{"id":"https://openalex.org/W51900997","doi":"https://doi.org/10.6092/1590-8577/376","title":"An Immunocytochemical Profile of the Endocrine Pancreas Using an Occlusive Duct Ligation Model","display_name":"An Immunocytochemical Profile of the Endocrine Pancreas Using an Occlusive Duct Ligation Model","publication_year":2011,"publication_date":"2011-06-15","ids":{"openalex":"https://openalex.org/W51900997","doi":"https://doi.org/10.6092/1590-8577/376","mag":"51900997","pmid":"https://pubmed.ncbi.nlm.nih.gov/11856861"},"language":"en","primary_location":{"id":"pmid:11856861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11856861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6092/1590-8577/376","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111383064","display_name":"Benedict John Page","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Page, Benedict J","raw_affiliation_strings":["Department of Anatomy and Histology, Faculty of Medicine, University of Stellenbosch. Tygerberg, South Africa. bjp@gerga.sun.ac.za"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Histology, Faculty of Medicine, University of Stellenbosch. Tygerberg, South Africa. bjp@gerga.sun.ac.za","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109190396","display_name":"Don F. Du Toit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Du Toit, Don F","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006611112","display_name":"Christo J. F. Muller","orcid":"https://orcid.org/0000-0001-6821-2120","observed_orcids":["https://orcid.org/0000-0001-6821-2120"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muller, Christo JF","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061453234","display_name":"J Mattysen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mattysen, Johannes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033936532","display_name":"R Lyners","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lyners, Romeo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0335,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.85145382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1","issue":"4","first_page":"191","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-duct-ligation","display_name":"pancreatic duct ligation","score":0.984000027179718},{"id":"https://openalex.org/keywords/endocrine-pancreas","display_name":"endocrine pancreas","score":0.8360000252723694},{"id":"https://openalex.org/keywords/pancreatic-islet-regeneration","display_name":"pancreatic islet regeneration","score":0.6690000295639038},{"id":"https://openalex.org/keywords/transdifferentiation","display_name":"transdifferentiation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.7450000047683716},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pancreatic-polypeptide","display_name":"pancreatic polypeptide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":1.0},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.7740594148635864},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.6474795937538147},{"id":"https://openalex.org/C2778108375","wikidata":"https://www.wikidata.org/wiki/Q246978","display_name":"Pancreatic polypeptide","level":4,"score":0.6179047226905823},{"id":"https://openalex.org/C2779960720","wikidata":"https://www.wikidata.org/wiki/Q668063","display_name":"Pancreatic duct","level":3,"score":0.6135104298591614},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.6116021871566772},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6091407537460327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5537214279174805},{"id":"https://openalex.org/C103395026","wikidata":"https://www.wikidata.org/wiki/Q5380231","display_name":"Enteroendocrine cell","level":4,"score":0.5296019315719604},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.5210970640182495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41840749979019165},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40138691663742065},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3862234354019165},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3228791058063507},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.308349072933197}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010191","descriptor_name":"Pancreatic Polypeptide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014185","descriptor_name":"Transplantation, Isogeneic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016332","descriptor_name":"Fetal Tissue Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019894","descriptor_name":"Peptide YY","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11856861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11856861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"Comparative Study"},{"id":"doi:10.6092/1590-8577/376","doi":"https://doi.org/10.6092/1590-8577/376","is_oa":true,"landing_page_url":"https://doi.org/10.6092/1590-8577/376","pdf_url":null,"source":{"id":"https://openalex.org/S7407050999","display_name":"Universit\u00e0 degli Studi di Napoli Federico