{"id":"https://openalex.org/W53148147","doi":"https://doi.org/10.1182/blood.v77.8.1787.1787","title":"Cytokine messenger RNA stability is enhanced in tumor cells","display_name":"Cytokine messenger RNA stability is enhanced in tumor cells","publication_year":1991,"publication_date":"1991-04-15","ids":{"openalex":"https://openalex.org/W53148147","doi":"https://doi.org/10.1182/blood.v77.8.1787.1787","mag":"53148147","pmid":"https://pubmed.ncbi.nlm.nih.gov/1849761"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v77.8.1787.1787","doi":"https://doi.org/10.1182/blood.v77.8.1787.1787","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v77.8.1787.1787","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113733979","display_name":"HJ Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HJ Ross","raw_affiliation_strings":["UCLA Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Department of Medicine","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042921448","display_name":"Naoki Sato","orcid":"https://orcid.org/0000-0001-6230-0410","observed_orcids":["https://orcid.org/0000-0001-6230-0410"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Sato","raw_affiliation_strings":["UCLA Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Department of Medicine","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108516004","display_name":"Yoshihito Ueyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Ueyama","raw_affiliation_strings":["UCLA Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Department of Medicine","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109114390","display_name":"HP Koeffler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HP Koeffler","raw_affiliation_strings":["UCLA Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Department of Medicine","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.78,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.84481808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"77","issue":"8","first_page":"1787","last_page":"1795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/au-rich-elements","display_name":"AU-rich elements","score":0.8100000023841858},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mrna-half-life","display_name":"mRNA half-life","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.8330000042915344},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.972000002861023},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9490000009536743},{"id":"https://openalex.org/keywords/lung-cancer-cells","display_name":"lung cancer cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.9449999928474426}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.7647947072982788},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6725581288337708},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6697522401809692},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6301225423812866},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6027119159698486},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5645449161529541},{"id":"https://openalex.org/C2779958370","wikidata":"https://www.wikidata.org/wiki/Q5711176","display_name":"Hematopoietic growth factor","level":4,"score":0.45505601167678833},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4281516671180725},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41950279474258423},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.4118771553039551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27726274728775024},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25496453046798706},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.22188371419906616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2165575623512268},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1385897994041443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v77.8.1787.1787","doi":"https://doi.org/10.1182/blood.v77.8.1787.1787","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v77.8.1787.1787","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v77.8.1787.bloodjournal7781787","doi":"https://doi.org/10.1182/blood.v77.8.1787.bloodjournal7781787","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v77.8.1787.bloodjournal7781787","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:1849761","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1849761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5331502463","display_name":"Signal Transduction in Oncogenesis","funder_award_id":"P01CA032737","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8251651957","display_name":"Pax5:Hematopoietic