{"id":"https://openalex.org/W52085803","doi":"https://doi.org/10.4161/cc.5.2.2367","title":"Epigenomics: Mapping the Methylome","display_name":"Epigenomics: Mapping the Methylome","publication_year":2005,"publication_date":"2005-12-06","ids":{"openalex":"https://openalex.org/W52085803","doi":"https://doi.org/10.4161/cc.5.2.2367","mag":"52085803","pmid":"https://pubmed.ncbi.nlm.nih.gov/16397413"},"language":"en","primary_location":{"id":"doi:10.4161/cc.5.2.2367","doi":"https://doi.org/10.4161/cc.5.2.2367","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.5.2.2367","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.2.2367?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.2.2367?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103643971","display_name":"Ian M. Wilson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian M Wilson","raw_affiliation_strings":["British Columbia Cancer Research Centre, Vancouver, BC, Canada. wilson@bccrc.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Columbia Cancer Research Centre, Vancouver, BC, Canada. wilson@bccrc.ca","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102163560","display_name":"Jonathan J. Davies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan J Davies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010500477","display_name":"Micha\u00ebl Weber","orcid":"https://orcid.org/0000-0003-3484-5821","observed_orcids":["https://orcid.org/0000-0003-3484-5821","https://orcid.org/0009-0008-6557-1193"]},"institutions":[{"id":"https://openalex.org/I4210145673","display_name":"Biotechnologie et Signalisation Cellulaire","ror":"https://ror.org/047fwb937","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210145673","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michael Weber","raw_affiliation_strings":["Biotechnologie et signalisation cellulaire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnologie et signalisation cellulaire","institution_ids":["https://openalex.org/I4210145673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032840824","display_name":"Carolyn J. Brown","orcid":"https://orcid.org/0000-0002-8959-0101","observed_orcids":["https://orcid.org/0000-0002-8959-0101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn J Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Carlos E Alvarez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos E Alvarez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015304965","display_name":"Calum E. MacAulay","orcid":"https://orcid.org/0000-0003-4440-2792","observed_orcids":["https://orcid.org/0000-0003-4440-2792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Calum MacAulay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022643303","display_name":"Dirk Sch\u00fcbeler","orcid":"https://orcid.org/0000-0002-9229-2228","observed_orcids":["https://orcid.org/0000-0002-9229-2228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dirk Sch\u00fcbeler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013908616","display_name":"Wan L. Lam","orcid":"https://orcid.org/0000-0002-0945-0644","observed_orcids":["https://orcid.org/0000-0002-0945-0644"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wan L Lam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.894,"has_fulltext":true,"cited_by_count":122,"citation_normalized_percentile":{"value":0.96115989,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"2","first_page":"155","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-methylome","display_name":"methylome","score":0.9559999704360962},{"id":"https://openalex.org/keywords/methylated-dna-immunoprecipitation","display_name":"methylated DNA immunoprecipitation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/array-based-comparative-genomic-hybridization","display_name":"array comparative genomic hybridization","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.7009999752044678},{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cancer-epigenetics","display_name":"cancer epigenetics","score":0.7519999742507935},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C116114238","wikidata":"https://www.wikidata.org/wiki/Q6823960","display_name":"Methylated DNA immunoprecipitation","level":5,"score":0.8797459602355957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8463695049285889},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.8291572332382202},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7808559536933899},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6607950925827026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5203306674957275},{"id":"https://openalex.org/C163002167","wikidata":"https://www.wikidata.org/wiki/Q7277124","display_name":"RNA-Directed DNA Methylation","level":5,"score":0.5071630477905273},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.49196144938468933},{"id":"https://openalex.org/C136953436","wikidata":"https://www.wikidata.org/wiki/Q6000286","display_name":"Illumina Methylation Assay","level":5,"score":0.4837917983531952},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4385860562324524},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4196981191635132},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.41318532824516296},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3495978116989136},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30161750316619873},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15496355295181274}],"mesh":[{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4161/cc.5.2.2367","doi":"https://doi.org/10.4161/cc.5.2.2367","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.5.2.2367","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.2.2367?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:16397413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16397413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02997143v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02997143","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Cycle, 2006, 5 (2), pp.155-158. ⟨10.4161/cc.5.2.2367⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.4161/cc.5.2.2367","doi":"https://doi.org/10.4161/cc.5.2.2367","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.5.2.2367","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.2.2367?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W52085803.pdf","grobid_xml":"https://content.openalex.org/works/W52085803.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W112435004","https://openalex.org/W152662877","https://openalex.org/W2164627030","https://openalex.org/W1582030261","https://openalex.org/W7096985957","https://openalex.org/W40641727","https://openalex.org/W2161057402","https://openalex.org/W2070925425","https://openalex.org/W2101259235","https://openalex.org/W1992848596"],"abstract_inverted_index":{"DNA":[0,49,80,98],"methylation":[1,31,81,122],"is":[2,43],"integral":[3],"to":[4,134],"normal":[5],"development":[6],"and":[7,76,89,96,116,127,156],"disease":[8],"processes.":[9],"However,":[10],"the":[11,34,106],"genomic":[12,62],"distribution":[13],"of":[14,30,69,105,154],"methylated":[15,48],"sequences--the":[16],"methylome--is":[17],"poorly":[18],"understood.":[19],"We":[20],"have":[21],"recently":[22],"developed":[23],"a":[24,38,47,67,131],"platform":[25],"technology":[26],"for":[27,53],"rapid":[28],"assessment":[29],"status":[32],"throughout":[33],"human":[35],"genome":[36,71],"in":[37,109,137,147],"high-resolution,":[39],"high-throughput":[40],"manner.":[41],"This":[42],"achieved":[44],"by":[45],"coupling":[46],"immunoprecipitation":[50],"(MeDIP)":[51],"method":[52],"isolating":[54],"methyl":[55],"cytosine":[56],"rich":[57],"fragments":[58],"with":[59,151],"array-based":[60],"comparative":[61],"hybridization":[63],"(array":[64],"CGH).":[65],"Using":[66],"combination":[68],"whole":[70],"tiling":[72],"path":[73],"BAC":[74],"arrays":[75],"CpG":[77],"island":[78],"microarrays,":[79],"profiles":[82],"are":[83],"obtained":[84],"simultaneously":[85],"at":[86],"both":[87],"genome-wide":[88],"locus-specific":[90],"levels.":[91],"A":[92],"comparison":[93],"between":[94,114],"male":[95],"female":[97],"using":[99],"MeDIP-array":[100],"CGH":[101],"revealed":[102],"unexpected":[103],"hypomethylation":[104],"inactive":[107],"x-chromosome":[108],"gene-poor":[110],"regions.":[111],"Furthermore,":[112],"comparisons":[113],"cancer":[115,149],"noncancer":[117],"cell":[118],"types":[119],"yielded":[120],"differential":[121],"patterns":[123],"that":[124],"link":[125],"genetic":[126,155],"epigenetic":[128,157],"instability":[129,146],"offering":[130],"new":[132,142],"approach":[133],"decipher":[135],"misregulation":[136],"cancer.":[138],"Finally,":[139],"we":[140],"provide":[141],"data":[143],"showing":[144],"epigenomic":[145],"lung":[148],"cells":[150],"concurrent":[152],"regions":[153],"alterations":[158],"harboring":[159],"known":[160],"oncogenes.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}