{"id":"https://openalex.org/W53016809","doi":null,"title":"2:16\u03b1-Hydroxyestrone Metabolite Ratio and Breast Cancer: A Combined Analysis","display_name":"2:16\u03b1-Hydroxyestrone Metabolite Ratio and Breast Cancer: A Combined Analysis","publication_year":2009,"publication_date":"2009-06-29","ids":{"openalex":"https://openalex.org/W53016809","mag":"53016809"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:6866","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/6866/1/DallalC_ETD2009.pdf","pdf_url":"https://d-scholarship.pitt.edu/6866/1/DallalC_ETD2009.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069551165","display_name":"Cher M. Dallal","orcid":"https://orcid.org/0000-0002-7946-3969","observed_orcids":["https://orcid.org/0000-0002-7946-3969"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cher M. Dallal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7946-3969","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5069551165"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00465333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-hydroxyestrone","display_name":"2-hydroxyestrone","score":0.9589999914169312},{"id":"https://openalex.org/keywords/16alpha-hydroxyestrone","display_name":"16\u03b1-hydroxyestrone","score":1.0},{"id":"https://openalex.org/keywords/urinary-estrogen-metabolites","display_name":"urinary estrogen metabolites","score":0.9049999713897705},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.8859999775886536},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.9440000057220459},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":1.0},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9539999961853027},{"id":"https://openalex.org/keywords/benign-breast-disease","display_name":"benign breast disease","score":0.9049999713897705},{"id":"https://openalex.org/keywords/age-at-menopause","display_name":"age at menopause","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7634668350219727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6792454123497009},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6201032400131226},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6177105903625488},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6161514520645142},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5982853770256042},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5015666484832764},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45879125595092773},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35102295875549316},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3403164744377136}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:6866","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/6866/1/DallalC_ETD2009.pdf","pdf_url":"https://d-scholarship.pitt.edu/6866/1/DallalC_ETD2009.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:53016809","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/6866/1/DallalC_ETD2009.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":175,"referenced_works":["https://openalex.org/W16253337","https://openalex.org/W126507251","https://openalex.org/W130625915","https://openalex.org/W1485062522","https://openalex.org/W1490695218","https://openalex.org/W1511930757","https://openalex.org/W1512059116","https://openalex.org/W1528009881","https://openalex.org/W1551632868","https://openalex.org/W1552027221","https://openalex.org/W1574620960","https://openalex.org/W1577465777","https://openalex.org/W1588517436","https://openalex.org/W1593442063","https://openalex.org/W1596841553","https://openalex.org/W1604979160","https://openalex.org/W1655441320","https://openalex.org/W1673057815","https://openalex.org/W1787370775","https://openalex.org/W1846302294","https://openalex.org/W1861209549","https://openalex.org/W1872161490","https://openalex.org/W1884538664","https://openalex.org/W1906526942","https://openalex.org/W1944331038","https://openalex.org/W1944571600","https://openalex.org/W1964172805","https://openalex.org/W1964435302","https://openalex.org/W1965734230","https://openalex.org/W1967607481","https://openalex.org/W1967711385","https://openalex.org/W1969748552","https://openalex.org/W1971032460","https://openalex.org/W1971545670","https://openalex.org/W1972395576","https://openalex.org/W1976996737","https://openalex.org/W1977660995","https://openalex.org/W1978281808","https://openalex.org/W1980357586","