{"id":"https://openalex.org/W53101685","doi":"https://doi.org/10.1007/s00018-003-2283-9","title":"Molecular mechanisms underlying suppression of lymphocyte responses by nonsteroidal antiinflammatory drugs","display_name":"Molecular mechanisms underlying suppression of lymphocyte responses by nonsteroidal antiinflammatory drugs","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W53101685","doi":"https://doi.org/10.1007/s00018-003-2283-9","mag":"53101685","pmid":"https://pubmed.ncbi.nlm.nih.gov/12861376","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11138749"},"language":"en","primary_location":{"id":"doi:10.1007/s00018-003-2283-9","doi":"https://doi.org/10.1007/s00018-003-2283-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00018-003-2283-9","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11138749/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037274141","display_name":"Silvia Rossi Paccani","orcid":"https://orcid.org/0000-0003-0136-9814","observed_orcids":["https://orcid.org/0000-0003-0136-9814"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Rossi Paccani","raw_affiliation_strings":["Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy","Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena (Italy), Fax: + 39 0577 234476, e-mail: baldari@unisi.it , IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena (Italy), Fax: + 39 0577 234476, e-mail: baldari@unisi.it , IT","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000683696","display_name":"Marianna Boncristiano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Boncristiano","raw_affiliation_strings":["Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena (Italy), Fax: + 39 0577 234476, e-mail: baldari@unisi.it , IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena (Italy), Fax: + 39 0577 234476, e-mail: baldari@unisi.it , IT","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011115538","display_name":"Cosima T. Baldari","orcid":"https://orcid.org/0000-0002-4414-6744","observed_orcids":["https://orcid.org/0000-0002-4414-6744"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. T. Baldari","raw_affiliation_strings":["Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena (Italy), Fax: + 39 0577 234476, e-mail: baldari@unisi.it , IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena (Italy), Fax: + 39 0577 234476, e-mail: baldari@unisi.it , IT","institution_ids":["https://openalex.org/I102064193"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102064193"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.5788,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.66350711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"60","issue":"6","first_page":"1071","last_page":"1083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.4413999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.8560000061988831},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptors","display_name":"peroxisome proliferator-activated receptors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":1.0},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lymphocyte-differentiation","display_name":"lymphocyte differentiation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lymphocyte-death","display_name":"lymphocyte death","score":0.7910000085830688},{"id":"https://openalex.org/keywords/lymphopoiesis","display_name":"lymphocyte development","score":0.9279999732971191},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.8136017322540283},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.527273952960968},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5123711824417114},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4910242557525635},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.4800083041191101},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4643210768699646},{"id":"https://openalex.org/C2910266098","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator","level":4,"score":0.4464169442653656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4039066433906555},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3408917784690857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3278757333755493},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1761516034603119},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16202765703201294}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00018-003-2283-9","doi":"https://doi.org/10.1007/s00018-003-2283-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00018-003-2283-9","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},{"id":"pmid:12861376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12861376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular life sciences : CMLS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11138749","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11138749/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"},{"id":"pmh:oai:usiena-air.unisi.it:11365/9736","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/9736","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11138749","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11138749/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W2657348","https://openalex.org/W25523353","https://openalex.org/W220512923","https://openalex.org/W1483555207","https://openalex.org/W1492737899","https://openalex.org/W1497061219","https://openalex.org/W1500692723","https://openalex.org/W1509936284","https://openalex.org/W1511195742","https://openalex.org/W1514093767","https://openalex.org/W1519407136","https://openalex.org/W1521499119","https://openalex.org/W1523110208","https://openalex.org/W1539079080","https://openalex.org/W1539392991","https://openalex.org/W1541948797","https://openalex.org/W1543871478","https://openalex.org/W1545327957","https://openalex.org/W1553386677","https://openalex.org/W1563827978","https://openalex.org/W1565847282","https://openalex.org/W1604608864","https://openalex.org/W1633340712","https://openalex.org/W1638240093","https://openalex.org/W1639924204","https://openalex.org/W1647832452","https://openalex.org/W1812573520","https://openalex.org/W1929551191","https://openalex.org/W1933814880","https://openalex.org/W1964081876","https://openalex.org/W1964094843","https://openalex.org/W1972365005","https://openalex.org/W1973557663","https://openalex.org/W1975139732","https://openalex.org/W1977726195","https://openalex.org/W1978380407","https://openalex.org/W1979201752","https://openalex.org/W1979492370","https://openalex.org/W1979655911","https://openalex.org/W1983229673","https://openalex.org/W1985689886","https://openalex.org/W1985758880","https://openalex.org/W1989619519","https://openalex.org/W1993743334","https://openalex.org/W1996267589","https://openalex.org/W2001018199","https://openalex.org/W2003115027","https://openalex.org/W2007187686","https://openalex.org/W2007740082","https://openalex.org/W2010237936","https://openalex.org/W2013690042","https://openalex.org/W2015690196","https://openalex.org/W2016648062","https://openalex.org/W2019328429","https://openalex.org/W2019774786","https://openalex.org/W2020528926","https://openalex.org/W2021137024","https://openalex.org/W2022742442","https://openalex.org/W2027045857","https://openalex.org/W2028089693","https://openalex.org/W2038212034","https://openalex.org/W2040040765","https://openalex.org/W2040565048","https://openalex.org/W2045016464","https://openalex.org/W2046730497","https://openalex.org/W2047621809","https://openalex.org/W2047688010","https://openalex.org/W2048628834","https://openalex.org/W2055379081","https://openalex.org/W2061957087","https://openalex.org/W2064021511","https://openalex.org/W2064331238","https://openalex.org/W2070835301","https://openalex.org/W2072696221","https://openalex.org/W2074126807","https://openalex.org/W2077641423","https://openalex.org/W2081619402","https://openalex.org/W2086136332","https://openalex.org/W2086458197","https://openalex.org/W2089272736","https://openalex.org/W2095290224","https://openalex.org/W2101866378","https://openalex.org/W2108237688","https://openalex.org/W2111251212","https://openalex.org/W2118025940","https://openalex.org/W2119322738","https://openalex.org/W2120580301","https://openalex.org/W2120859709","https://openalex.org/W2125376440","https://openalex.org/W2125471714","https://openalex.org/W2125610493","https://openalex.org/W2126043069","https://openalex.org/W2126615361","https://openalex.org/W2126853519","https://openalex.org/W2131578906","https://openalex.org/W2133452360","https://openalex.org/W2133872620","https://openalex.org/W2135291237","https://openalex.org/W2136073072","https://openalex.org/W2140014359","https://openalex.org/W2144711633","https://openalex.org/W2150769903","https://openalex.org/W2157393124","https://openalex.org/W2158969881","https://openalex.org/W2160292264","https://openalex.org/W2162960865","https://openalex.org/W2166893697","https://openalex.org/W2167029659","https://openalex.org/W2170717609","https://openalex.org/W2331119035","https://openalex.org/W2402132592"],"related_works":["https://openalex.org/W2108237688","https://openalex.org/W2080239719","https://openalex.org/W2023744150","https://openalex.org/W1582598567","https://openalex.org/W2057293870","https://openalex.org/W7097473265","https://openalex.org/W1994140458","https://openalex.org/W2234163498","https://openalex.org/W2613174831","https://openalex.org/W35361814"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
