{"id":"https://openalex.org/W52028792","doi":null,"title":"polymorphic varianTs of genes of cyTochrome p450 (cyp1a1, cyp2e1, cyp2d6) in developmenT of predisposiTions To professional Toxic defeaT of The liver","display_name":"polymorphic varianTs of genes of cyTochrome p450 (cyp1a1, cyp2e1, cyp2d6) in developmenT of predisposiTions To professional Toxic defeaT of The liver","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W52028792","mag":"52028792"},"language":"en","primary_location":{"id":"mag:2465617119","doi":null,"is_oa":false,"landing_page_url":"http://cyberleninka.ru/article/n/polimorfnye-varianty-genov-tsitohroma-p450-cyp1a1-cyp2e1-cyp2d6-v-razvitii-predraspolozhennosti-k-professionalnomu-toksicheskomu.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"parent_works":[],"lineage":["https://openalex.org/W52028792"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030035882","display_name":"\u041e. \u0421. \u0426\u0435\u043b\u043e\u0443\u0441\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-9124-9340","observed_orcids":["https://orcid.org/0000-0002-9124-9340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u041e. \u0421. \u0426\u0435\u043b\u043e\u0443\u0441\u043e\u0432\u0430","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9124-9340","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021393828","display_name":"Olga Vladimirovna Kochetova","orcid":"https://orcid.org/0000-0002-2944-4428","observed_orcids":["https://orcid.org/0000-0002-2944-4428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u041e. \u0412. \u041a\u043e\u0447\u0435\u0442\u043e\u0432\u0430","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2944-4428","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075289898","display_name":"\u0410\u0445\u043c\u0430\u0434\u0438\u0448\u0438\u043d\u0430 \u041b\u0435\u0439\u0441\u0430\u043d \u0417\u0438\u043d\u0443\u0440\u043e\u0432\u043d\u0430","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Z. Akhmadishina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0043-5090","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059901073","display_name":"\u041a\u043e\u0440\u044b\u0442\u0438\u043d\u0430 \u0413\u0443\u043b\u044c\u043d\u0430\u0437 \u0424\u0430\u0440\u0438\u0442\u043e\u0432\u043d\u0430","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. F. Koritina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070235915","display_name":"\u0412\u0438\u043a\u0442\u043e\u0440\u043e\u0432\u0430 \u0422\u0430\u0442\u044c\u044f\u043d\u0430 \u0412\u0438\u043a\u0442\u043e\u0440\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0001-8900-2480","observed_orcids":["https://orcid.org/0000-0001-8900-2480"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0422. V. Victorova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00615269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.07460000365972519,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.906000018119812},{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":1.0},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.39899998903274536},{"id":"https://openalex.org/keywords/petrochemical-workers","display_name":"petrochemical workers","score":0.8560000061988831},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7689999938011169},{"id":"https://openalex.org/keywords/protective-alleles","display_name":"protective alleles","score":0.42500001192092896},{"id":"https://openalex.org/keywords/n-heptane","display_name":"n-heptane","score":0.39500001072883606},{"id":"https://openalex.org/keywords/ethylbenzene","display_name":"ethylbenzene","score":0.9200000166893005},{"id":"https://openalex.org/keywords/styrene","display_name":"styrene","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.7862996459007263},{"id":"https://openalex.org/C140027455","wikidata":"https://www.wikidata.org/wiki/Q14864434","display_name":"CYP2E1","level":4,"score":0.7264630794525146},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6766344904899597},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6519094705581665},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5566672086715698},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.5464980006217957},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49677687883377075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4472157955169678},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4310283958911896},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.17762205004692078},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14182132482528687},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13525813817977905}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2465617119","doi":null,"is_oa":false,"landing_page_url":"http://cyberleninka.ru/article/n/polimorfnye-varianty-genov-tsitohroma-p450-cyp1a1-cyp2e1-cyp2d6-v-razvitii-predraspolozhennosti-k-professionalnomu-toksicheskomu.