{"id":"https://openalex.org/W52166947","doi":null,"title":"LETHAL WEAPONS - Novel approaches for receptor-targeted cancer cell elimination","display_name":"LETHAL WEAPONS - Novel approaches for receptor-targeted cancer cell elimination","publication_year":2010,"publication_date":"2010-12-17","ids":{"openalex":"https://openalex.org/W52166947","mag":"52166947"},"language":"en","primary_location":{"id":"pmh:oai:www.doria.fi:10024/69977","doi":null,"is_oa":false,"landing_page_url":"http://www.doria.fi/handle/10024/69977","pdf_url":null,"source":{"id":"https://openalex.org/S4377196760","display_name":"Doria (University of Helsinki)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133731052","host_organization_name":"University of Helsinki","host_organization_lineage":["https://openalex.org/I133731052"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral dissertation (article-based)"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002186647","display_name":"Emilia Peuhu","orcid":"https://orcid.org/0000-0003-4945-3046","observed_orcids":["https://orcid.org/0000-0003-4945-3046"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emilia Peuhu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4945-3046","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002186647"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.42719998955726624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trail-resistance","display_name":"TRAIL resistance","score":0.7950000166893005},{"id":"https://openalex.org/keywords/trail-sensitization","display_name":"TRAIL sensitization","score":0.824999988079071},{"id":"https://openalex.org/keywords/lignans","display_name":"lignans","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dibenzylbutyrolactone-lignans","display_name":"dibenzylbutyrolactone lignans","score":0.9599999785423279},{"id":"https://openalex.org/keywords/androgen-dependent-prostate-cancer","display_name":"androgen-dependent prostate cancer","score":0.824999988079071},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-inhibition","display_name":"receptor tyrosine kinase inhibition","score":0.7760000228881836},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9340000152587891},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5860000252723694},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.902999997138977},{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.6269999742507935},{"id":"https://openalex.org/keywords/mesoporous-silica-nanoparticles","display_name":"mesoporous silica nanoparticles","score":0.8360000252723694},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.765999972820282},{"id":"https://openalex.org/keywords/folate-receptor-targeting","display_name":"folate receptor targeting","score":0.48500001430511475},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49569690227508545},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42759090662002563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3345206379890442},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3230363130569458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30935636162757874},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16221562027931213}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.doria.fi:10024/69977","doi":null,"is_oa":false,"landing_page_url":"http://www.doria.fi/handle/10024/69977","pdf_url":null,"source":{"id":"https://openalex.org/S4377196760","display_name":"Doria (University of Helsinki)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133731052","host_organization_name":"University of Helsinki","host_organization_lineage":["https://openalex.org/I133731052"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral dissertation (article-based)"},{"id":"mag:52166947","doi":null,"is_oa":false,"landing_page_url":"http://bibbild.abo.fi/ediss/2010/peuhu_emilia.