https://openalex.org/W1983038564","https://openalex.org/W1990862723","https://openalex.org/W1992262527","https://openalex.org/W1992405425","https://openalex.org/W1995388182","https://openalex.org/W1995954745","https://openalex.org/W1996591436","https://openalex.org/W1997154179","https://openalex.org/W1997366241","https://openalex.org/W1998285113","https://openalex.org/W1999315349","https://openalex.org/W2001649722","https://openalex.org/W2001732788","https://openalex.org/W2001878743","https://openalex.org/W2005874919","https://openalex.org/W2008147612","https://openalex.org/W2009370455","https://openalex.org/W2009557171","https://openalex.org/W2011489663","https://openalex.org/W2012247080","https://openalex.org/W2012712610","https://openalex.org/W2013142209","https://openalex.org/W2015357565","https://openalex.org/W2017712076","https://openalex.org/W2018278220","https://openalex.org/W2018943612","https://openalex.org/W2021181493","https://openalex.org/W2021631648","https://openalex.org/W2022566217","https://openalex.org/W2024859916","https://openalex.org/W2025896944","https://openalex.org/W2026802581","https://openalex.org/W2028078504","https://openalex.org/W2028325343","https://openalex.org/W2028691872","https://openalex.org/W2030059080","https://openalex.org/W2031205416","https://openalex.org/W2031505687","https://openalex.org/W2033459779","https://openalex.org/W2036146383","https://openalex.org/W2037757221","https://openalex.org/W2037889931","https://openalex.org/W2038543463","https://openalex.org/W2040017782","https://openalex.org/W2047687060","https://openalex.org/W2051271592","https://openalex.org/W2052528439","https://openalex.org/W2054339472","https://openalex.org/W2055824301","https://openalex.org/W2057768258","https://openalex.org/W2058484311","https://openalex.org/W2058878155","https://openalex.org/W2060439544","https://openalex.org/W2061138960","https://openalex.org/W2061410957","https://openalex.org/W2062615522","https://openalex.org/W2067815741","https://openalex.org/W2071782217","https://openalex.org/W2074248456","https://openalex.org/W2075873287","https://openalex.org/W2076956960","https://openalex.org/W2080230233","https://openalex.org/W2080333083","https://openalex.org/W2083375435","https://openalex.org/W2083606926","https://openalex.org/W2083675642","https://openalex.org/W2087497728","https://openalex.org/W2089480413","https://openalex.org/W2090560500","https://openalex.org/W2096963077","https://openalex.org/W2098395524","https://openalex.org/W2098723642","https://openalex.org/W2099566272","https://openalex.org/W2099644906","https://openalex.org/W2100420920","https://openalex.org/W2101649975","https://openalex.org/W2101879098","https://openalex.org/W2101921392","https://openalex.org/W2103369932","https://openalex.org/W2105073560","https://openalex.org/W2105186145","https://openalex.org/W2106787323","https://openalex.org/W2107410297","https://openalex.org/W2107932490","https://openalex.org/W2109063533","https://openalex.org/W2109616578","https://openalex.org/W2110114459","https://openalex.org/W2111829340","https://openalex.org/W2112025328","https://openalex.org/W2117899344","https://openalex.org/W2120800179","https://openalex.org/W2121198301","https://openalex.org/W2122908256","https://openalex.org/W2123004380","https://openalex.org/W2127929460","https://openalex.org/W2128493033","https://openalex.org/W2130343048","https://openalex.org/W2135771868","https://openalex.org/W2136358824","https://openalex.org/W2137641599","https://openalex.org/W2138597496","https://openalex.org/W2138864933","https://openalex.org/W2139372524","https://openalex.org/W2144361690","https://openalex.org/W2150589843","https://openalex.org/W2151684674","https://openalex.org/W2151921197","https://openalex.org/W2154860988","https://openalex.org/W2155066257","https://openalex.org/W2158551759","https://openalex.org/W2160408484","https://openalex.org/W2161888675","https://openalex.org/W2162387275","https://openalex.org/W2163151567","https://openalex.org/W2163339050","https://openalex.org/W2163691194","https://openalex.org/W2164116103","https://openalex.org/W2164961968","https://openalex.org/W2165386266","https://openalex.org/W2165664908","https://openalex.org/W2167910977","https://openalex.org/W2168298835","https://openalex.org/W2169670651","https://openalex.org/W2170362892","https://openalex.org/W2171697357","https://openalex.org/W2186264475