{"id":"https://openalex.org/W5322158","doi":null,"title":"Integrins in cell adhesion and signaling.","display_name":"Integrins in cell adhesion and signaling.","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W5322158","mag":"5322158","pmid":"https://pubmed.ncbi.nlm.nih.gov/9183647"},"language":"en","primary_location":{"id":"pmid:9183647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9183647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human cell","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S K Akiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S K Akiyama","raw_affiliation_strings":["National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Akiyama@NIEHS.N1H.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Akiyama@NIEHS.N1H.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"],"apc_list":null,"apc_paid":null,"fwci":2.3086,"has_fulltext":false,"cited_by_count":217,"citation_normalized_percentile":{"value":0.87775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"3","first_page":"181","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9890000224113464},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8059999942779541},{"id":"https://openalex.org/keywords/integrin-alpha5beta1","display_name":"alpha5beta1 integrin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/rgd-motif","display_name":"RGD motif","score":0.9610000252723694},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pp125fak","display_name":"pp125FAK","score":0.7710000276565552},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/integrin-ligands","display_name":"integrin ligands","score":0.5170000195503235},{"id":"https://openalex.org/keywords/extracellular-matrix-assembly","display_name":"extracellular matrix assembly","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8605968356132507},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.8602606058120728},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6684978008270264},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.6455044746398926},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5530416369438171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4871227741241455},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.47039803862571716},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4578304886817932},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.4308062195777893},{"id":"https://openalex.org/C156585808","wikidata":"https://www.wikidata.org/wiki/Q18028043","display_name":"Integrin, beta 6","level":4,"score":0.4272354543209076},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3418377637863159},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32772189378738403},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2721208930015564},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25266197323799133}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9183647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9183647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human cell","raw_type":"Journal Article"},{"id":"mag:5322158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9183647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2023382907","https://openalex.org/W4241125123","https://openalex.org/W2008084933","https://openalex.org/W2062615007"],"related_works":["https://openalex.org/W2146502475","https://openalex.org/W1599110926","https://openalex.org/W2126582015","https://openalex.org/W2018876460","https://openalex.org/W7220766748","https://openalex.org/W2036691875","https://openalex.org/W1503632404","https://openalex.org/W1994330728","https://openalex.org/W1998765083","https://openalex.org/W2101244168"],"abstract_inverted_index":{"Cell":[0,28],"adhesive":[1,147,156,199,233,291],"interactions":[2,35],"play":[3],"important":[4,274,444],"roles":[5],"during":[6,20],"many":[7,101],"normal":[8],"physiological":[9,469],"processes":[10,455,470],"such":[11,25,123,141],"as":[12,26,129,142,324],"embryonic":[13],"development":[14,477],"and":[15,18,67,82,136,189,213,244,269,333,379,389,393,397,451,471],"wound":[16],"repair,":[17],"also":[19,273],"the":[21,33,50,106,113,154,204,207,211,220,230,256,263,266,278,289,297,319,351,373,441,452,457,473,476,483],"progression":[22],"of":[23,36,56,64,94,133,176,180,206,229,293,296,299,353,371,375,386,395,403,440,447,459,463,478,485],"diseases":[24],"cancer.":[27],"adhesion":[29,47,317