{"id":"https://openalex.org/W52809603","doi":"https://doi.org/10.1016/j.soc.2013.06.001","title":"Targeted Therapy for Cancer","display_name":"Targeted Therapy for Cancer","publication_year":2013,"publication_date":"2013-07-24","ids":{"openalex":"https://openalex.org/W52809603","doi":"https://doi.org/10.1016/j.soc.2013.06.001","mag":"52809603","pmid":"https://pubmed.ncbi.nlm.nih.gov/24012400","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4071221"},"language":"en","primary_location":{"id":"doi:10.1016/j.soc.2013.06.001","doi":"https://doi.org/10.1016/j.soc.2013.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.soc.2013.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S83884447","display_name":"Surgical Oncology Clinics of North America","issn_l":"1055-3207","issn":["1055-3207","1558-5042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical Oncology Clinics of North America","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4071221","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060380153","display_name":"Vinod P. Balachandran","orcid":"https://orcid.org/0000-0002-2956-223X","observed_orcids":["https://orcid.org/0000-0002-2956-223X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinod P. Balachandran","raw_affiliation_strings":["Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021772683","display_name":"Ronald P. DeMatteo","orcid":"https://orcid.org/0000-0002-7021-8852","observed_orcids":["https://orcid.org/0000-0002-7021-8852"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald P. DeMatteo","raw_affiliation_strings":["Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":0.2643,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.21728972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"4","first_page":"805","last_page":"821"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/kit-mutations","display_name":"KIT mutations","score":0.800000011920929},{"id":"https://openalex.org/keywords/pdgfra-mutation","display_name":"PDGFRA mutation","score":1.0},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/kinase-inhibitor-resistance","display_name":"kinase inhibitor resistance","score":0.6129999756813049},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8291041254997253},{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.8068854808807373},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.735560953617096},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.6888679265975952},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.6383323669433594},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6238757967948914},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5932627320289612},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5505134463310242},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5160865187644958},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4765399098396301},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.46690091490745544},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36433374881744385},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.34080803394317627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2598390281200409},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1352633237838745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11134210228919983},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07129785418510437},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.soc.2013.06.001","doi":"https://doi.org/10.1016/j.soc.2013.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.soc.2013.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S83884447","display_name":"Surgical Oncology Clinics of North America","issn_l":"1055-3207","issn":["1055-3207","1558-5042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical Oncology Clinics of North America","raw_type":"journal-article"},{"id":"pmid:24012400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24012400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical oncology clinics of North America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4071221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4071221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Surg Oncol Clin N Am","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4071221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4071221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Surg Oncol Clin N Am","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000863147","display_name":"Molecular Mechanisms in Gastrointestinal Stromal Tumor","funder_award_id":"R01CA102613","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W25562819","https://openalex.org/W1899319598","https://openalex.org/W1964703707","https://openalex.org/W1965871143","https://openalex.org/W1966889884","https://openalex.org/W1967431262","https://openalex.org/W1967570424","https://openalex.org/W1970063611","https://openalex.org/W1970687736","https://openalex.org/W1971947883","https://openalex.org/W1975941575","https://openalex.org/W1976823322","https://openalex.org/W1981491302","https://openalex.org/W1982984751","https://openalex.org/W1985861335","https://openalex.org/W1985872661","https://openalex.org/W1991891583","https://openalex.org/W1995930366","https://openalex.org/W1997103047","https://openalex.org/W1998192645","https://openalex.org/W2002060029","https://openalex.org/W2012072945","https://openalex.org/W2013837038","https://openalex.org/W2015015957","https://openalex.org/W2028750359","https://openalex.org/W2030379493","https://openalex.org/W2042529181","https://openalex.org/W2043696829","https://openalex.org/W2043700144","https://openalex.org/W2046841776","https://openalex.org/W2048030685","https://openalex.org/W2048404655","https://openalex.org/W2048513224","https://openalex.org/W2052874737","https://openalex.org/W2053142897","https://openalex.org/W2053210222","https://openalex.org/W2055158347","https://openalex.org/W2059242879","https://openalex.org/W2062655114","https://openalex.org/W2063299240","https://openalex.org/W2066315532","https://openalex.org/W2069244213","https://openalex.org/W2072847374","https://openalex.org/W2076516630","https://openalex.org/W2079420659","https://openalex.org/W2085009612","https://openalex.org/W2091448776","https://openalex.org/W2093070893","https://openalex.org/W2093792630","https://openalex.org/W2095460652","https://openalex.org/W2095974037","https://openalex.org/W2097457793","https://openalex.org/W2097980522","https://openalex.org/W2099200814","https://openalex.org/W2101986793","https://openalex.org/W2102659321","https://openalex.org/W2103304755","https://openalex.org/W2104275583","https://openalex.org/W2104580737","https://openalex.org/W2104810134","https://openalex.org/W2106631163","https://openalex.org/W2107191409","https://openalex.org/W2107464631","https://openalex.org/W2107570706","https://openalex.org/W2107651375","https://openalex.org/W2108431450","https://openalex.org/W2110082752","https://openalex.org/W2115068822","https://openalex.org/W2116788716","https://openalex.org/W2116922255","https://openalex.org/W2118084349","https://openalex.org/W2119501407","https://openalex.org/W2120718661","https://openalex.org/W2123534406","https://openalex.org/W2123571541","https://openalex.org/W2126694133","https://openalex.org/W2126920848","https://openalex.org/W2127919472","https://openalex.org/W2128518955","https://openalex.org/W2128542677","https://openalex.org/W2129931005","https://openalex.org/W2132190370","https://openalex.org/W2133771964","https://openalex.org/W2134094496","https://openalex.org/W2136146667","https://openalex.org/W2138297714","https://openalex.org/W2139236349","https://openalex.org/W2139511378","https://openalex.org/W2140626630","https://openalex.org/W2140765540","https://openalex.org/W2142564546","https://openalex.org/W2143060756","https://openalex.org/W2143295396","https://openalex.org/W2144928334","https://openalex.org/W2146384083","https://openalex.org/W2147474070","https://openalex.org/W2148064549","https://openalex.org/W2150475380","https://openalex.org/W2150501295","https://openalex.org/W2152769688","https://openalex.org/W2155503879","https://openalex.org/W2155741608","https://openalex.org/W2156266404","https://openalex.org/W2159360580","https://openalex.org/W2160275193","https://openalex.org/W2161821474","https://openalex.org/W2164452916","https://openalex.org/W2165105640","https://openalex.org/W2165837347","https://openalex.org/W2169348844","https://openalex.org/W2169363650","https://openalex.org/W2170257914","https://openalex.org/W2171620774","https://openalex.org/W2264714702","https://openalex.org/W2314511842","https://openalex.org/W2317628677","https://openalex.org/W2318605753","https://openalex.org/W2324850882","https://openalex.org/W2331096470","https://openalex.org/W6692946832"],"related_works":["https://openalex.org/W4200585566","https://openalex.org/W2470220460","https://openalex.org/W4229053943","https://openalex.org/W2399491744","https://openalex.org/W2104275583","https://openalex.org/W2395505945","https://openalex.org/W2019016907","https://openalex.org/W1615659742","https://openalex.org/W2160215400","https://openalex.org/W1994118036"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}