{"id":"https://openalex.org/W52810583","doi":"https://doi.org/10.1042/bj2790367","title":"Agonist-sensitive and -insensitive intracellular Ca2+ pools. Separate Ca2+-releasing mechanisms revealed by manoalide and benzohydroquinone","display_name":"Agonist-sensitive and -insensitive intracellular Ca2+ pools. Separate Ca2+-releasing mechanisms revealed by manoalide and benzohydroquinone","publication_year":1991,"publication_date":"1991-10-15","ids":{"openalex":"https://openalex.org/W52810583","doi":"https://doi.org/10.1042/bj2790367","mag":"52810583","pmid":"https://pubmed.ncbi.nlm.nih.gov/1659378","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1151615"},"language":"en","primary_location":{"id":"doi:10.1042/bj2790367","doi":"https://doi.org/10.1042/bj2790367","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2790367","pdf_url":"https://portlandpress.com/biochemj/article-pdf/279/2/367/604917/bj2790367.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/279/2/367/604917/bj2790367.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068367436","display_name":"Shmuel Muallem","orcid":"https://orcid.org/0000-0002-6189-4947","observed_orcids":["https://orcid.org/0000-0002-6189-4947"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Muallem","raw_affiliation_strings":["Department of Physiology, University of Texas Southwestern Medical Center, Dallas TX 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Texas Southwestern Medical Center, Dallas TX 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003104807","display_name":"P A Loessberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Loessberg","raw_affiliation_strings":["Department of Physiology, University of Texas Southwestern Medical Center, Dallas TX 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Texas Southwestern Medical Center, Dallas TX 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110090925","display_name":"George M. Sachs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Sachs","raw_affiliation_strings":["Laboratory of Membrane Biology, VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90073"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Membrane Biology, VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90073","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113209228","display_name":"Larry A. Wheeler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139498","display_name":"Allergan (United States)","ror":"https://ror.org/03pfqk412","country_code":"US","type":"company","lineage":["https://openalex.org/I2948728702","https://openalex.org/I4210139498"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L A Wheeler","raw_affiliation_strings":["Department of Biological Sciences, Discovery Research, Allergan Inc./Herbert Labs, Irvine, CA 92715, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Discovery Research, Allergan Inc./Herbert Labs, Irvine, CA 92715, U.S.A","institution_ids":["https://openalex.org/I4210139498"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9574,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.96351137,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"279","issue":"2","first_page":"367","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.27250000834465027,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.16660000383853912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.5350000262260437},{"id":"https://openalex.org/keywords/manoalide","display_name":"manoalide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.7799999713897705},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.5740000009536743},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.527999997138977},{"id":"https://openalex.org/keywords/cholecystokinin","display_name":"cholecystokinin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pancreatic-acini","display_name":"pancreatic acini","score":0.7889999747276306},{"id":"https://openalex.org/keywords/ar42j-cells","display_name":"AR42J cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/calcium-channel-inhibition","display_name":"calcium channel inhibition","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7642762064933777},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7597846984863281},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6818678379058838},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6461429595947266},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6205079555511475},{"id":"https://openalex.org/C2778470358","wikidata":"https://www.wikidata.org/wiki/Q908761","display_name":"Fura-2","level":4,"score":0.5454517006874084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49959897994995117},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.43700140714645386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27957871556282043},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.274568647146225},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27247729897499084},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09352433681488037},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006873","descriptor_name":"Hydroquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007811","descriptor_name":"Lanthanum","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj2790367","doi":"https://doi.org/10.1042/bj2790367","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2790367","pdf_url":"https://portlandpress.com/biochemj/article-pdf/279/2/367/604917/bj2790367.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1151615","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1151615","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:1659378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1659378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj2790367","doi":"https://doi.org/10.1042/bj2790367","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2790367","pdf_url":"https://portlandpress.com/biochemj/article-pdf/279/2/367/604917/bj2790367.