/W2037938317","https://openalex.org/W2038191752","https://openalex.org/W2039511031","https://openalex.org/W2041783025","https://openalex.org/W2042422560","https://openalex.org/W2044676804","https://openalex.org/W2052620947","https://openalex.org/W2053535373","https://openalex.org/W2060203462","https://openalex.org/W2061908536","https://openalex.org/W2063262493","https://openalex.org/W2067158051","https://openalex.org/W2070410172","https://openalex.org/W2074402689","https://openalex.org/W2077179016","https://openalex.org/W2082121020","https://openalex.org/W2085574028","https://openalex.org/W2088584253","https://openalex.org/W2088801302","https://openalex.org/W2092657822","https://openalex.org/W2100737164","https://openalex.org/W2110848383","https://openalex.org/W2114693836","https://openalex.org/W2120128108","https://openalex.org/W2121863482","https://openalex.org/W2121953515","https://openalex.org/W2126812800","https://openalex.org/W2130955565","https://openalex.org/W2136711352","https://openalex.org/W2137084548","https://openalex.org/W2139481962","https://openalex.org/W2145525520","https://openalex.org/W2147839245","https://openalex.org/W2150467310","https://openalex.org/W2158043714","https://openalex.org/W2162025519","https://openalex.org/W2167121080","https://openalex.org/W2171863181","https://openalex.org/W2181126866","https://openalex.org/W2186612937","https://openalex.org/W2286427420","https://openalex.org/W2401249191","https://openalex.org/W2412372419","https://openalex.org/W2417780477","https://openalex.org/W2423393228","https://openalex.org/W2893360057"],"related_works":["https://openalex.org/W2416557554","https://openalex.org/W2282773638","https://openalex.org/W132838860","https://openalex.org/W3145718343","https://openalex.org/W2781702144","https://openalex.org/W2383811585","https://openalex.org/W1973468622","https://openalex.org/W2419100878","https://openalex.org/W2063116472","https://openalex.org/W2000903010"],"abstract_inverted_index":{"Neuroendocrine":[0,11],"cells":[1],"are":[2,100],"one":[3],"of":[4,30,43,53,62,93,146],"the":[5,9,31,57,90],"epithelial":[6],"populations":[7],"in":[8,17,45,56,68,136,153],"prostate.":[10],"differentiation":[12],"(NED)":[13],"has":[14],"been":[15],"observed":[16],"prostate":[18,154],"cancer.":[19],"In":[20,96],"addition":[21],"to":[22,80,126],"small":[23],"cell":[24,116],"neuroendocrine":[25,94,115],"carcinomas":[26],"and":[27,40,60,86,118,120,130,149],"carcinoid":[28],"tumors":[29],"prostate,":[32],"prostatic":[33,46],"adenocarcinomas":[34],"may":[35],"have":[36],"NED.":[37],"The":[38],"incidence":[39],"clinical":[41,69,121,158],"relevance":[42],"NED":[44,63,152],"adenocarcinoma":[47],"is":[48,64,73],"not":[49,65,133],"clearly":[50],"understood":[51],"because":[52],"conflicting":[54],"results":[55],"reported":[58],"studies,":[59],"evaluation":[61],"routinely":[66],"performed":[67],"practice.":[70,159],"This":[71],"review":[72,98],"an":[74,78],"overall":[75],"synthesis":[76],"with":[77],"aim":[79],"develop":[81],"a":[82,143],"more":[83],"comprehensive":[84],"understanding":[85,145],"practical":[87],"approach":[88],"towards":[89],"current":[91,128],"knowledge":[92],"differentiation.":[95],"this":[97,137,147],"we":[99],"stratifying":[101],"these":[102],"lesions":[103],"into":[104],"separate":[105],"subtypes":[106],"based":[107],"on":[108],"histologic":[109],"parameters":[110],"such":[111],"as":[112],"tumor":[113],"morphology,":[114],"density":[117],"distribution":[119],"parameters.":[122],"We":[123],"also":[124],"want":[125],"identify":[127],"controversies":[129],"confusing":[131],"issues":[132],"totally":[134],"resolved":[135],"topic":[138],"for":[139],"further":[140],"investigations.":[141],"Eventually":[142],"clearer":[144],"phenomenon":[148],"appropriate":[150],"handling":[151],"cancer":[155],"will":[156],"benefit":[157]},"counts_by_year":[{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":29},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-10T00:00:00"}
