{"id":"https://openalex.org/W52842453","doi":null,"title":"Redox regulation of protein serine/threonine phosphatase calcineurin","display_name":"Redox regulation of protein serine/threonine phosphatase calcineurin","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W52842453","mag":"52842453"},"language":"en","primary_location":{"id":"pmh:oai:kops.uni-konstanz.de:123456789/6972","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-8498","pdf_url":"http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-8498","source":{"id":"https://openalex.org/S4306401487","display_name":"KOPS (University of Konstanz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189712700","host_organization_name":"University of Konstanz","host_organization_lineage":["https://openalex.org/I189712700"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-8498","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058799680","display_name":"Dmitry Namgaladze","orcid":"https://orcid.org/0000-0002-8282-1819","observed_orcids":["https://orcid.org/0000-0002-8282-1819"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dmitry Namgaladze","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8282-1819","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058799680"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.1941000074148178,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.875},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9649999737739563},{"id":"https://openalex.org/keywords/serine-threonine-protein-phosphatase","display_name":"serine/threonine phosphatase","score":0.8500000238418579},{"id":"https://openalex.org/keywords/redox-regulation","display_name":"redox regulation","score":0.777999997138977},{"id":"https://openalex.org/keywords/cysteine-oxidation","display_name":"cysteine oxidation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/thioredoxin","display_name":"thioredoxin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8349999785423279},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.7170000076293945},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6579999923706055},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/nfat-signaling","display_name":"NFAT signaling","score":0.777999997138977},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9290000200271606},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.7333166599273682},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.640275239944458},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.6260567307472229},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5916352272033691},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4704899787902832},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.45601561665534973},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43475914001464844},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3668663501739502},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3573075532913208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3002752959728241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17493531107902527},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12637943029403687},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kops.uni-konstanz.de:123456789/6972","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-8498","pdf_url":"http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-8498","source":{"id":"https://openalex.org/S4306401487","display_name":"KOPS (University of Konstanz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189712700","host_organization_name":"University of Konstanz","host_organization_lineage":["https://openalex.org/I189712700"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:doctoralThesis"},{"id":"mag:52842453","doi":null,"is_oa":false,"landing_page_url":"https://kops.uni-konstanz.de/bitstream/123456789/6972/1/Doktorarbeit.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:kops.uni-konstanz.de:123456789/6972","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-8498","pdf_url":"http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-8498","source":{"id":"https://openalex.org/S4306401487","display_name":"KOPS (University of Konstanz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189712700","host_organization_name":"University of