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":516,"referenced_works":["https://openalex.org/W32982348","https://openalex.org/W189263682","https://openalex.org/W1480948328","https://openalex.org/W1480949286","https://openalex.org/W1484817497","https://openalex.org/W1489284756","https://openalex.org/W1496036360","https://openalex.org/W1502639673","https://openalex.org/W1506642042","https://openalex.org/W1517945724","https://openalex.org/W1520292475","https://openalex.org/W1526451509","https://openalex.org/W1527985047","https://openalex.org/W1529674879","https://openalex.org/W1540507088","https://openalex.org/W1552645317","https://openalex.org/W1557061959","https://openalex.org/W1558473055","https://openalex.org/W1565425041","https://openalex.org/W1570044629","https://openalex.org/W1573146315","https://openalex.org/W1577393853","https://openalex.org/W1581622491","https://openalex.org/W1587890084","https://openalex.org/W1589415602","https://openalex.org/W1593219141","https://openalex.org/W1599806854","https://openalex.org/W1603284138","https://openalex.org/W1616121322","https://openalex.org/W1662819364","https://openalex.org/W1791153000","https://openalex.org/W1836073275","https://openalex.org/W1857854979","https://openalex.org/W1869623099","https://openalex.org/W1871308790","https://openalex.org/W1885550998","https://openalex.org/W1927914875","https://openalex.org/W1930279371","https://openalex.org/W1960299898","https://openalex.org/W1964081206","https://openalex.org/W1964304371","https://openalex.org/W1965110077","https://openalex.org/W1965319671","https://openalex.org/W1966133006","https://openalex.org/W1966291495","https://openalex.org/W1966372986","https://openalex.org/W1966798559","https://openalex.org/W1967224800","https://openalex.org/W1968160256","https://openalex.org/W1968328677","https://openalex.org/W1968574801","https://openalex.org/W1968991720","https://openalex.org/W1969121458","https://openalex.org/W1969187681","https://openalex.org/W1969213134","https://openalex.org/W1969358790","https://openalex.org/W1969461041","https://openalex.org/W1969893319","https://openalex.org/W1971615503","https://openalex.org/W1971895570","https://openalex.org/W1972414794","https://openalex.org/W1972860860","https://openalex.org/W1973109581","https://openalex.org/W1973777188","https://openalex.org/W1973792489","https://openalex.org/W1974454556","https://openalex.org/W1974968903","https://openalex.org/W1975361019","https://openalex.org/W1975903555","https://openalex.org/W1976141746","https://openalex.org/W1976264813","https://openalex.org/W1976562344","https://openalex.org/W1976692354","https://openalex.org/W1977150737","https://openalex.org/W1977267072","https://openalex.org/W1977479596","https://openalex.org/W1978018492","https://openalex.org/W1978559408","https://openalex.org/W1978917201","https://openalex.org/W1979758455","https://openalex.org/W1980471937","https://openalex.org/W1980721529","https://openalex.org/W1980919524","https://openalex.org/W1981463242","https://openalex.org/W1981600616","https://openalex.org/W1982141768","https://openalex.org/W1982861352","https://openalex.org/W1983018356","https://openalex.org/W1983154518","https://openalex.org/W1983244146","https://openalex.org/W1983361018","https://openalex.org/W1984113136","https://openalex.org/W1984169187","https://openalex.org/W1984405075","https://openalex.org/W1984547206","https://openalex.org/W1984709119","https://openalex.org/W1984731040","https://openalex.org/W1984858728","https://openalex.org/W1985648901","https://openalex.org/W1985720487","https://openalex.org/W1986308149","https://openalex.org/W1986320887","https://openalex.org/W1987432765","https://openalex.org/W1988605167","https://openalex.org/W1989294105","https://openalex.org/W1990214582","https://openalex.org/W1991761526","https://openalex.org/W1992215904","https://openalex.org/W1992514491","https://openalex.org/W1993129579","https://openalex.org/W1993262772","https://openalex.org/W1993327789","https://openalex.org/W1993390114","https://openalex.org/W1993572137","https://openalex.org/W1994471598","https://openalex.org/W1994480513","https://openalex.org/W1994704237","https://openalex.org/W1994874844","https://openalex.org/W1994976660","https://openalex.org/W1995061287","https://openalex.org/W1995340305","https://openalex.org/W1995523735","https://openalex.org/W1995980440","https://openalex.org/W1996359986","https://openalex.org/W1996619229","https://openalex.org/W1996840415","https://openalex.org/W1997813173","https://openalex.org/W1997859241","https://openalex.org/W1998226303","https://openalex.org/W1999185333","https://openalex.org/W1999507817","https://openalex.org/W1999660608","https://openalex.org/W1999750774","https://openalex.org/W1999941834","https://openalex.org/W2000586986","https://openalex.org/W2001562768","https://openalex.org/W2001917589","https://openalex.org/W2002318323","https://openalex.org/W2002681960","https://openalex.org/W2002915072","https://openalex.org/W2003137211","https://