{"id":"https://openalex.org/W53186727","doi":"https://doi.org/10.4049/jimmunol.186.supp.105.43","title":"Suppression and enhancement of HIV replication in macrophages by CD8+ lymphocytes (105.43)","display_name":"Suppression and enhancement of HIV replication in macrophages by CD8+ lymphocytes (105.43)","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W53186727","doi":"https://doi.org/10.4049/jimmunol.186.supp.105.43","mag":"53186727"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.186.supp.105.43","doi":"https://doi.org/10.4049/jimmunol.186.supp.105.43","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.105.43","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109351623","display_name":"Daniel G. Kavanagh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Kavanagh","raw_affiliation_strings":["Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA","1Ragon Institute of MGH, MIT, and Harvard, Charlestown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]},{"raw_affiliation_string":"1Ragon Institute of MGH, MIT, and Harvard, Charlestown, MA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091407768","display_name":"Marta Rodr\u00edguez\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0003-3336-8285","observed_orcids":["https://orcid.org/0000-0003-3336-8285","https://orcid.org/0009-0008-6628-0371","https://orcid.org/0000-0003-4104-0589"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Rodriguez-Garcia","raw_affiliation_strings":["Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA","1Ragon Institute of MGH, MIT, and Harvard, Charlestown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]},{"raw_affiliation_string":"1Ragon Institute of MGH, MIT, and Harvard, Charlestown, MA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002600388","display_name":"Karen Levi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Levi","raw_affiliation_strings":["Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA","1Ragon Institute of MGH, MIT, and Harvard, Charlestown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]},{"raw_affiliation_string":"1Ragon Institute of MGH, MIT, and Harvard, Charlestown, MA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078444774","display_name":"DE Kaufmann","orcid":"https://orcid.org/0000-0003-4467-136X","observed_orcids":["https://orcid.org/0000-0003-4467-136X"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Kaufmann","raw_affiliation_strings":["Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA","1Ragon Institute of MGH, MIT, and Harvard, Charlestown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]},{"raw_affiliation_string":"1Ragon Institute of MGH, MIT, and Harvard, Charlestown, MA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"186","issue":"1_Supplement","first_page":"105.43","last_page":"105.43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-replication","display_name":"HIV replication","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cd56-nk-cells","display_name":"CD56+ NK cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.878000020980835},{"id":"https://openalex.org/keywords/elite-controllers","display_name":"elite controllers","score":0.9210000038146973},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.75},{"id":"https://openalex.org/keywords/viral-suppression","display_name":"viral suppression","score":0.5360000133514404},{"id":"https://openalex.org/keywords/cell-contact-dependent-suppression","display_name":"cell contact-dependent suppression","score":0.5090000033378601},{"id":"https://openalex.org/keywords/chronic-hiv-infection","display_name":"chronic HIV infection","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.697727382183075},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.692528247833252},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6574971675872803},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.6519060134887695},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6010891795158386},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.5373204350471497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5195212960243225},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.48149192333221436},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.44736456871032715},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43135586380958557},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4050685465335846},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3665948510169983},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3464950919151306},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.044638991355895996}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.186.supp.105.43","doi":"https://doi.org/10.4049/jimmunol.186.supp.105.43","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.105.43","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2140559774","https://openalex.org/W7095971359","https://openalex.org/W2238350270","https://openalex.org/W2050389823","https://openalex.org/W2052243661","https://openalex.org/W2003227439","https://openalex.org/W2027631059","https://openalex.org/W7064537574","https://openalex.org/W1601810440","https://openalex.org/W2046594902"],"abstract_inverted_index":{"Abstract":[0],"CD8+":[1,52,73,194],"cytolytic":[2],"T":[3,91,106,114,118,136,151,195],"cells":[4,92,107,119,137,152,181,196],"can":[5],"suppress":[6,59,125,155],"HIV":[7,60,80,98,159,163,176],"replication":[8,81,99],"by":[9,146],"a":[10,76,147],"variety":[11],"of":[12,22,43,51],"lytic":[13],"and":[14,17,68,138,190],"nonlytic":[15],"mechanisms,":[16],"the":[18,44],"relative":[19],"clinical":[20],"importance":[21],"particular":[23],"CTL":[24,208],"functions":[25],"is":[26],"not":[27,124,154],"fully":[28],"understood.":[29],"Therefore":[30],"studies":[31],"have":[32,182,197],"utilized":[33],"various":[34],"in":[35,82,100,131,186,201],"vitro":[36],"viral":[37,211],"suppression":[38,111,164],"assays":[39],"as":[40],"an":[41],"indication":[42],"antiviral":[45,49,184,199],"efficacy.":[46],"We":[47],"measured":[48],"activities":[50],"lymphocytes":[53,74],"from":[54,63,69,93,120,141],"elite":[55,104,142,188],"controllers":[56,143,189],"who":[57],"spontaneously":[58],"without":[61],"medication,":[62],"chronically":[64],"infected":[65],"HIV+":[66,94,202],"donors,":[67,192],"HIVneg":[70,87,121],"donors.":[71,88,203],"Bulk":[72],"containing":[75],"CD56+":[77],"fraction":[78],"suppressed":[79,97],"autologous":[83],"macrophages,":[84],"even":[85],"for":[86,174],"CD56-depleted":[89,116],"CD8":[90,117,135,150],"donors":[95,122],"also":[96],"macrophage":[101],"targets,":[102],"with":[103],"controller":[105],"exerting":[108],"significantly":[109],"greater":[110],"than":[112],"progressor":[113],"cells.":[115],"did":[123,153],"but":[126,156],"rather":[127,157],"enhanced":[128,158,175],"HIV-replication":[129],"specifically":[130],"macrophages.":[132],"Finally,":[133],"when":[134],"HIV-infected":[139],"macrophages":[140],"were":[144],"separated":[145],"transwell":[148],"membrane,":[149],"replication,":[160],"indicating":[161],"that":[162],"was":[165],"cell-contact":[166],"dependent":[167],"while":[168,193],"soluble":[169],"factors":[170],"may":[171,209],"be":[172],"responsible":[173],"replication.":[177,212],"In":[178,204],"summary":[179],"CD8+CD56+":[180],"innate":[183],"activity":[185,200],"both":[187],"uninfected":[191],"specific":[198],"some":[205],"cases":[206],"inflammatory":[207],"enhance":[210]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}