Konstanz","host_organization_lineage":["https://openalex.org/I189712700"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W52842453.pdf","grobid_xml":"https://content.openalex.org/works/W52842453.grobid-xml"},"referenced_works_count":322,"referenced_works":["https://openalex.org/W19446119","https://openalex.org/W21746843","https://openalex.org/W73347127","https://openalex.org/W97463538","https://openalex.org/W898435981","https://openalex.org/W1447295675","https://openalex.org/W1483820378","https://openalex.org/W1489389999","https://openalex.org/W1489427730","https://openalex.org/W1492276448","https://openalex.org/W1492951734","https://openalex.org/W1493538154","https://openalex.org/W1495675572","https://openalex.org/W1516318762","https://openalex.org/W1516614567","https://openalex.org/W1523213544","https://openalex.org/W1531042454","https://openalex.org/W1532903931","https://openalex.org/W1532965434","https://openalex.org/W1534572318","https://openalex.org/W1540707536","https://openalex.org/W1553328291","https://openalex.org/W1555938743","https://openalex.org/W1560664021","https://openalex.org/W1563626309","https://openalex.org/W1564969903","https://openalex.org/W1567627398","https://openalex.org/W1577039421","https://openalex.org/W1579434350","https://openalex.org/W1587918801","https://openalex.org/W1592223340","https://openalex.org/W1593567129","https://openalex.org/W1593876346","https://openalex.org/W1595102998","https://openalex.org/W1595702560","https://openalex.org/W1604499135","https://openalex.org/W1606727311","https://openalex.org/W1608357281","https://openalex.org/W1633206935","https://openalex.org/W1646353701","https://openalex.org/W1655806072","https://openalex.org/W1657298386","https://openalex.org/W1671239168","https://openalex.org/W1692875606","https://openalex.org/W1749352888","https://openalex.org/W1767331507","https://openalex.org/W1774442194","https://openalex.org/W1796802340","https://openalex.org/W1805515669","https://openalex.org/W1821918060","https://openalex.org/W1866700903","https://openalex.org/W1868656715","https://openalex.org/W1888736125","https://openalex.org/W1897747135","https://openalex.org/W1913741367","https://openalex.org/W1928541796","https://openalex.org/W1932728046","https://openalex.org/W1952918366","https://openalex.org/W1963859587","https://openalex.org/W1963942415","https://openalex.org/W1964603858","https://openalex.org/W1965727075","https://openalex.org/W1967801563","https://openalex.org/W1967943295","https://openalex.org/W1969173610","https://openalex.org/W1969421704","https://openalex.org/W1969789360","https://openalex.org/W1969805662","https://openalex.org/W1969873453","https://openalex.org/W1970638737","https://openalex.org/W1970842110","https://openalex.org/W1971072760","https://openalex.org/W1971073113","https://openalex.org/W1971196869","https://openalex.org/W1973599563","https://openalex.org/W1974337917","https://openalex.org/W1974868223","https://openalex.org/W1975107946","https://openalex.org/W1976057396","https://openalex.org/W1978559408","https://openalex.org/W1979169606","https://openalex.org/W1979415715","https://openalex.org/W1980655244","https://openalex.org/W1980805550","https://openalex.org/W1980830385","https://openalex.org/W1981593511","https://openalex.org/W1981704948","https://openalex.org/W1982323880","https://openalex.org/W1982869248","https://openalex.org/W1984754431","https://openalex.org/W1985339191","https://openalex.org/W1987684167","https://openalex.org/W1987954645","https://openalex.org/W1988277042","https://openalex.org/W1988304711","https://openalex.org/W1989013981","https://openalex.org/W1989141809","https://openalex.org/W1989572906","https://openalex.org/W1989873586","https://openalex.org/W1990261175","https://openalex.org/W1990829962","https://openalex.org/W1991210089","https://openalex.org/W1991437749","https://openalex.org/W1991532862","https://openalex.org/W1992263554","https://openalex.org/W1992967227","https://openalex.org/W1993772406","https://openalex.org/W1994015734","https://openalex.org/W1994687513","https://openalex.org/W1996771841","https://openalex.org/W1997270063","https://openalex.org/W1999090451","https://openalex.org/W1999165695","https://openalex.org/W2000959758","https://openalex.org/W2002357878","https://openalex.org/W2003756602","https://openalex.org/W2003807987","https://openalex.org/W2003867505","https://openalex.org/W2004159036","https://openalex.org/W2004720912","https://openalex.org/W2005145242","https://openalex.org/W2005857572","https://openalex.org/W2006128611","https://openalex.org/W2006459253","https://openalex.org/W2009373189","https://openalex.org/W2009776346","https://openalex.org/W2010605892","https://openalex.org/W2010624429","https://openalex.org/W2011552468","https://openalex.org/W2011855358","https://openalex.org/W2012281093","https://openalex.org/W2013056080","https://openalex.org/W2014316556","https://openalex.org/W2014691533","https://openalex.org/W2016298276","https://openalex.org/W2016854943","https://openalex.org/W2017066852","https://openalex.org/W2018704573","https://openalex.org/W2019122675","https://openalex.org/W2020386376","https://openalex.org/W2020562971","https://openalex.org/W2022595505","https://openalex.org/W2022876115","https://openalex.org/W2023671075","https://openalex.org/W2023842903","https://openalex.org/W2023944172","https://openalex.org/W2024195272","https://openalex.org/W2024469777","https://openalex.org/W2025684146","https://openalex.org/W2026289215","https://openalex.org/W2028137082","https://openalex.org/W2028211858","https://openalex.org/W2028640190","https://openalex.org/W2030387038","https://openalex.org/W2030661199","https://openalex.org/W2031900710","https://openalex.org/W2033651841","https://openalex.org/W2033897994","https://openalex.org/W2035336615","https://openalex.org/W2036814206","https://openalex.org/W2037553208","https://openalex.org/W2039392072","https://openalex.org/W2039626545","https://openalex.org/W2039842713","https://openalex.org/W2040056874","https://openalex.org/W2040668930","https://openalex.org/W2040687623","https://openalex.org/W2040773927","https://openalex.org/W2040877209","https://openalex.org/W2041054640","https://openalex.org/W2042033660","https://openalex.org/W2042521039","https://openalex.org/W2043095820","https://openalex.org/W2043100717","https://openalex.org/W2044406741","https://openalex.org/W2045630665","https://openalex.org/W2047106546","https://openalex.org/W2047275534","https://openalex.org/W2047298649","https://openalex.org/W2047503478","https://openalex.org/W2048085771","https://openalex.org/W2048399816","https://openalex.org/W2048544857","https://openalex.org/W2048836639","https://openalex.org/W2049134173","https://openalex.org/W2049668076","https://openalex.org/W2049894741","https://openalex.org/W2052955480","https://openalex.org/W2053010478","https://openalex.org/W2053132428","https://openalex.org/W2053408708","https://openalex.org/W2053633405","https://openalex.org/W2054564943","https://openalex.org/W2054599718","https://openalex.org/W2054678898","https://openalex.org/W2055183364","https://openalex.org/W2056728969","https://openalex.org/W2058013605","https://openalex.org/W2058127221","https://openalex.org/W2058949874","https://openalex.org/W2059107115","https://openalex.org/W2059195281","https://openalex.org/W2060917764","https://openalex.org/W2061851471","https://openalex.org/W2062378730","https://openalex.org/W2062408735","https://openalex.org/W2062469526","https://openalex.org/W2064292592","https://openalex.org/W2065842157","https://openalex.org/W2066570473","https://openalex.org/W2066972790","https://openalex.org/W2067540846","https://openalex.org/W2067601423","https://openalex.org/W2067859370","https://openalex.org/W2069430337","https://openalex.org/W2070145205","https://openalex.org/W2071155271","https://openalex.org/W2072493995","https://openalex.org/W2072678654","https://openalex.org/W2072866112","https://openalex.org/W2072978915","https://openalex.org/W2073464836","https://openalex.org/W2074503341","https://openalex.org/W2074593407","https://openalex.org/W2074607472","https://openalex.org/W2074687883","https://openalex.org/W2077816197","https://openalex.org/W2078850134","https://openalex.org/W2079004695","https://openalex.org/W2079159599","https://openalex.org/W2079311079","https://openalex.org/W2080095222","https://openalex.org/W2080169144","https://openalex.org/W2080334198","https://openalex.org/W2080565111","https://openalex.org/W2080970400","https://openalex.org/W2082502466","https://openalex.org/W2084639805","https://openalex.org/W2084974035","https://openalex.org/W2085664820","https://openalex.org/W2086141071","https://openalex.org/W2086885752","https://openalex.org/W2086961654","https://openalex.org/W2087224286","https://openalex.org/W2088264073","https://openalex.org/W2088632050","https://openalex.org/W2088729275","https://openalex.org/W2089605114","https://openalex.org/W2090930525","https://openalex.org/W2091049794","https://openalex.org/W2091170381","https://openalex.org/W2091466873","https://openalex.org/W2092109378","https://openalex.org/W2093906292","https://openalex.org/W2093948248","https://openalex.org/W2094655287","https://openalex.org/W2097283858","https://openalex.org/W2097899781","https://openalex.org/W2099819774","https://openalex.org/W2101537600","https://openalex.org/W2101745219","https://openalex.org/W2101957581","https://openalex.org/W2102256305","https://openalex.org/W2103339981","https://openalex.org/W2103450164","https://openalex.org/W2104987037","https://openalex.org/W2105634866","https://openalex.org/W2106969589","https://openalex.org/W2109453374","https://openalex.org/W2110076050","https://openalex.org/W2110396329","https://openalex.org/W2111478988","https://openalex.org/W2112796828","https://openalex.org/W2114129755","https://openalex.org/W2114443210","https://openalex.org/W2114872541","https://openalex.org/W2115293457","https://openalex.org/W2116024266","https://openalex.org/W2116025920","https://openalex.org/W2118870612","https://openalex.org/W2119811365","https://openalex.org