openalex.org/W2003181901","https://openalex.org/W2003534444","https://openalex.org/W2003955264","https://openalex.org/W2004457956","https://openalex.org/W2005909927","https://openalex.org/W2006434892","https://openalex.org/W2007897263","https://openalex.org/W2008171455","https://openalex.org/W2008376982","https://openalex.org/W2008644522","https://openalex.org/W2008803356","https://openalex.org/W2008827059","https://openalex.org/W2008995928","https://openalex.org/W2009085926","https://openalex.org/W2009183764","https://openalex.org/W2009886463","https://openalex.org/W2010655741","https://openalex.org/W2011529790","https://openalex.org/W2011685332","https://openalex.org/W2012173926","https://openalex.org/W2012668596","https://openalex.org/W2012867962","https://openalex.org/W2013052118","https://openalex.org/W2013058828","https://openalex.org/W2013364831","https://openalex.org/W2013515819","https://openalex.org/W2013658872","https://openalex.org/W2013896822","https://openalex.org/W2013999789","https://openalex.org/W2014380713","https://openalex.org/W2015514848","https://openalex.org/W2015660395","https://openalex.org/W2015831734","https://openalex.org/W2016544505","https://openalex.org/W2016979416","https://openalex.org/W2017728303","https://openalex.org/W2017746519","https://openalex.org/W2017985723","https://openalex.org/W2018004937","https://openalex.org/W2018837825","https://openalex.org/W2019038132","https://openalex.org/W2019042150","https://openalex.org/W2019450833","https://openalex.org/W2021012077","https://openalex.org/W2023050624","https://openalex.org/W2023157569","https://openalex.org/W2023170312","https://openalex.org/W2023997582","https://openalex.org/W2024306318","https://openalex.org/W2024598687","https://openalex.org/W2025154830","https://openalex.org/W2025204866","https://openalex.org/W2025235714","https://openalex.org/W2025915824","https://openalex.org/W2026873116","https://openalex.org/W2028111124","https://openalex.org/W2028229153","https://openalex.org/W2028309691","https://openalex.org/W2028415754","https://openalex.org/W2028538255","https://openalex.org/W2029797799","https://openalex.org/W2030019992","https://openalex.org/W2030068760","https://openalex.org/W2030235387","https://openalex.org/W2030753594","https://openalex.org/W2030819637","https://openalex.org/W2030892254","https://openalex.org/W2031630601","https://openalex.org/W2032049833","https://openalex.org/W2032560191","https://openalex.org/W2032575813","https://openalex.org/W2032722537","https://openalex.org/W2032882923","https://openalex.org/W2033150364","https://openalex.org/W2033186975","https://openalex.org/W2033682281","https://openalex.org/W2034243683","https://openalex.org/W2034249182","https://openalex.org/W2034269086","https://openalex.org/W2034791599","https://openalex.org/W2035091743","https://openalex.org/W2035258932","https://openalex.org/W2035765569","https://openalex.org/W2036113930","https://openalex.org/W2036528355","https://openalex.org/W2036897993","https://openalex.org/W2038590671","https://openalex.org/W2038834120","https://openalex.org/W2039267077","https://openalex.org/W2039805273","https://openalex.org/W2040839599","https://openalex.org/W2042224403","https://openalex.org/W2042263670","https://openalex.org/W2042409437","https://openalex.org/W2042561434","https://openalex.org/W2043318290","https://openalex.org/W2044079387","https://openalex.org/W2044090247","https://openalex.org/W2044626031","https://openalex.org/W2044825593","https://openalex.org/W2045309873","https://openalex.org/W2045855955","https://openalex.org/W2046355336","https://openalex.org/W2046851174","https://openalex.org/W2047390867","https://openalex.org/W2047972729","https://openalex.org/W2048056641","https://openalex.org/W2048324577","https://openalex.org/W2048391184","https://openalex.org/W2048754817","https://openalex.org/W2048939368","https://openalex.org/W2049309238","https://openalex.org/W2049312704","https://openalex.org/W2049511973","https://openalex.org/W2050085273","https://openalex.org/W2051614379","https://openalex.org/W2051724400","https://openalex.org/W2052398986","https://openalex.org/W2052458656","https://openalex.org/W2052788415","https://openalex.org/W2052853635","https://openalex.org/W2053953221","https://openalex.org/W2055474071","https://openalex.org/W2056217426","https://openalex.org/W2056599488","https://openalex.org/W2057144074","https://openalex.org/W2057292793","