Transcription Factor Involved in ALL","funder_award_id":"R01CA026038","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8957295929","display_name":"Academic Training in Medical Oncology","funder_award_id":"T32CA009297","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W17708317","https://openalex.org/W28926443","https://openalex.org/W84204542","https://openalex.org/W340792320","https://openalex.org/W1524769916","https://openalex.org/W1547869235","https://openalex.org/W1578149674","https://openalex.org/W1588732487","https://openalex.org/W1589881672","https://openalex.org/W1669954301","https://openalex.org/W1863903014","https://openalex.org/W1893715971","https://openalex.org/W1900380445","https://openalex.org/W1909940207","https://openalex.org/W1963550266","https://openalex.org/W1965800476","https://openalex.org/W1966594068","https://openalex.org/W1969499012","https://openalex.org/W1972994253","https://openalex.org/W1973312385","https://openalex.org/W1976415203","https://openalex.org/W1977157092","https://openalex.org/W1998145026","https://openalex.org/W2004860726","https://openalex.org/W2009682070","https://openalex.org/W2014669590","https://openalex.org/W2015157953","https://openalex.org/W2015464447","https://openalex.org/W2017221814","https://openalex.org/W2025732397","https://openalex.org/W2027717448","https://openalex.org/W2034185792","https://openalex.org/W2036631709","https://openalex.org/W2046428819","https://openalex.org/W2048659444","https://openalex.org/W2049192006","https://openalex.org/W2058563741","https://openalex.org/W2066804997","https://openalex.org/W2068301222","https://openalex.org/W2068499309","https://openalex.org/W2069230850","https://openalex.org/W2071071925","https://openalex.org/W2072224250","https://openalex.org/W2080532845","https://openalex.org/W2081027426","https://openalex.org/W2095855940","https://openalex.org/W2120432042","https://openalex.org/W2144634347","https://openalex.org/W2290575488","https://openalex.org/W2409090309","https://openalex.org/W2463577369"],"related_works":["https://openalex.org/W2116410320","https://openalex.org/W2013358248","https://openalex.org/W338330417","https://openalex.org/W7217778564","https://openalex.org/W2025650658","https://openalex.org/W2051082511","https://openalex.org/W17708317","https://openalex.org/W2365681687","https://openalex.org/W2444223143","https://openalex.org/W1993968805"],"abstract_inverted_index":{"Hematopoietic":[0],"growth":[1,26],"factors":[2],"are":[3,155],"produced":[4],"by":[5,45],"a":[6,131],"number":[7],"of":[8,32,56,86,122,169,175],"human":[9,16,69],"tumors.":[10],"We":[11],"extracted":[12],"RNA":[13,43,52],"from":[14],"selected":[15],"tumor":[17,60,70,109,187],"cells":[18,47,61,96],"known":[19],"to":[20,48,76,127,140],"produce":[21,141],"at":[22],"least":[23],"one":[24],"hematopoietic":[25],"factor":[27,89],"and":[28,97],"found":[29],"high":[30],"levels":[31,103],"abnormally":[33],"stable":[34,157],"cytokine":[35,57,123,148,171],"messenger":[36],"(m)RNA.":[37],"Half-life":[38],"experiments":[39],"performed":[40],"after":[41],"preventing":[42],"synthesis":[44],"exposing":[46],"actinomycin":[49],"D":[50],"before":[51],"extraction":[53],"showed":[54],"stabilization":[55],"messages":[58],"in":[59,62,68,73,93,98,107,117,144,158,182,186],"liquid":[63],"culture":[64],"as":[65,67],"well":[66],"xenografts":[71],"grown":[72],"mice.":[74],"Exposure":[75],"the":[77,108,118,128,159,170,179],"phorbol":[78,80],"ester":[79],"12-myristate":[81],"13-acetate":[82],"(TPA)":[83],"caused":[84],"enhancement":[85],"granulocyte-macrophage":[87],"colony-stimulating":[88],"(GM-CSF)":[90],"message":[91],"level":[92],"lung":[94,145],"cancer":[95,146],"control":[99],"fibroblasts":[100],"but":[101],"elevated":[102],"persisted":[104],"far":[105],"longer":[106],"cells.":[110,188],"In":[111],"normal":[112],"cells,":[113,147],"an":[114],"AU-rich":[115,180],"sequence":[116],"3'":[119],"untranslated":[120],"region":[121,138,168,181],"mRNAs":[124],"confers":[125],"lability":[126],"message.":[129],"Although":[130],"beta-globin":[132],"gene":[133],"expression":[134],"vector":[135],"containing":[136],"this":[137,153],"appears":[139],"unstable":[142],"mRNA":[143,172,184],"mRNAs,":[149],"which":[150],"also":[151],"contain":[152],"sequence,":[154],"very":[156],"tumors":[160],"we":[161],"studied.":[162],"This":[163],"may":[164],"indicate":[165],"that":[166],"another":[167],"molecule":[173],"is":[174],"greater":[176],"importance":[177],"than":[178],"determining":[183],"stability":[185]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}