II","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:51900997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11856861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.6092/1590-8577/376","doi":"https://doi.org/10.6092/1590-8577/376","is_oa":true,"landing_page_url":"https://doi.org/10.6092/1590-8577/376","pdf_url":null,"source":{"id":"https://openalex.org/S7407050999","display_name":"Universit\u00e0 degli Studi di Napoli Federico II","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W31419375","https://openalex.org/W149350379","https://openalex.org/W1578284790","https://openalex.org/W1603492810","https://openalex.org/W1883901605","https://openalex.org/W1964811394","https://openalex.org/W1980141995","https://openalex.org/W1981167264","https://openalex.org/W1983101319","https://openalex.org/W1986366743","https://openalex.org/W1999179141","https://openalex.org/W2033936238","https://openalex.org/W2034089358","https://openalex.org/W2035927942","https://openalex.org/W2039415807","https://openalex.org/W2041088020","https://openalex.org/W2047316432","https://openalex.org/W2060623164","https://openalex.org/W2066077230","https://openalex.org/W2067389522","https://openalex.org/W2073121299","https://openalex.org/W2077141115","https://openalex.org/W2083329553","https://openalex.org/W2085870340","https://openalex.org/W2095687538","https://openalex.org/W2119798950","https://openalex.org/W2134955932","https://openalex.org/W2135610711","https://openalex.org/W2156116934","https://openalex.org/W2163232298","https://openalex.org/W2171814352","https://openalex.org/W2172252610","https://openalex.org/W2181937449","https://openalex.org/W2415438047","https://openalex.org/W2415579818"],"related_works":["https://openalex.org/W149350379","https://openalex.org/W238197410","https://openalex.org/W2412898848","https://openalex.org/W2181937449","https://openalex.org/W2290174710","https://openalex.org/W1981167264","https://openalex.org/W2067389522","https://openalex.org/W2049072441","https://openalex.org/W2018833949","https://openalex.org/W2089100818"],"abstract_inverted_index":{"CONTEXT:":[0],"Ligation":[1],"of":[2,48,66,145,154,176,209,232,245],"the":[3,11,46,93,143,149,182,213,230,243],"pancreatic":[4,124,165,226],"duct,":[5],"distally":[6],"to":[7,17,29,32,81,90,191,241],"its":[8],"confluence":[9],"into":[10],"bile":[12],"duct":[13,49,59,227],"has":[14,206],"been":[15],"shown":[16],"induce":[18],"endocrine":[19,24,151,156,178,234],"tissue":[20,25,157,211,235],"regeneration.":[21],"The":[22],"surplus":[23,233],"formed":[26],"is":[27,41],"presumed":[28],"be":[30,240],"able":[31],"replace":[33],"pathologically":[34],"and/or":[35],"experimentally":[36],"compromised":[37],"tissue.":[38,253],"OBJECTIVE:":[39],"This":[40],"a":[42,108,249],"quantitative":[43],"study":[44],"on":[45,63,107],"histology":[47],"ligated":[50,246],"pancreas":[51,94,247],"employing":[52],"immunocytochemistry":[53],"and":[54,85,97,117,126,134,142,167,173,198,219,222],"computerised":[55],"morphometry.":[56],"INTERVENTIONS:":[57],"Pancreatic":[58],"ligation":[60,84,228],"was":[61,137],"performed":[62],"25":[64],"groups":[65],"six":[67],"normal":[68,221],"Sprague-Dawley":[69],"rats.":[70,224],"Experimental":[71],"animals":[72],"were":[73,105,193],"sacrificed":[74],"at":[75],"12-hour":[76],"intervals":[77],"from":[78],"day":[79,91,186],"one":[80],"ten":[82],"post-duct":[83],"every":[86],"24":[87],"hours":[88],"thereafter":[89],"14,":[92],"removed,":[95],"fixed":[96],"processed.":[98],"Six":[99],"consecutive":[100],"3-6":[101],"micron":[102],"serial":[103],"sections":[104],"cut":[106],"rotary":[109],"hand":[110],"microtome,":[111],"floated":[112],"onto":[113],"3-aminopropyl-trimethoxysilan":[114],"coated":[115],"slides":[116],"alternatively":[118],"immunocytochemically":[119],"stained":[120],"for":[121,148,251],"insulin,":[122],"glucagon,":[123],"polypeptide":[125],"somatostatin.":[127],"RESULTS:":[128],"Pancreas":[129],"transformation":[130],"between":[131],"days":[132],"1/2":[133,136],"3":[135,187],"characterised":[138,194],"by":[139,164,185,195],"acinar":[140],"deletion":[141,172],"appearance":[144,175],"immunoreactive":[146],"cells":[147,162],"primary":[150],"hormones.":[152],"Transdifferentiation":[153],"existing":[155],"saw":[158],"islet":[159,199],"insulin":[160],"core":[161],"replaced":[163],"polypeptide-":[166],"somatostatin":[168],"positive":[169],"cells,":[170],"glucagon":[171],"random":[174],"all":[177],"cell":[179],"types":[180],"within":[181],"inter-islet":[183],"interstitium":[184],"1/2.":[188],"Days":[189],"4":[190],"14":[192],"cellular":[196],"migration":[197],"reconstruction.":[200],"CONCLUSIONS:":[201],"To":[202],"date":[203],"our":[204,236],"laboratory":[205],"investigated":[207],"transplantation":[208],"foetal":[210,252],"beneath":[212],"renal":[214],"capsule":[215],"in":[216],"syngeneic,":[217],"isogeneic":[218],"allogeneic":[220],"diabetic":[223],"As":[225],"induces":[229],"development":[231],"next":[237],"step":[238],"would":[239],"investigate":[242],"use":[244],"as":[248],"replacement":[250]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}