https://openalex.org/W2057477877","https://openalex.org/W2058138221","https://openalex.org/W2058247621","https://openalex.org/W2058369946","https://openalex.org/W2059657006","https://openalex.org/W2060960232","https://openalex.org/W2061214110","https://openalex.org/W2061226665","https://openalex.org/W2061655961","https://openalex.org/W2062014088","https://openalex.org/W2062089905","https://openalex.org/W2062214897","https://openalex.org/W2062265555","https://openalex.org/W2062843200","https://openalex.org/W2062853648","https://openalex.org/W2062949984","https://openalex.org/W2063362926","https://openalex.org/W2064216603","https://openalex.org/W2065079114","https://openalex.org/W2065413461","https://openalex.org/W2065616395","https://openalex.org/W2066395245","https://openalex.org/W2066571367","https://openalex.org/W2066620348","https://openalex.org/W2067104005","https://openalex.org/W2067301522","https://openalex.org/W2067449160","https://openalex.org/W2067534266","https://openalex.org/W2068427129","https://openalex.org/W2068606395","https://openalex.org/W2068912983","https://openalex.org/W2069075668","https://openalex.org/W2070517548","https://openalex.org/W2071244674","https://openalex.org/W2071562706","https://openalex.org/W2071622146","https://openalex.org/W2072864417","https://openalex.org/W2073338516","https://openalex.org/W2073341588","https://openalex.org/W2074881372","https://openalex.org/W2075056414","https://openalex.org/W2075174350","https://openalex.org/W2075809552","https://openalex.org/W2076966784","https://openalex.org/W2077186218","https://openalex.org/W2077478539","https://openalex.org/W2077705257","https://openalex.org/W2077828678","https://openalex.org/W2078725345","https://openalex.org/W2078951246","https://openalex.org/W2079930944","https://openalex.org/W2080389159","https://openalex.org/W2080439368","https://openalex.org/W2082007973","https://openalex.org/W2082293892","https://openalex.org/W2083309529","https://openalex.org/W2085173450","https://openalex.org/W2085233944","https://openalex.org/W2085333626","https://openalex.org/W2085419794","https://openalex.org/W2085591135","https://openalex.org/W2085851286","https://openalex.org/W2085926680","https://openalex.org/W2086232429","https://openalex.org/W2086436667","https://openalex.org/W2087221993","https://openalex.org/W2087261949","https://openalex.org/W2087423421","https://openalex.org/W2087880867","https://openalex.org/W2088223764","https://openalex.org/W2088291142","https://openalex.org/W2088580558","https://openalex.org/W2089370460","https://openalex.org/W2090204715","https://openalex.org/W2091267060","https://openalex.org/W2091520604","https://openalex.org/W2093628776","https://openalex.org/W2094068658","https://openalex.org/W2094334993","https://openalex.org/W2094399039","https://openalex.org/W2094464983","https://openalex.org/W2094863064","https://openalex.org/W2095013915","https://openalex.org/W2095084545","https://openalex.org/W2095248480","https://openalex.org/W2095407037","https://openalex.org/W2096186936","https://openalex.org/W2096443169","https://openalex.org/W2096714217","https://openalex.org/W2097767970","https://openalex.org/W2098280101","https://openalex.org/W2098535884","https://openalex.org/W2098544382","https://openalex.org/W2098641105","https://openalex.org/W2099113454","https://openalex.org/W2099661341","https://openalex.org/W2099724264","https://openalex.org/W2099876620","https://openalex.org/W2099899570","https://openalex.org/W2100225360","https://openalex.org/W2100237319","https://openalex.org/W2100567439","https://openalex.org/W2101801614","https://openalex.org/W2102121306","https://openalex.org/W2102828763","https://openalex.org/W2102986716","https://openalex.org/W2103278596","https://openalex.org/W2103373547","https://openalex.org/W2103513010","https://openalex.org/W2103699489","https://openalex.org/W2104064239","https://openalex.org/W2104251051","https://openalex.org/W2104473825","https://openalex.org/W2105555467","https://openalex.org/W2105572099","https://openalex.org/W2106284224","https://openalex.org/W2106327504","https://openalex.org/W2107377459","https://openalex.org/W2107423984","https://openalex.org/W2107495325","https://openalex.org/W2108307486","https://openalex.org/W2108902725","https://openalex.org/W2109510813","https://openalex.org/W2109587559","https://openalex.org/W2109785424","https://openalex.org/W2109799715","https://openalex.org/W2109956