{"id":"https://openalex.org/W51543430","doi":null,"title":"Antioxidant vitamins (A, C and E) and malondialdehyde levels in acute exacerbation and stable periods of patients with chronic obstructive pulmonary disease.","display_name":"Antioxidant vitamins (A, C and E) and malondialdehyde levels in acute exacerbation and stable periods of patients with chronic obstructive pulmonary disease.","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W51543430","mag":"51543430","pmid":"https://pubmed.ncbi.nlm.nih.gov/15305803"},"language":"en","primary_location":{"id":"pmid:15305803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15305803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and investigative medicine. Medecine clinique et experimentale","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11508/48274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107247440","display_name":"Tuncer Tu\u011f","orcid":"https://orcid.org/0000-0003-2622-5104","observed_orcids":["https://orcid.org/0000-0003-2622-5104"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tuncer Tug","raw_affiliation_strings":["Department of Chest Diseases, Faculty of Medicine, Firat University, Elazig, Turkey. tugtuncer@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Diseases, Faculty of Medicine, Firat University, Elazig, Turkey. tugtuncer@hotmail.com","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027051556","display_name":"Fikret Karata\u015f","orcid":"https://orcid.org/0000-0002-0884-027X","observed_orcids":["https://orcid.org/0000-0002-0884-027X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fikret Karatas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011564558","display_name":"Selim Murat Terzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Selim Murat Terzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.202,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.91731108,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"3","first_page":"123","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.17829999327659607,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":1.0},{"id":"https://openalex.org/keywords/acute-exacerbation","display_name":"acute exacerbation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/antioxidant-vitamins","display_name":"antioxidant vitamins","score":0.7870000004768372},{"id":"https://openalex.org/keywords/vitamin-a","display_name":"vitamin A","score":0.996999979019165},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.996999979019165},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":1.0},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.996999979019165},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9929999709129333},{"id":"https://openalex.org/keywords/serum-vitamin-levels","display_name":"serum vitamin levels","score":0.7990000247955322},{"id":"https://openalex.org/keywords/stable-period","display_name":"stable period","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.843457818031311},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.705562174320221},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.7017883062362671},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5534970164299011},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.4836381673812866},{"id":"https://openalex.org/C2993539680","wikidata":"https://www.wikidata.org/wiki/Q902552","display_name":"Antioxidant capacity","level":3,"score":0.4139351546764374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23806533217430115},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.15252909064292908},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06457710266113281},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.05581125617027283}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001784","descriptor_name":"Blood Gas Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008176","descriptor_name":"Lung Volume Measurements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15305803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15305803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and investigative medicine. Medecine clinique et experimentale","raw_type":"Clinical Trial"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/48274","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/48274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:51543430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15305803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:openaccess.firat.edu.tr:11508/48274","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/48274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965810224","https://openalex.org/W2060429277","https://openalex.org/W2100662719","https://openalex.org/W3173840038","https://openalex.org/W87493875","https://openalex.org/W7113700921","https://openalex.org/W3029691891","https://openalex.org/W2046151033","https://openalex.org/W1530761041","https://openalex.org/W2181970470"],"abstract_inverted_index":{"BACKGROUND:":[0],"People":[1],"with":[2,57,90,106,224],"chronic":[3],"obstructive":[4],"pulmonary":[5],"disease":[6],"(COPD)":[7],"undergo":[8,226],"oxidative":[9,228],"damage":[10],"during":[11,45,87,117,131,230,246],"exacerbations":[12,47,231],"that":[13,138,251],"continues":[14],"in":[15,28,43,68,95,115,166,190,213,233,262],"stable":[16,49,88,132,234],"periods,":[17,133,235],"gradually":[18],"contributing":[19],"to":[20,126],"pathogenesis.":[21],"Since":[22],"serum":[23,237],"concentrations":[24,42,72,238],"of":[25,73,139,239,254,267,271],"antioxidant":[26,37,240],"vitamins":[27,74,241,255],"COPD":[29,58,225],"patients":[30,44,56,116,223],"have":[31],"been":[32],"little":[33],"investigated,":[34],"we":[35],"studied":[36],"vitamin":[38,112,147,175],"and":[39,48,77,79,86,94,154,182,198,205,232,243,257,265],"lipid":[40],"peroxidation":[41],"acute":[46,69,118,153,181,204],"periods.":[50],"METHODS:":[51],"We":[52],"prospectively":[53],"recruited":[54],"24":[55],"(mean":[59,99],"age":[60,100],"51.8":[61],"yr,":[62],"standard":[63],"deviation":[64],"[SD]":[65],"6.7":[66],"yr)":[67,105],"exacerbation.":[70],"Serum":[71],"A,":[75],"C":[76],"E":[78,244,258],"malondialdehyde":[80],"(MDA)":[81],"were":[82],"determined":[83],"before":[84],"treatment":[85,266],"periods":[89],"high-performance":[91],"liquid":[92],"chromatography,":[93],"23":[96],"healthy":[97],"controls":[98,140,167,191,214],"48.0":[101],"yr;":[102],"SD":[103],"5.9":[104],"established":[107],"methods.":[108],"RESULTS:":[109],"The":[110],"mean":[111,164],"A":[113,242,256],"level":[114,165],"exacerbation":[119],"was":[120],"0.8":[121],"(SD":[122,128,150,156,178,184,201,207],"0.2)":[123,129],"microg/mL,":[124],"rising":[125],"1.0":[127],"microg/mL":[130,152,180],"both":[134,187,210],"significantly":[135,160],"less":[136],"than":[137,189,212],"(1.0":[141],"[SD":[142,169,193,216],"0.2]":[143,217],"microg/mL;":[144,171,195],"p":[145,172,196],"<0.01);":[146,197],"C,":[148],"5.0":[149],"2.2)":[151],"7.5":[155],"2.7)":[157],"stable,":[158,186,209],"neither":[159],"differing":[161],"from":[162],"the":[163,252,263,268],"(8.6":[168],"1.8]":[170],">":[173],"0.05);":[174],"E,":[176],"10.0":[177],"2.4)":[179],"11.1":[183],"2.6)":[185],"lower":[188],"(11.0":[192],"2.86]":[194],"MDA,":[199],"2.4":[200],"0.7)":[202],"nmol/mL":[203],"1.2":[206],"0.4)":[208],"higher":[211],"(0.9":[215],"nmol/mL;":[218],"p<":[219],"0.01).":[220],"CONCLUSIONS:":[221],"Whereas":[222],"increased":[227],"stress":[229],"their":[236],"decrease":[245],"exacerbations.":[247],"Our":[248],"findings":[249],"suggest":[250],"administration":[253],"may":[259],"be":[260],"beneficial":[261],"prevention":[264],"harmful":[269],"effects":[270],"COPD.":[272]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}