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:52028792","doi":null,"is_oa":false,"landing_page_url":"https://cyberleninka.ru/article/n/polimorfnye-varianty-genov-tsitohroma-p450-cyp1a1-cyp2e1-cyp2d6-v-razvitii-predraspolozhennosti-k-professionalnomu-toksicheskomu","pdf_url":null,"source":{"id":"https://openalex.org/S4210202044","display_name":"\u0411\u044e\u043b\u043b\u0435\u0442\u0435\u043d\u044c \u0412\u043e\u0441\u0442\u043e\u0447\u043d\u043e-\u0421\u0438\u0431\u0438\u0440\u0441\u043a\u043e\u0433\u043e \u043d\u0430\u0443\u0447\u043d\u043e\u0433\u043e \u0446\u0435\u043d\u0442\u0440\u0430 \u0421\u0438\u0431\u0438\u0440\u0441\u043a\u043e\u0433\u043e \u043e\u0442\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0430\u043a\u0430\u0434\u0435\u043c\u0438\u0438 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0445 \u043d\u0430\u0443\u043a","issn_l":"1811-0649","issn":["1811-0649","2541-9420","2587-9596"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4324001544","host_organization_name":"Infra-M Academic Publishing House","host_organization_lineage":["https://openalex.org/P4324001544"],"host_organization_lineage_names":["Infra-M Academic Publishing House"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0411\u044e\u043b\u043b\u0435\u0442\u0435\u043d\u044c \u0412\u043e\u0441\u0442\u043e\u0447\u043d\u043e-\u0421\u0438\u0431\u0438\u0440\u0441\u043a\u043e\u0433\u043e \u043d\u0430\u0443\u0447\u043d\u043e\u0433\u043e \u0446\u0435\u043d\u0442\u0440\u0430 \u0421\u0438\u0431\u0438\u0440\u0441\u043a\u043e\u0433\u043e \u043e\u0442\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0430\u043a\u0430\u0434\u0435\u043c\u0438\u0438 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0445 \u043d\u0430\u0443\u043a","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1914476337","https://openalex.org/W2002240712","https://openalex.org/W2012335460","https://openalex.org/W2019337449","https://openalex.org/W2084608875","https://openalex.org/W2168416261","https://openalex.org/W2279720402"],"related_works":["https://openalex.org/W2751419778","https://openalex.org/W51627405","https://openalex.org/W2126709084","https://openalex.org/W2354221750","https://openalex.org/W2162730098","https://openalex.org/W3012009520","https://openalex.org/W1855867928","https://openalex.org/W1964828966","https://openalex.org/W2405810388"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,10,23,62,80,96,98,104,109],"this":[3],"study":[4,90],"was":[5,37],"to":[6,64],"estimate":[7],"the":[8,21,51,66,102],"predisposition":[9,63,103],"influencing":[11],"possible":[12],"factors":[13],"causing":[14],"chemical":[15],"induced":[16],"abnormal":[17],"liver":[18],"function":[19],"on":[20,39],"basis":[22],"studying":[24],"cytochrome":[25,99],"P450":[26,100],"genes":[27,97],"((A4889G)":[28],"CYP1A1,":[29],"(\u0421188\u0422)":[30],"CYP2D6,":[31,40],"(C1091T)":[32],"CYP2E1).":[33],"No":[34],"significant":[35,93],"association":[36],"found":[38],"CYP2E1":[41],"genotypes":[42],"between":[43],"a":[44,54,92],"reference":[45],"group":[46],"and":[47,111],"petrochemical":[48],"workers.":[49],"Among":[50],"patients":[52],"with":[53],"occupational":[55,105],"toxic":[56],"hepatitis":[57],"are":[58,86],"established":[59],"genetic":[60],"marker":[61],"development":[65],"disease:":[67],"Ile/Val":[68],"gene":[69,81],"CYP1A1":[70,82],"(OR":[71,83],"=":[72,84],"5,78).":[73],"Our":[74],"results":[75],"suggest":[76],"that":[77],"genotype":[78],"Ile/Ile":[79],"0,17)":[85],"protective":[87],"variants.":[88],"This":[89],"demonstrates":[91],"combined":[94],"effect":[95],"in":[101],"pathology":[106],"at":[107],"workers":[108],"hepthyle":[110],"ethylebenzene-styrene.":[112]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}