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.5199999809265137,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G115289526","display_name":null,"funder_award_id":"DK 38938","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7504422089","display_name":"Hormone Regulation of [Ca2+] in Pancreatic Acinar Cells","funder_award_id":"R01DK038938","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W52810583.pdf","grobid_xml":"https://content.openalex.org/works/W52810583.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W87501499","https://openalex.org/W114978262","https://openalex.org/W145796029","https://openalex.org/W264835993","https://openalex.org/W1492343139","https://openalex.org/W1508055552","https://openalex.org/W1518984641","https://openalex.org/W1520080677","https://openalex.org/W1523169583","https://openalex.org/W1544518972","https://openalex.org/W1544601757","https://openalex.org/W1552536758","https://openalex.org/W1576209843","https://openalex.org/W1582797688","https://openalex.org/W1597049622","https://openalex.org/W1600993549","https://openalex.org/W1669858368","https://openalex.org/W1829437181","https://openalex.org/W1970807766","https://openalex.org/W1971936465","https://openalex.org/W1985086376","https://openalex.org/W1996024251","https://openalex.org/W1997093700","https://openalex.org/W2000523761","https://openalex.org/W2010070719","https://openalex.org/W2018130779","https://openalex.org/W2031478867","https://openalex.org/W2036145275","https://openalex.org/W2039818122","https://openalex.org/W2068877244","https://openalex.org/W2085514543","https://openalex.org/W2086669662","https://openalex.org/W2090708403","https://openalex.org/W2134868008","https://openalex.org/W2141260882","https://openalex.org/W2157963933","https://openalex.org/W2176210399","https://openalex.org/W2263282939","https://openalex.org/W2342100687","https://openalex.org/W2396028691","https://openalex.org/W2428055515","https://openalex.org/W4238781098","https://openalex.org/W6600602862","https://openalex.org/W6818072119"],"related_works":["https://openalex.org/W2057058455","https://openalex.org/W1600993549","https://openalex.org/W2210358277","https://openalex.org/W2301092763","https://openalex.org/W1991433609","https://openalex.org/W2262493202","https://openalex.org/W1597317128","https://openalex.org/W2341559793","https://openalex.org/W2082605695","https://openalex.org/W2061721293"],"abstract_inverted_index":{"The":[0,59,74],"mechanism":[1],"of":[2,4,39,72,95,100,107,133,139,152,156,187,213,229,246,252,273],"action":[3],"a":[5,45,56,198],"novel":[6],"compound,":[7],"2,5-di-(t-butyl)-1,4-benzohydroquinone":[8],"(BHQ),":[9],"used":[10],"to":[11,33,64,79,104,180,249,266],"modulate":[12],"cell":[13],"free":[14],"cytosolic":[15],"Ca2+":[16,41,65,80,119,159,174,188,208,211,276,281],"concentration":[17],"([Ca2+]i)":[18],"was":[19,62,77,163],"studied":[20],"in":[21,143,182,197,224,238,256,282],"AR42J":[22,108,145],"cells":[23,109,146],"and":[24,51,89,121,194,200,210,227,259],"pancreatic":[25],"acini":[26],"by":[27,55,87,147,161],"using":[28],"single-cell":[29],"fluorescence":[30],"techniques":[31],"applied":[32],"Fura-2-loaded":[34],"cells.":[35,242],"In":[36],"the":[37,131,140,157,214,220,225,244,257,274],"presence":[38,228],"extracellular":[40],"(Ca(2+)out),":[42],"BHQ":[43,111,134,148,162,169,232,247],"induced":[44],"biphasic":[46],"[Ca2+]i":[47,192,195,222],"increase,":[48],"an":[49,92,171,185],"initial":[50,60],"rapid":[52],"transient":[53],"followed":[54],"sustained":[57,75],"increase.":[58],"increase":[61,196,223],"due":[63,78],"release":[66,120],"from":[67],"intracellular":[68,173,260],"stores,":[69],"being":[70,82],"independent":[71],"Ca(2+)out.":[73,230],"response":[76],"entry,":[81,97],"dependent":[83],"on":[84,135,206],"Ca(2+)out,":[85],"blocked":[86,117],"La3+":[88],"correlated":[90],"with":[91,110],"increased":[93,101],"rate":[94],"Mn2+":[96],"all":[98],"indicative":[99],"plasma-membrane":[102],"permeability":[103],"Ca2+.":[105],"Treatment":[106],"for":[112,279],"about":[113],"5":[114,150],"min":[115,151],"reversibly":[116],"agonist-dependent":[118],"oscillations,":[122],"whereas":[123],"agonist":[124],"pretreatment":[125],"decreased,":[126],"but":[127],"did":[128,177],"not":[129,178,264],"prevent,":[130],"effects":[132],"[Ca2+]i.":[136],"Accordingly,":[137],"depletion":[138],"Ins(1,4,5)P3-mobilizable":[141],"pool":[142,175],"permeabilized":[144],"required":[149],"incubation,":[153],"although":[154],"inhibition":[155,272],"internal":[158,207,215],"pump":[160],"rapid.":[164],"These":[165],"observations":[166],"suggest":[167],"that":[168,176,262],"mobilized":[170],"additional":[172],"respond":[179,265],"changes":[181],"Ins(1,4,5)P3.":[183],"Manoalide,":[184],"inhibitor":[186],"channels,":[189],"inhibited":[190,219],"agonist-evoked":[191],"oscillation":[193],"dose-":[199],"time-dependent":[201],"manner":[202],"without":[203],"significant":[204],"effect":[205,245],"pumps":[209,277],"content":[212],"stores.":[216],"Manoalide":[217],"also":[218],"BHQ-evoked":[221],"absence":[226],"Neither":[231],"nor":[233],"manoalide":[234],"affected":[235],"Ins(1,4,5)P3":[236],"levels":[237],"resting":[239],"or":[240],"stimulated":[241],"Therefore,":[243],"appears":[248],"involve":[250],"unmasking":[251],"passive":[253],"Ca(2+)-permeation":[254],"pathways":[255],"plasma":[258],"membranes":[261],"do":[263],"cholecystokinin":[267],"octapeptide,":[268],"following":[269],"its":[270],"described":[271],"internal-store":[275],"responsible":[278],"accumulating":[280],"these":[283],"pools.":[284]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