,321,368,446],"is":[30,73,112,168,171,272,311,318],"mediated":[31],"by":[32,410],"specific":[34],"cell":[37,46,155,198,232,290,316,367],"surface":[38],"receptors":[39,48],"with":[40,76],"extracellular":[41,80,134],"glycoproteins.":[42],"The":[43,163,226,328,438],"best":[44,164],"characterized":[45,165],"are":[49,144,150,281,339,406],"integrins.":[51],"Integrins":[52],"comprise":[53],"a":[54,68,74,77,83,172,245,411],"family":[55],"more":[57],"than":[58,96],"23":[59],"noncovalent,":[60],"heterodimeric":[61],"complexes":[62],"consisting":[63,93],"an":[65,376,461],"alpha":[66,107,221,257],"beta":[69,109,223,259,329,331,334,354],"subunit.":[70],"Each":[71],"subunit":[72],"glycoprotein":[75,174],"large,":[78],"globular":[79],"domain":[81],"transmembrane":[84],"domain.":[85],"Most":[86],"integrins":[87,102],"have":[88],"relatively":[89],"small":[90],"cytoplasmic":[91,308,387],"domains":[92,338,357],"fewer":[95],"60":[97],"amino":[98,238],"acids.":[99],"Although":[100],"can":[103,349],"bind":[104],"fibronectin,":[105,143],"5,":[108],"1,":[110,330],"integrin":[111,121,166,336,355,416],"major":[114],"fibronectin":[115,127],"receptor":[116,417],"on":[117],"most":[118],"cells.":[119],"This":[120],"mediates":[122],"cellular":[124],"responses":[125,365],"to":[126,160,219,255,286,315,341,358,366,424],"substrates":[128],"adhesion,":[130],"migration,":[131,372],"assembly":[132,374],"matrix,":[135],"signal":[137,161,301,343,361,404],"transduction.":[138,162,362],"Integrin":[139],"ligands,":[140],"not":[145,284],"passive":[146],"molecules":[148],"but":[149,283],"active":[151],"participants":[152],"in":[153,210,251,313,360,422,467],"process":[157],"that":[158,310,413],"leads":[159],"ligand":[167,420,429],"fibronectin.":[169,294],"Fibronectin":[170,192],"multifunctional":[173],"comprised":[175],"three":[177],"different":[178,436],"types":[179],"homologous":[181],"repeating":[182],"units":[183],"(termed":[184],"type":[185,187,190,215],"I,":[186],"II,":[188],"III).":[191],"has":[193,456],"at":[194],"least":[195],"two":[196,236],"independent":[197],"regions:":[200],"one":[201],"located":[202],"near":[203],"center":[205],"polypeptide":[208],"chain":[209],"ninth":[212],"tenth":[214],"III":[216],"modules":[217],"binds":[218],"5":[222,258,335],"1":[224,260],"integrin.":[225,261],"biological":[227],"function":[228,250],"central":[231],"region":[234],"requires":[235,414],"critical":[237],"acid":[239],"sequences--an":[240],"Arg-Gly-Asp":[241],"(RGD)":[242],"sequence":[243],"Pro-His-Ser-Arg-Asn":[246],"(PHSRN)":[247],"sequence,":[248],"which":[249],"synergy--for":[252],"optimal":[253],"binding":[254],"Furthermore,":[262,346],"spacing":[264],"between":[265],"crucial":[267],"RGD":[268],"PHSRN":[270],"sequences":[271,279],"for":[275,288,435,445,475,482],"activity,":[276],"suggesting":[277],"themselves":[280],"necessary,":[282],"sufficient,":[285],"account":[287],"activity":[292,434],"One":[295,307],"manifestations":[298],"integrin-mediated":[300],"transduction":[302,344,405],"including":[303],"protein":[304,309],"tyrosine":[305,432],"phosphorylation.":[306],"phosphorylated":[312],"response":[314],"focal":[320,383],"kinase":[322,433],"known":[323],"pp125FAK":[325],"or":[326,426],"FAK.":[327],"3,":[332],"intracellular":[337,356,364],"sufficient":[340],"initiate":[342],"pathways.":[345],"alternative":[347],"splicing":[348],"regulate":[350],"ability":[352],"participate":[359],"Other":[363],"include":[369],"stimulation":[370],"F-actin":[377],"cytoskeleton":[378],"specialized":[380],"structures":[381],"called":[382],"contacts,":[384],"changes":[385],"pH":[388],"calcium":[390],"ion":[391],"concentration,":[392],"modulation":[394],"proliferation":[396],"gene":[398],"expression.":[399],"Such":[400],"varied":[401],"modes":[402],"probably":[407],"differentially":[408],"controlled":[409],"mechanism":[412],"either":[415],"clustering":[418,427],"alone,":[419],"occupancy":[421,430],"addition":[423],"clustering,":[425],"and/or":[428],"plus":[431],"responses.":[437],"examination":[439],"fundamental":[442],"mechanisms":[443,465],"cultured":[448],"human":[449,486],"cells":[450],"resultant":[453],"signaling":[454],"potential":[458],"providing":[460],"understanding":[462],"molecular":[464],"involved":[466],"complex":[468],"serving":[472],"basis":[474],"novel":[479],"therapeutic":[480],"agents":[481],"treatment":[484],"disease.":[487]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}