","https://openalex.org/W2188748308","https://openalex.org/W2243393194","https://openalex.org/W2272676565","https://openalex.org/W2285443694","https://openalex.org/W2330411228","https://openalex.org/W2410866476","https://openalex.org/W2412734901","https://openalex.org/W2414835970","https://openalex.org/W2519064875","https://openalex.org/W3138780921"],"related_works":["https://openalex.org/W2075620858","https://openalex.org/W2027608391","https://openalex.org/W2118156630","https://openalex.org/W2059769560","https://openalex.org/W2138044238","https://openalex.org/W2058713179","https://openalex.org/W1983038564","https://openalex.org/W2122908256","https://openalex.org/W2163151567","https://openalex.org/W1971545670"],"abstract_inverted_index":{"Estrogen":[0],"metabolites":[1,50,101,114,199,258,292,316],"may":[2,318],"play":[3],"an":[4,253],"important":[5],"role":[6],"in":[7,12,275],"breast":[8,52,116,163,243,260,294,328,337],"carcinogenesis.":[9],"Animal":[10],"and":[11,23,51,56,73,96,99,112,115,123,220,239,259,284,297],"vitro":[13],"studies":[14,42,69,207],"suggest":[15,272],"differing":[16],"biological":[17],"effects":[18],"of":[19,32,37,67,133,157,197,204,241,290,301,314,327,336],"the":[20,30,45,59,75,85,90,106,109,201,205],"2-hydroxyestrone":[21],"(2-OHE1)":[22],"16\u03b1-hydroxyestrone":[24],"(16\u03b1-OHE1)":[25],"metabolites,":[26],"lending":[27],"support":[28,252],"to":[29,78,82,278,307,321],"use":[31],"2:16\u03b1-OHE1":[33,113,158,221],"as":[34,330,332],"a":[35,130,304],"measure":[36],"estrogen":[38,100,198,257,279,291,315],"balance.":[39],"Although":[40],"previous":[41],"have":[43,61],"evaluated":[44,105,194],"association":[46,107,254],"between":[47,92,108,233,255],"these":[48],"specific":[49],"cancer":[53,117,164,261,295,329,338],"among":[54,118,165,200,226,262,282,293,298],"pre-":[55,166,263,283],"postmenopausal":[57,124,168,227,285],"women,":[58,213],"results":[60,270],"been":[62],"inconclusive.":[63],"The":[64],"sample":[65],"size":[66],"individual":[68,134],"is":[70,303],"often":[71],"small":[72],"lacks":[74],"statistical":[76],"power":[77],"draw":[79],"conclusions":[80],"or":[81,167,264],"adequately":[83],"assess":[84],"relationships":[86],"within":[87],"subgroups.":[88],"Furthermore,":[89],"relationship":[91],"various":[93,195],"lifestyle":[94],"factors":[95,276],"personal":[97],"characteristics":[98],"remains":[102],"unclear.":[103],"We":[104],"2-OHE1,":[110],"16\u03b1-OHE1":[111],"premenopausal":[119,212],"(183":[120],"cases/548":[121],"controls)":[122,127],"(319":[125],"cases/647":[126],"women":[128,169,228,302,323],"using":[129],"combined":[131,248],"analysis":[132,249],"level":[135],"data":[136],"from":[137],"previously":[138],"published":[139],"research":[140],"studies.":[141],"In":[142,245],"separate":[143],"study":[144],"adjusted":[145,190],"conditional":[146],"logistic":[147],"regression":[148,188],"models":[149],"matched":[150],"on":[151],"5-year":[152],"age":[153,235],"groups,":[154],"higher":[155,325],"levels":[156,281],"were":[159],"not":[160,251],"associated":[161,217],"with":[162,218],"[Premenopausal:":[170],"OR\u22652.67":[171],"vs.":[172,180],"<1.76=0.81":[173],"(95%":[174,182],"CI:":[175,183],"0.49,":[176],"1.32);":[177],"Postmenopausal:":[178],"OR\u22652.46":[179],"<1.53=0.87":[181],"0.58,":[184],"1.29)].":[185],"Using":[186],"multivariable":[187],"analyses":[189],"for":[191],"study,":[192],"we":[193,317],"predictors":[196],"control":[202],"populations":[203,300],"participating":[206],"(544":[208],"premenopausal/720":[209],"postmenopausal).":[210],"Among":[211],"BMI":[214],"was":[215],"negatively":[216],"2-OHE1":[219],"(p":[222],"<":[223],"0.05).":[224],"Analyses":[225],"revealed":[229],"significant":[230,305],"associations":[231],"(p<0.05)":[232],"age,":[234],"at":[236,324],"menopausal":[237,266],"status,":[238],"history":[240],"benign":[242],"disease.":[244],"summary,":[246],"this":[247],"does":[250],"urinary":[256],"post":[265],"women.":[267,286],"However,":[268],"our":[269,288,312,334],"do":[271],"potential":[273],"differences":[274],"related":[277],"metabolite":[280],"Enhancing":[287],"knowledge":[289],"patients":[296],"healthy":[299],"contribution":[306],"public":[308],"health.":[309],"By":[310],"improving":[311],"understanding":[313,335],"be":[319],"able":[320],"identify":[322],"risk":[326],"well":[331],"increase":[333],"etiology.":[339]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}