{"id":"https://openalex.org/W53062151","doi":null,"title":"Comparative analysis of cytokine induction in human vascular endothelial and smooth muscle cells.","display_name":"Comparative analysis of cytokine induction in human vascular endothelial and smooth muscle cells.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W53062151","mag":"53062151","pmid":"https://pubmed.ncbi.nlm.nih.gov/2789322"},"language":"en","primary_location":{"id":"pmid:2789322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2789322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lymphokine research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052933132","display_name":"Harald Loppnow","orcid":"https://orcid.org/0000-0003-0297-3327","observed_orcids":["https://orcid.org/0000-0003-0297-3327"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Loppnow","raw_affiliation_strings":["USDA Human Nutrition Research Center on Aging, Tufts University, Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA Human Nutrition Research Center on Aging, Tufts University, Medical Center, Boston, MA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043201732","display_name":"Peter Libby","orcid":"https://orcid.org/0000-0002-1502-502X","observed_orcids":["https://orcid.org/0000-0002-1502-502X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Libby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0498,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.74806229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"3","first_page":"293","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.17829999327659607,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9409999847412109},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lipid-a","display_name":"lipid A","score":0.9869999885559082},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytokine-induction","display_name":"cytokine induction","score":0.8949999809265137},{"id":"https://openalex.org/keywords/vascular-wall","display_name":"vascular wall","score":0.6510000228881836},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.49900001287460327},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6895561814308167},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6248425245285034},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5529426336288452},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.5067341923713684},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.49277999997138977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48963814973831177},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37371066212654114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3657263219356537},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3227683901786804},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3044777512550354}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2789322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2789322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lymphokine research","raw_type":"Comparative Study"},{"id":"mag:53062151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2789322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2074284980","https://openalex.org/W2074977347","https://openalex.org/W2405122015","https://openalex.org/W1966344271","https://openalex.org/W2409960786","https://openalex.org/W1494240315","https://openalex.org/W2410303618","https://openalex.org/W1501935155","https://openalex.org/W2114631256","https://openalex.org/W2114576105"],"abstract_inverted_index":{"Cells":[0],"of":[1,12,27,47,72,137,199,215],"the":[2,45,135,216],"blood":[3],"vessel":[4,202],"wall":[5,203],"are":[6],"both":[7,111],"targets":[8],"for":[9],"and":[10,29,38,49,113,124,130,168,180,189,192],"sources":[11],"certain":[13],"cytokines.":[14],"Various":[15],"stimuli":[16],"including":[17],"bacterial":[18],"lipopolysaccharides":[19],"(LPS)":[20],"or":[21,60,176,218],"Interleukin":[22],"1":[23],"(IL1)":[24],"induce":[25],"elaboration":[26,100],"immunoregulatory":[28],"inflammatory":[30,219],"mediators":[31],"by":[32,110,122],"human":[33],"vascular":[34],"endothelial":[35],"cells":[36,41,204],"(EC)":[37],"smooth":[39],"muscle":[40],"(SMC).":[42],"We":[43],"compared":[44,117],"capacity":[46,198],"EC":[48,90,112,123,141,147,179],"SMC":[50,66,125,161,181],"to":[51,58,80,85,96,128,153,174,195,205,212],"produce":[52],"interleukin":[53],"6":[54],"(IL6)":[55],"in":[56,83,126,169,186,193],"response":[57,84,127,194],"LPS":[59,97,175],"its":[61],"lipid":[62],"A":[63,105],"moiety.":[64],"Cultured":[65],"release":[67],"IL6":[68,76,99,108,120,164,187],"even":[69],"without":[70,165],"addition":[71],"stimuli,":[73],"this":[74,207],"basal":[75],"secretion":[77],"increased":[78,98],"2":[79],"4":[81],"fold":[82],"LPS.":[86,196],"In":[87],"contrast,":[88],"unstimulated":[89],"released":[91,148],"little":[92],"IL6,":[93,145,151],"but":[94],"exposure":[95,173],"approximately":[101],"10":[102],"fold.":[103],"Lipid":[104],"also":[106],"augmented":[107],"production":[109],"SMC.":[114],"Radioimmunoprecipitation":[115],"experiments":[116],"de":[118],"novo":[119],"synthesis":[121,188],"LPS,":[129],"yielded":[131],"results":[132],"consistent":[133],"with":[134],"studies":[136],"biological":[138],"activity.":[139],"Unstimulated":[140],"produced":[142],"no":[143],"precipitable":[144,163],"LPS-stimulated":[146],"newly":[149],"synthesized":[150],"although":[152],"a":[154],"lesser":[155],"extent":[156],"than":[157],"did":[158],"IL1-stimulated":[159],"cells.":[160],"secreted":[162],"added":[166],"stimulus":[167],"increasing":[170],"amounts":[171],"following":[172],"IL1.":[177],"Thus":[178],"exhibit":[182],"substantial":[183],"quantitative":[184],"differences":[185],"release,":[190],"basally":[191],"The":[197],"these":[200],"intrinsic":[201],"secrete":[206],"important":[208],"immunomodulator":[209],"might":[210],"contribute":[211],"local":[213],"regulation":[214],"immune":[217],"responses.":[220]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
