{"id":"https://openalex.org/W51555640","doi":"https://doi.org/10.1016/s0531-5565(99)00010-8","title":"The mitochondrial theory of aging:","display_name":"The mitochondrial theory of aging:","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W51555640","doi":"https://doi.org/10.1016/s0531-5565(99)00010-8","mag":"51555640","pmid":"https://pubmed.ncbi.nlm.nih.gov/10530787"},"language":"en","primary_location":{"id":"doi:10.1016/s0531-5565(99)00010-8","doi":"https://doi.org/10.1016/s0531-5565(99)00010-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0531-5565(99)00010-8","pdf_url":null,"source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111817663","display_name":"David Gershon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"David Gershon","raw_affiliation_strings":["Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel. dgershon@tx.technion.ac.il","Dept of Biology, Technion\u2010Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel. dgershon@tx.technion.ac.il","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Dept of Biology, Technion\u2010Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111817663"],"corresponding_institution_ids":["https://openalex.org/I174306211"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.7661,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.64798866,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"34","issue":"5","first_page":"613","last_page":"619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.13210000097751617,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-theory-of-aging","display_name":"mitochondrial theory of aging","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitochondrial-damage","display_name":"mitochondrial damage","score":0.9750000238418579},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.847000002861023},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.8799999952316284},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6359999775886536},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mitochondrial-degradation","display_name":"mitochondrial degradation","score":0.6000000238418579},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.8198081254959106},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.6511950492858887},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5085612535476685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5082123279571533},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.49633246660232544},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.49428367614746094},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.47191742062568665},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46895068883895874},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3685426414012909},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2612378001213074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23539921641349792}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0531-5565(99)00010-8","doi":"https://doi.org/10.1016/s0531-5565(99)00010-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0531-5565(99)00010-8","pdf_url":null,"source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},{"id":"pmid:10530787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10530787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental gerontology","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1576953405","https://openalex.org/W1834837759","https://openalex.org/W1979279686","https://openalex.org/W1984630129","https://openalex.org/W1991221089","https://openalex.org/W2056620406","https://openalex.org/W2075987767","https://openalex.org/W2098992864","https://openalex.org/W2113999599","https://openalex.org/W2154812708","https://openalex.org/W2317370642","https://openalex.org/W2416297360","https://openalex.org/W2462855682","https://openalex.org/W2615749116"],"related_works":["https://openalex.org/W1984630129","https://openalex.org/W1487703397","https://openalex.org/W2045159593","https://openalex.org/W2056293291","https://openalex.org/W1992712867","https://openalex.org/W1494360569","https://openalex.org/W2125443686","https://openalex.org/W95332934","https://openalex.org/W2016344840","https://openalex.org/W1974407610"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}