/W2123099861","https://openalex.org/W2123523184","https://openalex.org/W2127609693","https://openalex.org/W2127993666","https://openalex.org/W2130734362","https://openalex.org/W2130874431","https://openalex.org/W2130900795","https://openalex.org/W2132723128","https://openalex.org/W2136546365","https://openalex.org/W2136734166","https://openalex.org/W2137334802","https://openalex.org/W2138281171","https://openalex.org/W2140707292","https://openalex.org/W2141273282","https://openalex.org/W2144179854","https://openalex.org/W2145303230","https://openalex.org/W2146555288","https://openalex.org/W2147022900","https://openalex.org/W2147704847","https://openalex.org/W2149863399","https://openalex.org/W2152358306","https://openalex.org/W2156433522","https://openalex.org/W2156504280","https://openalex.org/W2159410139","https://openalex.org/W2164503407","https://openalex.org/W2165539758","https://openalex.org/W2166364997","https://openalex.org/W2167335405","https://openalex.org/W2169714384","https://openalex.org/W2170136499","https://openalex.org/W2170457471","https://openalex.org/W2170532212","https://openalex.org/W2172196619","https://openalex.org/W2209831038","https://openalex.org/W2218341073","https://openalex.org/W2252988123","https://openalex.org/W2327006078","https://openalex.org/W2343603404","https://openalex.org/W2394484217","https://openalex.org/W2808792907","https://openalex.org/W4319308505"],"related_works":["https://openalex.org/W1492276448","https://openalex.org/W2080334198","https://openalex.org/W7135276074","https://openalex.org/W2020562971","https://openalex.org/W7005640974","https://openalex.org/W3184115419","https://openalex.org/W2405509096","https://openalex.org/W1554908071","https://openalex.org/W1991163286","https://openalex.org/W3002078105"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species":[2],"(ROS)":[3],"are":[4],"now":[5],"recognized":[6],"as":[7,174],"important":[8],"mediators":[9],"of":[10,24,76,98,113,124,167,177,180,206,224,233,238,262],"the":[11,25,47,170,175,188,199,207,221],"cellular":[12],"responses":[13],"to":[14,21,91,118,136,213],"environmental":[15],"changes.":[16],"Reversible":[17],"protein":[18,37,77],"phosphorylation":[19],"appears":[20],"be":[22,92,258],"one":[23],"major":[26],"intracellular":[27],"signal":[28],"transduction":[29],"mechanisms":[30,48],"modulated":[31,53],"by":[32,54,69,101,138,151,155,161],"ROS.":[33],"Calcineurin":[34],"is":[35,52],"a":[36,141],"serine/threonine":[38],"phosphatase":[39],"involved":[40,74],"in":[41,59,140,169,198,210,231,247],"calcium-dependent":[42],"signaling.":[43,264],"In":[44,79,242],"this":[45],"work":[46],"whereby":[49],"calcineurin":[50,95,99,114,128,132,148,158,193,234,251,256],"activity":[51,100,235],"ROS":[55,88,245],"were":[56,129],"investigated.":[57],"H2O2":[58],"submillimolar":[60],"concentrations":[61],"inhibited":[62],"calcineurin.":[63,110,181],"This":[64],"inhibition":[65,137,150,179,232],"was":[66,89,103,133,159],"partly":[67],"reversible":[68],"DTT":[70],"and":[71,73,81,143,163,184,203,216,236],"thioredoxin":[72],"oxidation":[75,121,166],"cysteines.":[78],"tissue":[80],"cell":[82],"homogenates":[83],"superoxide,":[84],"but":[85,153],"not":[86,154],"other":[87],"found":[90],"an":[93,259],"effective":[94],"inhibitor.":[96],"Inhibition":[97],"superoxide":[102,107,139,152,178],"calcium-dependent.":[104],"NO":[105,146],"antagonized":[106],"action":[108],"on":[109],"By":[111],"modification":[112],"isolation":[115],"procedure":[116],"aiming":[117],"avoid":[119],"enzyme":[120,171,200,208],"milligram":[122],"amounts":[123],"highly":[125],"active":[126,172,192,201],"porcine":[127],"isolated.":[130],"Porcine":[131],"very":[134],"sensitive":[135],"calcium":[142],"calmodulin-dependent":[144],"manner.":[145],"protected":[147],"against":[149],"H2O2.":[156],"Superoxide-inhibited":[157],"reactivated":[160],"ascorbate":[162],"Fe2+/ascorbate":[164],"suggesting":[165],"Fe2+":[168],"center":[173,197,215],"mechanism":[176],"Metal":[182],"analysis":[183],"EPR":[185],"spectroscopy":[186],"confirmed":[187],"hypothesis":[189],"that":[190,255],"native,":[191],"has":[194],"Fe2+-Zn2+":[195],"binuclear":[196],"site":[202],"oxidative":[204],"inactivation":[205],"results":[209],"its":[211],"conversion":[212],"Fe3+-Zn2+":[214],"partial":[217],"Fe":[218],"release":[219],"from":[220],"enzyme.":[222],"Treatment":[223],"Jurkat":[225],"T-lymphoma":[226],"cells":[227],"with":[228],"oxidants":[229],"resulted":[230],"blockade":[237],"calcineurin-NFAT":[239],"signaling":[240],"cascade.":[241],"addition,":[243],"endogenous":[244,260],"generation":[246],"activated":[248],"macrophages":[249],"caused":[250],"inhibition,":[252],"providing":[253],"evidence":[254],"could":[257],"effector":[261],"ROS-mediated":[263]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}