888","https://openalex.org/W2110077740","https://openalex.org/W2111789508","https://openalex.org/W2112327309","https://openalex.org/W2113155222","https://openalex.org/W2113972541","https://openalex.org/W2114060881","https://openalex.org/W2114373278","https://openalex.org/W2115207474","https://openalex.org/W2115806147","https://openalex.org/W2116973510","https://openalex.org/W2117098665","https://openalex.org/W2118603147","https://openalex.org/W2118844383","https://openalex.org/W2118880189","https://openalex.org/W2119326933","https://openalex.org/W2119500275","https://openalex.org/W2119504728","https://openalex.org/W2119785019","https://openalex.org/W2120292596","https://openalex.org/W2121870152","https://openalex.org/W2123513769","https://openalex.org/W2123744235","https://openalex.org/W2124048728","https://openalex.org/W2125746450","https://openalex.org/W2126375207","https://openalex.org/W2127072511","https://openalex.org/W2128575466","https://openalex.org/W2129753509","https://openalex.org/W2130002810","https://openalex.org/W2130479712","https://openalex.org/W2130988210","https://openalex.org/W2130994318","https://openalex.org/W2131060408","https://openalex.org/W2131207360","https://openalex.org/W2132106223","https://openalex.org/W2132270233","https://openalex.org/W2132954482","https://openalex.org/W2133035274","https://openalex.org/W2133212644","https://openalex.org/W2133312268","https://openalex.org/W2133529666","https://openalex.org/W2133669258","https://openalex.org/W2133958296","https://openalex.org/W2134520622","https://openalex.org/W2134706781","https://openalex.org/W2136020971","https://openalex.org/W2137519679","https://openalex.org/W2137741745","https://openalex.org/W2138509357","https://openalex.org/W2138980158","https://openalex.org/W2139287440","https://openalex.org/W2139816864","https://openalex.org/W2139992429","https://openalex.org/W2140917226","https://openalex.org/W2141584283","https://openalex.org/W2142120946","https://openalex.org/W2142561620","https://openalex.org/W2142790993","https://openalex.org/W2144037068","https://openalex.org/W2144535282","https://openalex.org/W2145096163","https://openalex.org/W2146157811","https://openalex.org/W2147114673","https://openalex.org/W2148894303","https://openalex.org/W2148942767","https://openalex.org/W2149789119","https://openalex.org/W2150315067","https://openalex.org/W2150392826","https://openalex.org/W2150491978","https://openalex.org/W2150758813","https://openalex.org/W2151817307","https://openalex.org/W2151972443","https://openalex.org/W2152617921","https://openalex.org/W2152752812","https://openalex.org/W2152807226","https://openalex.org/W2152931086","https://openalex.org/W2153712534","https://openalex.org/W2154011626","https://openalex.org/W2154757961","https://openalex.org/W2156451942","https://openalex.org/W2156777559","https://openalex.org/W2157192075","https://openalex.org/W2157935840","https://openalex.org/W2157970128","https://openalex.org/W2158180864","https://openalex.org/W2158477462","https://openalex.org/W2158558808","https://openalex.org/W2159493805","https://openalex.org/W2159650080","https://openalex.org/W2161513899","https://openalex.org/W2161810908","https://openalex.org/W2162283582","https://openalex.org/W2162560719","https://openalex.org/W2162653594","https://openalex.org/W2163294691","https://openalex.org/W2163747546","https://openalex.org/W2164032619","https://openalex.org/W2164660906","https://openalex.org/W2164682544","https://openalex.org/W2165204791","https://openalex.org/W2166583852","https://openalex.org/W2167806590","https://openalex.org/W2169258216","https://openalex.org/W2169618461","https://openalex.org/W2169632964","https://openalex.org/W2169850451","https://openalex.org/W2170196292","https://openalex.org/W2170298919","https://openalex.org/W2171374349","https://openalex.org/W2176899369","https://openalex.org/W2319486658","https://openalex.org/W2320870975","https://openalex.org/W2325862576","https://openalex.org/W2330709458","https://openalex.org/W2344690430","https://openalex.org/W2410161685","https://openalex.org/W2567526623","https://openalex.org/W2614446987","https://openalex.org/W2963392700","https://openalex.org/W3012002131","https://openalex.org/W3023255929"],"related_works":["https://openalex.org/W1969555739","https://openalex.org/W2057052591","https://openalex.org/W1967899052","https://openalex.org/W2180092880","https://openalex.org/W1950812539","https://openalex.org/W2163057363","https://openalex.org/W1996621261","https://openalex.org/W4319935503","https://openalex.org/W4301183219","https://openalex.org/W2925499610"],"abstract_inverted_index":{"The":[0,251,284,305,344],"currently":[1],"used":[2,222],"forms":[3,38],"of":[4,26,39,55,66,157,169,183,192,229,244,270,279,323,334,353],"cancer":[5,62,121,195,212,262,303,320,342,359],"therapy":[6],"are":[7,21,46,214],"associated":[8],"with":[9,292],"drug":[10,241],"resistance":[11,76],"and":[12,29,80,101,118,133,188,232,329],"toxicity":[13],"to":[14,52,57,77,144,197,220,233,273,295,358],"healthy":[15],"tissues.":[16],"Thus,":[17],"more":[18],"efficient":[19,182,211,267],"methods":[20],"needed":[22],"for":[23,83,163,261,319,331,350],"cancer-specific":[24],"induction":[25,333],"growth":[27],"arrest":[28],"programmed":[30],"cell":[31,67,110,135,263,336],"death,":[32],"also":[33,361],"known":[34],"as":[35,179],"apoptosis.":[36,199],"Therapeutic":[37],"tumor":[40],"necrosis":[41],"factor-related":[42],"apoptosis-inducing":[43],"ligand":[44],"(TRAIL)":[45],"investigated":[47],"in":[48,61,88,99,190,223,259,317,338,362],"clinical":[49],"trials":[50],"due":[51],"the":[53,139,154,158,164,173,180,184,266,274,310],"capability":[54],"TRAIL":[56,146],"trigger":[58],"apoptosis":[59,79],"specifically":[60,357],"cells":[63,122,196,208,236,360],"by":[64,299],"activation":[65],"surface":[68,277],"death":[69,111,337],"receptors.":[70],"Many":[71],"tumors,":[72],"however,":[73],"have":[74,103,247],"acquired":[75],"TRAIL-induced":[78,109,198],"sensitizing":[81,106],"drugs":[82,213,231],"combinatorial":[84,202],"treatments":[85],"are,":[86],"therefore,":[87],"high":[89],"demand.":[90],"This":[91],"study":[92],"demonstrates":[93],"that":[94,125,153,256,309],"lignans,":[95],"natural":[96],"polyphenols":[97],"enriched":[98],"seeds":[100],"cereal,":[102],"a":[104],"remarkable":[105],"effect":[107],"on":[108],"at":[112],"non-toxic":[113],"lignan":[114,174],"concentrations.":[115],"In":[116],"TRAIL-resistant":[117],"androgen-dependent":[119],"prostate":[120,194],"we":[123,257],"observe":[124],"lignans":[126,160,187],"repress":[127],"receptor":[128,301,340],"tyrosine":[129],"kinase":[130],"(RTK)":[131],"activity":[132,168],"downregulate":[134],"survival":[136],"signaling":[137],"via":[138],"Akt":[140],"pathway,":[141],"which":[142],"leads":[143],"increased":[145],"sensitivity.":[147],"A":[148],"structure-activity":[149],"relationship":[150],"analysis":[151],"reveals":[152],"\u03b3-butyrolactone":[155],"ring":[156],"dibenzylbutyrolactone":[159],"is":[161,177],"essential":[162],"rapidly":[165],"reversible":[166],"TRAIL-sensitizing":[167],"these":[170],"compounds.":[171],"Furthermore,":[172],"nortrachelogenin":[175],"(NTG)":[176],"identified":[178],"most":[181],"27":[185],"tested":[186,258,345],"norlignans":[189],"sensitization":[191],"androgen-deprived":[193],"While":[200],"this":[201],"anticancer":[203,355],"approach":[204],"may":[205],"leave":[206],"normal":[207,235],"unharmed,":[209],"several":[210,354],"too":[215],"toxic,":[216],"insoluble":[217],"or":[218,325],"unstable":[219],"be":[221,315],"systemic":[224],"therapy.":[225],"To":[226],"enable":[227],"use":[228],"such":[230],"protect":[234],"from":[237],"cytotoxic":[238],"effects,":[239],"cancer-targeted":[240],"delivery":[242,322,352],"vehicles":[243],"nanometer":[245],"scale":[246],"recently":[248],"been":[249],"generated.":[250],"newly":[252],"developed":[253,311],"nanoparticle":[254],"system":[255,313,347],"vitro":[260,318],"targeting":[264],"combines":[265],"drug-loading":[268],"capacity":[269],"mesoporous":[271,285],"silica":[272,287],"versatile":[275],"particle":[276],"functionalization":[278],"hyperbranched":[280],"poly(ethylene":[281],"imine),":[282],"PEI.":[283],"hybrid":[286],"nanoparticles":[288],"(MSNs)":[289],"were":[290],"functionalized":[291],"folic":[293],"acid":[294],"promote":[296],"targeted":[297],"internalization":[298],"folate":[300,339],"overexpressing":[302],"cells.":[304,343],"presented":[306],"results":[307],"demonstrate":[308],"carrier":[312,346],"can":[314],"employed":[316],"selective":[321,332],"adsorbed":[324],"covalently":[326],"conjugated":[327],"molecules":[328],"furthermore,":[330],"apoptotic":[335],"expressing":[341],"displays":[348],"potential":[349],"simultaneous":[351],"agents":[356],"vivo.":[363]},"counts_by_year":[],"updated_date":"2026-08-25T07:29:55.448023","created_date":"2016-06-24T00:00:00"}